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21. 发明授权

US4567261A Preparation of riboflavin 失效
标题翻译：核黄素的制备
公开(公告)号：US4567261A
公开(公告)日：1986-01-28
申请号：US570457
申请日：1984-01-13
申请人： Hansgeorg Ernst , Wolfram Schmidt , Joachim Paust
发明人： Hansgeorg Ernst , Wolfram Schmidt , Joachim Paust
IPC分类号： C07D475/14 , C07D475/02
CPC分类号： C07D475/02
摘要： Riboflavin of the formula I ##STR1## is prepared by condensing a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline of the formula II ##STR2## where R is H or --Cl, --NO.sub.2 or --CH.sub.3 in the o- or p-position, with barbituric acid of the formula III ##STR3## in the presence of an acid as the condensing agent, by an improved process in which the acidic condensing agent used is an aliphatic or cycloaliphatic/aliphatic tertiary carboxylic acid of the general formula IV ##STR4## where R.sup.1, R.sup.2 and R.sup.3 are each a lower alkyl group, R.sup.1, R.sup.2 and R.sup.3 together containing 3 to 20, preferably 3 to 10, carbon atoms, or R.sup.1 is a lower alkyl group, in particular methyl, and R.sup.2 and R.sup.3 together form a tetramethylene or pentamethylene group.The process can be particularly advantageously carried out using trimethylacetic acid or a commercial mixture of saturated tertiary carboxylic acids, e.g. Versatic .sup.R 10-acid.
摘要翻译：式I（I）的核黄素通过将式II的4,5-二甲基-N-（D） - 二乙基苯基偶氮苯胺（II）缩合制备，其中R是H或-Cl ，在邻位或对位的-NO 2或-CH 3与通式III的巴比妥酸（III）在作为缩合剂的酸存在下，通过改进的方法，其中使用酸性缩合剂是通式IV（IV）的脂族或脂环族/脂肪族三羧酸，其中R 1，R 2和R 3各自为低级烷基，R 1，R 2和R 3一起含有3至20，优选3至10，碳原子，或R 1是低级烷基，特别是甲基，R 2和R 3一起形成四亚甲基或五亚甲基。该方法可以特别有利地使用三甲基乙酸或饱和叔羧酸的商业混合物，例如，通用R10酸。

22. 发明授权

US08673598B2 Microbial succinic acid producers and purification of succinic acid 有权
标题翻译：微生物琥珀酸生产商和琥珀酸的纯化
公开(公告)号：US08673598B2
公开(公告)日：2014-03-18
申请号：US13201547
申请日：2010-02-12
申请人： Hartwig Schroder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
发明人： Hartwig Schroder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
IPC分类号： C12N1/32 , C12P7/46 , C12P1/04 , C12P17/10 , C12P7/40
CPC分类号： C12P7/46 , C12N1/32 , C12N9/1029 , C12R1/01 , C12Y203/01054
摘要： The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
摘要翻译：本发明涉及能够利用甘油作为发酵生产琥珀酸的碳源的细菌菌株，其中所述菌株被遗传修饰，使得它们包含其内源性丙酮酸 - 甲酸裂解酶活性的失调，以及涉及通过利用这种微生物生产有机酸，特别是琥珀酸的方法。本发明还涉及通过阳离子交换层析对所生产的有机酸的下游加工。

23. 发明申请

US20110300589A1 Novel Microbial Succinic Acid Producers and Purification of Succinic Acid 有权
标题翻译：新型微生物琥珀酸生产商和琥珀酸的纯化
公开(公告)号：US20110300589A1
公开(公告)日：2011-12-08
申请号：US13201547
申请日：2010-02-12
申请人： Hartwig Schroder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
发明人： Hartwig Schroder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
IPC分类号： C12P7/46 , C12P1/04 , C12P17/04 , C12P17/10 , C12N1/20 , C12P7/40
CPC分类号： C12P7/46 , C12N1/32 , C12N9/1029 , C12R1/01 , C12Y203/01054
摘要： The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
摘要翻译：本发明涉及能够利用甘油作为发酵生产琥珀酸的碳源的细菌菌株，其中所述菌株被遗传修饰，使得它们包含其内源性丙酮酸 - 甲酸裂解酶活性的失调，以及涉及通过利用这种微生物生产有机酸，特别是琥珀酸的方法。本发明还涉及通过阳离子交换层析对所生产的有机酸的下游加工。

24. 发明申请

US20110196170A1 METHOD FOR PRODUCING ASTAXANTHIN DIMETHYLDISUCCINATE 有权
标题翻译：生产酪氨酸二甲酯的方法
公开(公告)号：US20110196170A1
公开(公告)日：2011-08-11
申请号：US13021173
申请日：2011-02-04
申请人： HANSGEORG ERNST , Walter Dobler , Andreas Keller , Klaus Henrich
发明人： HANSGEORG ERNST , Walter Dobler , Andreas Keller , Klaus Henrich
IPC分类号： C07C67/14
CPC分类号： C07C403/24 , C07C2601/16
摘要： The present invention relates to an improved method for producing all-E astaxanthin dimethyldisuccinate of the formula I.
摘要翻译：本发明涉及一种制备式I的全-E虾青素二甲基丁二酸酯的改进方法。

25. 发明申请

US20100041922A1 METHOD FOR THE ENANTIOSELECTIVE PRODUCTION OF OPTICALLY ACTIVE 4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-2-ENONE DERIVATIVES 审中-公开
标题翻译：光学活性4-羟基-2,6,6-三甲基环己酮-2-酮衍生物的选择性生产方法
公开(公告)号：US20100041922A1
公开(公告)日：2010-02-18
申请号：US12593466
申请日：2008-02-22
申请人： Rainer Stürmer , Hansgeorg Ernst
发明人： Rainer Stürmer , Hansgeorg Ernst
IPC分类号： C07C45/61
CPC分类号： C07C403/24 , C07B53/00 , C07C45/64 , C07C49/713
摘要： The present invention relates to a process for enantioselectively preparing optically active 4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-one derivatives of the formulae (I) or (Ia) and to a process for preparing (3S,3′S)-astaxanthin of the formula (III), comprising the process for preparing the compound of the formula (I).
摘要翻译：本发明涉及对映选择性制备式（I）或（Ia）的光学活性4-羟基-2,6,6-三甲基环己-2-烯-1-酮衍生物的方法和制备（3S ，3'S） - 式（III）的黄质黄素，包括制备式（I）化合物的方法。

26. 发明授权

US06743954B2 Process for the preparation of meso-zeaxanthin 失效
公开(公告)号：US06743954B2
公开(公告)日：2004-06-01
申请号：US10237807
申请日：2002-09-10
申请人： Hansgeorg Ernst , Klaus Henrich , Klaus Ditrich
发明人： Hansgeorg Ernst , Klaus Henrich , Klaus Ditrich
IPC分类号： C07C3518
CPC分类号： C07C403/24 , C07B2200/07 , C07C29/74 , C07C35/18 , C07C69/65 , C07C2601/14 , Y02P20/55 , C07C35/26
摘要： A process for the preparation of optically pure acetylenediols of the formulae R-I and S-I and their further reaction to give meso-zeaxanthin are described.

27. 发明授权

US5773635A Preparation of polyenecarbonyl compounds having a high content of the all-E isomer, and of their acetals or ketals 失效
标题翻译：具有全E异构体含量高的多烯羰基化合物及其缩醛或缩酮的制备
公开(公告)号：US5773635A
公开(公告)日：1998-06-30
申请号：US498840
申请日：1995-07-06
申请人： Walter Dobler , Wolfgang Krause , Joachim Paust , Otto Worz , Udo Rheude , Wolfram Burst , Gunter Dauwel , Armin Bertram , Bernhard Schulz , Gunter Wegner , Peter Munster , Hansgeorg Ernst , Arno Kochner , Heinz Etzrodt
发明人： Walter Dobler , Wolfgang Krause , Joachim Paust , Otto Worz , Udo Rheude , Wolfram Burst , Gunter Dauwel , Armin Bertram , Bernhard Schulz , Gunter Wegner , Peter Munster , Hansgeorg Ernst , Arno Kochner , Heinz Etzrodt
IPC分类号： C07C51/16 , C07C403/00 , C07C403/20
CPC分类号： C07C403/20 , C07C403/16 , C07B2200/09 , C07C2101/16
摘要： A process for preparing polyenecarbonyl compounds having a high all-E content and their acetals or ketals by aldol condensation or Horner-Emmons reaction comprises carrying out the reaction, for the purposes of the preferred formation of a double bond of E configuration and in order to maintain the E configuration of the double bonds in the stating compounds as completely as possible, in the presence of oxygen or an oxygen-inert gas mixture or nitric oxide or a nitric oxide-inert gas mixture and/or in the presence of specific stable radicals and/or in the presence of quinones or quinone derivatives.
摘要翻译：通过醛醇缩合或霍纳 - 埃蒙斯反应制备具有高全E含量的多元羰基化合物及其缩醛或缩酮的方法包括进行反应，为了优选形成E构型的双键，为了在氧气或氧惰性气体混合物或一氧化氮或一氧化氮惰性气体混合物的存在下和/或在特定的稳定基团的存在下，尽可能地完全地保持化合物中双键的E构型和/或在醌或醌衍生物的存在下。

28. 发明授权

US5625099A Preparation of astaxanthin, novel intermediates therefor and the preparation thereof 失效
标题翻译：虾青素的制备及其新型中间体及其制备方法
公开(公告)号：US5625099A
公开(公告)日：1997-04-29
申请号：US471314
申请日：1995-05-23
申请人： Hansgeorg Ernst , Walter Dobler , Joachim Paust , Udo Rheude
发明人： Hansgeorg Ernst , Walter Dobler , Joachim Paust , Udo Rheude
IPC分类号： C07C41/18 , C07C45/45 , C07C49/303 , C07C403/24 , C07D317/46 , C07D317/50 , C07D317/54 , C07D407/06 , C07D407/12 , C07F9/54 , C09B23/10
CPC分类号： C07C403/24 , C07C403/04 , C07C403/08 , C07C403/10 , C07D317/46 , C07F9/5435 , C07F9/5442 , C07C2101/16 , Y02P20/55
摘要： Abstract of the Disclosure: Compounds of the formula I ##STR1## where R.sup.1 is H or C.sub.1 -C.sub.4 -alkyl, R.sup.2 is C.sub.1 -C.sub.4 -alkyl and R.sup.3 is an ether, silyl ether or acetal protective group which can be converted into a hydroxyl group by hydrolysis, in particular one of the radicals ##STR2## and a process for preparing these compounds by reacting an alkenyne of the formula II ##STR3## in an inert solvent in the presence of lithium amide with a cyclohexenone of the formula III ##STR4## and the use of the compounds of the formula I for preparing astaxanthin, are described.
摘要翻译：本发明摘要：式Ⅰ化合物其中R 1为H或C 1 -C 4烷基，R 2为C 1 -C 4烷基，R 3为醚，可转化的甲硅烷基醚或缩醛保护基通过水解形成羟基，特别是一个基团，以及通过在惰性溶剂中在酰胺与环己烯酮的存在下使式II的烯键（II）反应来制备这些化合物的方法描述了式III（III）化合物和式I化合物用于制备虾青素的用途。

29. 发明授权

US4937308A Preparation of alkyl O,O-dialkyl-.gamma.-phosphonotiglates 失效
标题翻译：烷基O，O-二烷基-γ-膦酸吡啶的制备
公开(公告)号：US4937308A
公开(公告)日：1990-06-26
申请号：US205283
申请日：1988-06-10
申请人： Guenter H. Knaus , Hansgeorg Ernst , Marco Thyes , Joachim Paust
发明人： Guenter H. Knaus , Hansgeorg Ernst , Marco Thyes , Joachim Paust
IPC分类号： C07F9/40
CPC分类号： C07F9/4015
摘要： Alkyl .gamma.-halotiglates of the general formula I ##STR1## where X is Cl or Br and R.sup.2 is alkyl of 1 to 3 carbon atoms, having a high E isomer content, are prepared by a process in which(a) the corresponding 2-methyl-but-3-enoate of the general formula II ##STR2## is reacted with chlorine or bromine in the absence of a solvent and (b) the resulting 2-methyl-3,4-dihalobutyrate of the general formula III ##STR3## is dehydrohalogenated by reaction with a solution of an alkali metal hydroxide in an alcohol R.sup.2 OH, where R.sup.2 has the stated meaning, or in a mixture of water and an alcohol R.sup.2 OH, and the products are further processed to give O,O-dialkyl-.gamma.-phosphonotiglates of the general formula IV ##STR4## where R.sup.1 is alkyl of 1 to 4 carbon atoms and R.sup.2 is alkyl of 1 to 3 carbon atoms, preferably ethyl, by reaction with a trialkyl phosphite and thermal isomerization. The process gives C.sub.5 building blocks which are extremely interesting for polyene chemistry, the said building blocks being obtained in good yields and essentially in the form of the required E isomers.
摘要翻译：通过以下方法制备通式I的烷基γ-卤代吡咯烷酮，其中X是Cl或Br，R2是具有高E异构体含量的1至3个碳原子的烷基，其中（a）在不存在溶剂的情况下，使通式II（II）的相应的2-甲基 - 丁-3-烯酸酯与氯或溴反应，和（b）所得的2-甲基-3,4-二卤代丁酸酯通过与碱金属氢氧化物在醇R2OH中的溶液（其中R2具有所述含义）或在水和醇R2OH的混合物中进行反应脱卤化氢，并将产物进一步加工得到通式IV（IV）的O，O-二烷基-γ-膦腈吡咯烷酮，其中R 1为1至4个碳原子的烷基，R 2为1至3个碳原子的烷基，优选为乙基，通过与亚磷酸三烷基酯和热异构化。该方法提供了对多烯化学非常有趣的C5构建块，所述构建块以良好的产率获得并且基本上以所需的E异构体的形式获得。

30. 发明授权

US4806686A Preparation of ribitylxylidine 失效
标题翻译：核苷酸的制备
公开(公告)号：US4806686A
公开(公告)日：1989-02-21
申请号：US042823
申请日：1987-04-27
申请人： Hansgeorg Ernst , Hartmut Leininger , Joachim Paust
发明人： Hansgeorg Ernst , Hartmut Leininger , Joachim Paust
IPC分类号： C07B61/00 , B01J25/00 , B01J25/02 , C07C67/00 , C07C213/00 , C07C213/02 , C07C215/10 , C07C215/16 , C07H5/04 , C07C85/02
CPC分类号： C07H5/04
摘要： N-(D)-ribitylxylidine (I) is prepared by reacting (D)-ribose (II) with 3,4-dimethylaniline (III) or 3,4-dimethyl-1-nitrobenzene (IV) in aqueous or aqueous/organic solution or in solution in a water-soluble organic solvent under an elevated hydrogen pressure and in the presence of a hydrogenation catalyst and of a boric acid compound,(a) using the boric acid compound in a catalytic amount of from about 6 to 35 mmol, preferably from 6 to 20 mmol, per mol of ribose,(b) carrying out the reaction under a hydrogen pressure of from 1 to 20, preferably from 2 to 9, bar and(c) carrying out the hydrogenation at from 40.degree. to 80.degree. C. over Raney nickel as hydrogenation catalyst.
摘要翻译：通过（D） - 核糖（II）与3,4-二甲基苯胺（III）或3,4-二甲基-1-硝基苯（IV）的水溶液或水/有机物（I）反应制备N-（D） - 二硫代吗啉溶液或在水溶性有机溶剂中的溶液中，在升高的氢气压力下和在氢化催化剂和硼酸化合物的存在下，（a）使用催化量的约6至35mmol的硼酸化合物，优选6至20mmol，每摩尔核糖，（b）在1至20，优选2至9巴的氢气压力下进行反应，和（c）在40℃至40℃进行氢化 80℃，以阮内镍为加氢催化剂。

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