专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US5036074A Certain 2,4-dichloro-phenyl(loweralkylidene) pyridines having fungicidal activity 失效
标题翻译：某些具有杀真菌活性的2,4-二氯 - 苯基（低级亚烷基）吡啶
公开(公告)号：US5036074A
公开(公告)日：1991-07-30
申请号：US481264
申请日：1990-02-20
申请人： Hans P. Isenring , Beat Zehnder , Hugo Ziegler
发明人： Hans P. Isenring , Beat Zehnder , Hugo Ziegler
IPC分类号： A01N43/40 , C07D213/26 , C07D213/30 , C07D213/89 , C07F1/00
CPC分类号： C07D213/30 , A01N43/40 , C07D213/26 , C07D213/89 , C07F1/005
摘要： The invention concerns new pyridine derivatives of the formula ##STR1## wherein X signifies a group ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the significances given in the description, and their N-oxides, N-amino salts, copper complexes and acid addition salts, processes for the manufacture of these substances, fungicidal compositions which contain these substances as the active ingredient and the use of such substances and compositions for the control of fungi in agriculture and in horticulture.
摘要翻译：本发明涉及式（I）所示的新的吡啶衍生物，其中X表示基团（a）或（IMA）（b），R1，R2，R3，R4和R5具有说明书中给出的含义，它们的N-氧化物，N-氨基盐，铜络合物和酸加成盐，这些物质的制造方法，含有这些物质作为活性成分的杀真菌组合物，以及使用这些物质和组合物来控制农业中的真菌和园艺。

22. 发明申请

US20120129786A1 NOVEL COMPOSITION 有权
标题翻译：新组合
公开(公告)号：US20120129786A1
公开(公告)日：2012-05-24
申请号：US13264059
申请日：2010-04-23
申请人： Marc Heidl , Roman Wille , Hugo Ziegler
发明人： Marc Heidl , Roman Wille , Hugo Ziegler
IPC分类号： A61K8/64 , C01D15/04 , C01F11/24 , C01D3/04 , C01F5/30 , A61Q19/00 , C01G9/04
CPC分类号： C07K5/0815 , A61K8/19 , A61K8/64 , A61Q19/00 , A61Q19/06 , C07K5/1019
摘要： The present invention relates to compositions comprising a peptide with 2-12 amino acids substituted with a lipophilic moiety and a water soluble salt of an alkali, earth alkaline metal or transition metal. Furthermore, the invention relates to a container comprising such compositions. Additionally, the invention relates to the use of a water soluble salt of an alkali, earth alkaline metal or transition metal for reducing the adhesion of a peptide with 2-12 amino acids substituted with a lipophilic moiety to a surface.
摘要翻译：本发明涉及包含用亲脂性部分取代的2-12个氨基酸的肽和碱金属，碱土金属或过渡金属的水溶性盐的组合物。此外，本发明涉及包含这种组合物的容器。此外，本发明涉及碱，碱土金属或过渡金属的水溶性盐用于降低被亲脂性部分取代的2-12个氨基酸与表面的粘附的用途。

23. 发明申请

US20110177140A1 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE 审中-公开
标题翻译：用于化妆和/或皮肤用途的4-氨基苯甲酰胺
公开(公告)号：US20110177140A1
公开(公告)日：2011-07-21
申请号：US12674399
申请日：2007-08-31
申请人： Rainer Voegeli , Hugo Ziegler , Mathias Gempeler
发明人： Rainer Voegeli , Hugo Ziegler , Mathias Gempeler
IPC分类号： A61K8/64 , C07C311/18 , A61K8/66 , A61K38/48 , A61K38/06 , A61K38/08 , A61K8/65 , A61K38/38 , A61K38/18 , A61K38/30 , A61K38/19 , A61K38/46 , A61K38/44 , A61K8/97 , A61K8/14 , A61K8/11 , A61K8/73 , A61Q19/00 , A61P17/04 , A61P17/00 , A61Q19/08 , A61P17/10 , A61Q17/04
CPC分类号： A61K8/64 , A61K8/02 , A61K8/0208 , A61K8/0212 , A61K8/0229 , A61K8/042 , A61K8/046 , A61K2800/782 , A61K2800/872 , A61Q5/006 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/005 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： This invention relates to the use of 4-amidino benzylamine derivatives as cosmetic ingredients and to cosmetic compositions, as well as to non-therapeutic methods for the cosmetic treatment of the skin and the scalp. Said derivatives and compositions can be used as urokinase inhibitors to prevent and restore damage of the epidermal barrier. Barrier abnormalities and disruptions respectively are often the starting point of a dry skin state, of itching, of dandruff and of the perception of sensitive skin. These 4-amidino benzylamine derivatives can be used for topical skin and scalp care applications in form of creams, lotions, gels, shampoos and the like.
摘要翻译：本发明涉及4-脒基苄胺衍生物作为化妆品成分和化妆品组合物的用途，以及用于美容处理皮肤和头皮的非治疗方法。所述衍生物和组合物可用作尿激酶抑制剂以预防和恢复表皮屏障的损伤。障碍异常和破坏通常是干性皮肤状态，瘙痒，头皮屑和敏感皮肤感觉的起点。这些4-脒基苄胺衍生物可用于霜剂，洗剂，凝胶，洗发剂等形式的局部皮肤和头皮护理应用。

24. 发明授权

US07863417B2 Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure 有权
标题翻译：用于化妆品应用的三肽及其衍生物，以改善皮肤结构
公开(公告)号：US07863417B2
公开(公告)日：2011-01-04
申请号：US10555994
申请日：2004-05-07
申请人： Hugo Ziegler , Marc Heidl , Dominik Imfeld
发明人： Hugo Ziegler , Marc Heidl , Dominik Imfeld
IPC分类号： C07K5/08
CPC分类号： C07K7/08 , A61K8/64 , A61Q19/08
摘要： The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24) alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or —NH—; or XR5 with X═O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).
摘要翻译：本发明涉及对应于通式（I）的化合物及其化学上可接受的盐，其中：R 1表示H，-C（O）-R 6，-SO 2 -R 6或-C（O）-XR 6; R 2和R 4彼此独立地表示（CH 2）n -NH 2或（CH 2）3 -NHC（NH）NH 2; n等于1 4; R3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢，任选取代的（C 1 -C 24）烷基，任选取代的C 2 -C 24烯基，任选取代的苯基，任选取代的苯基-C 1 -C 4烷基或9-芴基 - 甲基; X表示氧（-O-）或-NH-; 或具有X = O的XR5也表示α-生育酚，生育三烯酚或视黄醇的酯，其条件是R1和R5不表示氢，X不同时代表氧。本发明还涉及通式（I）的化合物的生产和含有至少一种式（I）化合物的化妆品活性组合物。

25. 发明申请

US20090169608A1 TOPICALLY APPLICABLE COMPOSITION FOR USE AS A SKIN BLEACHING AGENT 审中-公开
标题翻译：用作皮肤漂白剂的主要适用组合物
公开(公告)号：US20090169608A1
公开(公告)日：2009-07-02
申请号：US12089654
申请日：2006-10-09
申请人： Hugo Ziegler , Peter Wikstroem , Martin Stockli
发明人： Hugo Ziegler , Peter Wikstroem , Martin Stockli
IPC分类号： A61K9/127 , C07C279/12 , A61K31/155 , A61K9/48 , A61K9/50 , A61K8/43
CPC分类号： A61Q19/02 , A61K8/46
摘要： Topical composition for use especially as a skin lightener, characterized in that it contains an effective amount of at least one compound of general formula (I) or a mixture of such compounds and/or an acid addition salt thereof: in which X is NH or a direct bond and n is 2, 3 or 4, preferably 2 or 3, and its use for lightening skin colour, for depigmenting liver spots and for evening out non-uniformities in skin colouration. The invention further relates to dermatologically effective compositions containing at least one disulfide of general formula (I) and at least one additional skin care ingredient.
摘要翻译：特别用作皮肤增亮剂的局部组合物，其特征在于其含有有效量的至少一种通式（I）化合物或这类化合物和/或其酸加成盐的混合物：其中X为NH或直接键合，n为2,3或4，优选2或3，其用于减轻皮肤颜色，用于褪色肝斑和褪色皮肤着色中的不均匀性。本发明还涉及含有至少一种通式（I）的二硫化物和至少一种另外的护肤成分的皮肤病学有效的组合物。

26. 发明申请

US20090155347A1 Cosmetic Composition for Stimulating the Synthesis of Proteins of the Basement Membrane 有权
标题翻译：用于刺激基底膜蛋白质合成的化妆品组合物
公开(公告)号：US20090155347A1
公开(公告)日：2009-06-18
申请号：US12226191
申请日：2006-04-28
申请人： Hugo Ziegler , Dominik Imfeld , Martin Stockli , Marc Heidl
发明人： Hugo Ziegler , Dominik Imfeld , Martin Stockli , Marc Heidl
IPC分类号： A61K9/127 , C07K5/09 , A61K38/06
CPC分类号： A61Q19/08 , A61K8/64 , C07K5/0815 , C07K5/1019
摘要： Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or aryl-C1-C4-alkyl, n is 1-4, X is —O—, —NH— or —NR2— and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR2— and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.
摘要翻译：可以局部施用的化妆品组合物，其包含至少一种通式（I）的化合物，其中R 1是H，C 1 -C 20 - 烷基，环烷基或芳基-C 1 -C 4 - 烷基，n是1-4，X是 -O - ， - NH-或-NR 2 - 和R 2 H或C 1 -C 20 - 烷基; 和至少一种对应于上述式（I）的化合物，但其中具有可能含义为-NH-的X的XR1为α-氨基酸的残基; 使用这些化合物和组合物刺激基底膜的蛋白质的合成; 以及其中X为-NR 2 - 且R 1和R 2不同于H的式（I）化合物以及对应于式（I）的化合物，但其中具有可能含义为-NH的X的XR1 - 是这样的α-氨基酸的残基。

27. 发明申请

US20070123706A1 Method for producing 3-amidinophenylalanine derivatives 有权
标题翻译：制备3-脒基苯丙氨酸衍生物的方法
公开(公告)号：US20070123706A1
公开(公告)日：2007-05-31
申请号：US11699228
申请日：2007-01-29
申请人： Hugo Ziegler , Peter Wikstroem
发明人： Hugo Ziegler , Peter Wikstroem
IPC分类号： A61K31/495 , C07C311/45
CPC分类号： C07D295/205 , C07D211/60
摘要： The present invention describes a method for the synthesis of enantiomerically pure 3-amidinophenylalanine derivatives, which are used as pharmaceutically effective urokinase inhibitors, by starting from 3-cyanophenylalanine derivatives. The methods of manufacture comprising only one synthesis step lead to new intermediates, namely 3-hydroxyamidino- and 3-amidrazonophenylalanine derivatives. These intermediates or their acetyl derivatives can be reduced into the desired 3-amidinophenylalanine derivatives under gentle conditions (H2 or ammonium formiate, Pd/C (approx. 10%), ethanol/water, room temperature, normal pressure or also H2, Pd/C, AcOH or HCl/ethanol, 1-3 bar) in excellent yields and in an enantiomeric excess of up to 99.9%.
摘要翻译：本发明描述了通过从3-氰基苯丙氨酸衍生物开始合成用作药物有效的尿激酶抑制剂的对映体纯的3-脒基苯丙氨酸衍生物的方法。仅包含一个合成步骤的制备方法导致新的中间体，即3-羟基脒基 - 和3-酰胺基苯丙氨酸衍生物。这些中间体或它们的乙酰基衍生物可以在温和条件（H 2 N 2或甲酸铵，Pd / C（约10％），乙醇/水，室温）下还原成所需的3-脒基苯丙氨酸衍生物，正常压力或者H 2 Cl 2，Pd / C，AcOH或HCl /乙醇，1-3巴），产率高，对映体过量高达99.9％。

28. 发明申请

US20050065090A1 Dermopharmaceutically and cosmetically active oligopeptides 有权
标题翻译：药物和化妆品活性寡肽
公开(公告)号：US20050065090A1
公开(公告)日：2005-03-24
申请号：US10493856
申请日：2002-10-30
申请人： Christian Ludin , Marc Heidl , Hugo Ziegler
发明人： Christian Ludin , Marc Heidl , Hugo Ziegler
IPC分类号： A61K38/00 , A61P17/00 , C07K5/068 , C07K14/78 , A61K38/08 , C07K7/06
CPC分类号： C07K14/78 , A61K38/00 , C07K5/06086
摘要： Oligopeptides and derivatives thereof, peptide analogs and derivatives thereof as well as pharmaceutically acceptable salts of these compounds, which correspond to general formula (I) wherein R1 represents H, —C(O)—R7, —SO2—R7, —C(O)—OR7 or —C(O)—N(R7)2 R2 represents, independent of one another, H or —(C1-C4)-alkyl, R3 and R6 represent, independent of one another, —(CH2)q—N(R1)R8 R4 and R5 represent, independent of one another, —CH2—OR2, —CH(CH3)OR8 or —CH2—CH2—OR8 R7 represents hydrogen, optionally substituted (C1-C19)-alkyl; optionally substituted (C1-C19)-alkenyl; phenyl-(C1-C4)-alkyl whose phenyl radical is optionally substituted with amino in the para position R8 represents H, —(C1-C4)-alkyl, —C(O)—R7, —C(O)—OR7, —C(O)—N(R7)2 or —SO2—R7 X represents oxygen (—O—) or —NH—; or XR7, with X=O, also represents the esters of α-tocopherol, tocotrienol or retinol or the carboxylic acid (with R7=H) m, n, p represent, independent of one another, zero or 1 and q in R3 and R6 represent, independent of one another, an integer from 1 to 4, with the provision that the following conditions do not simultaneously occur: R4=—CH(CH3)—OH and R5=—CH(CH3)—OH and R6=—(CH2)4—NH2; dermopharmaceutically and/or cosmetically active compositions containing at least one compound of formula (I).
摘要翻译：对应于通式（I）的寡肽及其衍生物，肽类似物及其衍生物以及这些化合物的药学上可接受的盐，其中R 1表示H，-C（O）-R 7，-SO 2 - R 7，-C（O）-OR 7或-C（O）-N（R 7）2 R 2彼此独立地表示H或 - （C 1 -C 4） - 烷基，R 3和R 6彼此独立地表示 - （CH 2）q N（R 1）R 8 R 4和R 5彼此独立地表示 - CH2-OR2，-CH（CH3）OR8或-CH2-CH2-OR8表示氢，任选取代的（C 1 -C 19） - 烷基; 任选取代的（C 1 -C 19） - 烯基; 苯基 - （C 1 -C 4） - 烷基，其苯基任选被对位R 8中的氨基取代，代表H， - （C 1 -C 4） - 烷基，-C（O）-R 7，-C （O）-OR 7，-C（O）-N（R 7）2或-SO 2 -R 7表示氧（-O-）或-NH-; 或XR 7，X = O也表示α-生育酚，生育三烯酚或视黄醇或羧酸（R 7 = H）m，n，p彼此独立地为0或 1和q在R 3和R 6中彼此独立地表示1至4的整数，条件是不同时发生以下条件：R 4 = -CH（CH 3） - OH和R 5 = -CH（CH 3）-OH，R 6 = - （CH 2）4 -NH 2; 含有至少一种药物的药物和/或化妆品活性组合物

29. 发明授权

US06486341B1 N-alkoxy-n-phenylcarbamate derivatives 失效
标题翻译： N-烷氧基 - 正 - 苯基氨基甲酸酯衍生物
公开(公告)号：US06486341B1
公开(公告)日：2002-11-26
申请号：US09889024
申请日：2001-07-10
申请人： Hugo Ziegler
发明人： Hugo Ziegler
IPC分类号： C07C26100
CPC分类号： C07C251/88
摘要： Compounds of formula (I) wherein R1 is C1-C4-alkyl or cyclopropyl; R2 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl; or C1-C6-alkyl substituted by 1 to 5 fluorine atoms; R3 is C1-C6-alkyl, C1-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkoxy, C2-C6-alkenyl, C2-C6-alkenyloxy, C2-C6-alkinyl, C2-C6-alkinyloxy, C1-C6-alkoxycarbonyl, CN, or aryl, heteroaryl, heterocyclyl, aryloxy, heteroaryloxy or heterocyclyloxy, whereby the above-mentioned groups may be substituted by identical of different substituents, R5 signifies hydrogen or methyl; R6 and R7 are C1-C4-alkyl; have microbicidal, insecticidal and acaricidal activity and may be used for the control of pests and plant-pathogenic fungi in agriculture, horticulture and in the field of hygiene.
摘要翻译：其中R1是C1-C4烷基或环丙基的式（Ⅰ）化合物; R2是C1-C6-烷基，C2-C6-烯基，C2-C6-炔基; 或被1至5个氟原子取代的C 1 -C 6烷基; R3是C1-C6-烷基，C1-C6-烷氧基，C3-C6-环烷基，C3-C6-环烷氧基，C2-C6-烯基，C2-C6-烯氧基，C2-C6-炔基，C2-C6-烷氧基， C 1 -C 6烷氧基羰基，CN或芳基，杂芳基，杂环基，芳氧基，杂芳氧基或杂环氧基，其中上述基团可以被相同的不同取代基取代，R 5表示氢或甲基; R6和R7是C1-C4-烷基; 具有杀菌，杀虫和杀螨活性，可用于控制农业，园艺和卫生领域的害虫和植物致病真菌。

30. 发明授权

US06436981B1 Dihydrotriazolone derivatives as pesticides 失效
标题翻译：二氢三唑酮衍生物作为农药
公开(公告)号：US06436981B1
公开(公告)日：2002-08-20
申请号：US09736694
申请日：2000-12-13
申请人： Hugo Ziegler
发明人： Hugo Ziegler
IPC分类号： A01N43653
CPC分类号： C07D401/12 , A01N43/653 , C07D249/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula 1 wherein: Y signifies halogen, C1-C4-alkoxy, C1-C4-alkylthio or hydroxy; R1 signifies methyl, ethyl or cyclopropyl; R2 signifies C1-C6-alkyl or C1-C6-alkyl substituted by 1 to 5 fluorine atoms; R3 is C1-C6-alkyl, C1-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkoxy, C2-C6-alkenyl, C2-C6-alkenyloxy, C2-C6-alkinyl, C2-C6-alkinyloxy, C1-C6-alkoxycarbonyl or CN, whereby, with the exception of CN, the above-mentioned groups may be substituted by identical or different substituents; or R3 is aryl, heteroaryl, heterocyclyl, aryloxy, heteroaryloxy or heterocyclyloxy, whereby the above-mentioned groups may be substituted by identical or different substituents, R5 signifies hydrogen or methyl; have microbicidal, insecticidal and acaricidal activity and may be used to control insects and plant-pathogenic fungi in agriculture, horticulture and in the field of hygiene.
摘要翻译：式1的化合物，其中Y表示卤素，C 1 -C 4 - 烷氧基，C 1 -C 4 - 烷硫基或羟基; R 1表示甲基，乙基或环丙基; R 2表示被1至5个氟取代的C 1 -C 6 - 烷基或C 1 -C 6烷基原子; R 3是C 1 -C 6烷基，C 1 -C 6 - 烷氧基，C 3 -C 6 - 环烷基，C 3 -C 6环烷氧基，C 2 -C 6 - 烯基，C 2 -C 6 - 烯氧基，C 2 -C 6 - 炔基，C 2 -C 6 - 烷氧基，C 1 -C 6烷氧基羰基或CN，其中除CN之外，上述基团可以被相同或不同的取代基取代; 或R 3为芳基，杂芳基，杂环基，芳氧基，杂芳氧基或杂环氧基，其中上述基团可被相同或不同的取代基取代，R 5表示氢或甲基; 具有杀菌，杀虫和杀螨活性，可用于控制农业，园艺和卫生领域的昆虫和植物致病真菌。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式