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21. 发明授权

US09554783B2 Closure device and method of closing a bodily opening 有权
标题翻译：关闭装置和关闭身体开口的方法
公开(公告)号：US09554783B2
公开(公告)日：2017-01-31
申请号：US12533731
申请日：2009-07-31
申请人： Dusan Pavcnik , Kurt J. Tekulve
发明人： Dusan Pavcnik , Kurt J. Tekulve
IPC分类号： A61B17/08 , A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00243 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/0061 , A61B2017/00615 , A61B2017/00623
摘要： In one embodiment, a device for closing or occluding ASDs and PFOs, or other bodily passageways, includes a circumferential frame, a sheet of biocompatible material attached to the frame, and at least one anchor attached to the sheet of biocompatible material. In another embodiment, the closure device includes a circumferential frame, at least one crossbar extending across and attached to the frame, at least one anchor connected to at least one crossbar; and at least one sheet of biocompatible material (such as ECM material) attached to the frame. The anchor includes at least one grasping member having a structure, such as a wired loop, which is configured for releasable attachment to a delivery release member, which facilitates delivery of a closure device collapsibly disposed in a delivery catheter. Alternatively, one or more anchor end pairs may be connected to a delivery bar enhancing delivery and retrieval of the device.
摘要翻译：在一个实施例中，用于关闭或闭塞ASD和PFO或其他身体通道的装置包括周边框架，附接到框架的生物相容性材料片以及附着到生物相容性材料片上的至少一个锚固件。在另一个实施例中，闭合装置包括圆周框架，至少一个跨越框架延伸并连接到框架的横杆，至少一个连接至至少一个横梁的锚固件; 和至少一张生物相容性材料（例如ECM材料）连接到框架上。锚固件包括至少一个抓握构件，其具有诸如布线环的结构，构造成用于可释放地附接到输送释放构件，其有利于输送可递送地布置在输送导管中的封闭装置。或者，一个或多个锚定端对可以连接到递送杆，以增强装置的递送和检索。

22. 发明授权

US08734483B2 Spider PFO closure device 有权
标题翻译：蜘蛛PFO封闭装置
公开(公告)号：US08734483B2
公开(公告)日：2014-05-27
申请号：US11845423
申请日：2007-08-27
申请人： Kurt J. Tekulve , Dusan Pavcnik
发明人： Kurt J. Tekulve , Dusan Pavcnik
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00623 , A61B2017/00867
摘要： A device for occluding septal defects or other bodily passageways including PFOs, includes an occluding body formed from a plurality of flexible outwardly radiating occluding wires connected to one or more biocompatible sheet materials. The occluding wires are joined together at proximal wire ends. Linking members connectively link the occluding body to a flexible, substantially linear anchor formed from at least one tube, coil, or bar. The anchor is configured for placement on one side of bodily passageway, whereby the longitudinal axis of at least one anchor extends across a transverse cross-section of the bodily passageway, anchoring the occluding body in place against the other side of a bodily passageway to close, occlude, or fill at least a lumenal portion of a bodily passageway. The anchor may include one or more grasping member(s) integrally formed or connected to the tube, coil, or bar for releasable attachment to an anchor engaging member, such as a biopsy forceps. In a further aspect, a closure device assembly includes a delivery catheter housing a collapsibly disposed closure device linked to a biopsy forceps. The biopsy forceps may be positioned in a locking catheter, which is configured to prevent inadvertent release of the closure device when held in a compressed state inside the delivery catheter. By positioning the catheter near a bodily passageway, such as a PFO, and disengaging the anchor engaging member from the grasping member, the closure device may be released so as to facilitate stable closure of the bodily passageway.
摘要翻译：用于阻塞间隔缺损或其他身体通道（包括PFO）的装置包括由连接到一个或多个生物相容性片材的多个柔性向外辐射阻塞线形成的闭塞体。封闭线在近端线末端连接在一起。连接构件将闭塞体连接到由至少一个管，线圈或杆形成的柔性基本线性的锚固件。该锚固件构造成用于放置在身体通道的一侧上，由此至少一个锚固件的纵向轴线延伸穿过身体通道的横向横截面，将闭塞体固定在身体通道的另一侧以封闭，闭塞或填充身体通道的至少腔内部分。锚固件可以包括一个或多个整体形成或连接到管，线圈或杆的抓握构件，用于可释放地附接到锚固件接合构件，例如活检钳。在另一方面，闭合装置组件包括输送导管，其容纳与活检钳连接的可折叠地设置的闭合装置。活检钳可以定位在锁定导管中，锁定导管被构造成防止当将输送导管保持在压缩状态时封闭装置的意外释放。通过将导管定位在诸如PFO的身体通道附近，并且将锚定接合构件与抓握构件脱离接合，可以释放闭合装置，以便于身体通道的稳定关闭。

23. 发明授权

US08617205B2 Closure device 有权
标题翻译：封闭装置
公开(公告)号：US08617205B2
公开(公告)日：2013-12-31
申请号：US12813489
申请日：2010-06-10
申请人： Dusan Pavcnik , Kurt J. Tekulve , Michael D. Deckard
发明人： Dusan Pavcnik , Kurt J. Tekulve , Michael D. Deckard
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B10/06 , A61B90/39 , A61B2017/00243 , A61B2017/00526 , A61B2017/00575 , A61B2017/00584 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , Y10T29/49826
摘要： A closure device for closing a bodily passageway is provided. The device includes first and second frames and first and second crossbars. A sheet of biocompatible material is attached to one or more of the frames. The first crossbar extends across the first frame and has terminal crossbar ends connectively linked to separate sites on the first frame; the second crossbar is similarly linked to the second frame. The crossbars are attached to each other at a connection point, and they are each configured to bend away from the connection point when the closure device is deployed to close a bodily passageway. A method of making the closure device is provided, as well as a method for closing a bodily passageway using such a device. Further, a closure device assembly is provided, including a closure device, a delivery catheter housing, and a delivery release member.
摘要翻译：提供了用于关闭身体通道的闭合装置。该装置包括第一和第二框架以及第一和第二横梁。一片生物相容性材料附着到一个或多个框架。第一横杆延伸穿过第一框架并且具有连接到第一框架上的分离位置的端子横杆端部; 第二横杆与第二框架类似地连接。十字杆在连接点处彼此附接，并且它们各自被配置成当关闭装置展开以便关闭身体通道时远离连接点弯曲。提供一种制造闭合装置的方法，以及使用这种装置关闭身体通道的方法。此外，提供了一种闭合装置组件，包括封闭装置，输送导管壳体和递送释放构件。

24. 发明授权

US08613763B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US08613763B2
公开(公告)日：2013-12-24
申请号：US12258757
申请日：2008-10-27
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , John A. DeFord , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , John A. DeFord , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：多面医疗装置包括包括线或其它弹性材料并具有一系列弯曲和互连侧的框架。该装置具有扁平构型和第二折叠构造，其大致蛇形形状。该装置从输送导管推入管道或容器的内腔，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料如DACRON，PTFE或基于胶原的材料如小肠粘膜下层（SIS）的全部或部分覆盖物可以被缝合或附着到框架上以形成闭塞装置，支架移植物，或可植入的管腔内瓣膜，例如用于矫正小腿和脚部的无能力的静脉。

25. 发明授权

US07909862B2 Delivery systems and methods for deploying expandable intraluminal medical devices 有权
标题翻译：用于部署扩张型管腔内医疗器械的输送系统和方法
公开(公告)号：US07909862B2
公开(公告)日：2011-03-22
申请号：US10804386
申请日：2004-03-19
申请人： Michael L. Garrison , Brian C. Case , Andrew K. Hoffa , Jacob A. Flagle , Dusan Pavcnik
发明人： Michael L. Garrison , Brian C. Case , Andrew K. Hoffa , Jacob A. Flagle , Dusan Pavcnik
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/95 , A61F2/013 , A61F2/966 , A61F2002/011 , A61F2002/015 , A61F2230/0006 , A61F2230/005
摘要： Methods and devices for delivering and deploying expandable intraluminal medical devices at a desired point of treatment within a body vessel are provided. A delivery device is provided, inserted into a body vessel, and navigated through the vessel to place an associated expandable intraluminal medical device at a desired point of treatment. Once the desired location is reached, an elongate member on which the expandable intraluminal medical device is disposed is spaced from a wall surface of the body vessel using an expandable wire basket, balloon, or other suitable structure. The expandable intraluminal medical device is deployed from the delivery system, which can ultimately be withdrawn from the body vessel.
摘要翻译：提供了用于在体内容器内的期望治疗点递送和部署可膨胀管腔内医疗装置的方法和装置。提供输送装置，插入体内容器，并通过血管导航，将相关的可扩张的管腔内医疗装置放置在期望的治疗点。一旦达到所需的位置，可扩张的管腔内医疗装置就位于其上的细长构件就可以使用可膨胀的丝网筐，球囊或其它合适的结构与身体容器的壁表面间隔开。可扩展的管腔内医疗装置从输送系统部署，其最终可以从体内容器中取出。

26. 发明授权

US07458987B2 Vascular valves having implanted and target configurations and methods of preparing the same 有权
标题翻译：具有植入和靶构造的血管瓣及其制备方法
公开(公告)号：US07458987B2
公开(公告)日：2008-12-02
申请号：US11260770
申请日：2005-10-27
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , F. Joseph Obermiller , Dusan Pavcnik
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , F. Joseph Obermiller , Dusan Pavcnik
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2210/0004 , A61F2220/0016 , A61F2250/0067
摘要： Described are vascular valve devices for implantation in a patient. The vascular valve devices are designed to compensate for the retraction characteristics of a remodelable material used to form one or more leaflets. Alternatively, or in addition, the devices are designed to reduce retraction of the remodelable leaflet-forming material. Further described are methods for preparing and using these vascular valve devices.
摘要翻译：描述了用于植入患者体内的血管瓣膜装置。血管瓣膜装置被设计成补偿用于形成一个或多个传单的可重塑材料的回缩特性。或者或另外，设备被设计成减少可重塑的小叶形成材料的缩回。进一步描述了制备和使用这些血管瓣膜装置的方法。

27. 发明申请

US20080215087A1 BODILY LUMEN CLOSURE APPARATUS AND METHOD 有权
标题翻译：身体闭合装置和方法
公开(公告)号：US20080215087A1
公开(公告)日：2008-09-04
申请号：US12109574
申请日：2008-04-25
申请人： Dusan Pavcnik , John Kaufman , Clay D. Fette
发明人： Dusan Pavcnik , John Kaufman , Clay D. Fette
IPC分类号： A61B17/12 , A61F6/20
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12118 , A61B17/1219 , A61B2017/00004 , A61B2017/00637 , A61B2017/00641 , A61B2017/00654 , A61B2017/00898 , A61F2/07 , A61F2/89 , A61F6/225 , A61F6/24 , A61F2002/061 , A61F2002/065 , A61F2002/077 , A61F2230/005
摘要： An absorbable and expandable closure member used to occlude or exclude a body lumen or cavity, such as a blood vessel, fallopian tube, duct, aneurysmal sac, etc., comprising a closure member comprising one of more sheets of a biomaterial that are rolled, stacked, or folded to form a multilayer construct of a generally cylindrical configuration for deployment through a delivery system, either as a singularly or part of a multiplicity of closure members. The biomaterial is derived from a source material, such as small intestinal submucosa or another remodelable material (e.g., an extracellular matrix) having properties for stimulating ingrowth of adjacent tissue into the biomaterial deployed within the bodily lumen. The closure member is deployed to the bodily lumen from a delivery sheath, cartridge, and/or over a inner guiding member, such as a wire guide or catheter.
摘要翻译：一种可吸收和可膨胀的封闭构件，其用于闭塞或排除体腔或腔体，例如血管，输卵管，导管，动脉瘤囊等，其包括封闭构件，该闭合构件包括多个生物材料片材中的一个，堆叠或折叠以形成大致圆柱形构造的多层构造，用于通过输送系统进行部署，作为单个或多个闭合构件的一部分。生物材料衍生自源材料，例如小肠粘膜下层或具有用于刺激相邻组织的向内生长进入体内部署的生物材料的特性的另一种可重塑材料（例如细胞外基质）。封闭构件从输送护套，药筒和/或内部引导构件（例如电线引导件或导管）部署到身体管腔。

28. 发明申请

US20050143807A1 Implantable vascular device comprising a bioabsorbable frame 审中-公开
标题翻译：可植入血管装置，其包括生物可吸收框架
公开(公告)号：US20050143807A1
公开(公告)日：2005-06-30
申请号：US10910490
申请日：2004-08-03
申请人： Dusan Pavcnik , Frederick Keller , Josef Rosch , Thomas Osborne , John Deford , Joseph Obermiller , Joe Roberts , Paul Amarant
发明人： Dusan Pavcnik , Frederick Keller , Josef Rosch , Thomas Osborne , John Deford , Joseph Obermiller , Joe Roberts , Paul Amarant
IPC分类号： A61F2/01 , A61F2/24 , A61F2/06
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided valve for implantation within a body vessel comprising a frame comprising a bioabsorbable material is provided. The devices can be pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material, or a bioabsorbable material, including a collagen-based material such as small intestinal submucosa (SIS), may be attached to the frame to form an occlusion device, a graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：提供了用于植入体内容器的多侧阀，其包括包含生物可吸收材料的框架。这些装置可以从输送导管推入管道或容器的内腔，并且可以包括用于锚固目的的一个或多个倒钩。织物或其他柔性材料或包括基于胶原的材料如小肠粘膜下层（SIS）的生物可吸收材料的全部或部分覆盖物可以附接到框架上以形成闭塞装置，移植物或植入物，腔内瓣膜，如用于矫正小腿和脚部无力静脉。

29. 发明授权

US5643317A Closure prosthesis for transcatheter placement 失效
标题翻译：闭经假体用于经导管放置
公开(公告)号：US5643317A
公开(公告)日：1997-07-01
申请号：US244580
申请日：1994-05-27
申请人： Dusan Pavcnik , Sidney Wallace , Kenneth C. Wright
发明人： Dusan Pavcnik , Sidney Wallace , Kenneth C. Wright
IPC分类号： A61B17/00 , A61B17/12 , A61B17/08
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12172 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606
摘要： A closure prosthesis and transcatheter delivery system includes a closure prosthesis for sealing across all opening of a fluid passageway within a living body. The closure prosthesis is a flexible disk including a flexible ring and diaphragm having a plurality of hollow flexible wire segments attached thereto. Delivery of the closure prosthesis is accomplished using a hollow sheath and a pusher catheter slidable within the sheath, wherein filaments are looped through the wire segments to releasably connect the disk to the pusher catheter. The disk is resiliently compressed within the sheath and, upon release therefrom, the disk resiliently expands into a larger, unrestrained shape. Tension applied to the filaments resiliently bends the wire segments so that they may be drawn through the opening of the defect. Upon releasing the filaments from the disk, the wire segments resiliently expand to trap the disk in place to seal across the opening.
摘要翻译： PCT No.PCT / US92 / 10141 Sec。 371日期：1994年5月27日 102（e）日期1994年5月27日PCT提交1992年11月25日PCT公布。公开号WO93 / 10714 PCT 日期1993年6月10日闭合假体和经导管递送系统包括用于密封活体内的流体通道的所有开口的闭合假体。闭合假体是包括柔性环和隔膜的柔性盘，其具有附接到其上的多个中空柔性线段。闭合假体的传送使用中空护套和在护套内可滑动的推动导管来实现，其中细丝环绕穿过线段以可释放地将盘连接到推动导管。盘在护套内被弹性地压缩，并且在从其释放时，盘弹性地膨胀成更大的，无限制的形状。应用于细丝的张力弹性地弯曲线段，使得它们可以被拉过缺陷的开口。当从盘释放细丝时，线段弹性地膨胀以将盘捕获到适当的位置以密封穿过开口。

30. 发明授权

US5350398A Self-expanding filter for percutaneous insertion 失效
标题翻译：用于经皮插入的自扩张过滤器
公开(公告)号：US5350398A
公开(公告)日：1994-09-27
申请号：US68594
申请日：1993-05-28
申请人： Dusan Pavcnik , Sidney Wallace , Kenneth C. Wright
发明人： Dusan Pavcnik , Sidney Wallace , Kenneth C. Wright
IPC分类号： A61F2/01 , A61F2/06 , A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/8483 , A61F2230/0006 , A61F2230/0069
摘要： A flexible vena cava filter comprises a flexible stent having a plurality of flexible wire segments attached across the ends of the stent. The filter is resiliently compressible for percutaneous insertion into a fluid passageway and expands against the passageway upon placement therein. The filter includes different levels of filtration.
摘要翻译：柔性腔静脉过滤器包括柔性支架，其具有穿过支架的端部附接的多个柔性线段。过滤器是可弹性压缩的，用于经皮插入流体通道中并且在放置在其中时抵靠通道膨胀。过滤器包括不同级别的过滤。

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