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21. 发明申请

US20080166470A1 Enhanced Bonding Layers on Native Oxide Surfaces 有权
标题翻译：天然氧化物表面上增强的粘结层
公开(公告)号：US20080166470A1
公开(公告)日：2008-07-10
申请号：US11855847
申请日：2007-09-14
申请人： Jeffrey Schwartz , Michael Danahy , Michael Avaltroni , Jing Guo
发明人： Jeffrey Schwartz , Michael Danahy , Michael Avaltroni , Jing Guo
IPC分类号： A61L27/06
CPC分类号： B82Y30/00 , B05D1/185 , B82Y40/00 , C23C14/06
摘要： Process for forming a coated article by (a) depositing a layer of an omega functionalized organophosphorous compound on an oxide substrate; (b) heating the substrate of step (a) to a temperature sufficient to bond the omega functionalized organophosphorous compound to the oxide substrate; (c) depositing a separate layer onto the layer produced by step (b); and (d) bonding the layers produced by steps (b) and (c) through the omega functional group.
摘要翻译：通过（a）在氧化物基底上沉积Ω官能化的有机磷化合物层来形成涂覆制品的方法; （b）将步骤（a）的基底加热到足以将ω官能化的有机磷化合物键合到氧化物基底上的温度; （c）在由步骤（b）制备的层上沉积单独的层; 和（d）通过步骤（b）和（c）产生的层通过ω官能团键合。

22. 发明申请

US20080102918A1 System and method for playing a game of chance having a base game and a bonus game 审中-公开
标题翻译：用于玩基本游戏和奖励游戏的机会游戏的系统和方法
公开(公告)号：US20080102918A1
公开(公告)日：2008-05-01
申请号：US11976704
申请日：2007-10-26
申请人： Michael Campagno , Jeffrey Schwartz
发明人： Michael Campagno , Jeffrey Schwartz
IPC分类号： A63F9/24
CPC分类号： G07F17/3258 , G07F17/32
摘要： Embodiments of the invention include method and system for providing a bonus game of chance in conjunction with a plurality of base games of chance over a plurality of gaming locations. The bonus game is associated with a vault including a bonus prize and a secret combination of discrete elements. A player is qualified to participate in the bonus game upon meeting at least one winning criterion on the base game of chance. An input device is provided to be presented to the player, wherein the player inputs a guess at the secret combination. The player guess at the secret combination is then received through the input device and a determination is won as to whether the bonus prize is won based on the secret combination, the player guess, and a matching criteria associated with the secret combination.
摘要翻译：本发明的实施例包括用于在多个游戏位置结合多个机会的基本游戏提供机会的奖励游戏的方法和系统。奖金游戏与包括奖金奖金和离散元素的秘密组合的保险库相关联。一名玩家有资格参加奖金游戏，符合基本游戏机会的至少一项获胜标准。提供输入设备以呈现给玩家，其中玩家输入秘密组合的猜测。然后，通过输入装置接收玩家对秘密组合的猜测，并且基于秘密组合，玩家猜测以及与秘密组合相关联的匹配标准，赢得奖金奖金是否获胜。

23. 发明授权

US5608135A Process for decreasing chlorine content of chlorinated hydrocarbons 失效
标题翻译：降低氯代烃含量的方法
公开(公告)号：US5608135A
公开(公告)日：1997-03-04
申请号：US211983
申请日：1994-08-15
申请人： Jeffrey Schwartz , Yumin Liu
发明人： Jeffrey Schwartz , Yumin Liu
IPC分类号： A62D3/00 , A62D3/33 , A62D3/34 , A62D3/36 , A62D3/37 , A62D101/22 , B01D53/86 , C02F1/70 , C07C17/23 , C07C209/36 , C07C209/42 , C07G99/00 , C07C25/18 , C07C25/00
CPC分类号： A62D3/37 , A62D3/34 , B01D53/8662 , B01D53/8668 , C02F1/70 , C07C17/23 , C07C209/36 , C07C209/42 , A62D2101/22 , A62D2203/04
摘要： The chlorine content in a chlorinated hydrocarbon in the presence or absence of air and moisture can be reduced by bringing the chlorinated hydrocarbon into contact with a dechlorination reagent which comprises (i) a complex of a substantially nontoxic metal having at least two oxidation states and (ii) a reducing agent which reductively returns the complex from its second oxidation step to its first oxidation stage. A representative embodiment involves bis-(.eta..sup.5 -cyclopentadienyl)titanium dichloride and sodium tetrahydridoborate.
摘要翻译： PCT No.PCT / US93 / 03529 Sec。 371日期：1994年8月15日 102（e）日期1994年8月15日PCT提交1993年4月14日PCT公布。出版物WO93 / 21117 日期：1993年10月28日氯化烃中存在或不存在空气和水分的氯含量可以通过使氯化烃与脱氯试剂接触来降低，所述脱氯试剂包括（i）至少具有至少两种氧化态和（ii）还原剂，其将络合物从其第二氧化步骤还原至其第一氧化阶段。代表性的实施方案涉及双（（η）5-环戊二烯基）二氯化钛和四氢化硼酸钠。

24. 发明授权

US5345031A Reduction of aromatic halide content 失效
标题翻译：芳香卤化物含量的降低
公开(公告)号：US5345031A
公开(公告)日：1994-09-06
申请号：US136660
申请日：1993-10-14
申请人： Jeffrey Schwartz , Yumin Liu
发明人： Jeffrey Schwartz , Yumin Liu
IPC分类号： A62D3/00 , A62D3/34 , A62D3/36 , A62D3/37 , A62D101/22 , B01D53/86 , C02F1/70 , C07C17/23 , C07G99/00 , C07C1/26
CPC分类号： B01D53/8662 , A62D3/34 , A62D3/37 , B01D53/8668 , C02F1/70 , C07C17/23 , A62D2101/22
摘要： The halide content of halogenated aromatic hydrocarbons such as PCBs can be reduced by treatment with a reagent comprising (i) at least one complex of a transition metal of group 4 or 5 with a multidentate or unidentate organic or inorganic ligand and (ii) a reducing agent. The reaction is conducted in the presence of an aliphatic or aromatic amine, optionally in the presence of an inert organic solvent.
摘要翻译：卤代芳烃如PCBs的卤化物含量可以通过用包含（i）至少一种第4或5族的过渡金属配合物与多齿或无齿的有机或无机配体的复合物进行处理来降低，和（ii）还原代理商反应在脂族或芳族胺的存在下进行，任选在惰性有机溶剂的存在下进行。

25. 发明授权

US5132111A CRF analog conjugates 失效
标题翻译： CRF类似物共轭物
公开(公告)号：US5132111A
公开(公告)日：1992-07-21
申请号：US508258
申请日：1990-04-11
申请人： Wylie W. Vale, Jr. , Jean E. F. Rivier , Jeffrey Schwartz
发明人： Wylie W. Vale, Jr. , Jean E. F. Rivier , Jeffrey Schwartz
IPC分类号： C07K14/575
CPC分类号： C07K14/57509 , Y10S514/805 , Y10S530/807 , Y10S930/28
摘要： Agonists and antagonists of rCRF are disclosed that exhibit good binding affinity to CRF receptors. One exemplary agonist is: H-Ser-Gln-Glu-Pro-Pro-Ile-Ser- Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met- Ala-Arg-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg- Leu-Leu-Leu-Glu-Glu-Ala-NH.sub.2. In the agonists, one or more of the first five N-terminal residues may be deleted or may be substituted by a peptide up to 10 amino acids long. A number of other substitutions may also be made throughout the chain. Similar peptides which function as CRF antagonists are created by deleting the first 7, 8 or 9 N-terminal residues. These analogs are coupled to a cytotoxin, such as gelonin, by a dialdehyde or the like, e.g., glutaraldehyde. The conjugates may be used to eliminate CRF Target Cells, and thus to regulate secretion of ACTH, .beta.-lipotropin and the like. Such conjugates can also be administered to alleviate conditions associated with hyperactivity of the hypothalamus-pituitary adrenal axis as well as neoplastic diseases associated with tumors that express CRF receptor.
摘要翻译：公开了rCRF的激动剂和拮抗剂，其表现出对CRF受体的良好结合亲和力。一个示例性的激动剂是：H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met- -Arg-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2。在激动剂中，前5个N-末端残基中的一个或多个可以被缺失，或者可被长达10个氨基酸的肽取代。还可以在整个链中进行许多其它取代。作为CRF拮抗剂起作用的相似肽通过缺失第7,8或9个N-末端残基而产生。这些类似物通过二醛或类似物例如戊二醛与细胞毒素（例如gelonin）偶联。缀合物可用于消除CRF靶细胞，并因此调节ACTH，β-Lipotropin等的分泌。也可以施用这样的缀合物以减轻与下丘脑 - 垂体肾上腺轴的多动症相关的病症以及与表达CRF受体的肿瘤相关的肿瘤疾病。

26. 发明申请

US20120208758A1 COMPOSITION FOR THE ATTACHMENT OF IMPLANTS TO COLLAGEN OR OTHER COMPONENTS OF BIOLOGICAL TISSUE 有权
标题翻译：将植入物粘附到生物组织或其他组成部分的组合物
公开(公告)号：US20120208758A1
公开(公告)日：2012-08-16
申请号：US13353952
申请日：2012-01-19
申请人： Suzanne A. Maher , Jeffrey Schwartz , Axel Oscar Magnus Hook , Brooke Hageman Russell , Casey Marie Jones
发明人： Suzanne A. Maher , Jeffrey Schwartz , Axel Oscar Magnus Hook , Brooke Hageman Russell , Casey Marie Jones
IPC分类号： A61K38/36 , A61K38/39 , A61K38/02
CPC分类号： A61K38/39 , A61K38/17 , A61K38/18 , A61K38/36 , A61K47/64 , A61K47/6957
摘要： The present invention relates to a novel composition comprising an implant, scaffold or construct bound to a biological or chemical moiety. The bound moiety has the ability to bind to a component of the extracellular matrix of biological tissue, allowing the implant to be bound to the biological tissue in a short period of time after implantation. The invention also relates to the use and manufacture of this novel composition, as well as a novel use for the protein CNA.
摘要翻译：本发明涉及包含与生物或化学部分结合的植入物，支架或构建体的新型组合物。结合的部分具有结合生物组织的细胞外基质的组分的能力，允许植入物在植入后的短时间内结合生物组织。本发明还涉及这种新型组合物的使用和制备，以及蛋白质CNA的新用途。

27. 发明授权

US07931943B2 Enhanced bonding layers on native oxide surfaces 有权
标题翻译：在自然氧化物表面上增强粘结层
公开(公告)号：US07931943B2
公开(公告)日：2011-04-26
申请号：US11855847
申请日：2007-09-14
申请人： Jeffrey Schwartz , Michael Danahy , Michael Avaltroni , Jing Guo
发明人： Jeffrey Schwartz , Michael Danahy , Michael Avaltroni , Jing Guo
IPC分类号： B05D1/38
CPC分类号： B82Y30/00 , B05D1/185 , B82Y40/00 , C23C14/06
摘要： Process for forming a coated article by (a) depositing a layer of an omega functionalized organophosphorous compound on an oxide substrate; (b) heating the substrate of step (a) to a temperature sufficient to bond the omega functionalized organophosphorous compound to the oxide substrate; (c) depositing a separate layer onto the layer produced by step (b); and (d) bonding the layers produced by steps (b) and (c) through the omega functional group.
摘要翻译：通过（a）在氧化物基底上沉积Ω官能化的有机磷化合物层来形成涂覆制品的方法; （b）将步骤（a）的基底加热到足以将ω官能化的有机磷化合物键合到氧化物基底上的温度; （c）在由步骤（b）制备的层上沉积单独的层; 和（d）通过步骤（b）和（c）产生的层通过ω官能团键合。

28. 发明授权

US07815963B2 Enhanced bonding layers on titanium materials 有权
标题翻译：在钛材料上增强粘结层
公开(公告)号：US07815963B2
公开(公告)日：2010-10-19
申请号：US12115067
申请日：2008-05-05
申请人： Jeffrey Schwartz , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Ellen Gawalt
发明人： Jeffrey Schwartz , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Ellen Gawalt
IPC分类号： A61L6/083
CPC分类号： B05D1/185 , B82Y30/00 , B82Y40/00 , C23C14/06
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译：本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞粘附促进和增殖促进涂层的致密表面覆盖。

29. 发明申请

US20080206443A1 ENHANCED BONDING LAYERS ON TITANIUM MATERIALS 有权
标题翻译：钛金属材料的增强粘结层
公开(公告)号：US20080206443A1
公开(公告)日：2008-08-28
申请号：US12115067
申请日：2008-05-05
申请人： Jeffrey Schwartz , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Ellen S. Gawalt
发明人： Jeffrey Schwartz , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Ellen S. Gawalt
IPC分类号： A61L27/28 , B05D3/00
CPC分类号： B05D1/185 , B82Y30/00 , B82Y40/00 , C23C14/06
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译：本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞粘附促进和增殖促进涂层的致密表面覆盖。

30. 发明授权

US07396594B2 Carrier applied coating layers 有权
标题翻译：载体涂层
公开(公告)号：US07396594B2
公开(公告)日：2008-07-08
申请号：US10876294
申请日：2004-06-23
申请人： Jeffrey Schwartz , Michael J. Avaltroni , Michael P. Danahy , Brett M. Silverman
发明人： Jeffrey Schwartz , Michael J. Avaltroni , Michael P. Danahy , Brett M. Silverman
IPC分类号： B32B15/04 , B32B15/09 , B32B18/00 , B32B27/06 , B32B27/36
CPC分类号： C03C17/001 , B05D1/185 , B82Y30/00 , B82Y40/00 , C03C17/23 , C23C14/06 , C23C22/02 , C23C22/48 , Y10T428/12569 , Y10T428/12611 , Y10T428/31786
摘要： The present invention provides a process for providing on the surface of a substrate an adherent phorphorous acid-based coating layer, the method comprising contacting said surface with a carrier conveying a coating composition comprising an acid selected from the group consisting of phosphoroic acids, organo-phosphoric acids, phosphonic acids, and mixtures thereof, at a sufficient temperature and for a sufficient time to bond at least a portion of the acid in the compositon to the oxide surface.
摘要翻译：本发明提供了一种在基材的表面上提供粘附的基于磷酸的涂层的方法，所述方法包括使所述表面与输送包含选自以下的酸的涂料接触：载体：磷酸，有机 - 磷酸，膦酸及其混合物，在足够的温度下和足够的时间将组合物中的酸的至少一部分与氧化物表面结合。

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