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21. 发明申请

WO2013078257A3 IMPLANTABLE SOLID-LIQUIG DRUG DELIVERY APPARATUS, FORMULATIONS, AND METHODS OF USE 审中-公开
公开(公告)号：WO2013078257A3
公开(公告)日：2013-05-30
申请号：PCT/US2012/066161
申请日：2012-11-20
申请人： INCUBE LABS, INC , IMRAN, Mir
发明人： IMRAN, Mir
IPC分类号： A61M37/00 , A61M31/00 , A61M5/145
摘要： Embodiments provide apparatus and methods for delivering liquid form medication within the body wherein the medication is stored in solid form and then mixed with a liquid in an apparatus implanted within the body. One embodiment provides an implantable apparatus for in vivo delivery of medication comprising a housing including a reservoir, a store of solid form medication (SSM) and a pump. An SSM element is added to the reservoir along with fluid to form a medication solution comprising at least one drug. The medication solution is then delivered to a delivery site using a pumping means to pump solution from the reservoir through a delivery member such as catheter to a delivery site. Embodiments of the invention are particularly useful for delivering medication to a patient to treat a medical condition over an extended period of time without requiring the patient to take external medication.

22. 发明申请

WO2013078256A1 MYOCARDIAL DRUG DELIVERY APPARATUS AND METHODS 审中-公开
标题翻译： MYOCARDIAL DRUG DELIVERY装置和方法
公开(公告)号：WO2013078256A1
公开(公告)日：2013-05-30
申请号：PCT/US2012/066156
申请日：2012-11-20
申请人： INCUBE LABS, LLC , IMRAN, Mir , SPEHR, Paul
发明人： IMRAN, Mir , SPEHR, Paul
IPC分类号： A61M37/00 , A61M25/088 , A61M5/14
CPC分类号： A61M5/14 , A61B5/0422 , A61B5/4839 , A61B5/6852 , A61B5/6869 , A61M37/0069 , A61N1/362 , A61N1/3962
摘要： Embodiments provide apparatus and methods for delivering solid form drug (SFD) to various locations in the body. In one embodiment, the invention provides an apparatus for treatment of arrhythmia comprising a drug delivery member (DDM) coupled to a drug storage device (DSD). The DSD is configured to store and advance SFD (e.g., drug pellets) through the DDM to a target tissue site (TTS) in or on the heart. A drug advancement member may be used to advance the SFD through the DSD. A capture chamber (CC) may be coupled to the DDM. and is configured to be positioned on a heart surface and allow SFD to dissolve to deliver a drug solution to the heart. The DSD can be implanted subcutaneously e.g., in the pectoral area. Embodiments of the apparatus can be used to store and deliver SFD to the heart or other TTS over an extended period of years.
摘要翻译：实施例提供了将固体形式药物（SFD）递送到体内各个位置的装置和方法。在一个实施方案中，本发明提供了一种用于治疗心律失常的装置，其包括联接到药物储存装置（DSD）的药物递送构件（DDM）。 DSD被配置为将SFD（例如，药丸）通过DDM存储并提前到心脏中或心脏上的目标组织部位（TTS）。药物推进会员可用于通过DSD推进SFD。捕获室（CC）可以耦合到DDM。并且被配置为定位在心脏表面上并且允许SFD溶解以将药物溶液递送到心脏。 DSD可以皮下植入，例如在胸部区域。该装置的实施例可以用于在多年的延长时间内将SFD存储并传送到心脏或其他TTS。

23. 发明申请

WO2013025843A1 SYSTEM AND METHOD FOR THERMOELECTRIC ENERGY GENERATION 审中-公开
标题翻译：用于热电能生成的系统和方法
公开(公告)号：WO2013025843A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/051010
申请日：2012-08-15
申请人： INCUBE LABS, LLC , IMRAN, Mir , HARRISON, Matthew
发明人： IMRAN, Mir , HARRISON, Matthew
IPC分类号： H01L35/02 , H01L35/34
CPC分类号： F01K21/00 , H01L35/30 , H02J7/34
摘要： Embodiments of the invention provide methods and apparatus for using a controllable heat source to generate electricity. One embodiment provides an energy generation module comprising a controllable heat source, one or more jackets of thermoelectric devices, and heat conducting fluids surrounding or otherwise thermally coupled to the jackets. The energy generation module can be used to convert heat from a heat source such as a gas combustion chamber into electricity. Embodiments of the invention are particularly useful for generating electricity when electrical power is not existent, cost prohibitive or otherwise in short supply. The generated electricity can be used by the user, stored in an electrical storage battery or sold to a local or remote power grid.
摘要翻译：本发明的实施例提供了使用可控热源来发电的方法和装置。一个实施例提供了一种能量产生模块，其包括可控热源，一个或多个热电装置夹套，以及围绕或以其它方式热耦合到外套的导热流体。能量产生模块可用于将来自诸如气体燃烧室的热源的热量转换成电。本发明的实施例对于在不存在电力，成本过高或其他不足的情况下发电而特别有用。所产生的电力可由用户使用，存储在蓄电池中或出售给本地或远程电网。

24. 发明申请

WO2012161670A2 METHOD FOR TREATING DIABETES AND OTHER GLUCOSE REGULATION DISORDERS USING STEM CELLS 审中-公开
标题翻译：使用干细胞治疗糖尿病和其他葡萄糖调节性疾病的方法
公开(公告)号：WO2012161670A2
公开(公告)日：2012-11-29
申请号：PCT/US2011/000633
申请日：2011-04-07
申请人： INCUBE LABS, LLC , IMRAN, Mir
发明人： IMRAN, Mir
IPC分类号： A61K35/28 , A61K35/50 , A61K35/12 , A61P3/10 , A61P3/00
CPC分类号： C12N5/0679 , A61K35/38 , C12N2502/1352 , C12N2502/1358 , C12N2502/23 , C12N2506/1346 , C12N2506/1353

25. 发明申请

WO2012092628A3 PATCHES AND METHODS FOR THE TRANSDERMAL DELIVERY OF AGENTS TO TREAT HAIR LOSS 审中-公开
标题翻译：用于经皮递送代理以治疗毛发损伤的补丁和方法
公开(公告)号：WO2012092628A3
公开(公告)日：2012-09-27
申请号：PCT/US2012020116
申请日：2012-01-03
申请人： INCUBE LABS LLC , IMRAN MIR , MORGAN PHIL , HASHIM MIR , HARRIS JOEL
发明人： IMRAN MIR , MORGAN PHIL , HASHIM MIR , HARRIS JOEL
IPC分类号： A61K9/70 , A61P17/00 , A61P17/14
CPC分类号： A61K8/0208 , A61K8/19 , A61K9/0009 , A61K9/0021 , A61K9/7046 , A61K33/26 , A61K33/42 , A61K2800/83 , A61Q7/00
摘要： Embodiments of the invention provide patches for the transdermal delivery of compositions to treat an individual suffering from hair loss. Many embodiments provide an iontophoretic patch for the transdermal delivery hair growth stimulating agents for the treatment of hair loss by stimulating the growth of new hair in areas of the scalp exhibiting hair loss. The patch comprises an electrode and a reservoir containing a composition comprising iron containing compound, such as a chelated iron compound for the delivery of the therapeutically effective amount of iron. The patch can be shaped to be placed and remain on the head. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a hair growth stimulating agent such as a chelated iron compound, minoxidil and finasteride to the scalp and other areas exhibiting hair loss. Such methods can be used for re-growing hair, and/or preventing or slowing hair loss.
摘要翻译：本发明的实施方案提供了用于经皮递送组合物以治疗患有脱发的个体的贴剂。许多实施方案提供用于透皮递送生发刺激剂的离子电渗贴剂，用于通过刺激头发显示脱发的区域中的新发育物生长来治疗脱发。所述贴片包含电极和储存器，所述储存器含有包含含铁化合物的组合物，例如用于递送治疗有效量的铁的螯合铁化合物。贴片可以成形为放置并保留在头上。各种实施方案提供了使用离子电渗贴剂的实施方案的方法，用于将头发生长刺激剂例如螯合的铁化合物，米诺地尔和非那甾胺递送至头皮和其他显示脱发的区域。这种方法可用于重新生长头发，和/或预防或减缓脱发。

26. 发明申请

WO2012040254A2 DEVICE, SYSTEM AND METHOD FOR MONITORING AND COMMUNICATING BIOMETRIC DATA OF A DIVER 审中-公开
标题翻译：监测和传播潜水员生物统计数据的装置，系统和方法
公开(公告)号：WO2012040254A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052429
申请日：2011-09-20
申请人： INCUBE LABS, LLC , IMRAN, Mir
发明人： IMRAN, Mir
IPC分类号： A61B5/145 , A61B5/1455 , A61B5/02 , H04B7/24
CPC分类号： A61B5/14551 , A61B5/0002 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/02416 , A61B5/0816 , A61B5/6826 , A61B5/6831 , A61B5/7228 , A61B5/7278 , A61B5/7296 , A61B5/7405 , A61B5/746 , A61B2560/0214 , A61B2560/0242 , A61B2560/0247 , A61B2560/0252 , A61B2562/18 , B63B22/00 , B63B35/00 , B63B2035/007 , B63C11/02 , B63C11/26
摘要： A system and method for monitoring biometric data of a diver and signaling those data from a first communication device to other communication devices, e.g., those of other divers, on a ship or buoy. A signal generated from a device of the diver can generate a diver identifier, an indication of a stress state of the diver and the diver's location.
摘要翻译：用于监视潜水员的生物统计数据并将这些数据从第一通信设备发送到船舶或浮标上的其他通信设备（例如，其他潜水员的那些通信设备）的系统和方法。从潜水员的设备产生的信号可以生成潜水员标识符，潜水员的压力状态和潜水员的位置的指示。

27. 发明申请

WO2011112229A2 THERAPEUTIC AGENT PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG DELIVERY DEVICE 审中-公开
标题翻译：使用易于使用的药物递送装置将治疗剂用于输送入真菌感染物的制剂
公开(公告)号：WO2011112229A2
公开(公告)日：2011-09-15
申请号：PCT/US2010/062073
申请日：2010-12-23
申请人： INCUBE LABS, LLC , IMRAN, Mir A.
发明人： IMRAN, Mir A.
IPC分类号： A61K9/48 , A61K9/22 , A61K9/20 , A61K38/28 , A61P3/10
CPC分类号： A61K38/28 , A61K9/0097 , A61K9/4816 , A61M31/002
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to an actuator having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
摘要翻译：本发明的实施方案提供了可在胃肠道内递送药物和其它治疗剂的吞咽装置，制剂和方法。许多实施例提供了用于递送药剂的吞咽装置。具体实施方案提供了可吞咽的装置，例如用于将药物输送到肠壁或其它胃肠腔中的胶囊。实施方案还提供了各种药物制剂，其被配置为容纳在胶囊内，从胶囊进入肠壁并在壁内降解以释放药物以产生治疗效果。制剂可以联接到具有第一配置的致动器，其中制剂被包含在胶囊中，并且第二配置将制剂从胶囊推出到肠壁中。本发明的实施方案对于递送胃肠道内吸收不良，耐受和/或降解的药物特别有用。

28. 发明申请

WO2011005879A3 RING ELECTRODE ASSEMBLY AND APPLICATIONS THEREOF 审中-公开
标题翻译：环形电极组件及其应用
公开(公告)号：WO2011005879A3
公开(公告)日：2011-04-21
申请号：PCT/US2010041239
申请日：2010-07-07
申请人： INCUBE LABS LLC , IMRAN MIR
发明人： IMRAN MIR
IPC分类号： A61B5/04 , A61B5/0478 , A61B5/05
CPC分类号： A61N1/044 , A61N1/0428
摘要： A pair of electrodes having a concentric arrangement and a medium. One of the pair of electrodes known as the delivery electrode (typically the inner electrode), is coupled to an electrical current source. The other electrode, known as the floater electrode is electrically isolated from the delivery electrode. The medium is directly or otherwise electrically coupled to one of the electrodes.
摘要翻译：一对具有同心排列和介质的电极。称为输送电极（通常为内部电极）的一对电极之一耦合到电流源。称为浮子电极的另一电极与输送电极电隔离。介质直接或以其他方式电耦合到一个电极。

29. 发明申请

WO2011044175A2 PATCH AND PATCH ASSEMBLY FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF ACTIVE AGENTS FOR THERAPEUTIC AND MEDICINAL PURPOSES 审中-公开
标题翻译：用于治疗和药物用途的活性剂的静电转运的配对和分配组件
公开(公告)号：WO2011044175A2
公开(公告)日：2011-04-14
申请号：PCT/US2010051541
申请日：2010-10-05
申请人： INCUBE LABS LLC , IMRAN MIR
发明人： IMRAN MIR
IPC分类号： A61N1/30 , A61F13/02 , A61K9/70 , A61L15/44 , A61M35/00
CPC分类号： A61N1/30 , A61M37/00 , A61M2037/0007
摘要： Embodiments of the invention provide patch assemblies for iontophoretic transdermal delivery of therapeutic agents. An embodiment provides a patch assembly comprising a conformable patch for delivery of the agent and having a tissue contacting side including an adhesive. The housing has a bottom surface for engaging a non-tissue contacting side of the patch, a current source such as a battery and a controller for controlling the delivery of the agent. The housing has sufficient flexibility such that when it is engaged with the patch to form the patch assembly and the patch is adhered to a target site on the patient's skin, the assembly has sufficient flexibility to deform with movement of the patient's skin to remain sufficiently adhered to the skin over an extended period of time to transdermally deliver a desired dose of the agent. Embodiments of the assembly may used to deliver a variety of therapeutic agents.
摘要翻译：本发明的实施方案提供了用于治疗剂的离子电渗透皮递送的贴片组件。一个实施方案提供一种贴片组件，其包括用于递送药剂并具有包括粘合剂的组织接触侧的适形贴片。壳体具有用于接合贴片的非组织接触侧的底表面，诸如电池的电流源和用于控制药剂递送的控制器。外壳具有足够的灵活性，使得当其与贴片接合以形成贴片组件并且贴片粘附到患者皮肤上的目标部位时，该组件具有足够的柔性以随着患者皮肤的运动而变形以保持充分粘附在延长的时间段内向皮肤透皮递送所需剂量的试剂。该组件的实施方案可用于递送各种治疗剂。

30. 发明申请

WO2011005879A2 RING ELECTRODE ASSEMBLY AND APPLICATIONS THEREOF 审中-公开
标题翻译：环电极组件及其应用
公开(公告)号：WO2011005879A2
公开(公告)日：2011-01-13
申请号：PCT/US2010/041239
申请日：2010-07-07
申请人： INCUBE LABS, LLC , IMRAN, Mir
发明人： IMRAN, Mir
IPC分类号： A61B5/04 , A61B5/0478 , A61B5/05
CPC分类号： A61N1/044 , A61N1/0428
摘要： A pair of electrodes having a concentric arrangement and a medium. One of the pair of electrodes known as the delivery electrode (typically the inner electrode), is coupled to an electrical current source. The other electrode, known as the floater electrode is electrically isolated from the delivery electrode. The medium is directly or otherwise electrically coupled to one of the electrodes.
摘要翻译：一对具有同心排列和介质的电极。称为传送电极（通常为内部电极）的一对电极中的一个电极与电流源耦合。被称为浮动电极的另一电极与输送电极电隔离。介质直接或以其他方式电耦合到其中一个电极。

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