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22. 发明专利

GB0116786D0 Plastic floor board 未知
公开(公告)号：GB0116786D0
公开(公告)日：2001-08-29
申请号：GB0116786
申请日：2001-07-10
申请人： KAY DAVID A , SHORT JAMES G

23. 发明专利

ES88488A1 Un generador de vapor. 未知
公开(公告)号：ES88488A1
公开(公告)日：1924-07-01
申请号：ES88488
申请日：1924-02-25
申请人： BRUNLER ANTON OSCAR , MAC KAY DAVID MACPHERSON

24. 发明申请

WO2013126966A1 A WALK-IN SHOWER AND TEMPORARY BATH 审中-公开
标题翻译：一个WALK-IN淋浴和临时浴
公开(公告)号：WO2013126966A1
公开(公告)日：2013-09-06
申请号：PCT/AU2013/000193
申请日：2013-03-01
申请人： DESIGN ENTERPRISES LIMITED , KAY, David Roy
发明人： KAY, David Roy
IPC分类号： A47K3/20 , A47K3/14
CPC分类号： A47K3/30 , A47K3/006 , A47K3/007 , A47K3/022 , A47K3/14 , A47K3/20 , A47K3/282 , A47K3/34 , A47K3/36 , A47K3/362 , A47K3/405 , A47K4/00
摘要： A walk-in shower having at least one fixed wall portion and a deployable wall portion operable in at least two configurations, namely a first shower configuration in which the deployable wall portion is located adjacent to one of the at least three wall portions leaving a walk in open entry and exit from the shower and a second bath configuration in which the deployable wall portion is located to close and seal the open entry and exit with movement of the deployable wall creating a bath enclosure to hold a volume of liquid at least temporarily.
摘要翻译：具有至少一个固定壁部分和可展开壁部分的步入式淋浴器，其可操作至少两种构造，即第一淋浴结构，其中可展开的壁部分位于与所述至少三个壁部分中的一个相邻的位置上，以进行步行在打开进入和离开淋浴器以及第二浴室构造中，可展开的壁部分位于其中，以便通过可部署壁的移动来关闭和密封打开的入口和出口，从而形成浴室，以至少暂时保持一定体积的液体。

25. 发明申请

WO2012138938A1 AMINOPYRAZINE COMPOUNDS USEFUL AS INHIBITORS OF TRA KINASE 审中-公开
标题翻译：氨基亚氨基化合物有用作TRA激酶的抑制剂
公开(公告)号：WO2012138938A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/032438
申请日：2012-04-05
申请人： VERTEX PHARMACEUTICALS INCORPORATED , CHARRIER, Jean-Damien , MACCORMICK, Somhairle , STORCK, Pierre-Henri , PINDER, Joanne , O'DONNELL, Michael, Edward , KNEGTEL, Ronald Marcellus, Alphonsus , YOUNG, Stephen, Clinton Young , KAY, David , REAPER, Philip, Michael , DURRANT, Steven, John , TWIN, Heather, Clare , DAVIS, Christopher, John
发明人： CHARRIER, Jean-Damien , MACCORMICK, Somhairle , STORCK, Pierre-Henri , PINDER, Joanne , O'DONNELL, Michael, Edward , KNEGTEL, Ronald Marcellus, Alphonsus , YOUNG, Stephen, Clinton Young , KAY, David , REAPER, Philip, Michael , DURRANT, Steven, John , TWIN, Heather, Clare , DAVIS, Christopher, John
IPC分类号： C07D413/14 , A61K31/497 , A61P35/00
CPC分类号： C07D413/14 , A61K31/497 , A61K31/501 , A61K31/5377 , A61K31/55 , A61K31/555 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K45/06 , C07D453/00 , C07D453/02 , C07D495/04 , A61K2300/00
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I): wherein the variables are as defined herein.
摘要翻译：本发明涉及可用作ATR蛋白激酶抑制剂的化合物。本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。本发明的化合物具有式（I）：其中变量如本文所定义。

26. 发明申请

WO2012048024A1 GATE VALVE 审中-公开
标题翻译：闸阀
公开(公告)号：WO2012048024A1
公开(公告)日：2012-04-12
申请号：PCT/US2011/054958
申请日：2011-10-05
申请人： NATIONAL OILWELL VARCO, L.P. , DHAWAN, Samir , WHALEY, Jason Neal , KAY, David , KENNEDY, Neil Colin , WEAVER, Randall Ferrain
发明人： DHAWAN, Samir , WHALEY, Jason Neal , KAY, David , KENNEDY, Neil Colin , WEAVER, Randall Ferrain
IPC分类号： F16K3/02 , F16K3/20
CPC分类号： F16K3/0236 , F16K3/0209 , F16K3/20
摘要： A gate valve comprises a valve body having an internal working fluid passage with a longitudinal axis and an internal gate chamber extending transverse to the working fluid passage. In addition, the gate valve comprises a gate disposed in the internal gate chamber and movable within the gate chamber between a closed position obstructing fluid flow through the working fluid passage and an open position allowing fluid flow through the working fluid passage. Further, the gate valve comprises an internal sealing arrangement coaxially disposed in the working fluid passage and extending between the valve body and the gate to form a barrier between the internal working fluid passage and internal gate chamber. Still further, the gate valve comprises an internal venting passage extending from the internal gate chamber to the internal working fluid passage for selective venting of fluid pressure from the internal gate chamber to the internal working fluid passage.
摘要翻译：闸阀包括具有纵向轴线的内部工作流体通道和横向于工作流体通道延伸的内部门室的阀体。此外，闸阀包括设置在内部门室中的门，并且可在门室内在阻塞流过工作流体通道的流体的关闭位置和允许流体流过工作流体通道的打开位置之间移动。此外，闸阀包括同轴地设置在工作流体通道中并且在阀体和门之间延伸的内部密封装置，以在内部工作流体通道和内部门室之间形成屏障。此外，闸阀包括从内部门室延伸到内部工作流体通道的内部通气通道，用于将流体压力从内部门室选择性地排放到内部工作流体通道。

27. 发明申请

WO2011038185A2 METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：用于制备作为蛋白激酶抑制剂有用的吡啶衍生物的方法
公开(公告)号：WO2011038185A2
公开(公告)日：2011-03-31
申请号：PCT/US2010/050132
申请日：2010-09-24
申请人： VERTEX PHARMACEUTICALS INCORPORATED , CHARRIER, Jean-Damien , DURRANT, Steven , KAY, David
发明人： CHARRIER, Jean-Damien , DURRANT, Steven , KAY, David
IPC分类号： C07D487/14
CPC分类号： C07D487/14
摘要： A method of preparing a compound represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and claims, comprises the step of: a) cyclizing a compound represented by Structural Formula (A) under suitable reductive cyclisation conditions to form a compound represented by Structural Formula (B) wherein R 10 is LG 1 or -X 1 R 1 , and -LG 1 is a suitable leaving group; and b) optionally, when R 10 of Structural Formula (B) is LG 1 , further comprising the step of replacing the -LG 1 of Structural Formula (B) with -X 1 R 1 to form the compound represented by Structural Formula (I).
摘要翻译：一种制备由结构式（I）表示的化合物或其药学上可接受的盐的方法，其中结构式（I）的变量如说明书和权利要求书中所述，包括以下步骤：a）使代表的化合物通过结构式（A）在合适的还原环化条件下形成由结构式（B）表示的化合物，其中R 10是LG1或-X1R1，-LG1是合适的离去基团; 和b）任选地，当结构式（B）的R 10是LG 1时，还包括用-X1R1替代结构式（B）的-LG1以形成由结构式（I）表示的化合物的步骤。

28. 发明申请

WO2011005327A1 OSTEOTOMY PLATE, PLATE DRIVER AND METHOD FOR THEIR USE 审中-公开
标题翻译： OSTEOTOMY板，板驱动器及其使用方法
公开(公告)号：WO2011005327A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/001936
申请日：2010-07-09
申请人： ORTHOHELIX SURGICAL DESIGNS, INC. , JOHNSON, Jeffrey , KAY, David B. , HEAVENER, Jackson R.
发明人： JOHNSON, Jeffrey , KAY, David B. , HEAVENER, Jackson R.
IPC分类号： A61B17/56
CPC分类号： A61B17/8014 , A61B17/1728 , A61B17/1775 , A61B17/1782 , A61B17/8052 , A61B17/8057 , A61B17/8061 , A61B17/808 , A61B17/809 , A61B17/8605 , A61B17/92
摘要： An orthopedic plate is specifically configured for use in osteotomies, in which part of the plate extends into a portion of a first bone segment and part is external to the cortical surface of an adjacent bone segment to fix the segments to allow them to fuse. The plate has a first end and a second end where the end which is inserted into the bone has a chamfer and a through hole having a hole axis optionally at an oblique angle to the longitudinal axis of the plate, and which can receive a screw, peg or pin. The second end of the plate includes a locking screw hole and optionally including a compression slot extending in a direction toward a screw hole in the opposing end. A plate driver having a recess that holds the plate is used to insert the plate into the bone.
摘要翻译：矫形板被特别地构造用于截骨术，其中板的一部分延伸到第一骨段的一部分中，并且部分在相邻骨段的皮质表面的外部，以固定段以允许它们熔合。板具有第一端和第二端，其中插入骨头的端部具有倒角和通孔，该孔具有任选地与板的纵向轴线成倾斜角的孔轴，并且其可以容纳螺钉，钉或针。板的第二端包括锁定螺钉孔，并且可选地包括在朝向相对端的螺钉孔的方向上延伸的压缩槽。使用具有保持板的凹部的板驱动器将板插入骨中。

29. 发明申请

WO2010054398A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 审中-公开
标题翻译：化合物作为ATR激酶的抑制剂有用
公开(公告)号：WO2010054398A1
公开(公告)日：2010-05-14
申请号：PCT/US2009/063922
申请日：2009-11-10
申请人： VERTEX PHARMACEUTICALS INCORPORATED , CHARRIER, Jean-damien , DURRANT, Steven , KAY, David , O'DONNELL, Michael , KNEGTEL, Ronald , MACCORMICK, Somhairle , PINDER, Joanne , VIRANI, Anisa , YOUNG, Stephen , BINCH, Hayley , CLEVELAND, Thomas , FANNING, Lev, T.d. , HURLEY, Dennis , JOSHI, Pramod , SHETH, Urvi , SILINA, Alina
发明人： CHARRIER, Jean-damien , DURRANT, Steven , KAY, David , O'DONNELL, Michael , KNEGTEL, Ronald , MACCORMICK, Somhairle , PINDER, Joanne , VIRANI, Anisa , YOUNG, Stephen , BINCH, Hayley , CLEVELAND, Thomas , FANNING, Lev, T.d. , HURLEY, Dennis , JOSHI, Pramod , SHETH, Urvi , SILINA, Alina
IPC分类号： C07D401/04 , C07D403/04 , C07D413/04 , A61K31/4965 , A61P35/00
CPC分类号： C07D403/14 , A61K31/497 , A61K31/541 , A61K31/551 , A61K45/06 , C07D241/28 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/113
摘要： The present disclosure relates to pyrazine compounds of formula (I) wherein L, n, R 1 , and R 2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
摘要翻译：本公开涉及式（I）的吡嗪化合物，其中L，n，R 1和R 2如说明书中所述。这些化合物可用作ATR蛋白激酶的抑制剂。本公开还涉及包含本公开内容的化合物的药学上可接受的组合物; 使用本公开的化合物治疗各种疾病，病症和病症的方法; 制备本公开的化合物的方法; 用于制备本公开的化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。

30. 发明申请

WO2008076392A3 COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：化合物作为蛋白激酶抑制剂有用
公开(公告)号：WO2008076392A3
公开(公告)日：2008-08-07
申请号：PCT/US2007025688
申请日：2007-12-14
申请人： VERTEX PHARMA , CHARRIER JEAN DAMIEN , KAY DAVID , KNEGTEL RONALD
发明人： CHARRIER JEAN DAMIEN , KAY DAVID , KNEGTEL RONALD
IPC分类号： C07D475/12
CPC分类号： C07D475/00
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。本发明还提供了制备本发明化合物的方法。

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