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21. 发明授权

US09046507B2 Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure 有权
标题翻译：用于在自动化流体转移过程中并入电容式接近感测的方法，系统和装置
公开(公告)号：US09046507B2
公开(公告)日：2015-06-02
申请号：US13192828
申请日：2011-07-28
申请人： Byron J. Knight , David Opalsky , Brian Schroeter
发明人： Byron J. Knight , David Opalsky , Brian Schroeter
IPC分类号： G01F23/26 , G01N35/10
CPC分类号： G01N35/1011 , G01F23/263 , G01N2035/1013
摘要： A fluid transfer apparatus includes a fluid transfer probe, a fluid level detection system, and a tip detection system. The fluid level detection system is configured to detect contact by the fluid transfer probe with a fluid surface within a receptacle from a signal based on the capacitance of the fluid transfer probe. The tip detection system is configured to detect the presence or absence of a tip at a distal end of the fluid transfer probe from a signal based on the capacitance of the fluid transfer probe.
摘要翻译：液体输送装置包括流体转移探针，液位检测系统和尖端检测系统。流体液位检测系统配置成基于流体转移探针的电容从信号中检测流体转移探针与容器内的流体表面的接触。尖端检测系统被配置为基于流体转移探针的电容从信号中检测流体转移探针的远端处的尖端的存在或不存在。

22. 发明授权

US08939364B2 Contamination control for liquid handling 有权
标题翻译：液体处理的污染控制
公开(公告)号：US08939364B2
公开(公告)日：2015-01-27
申请号：US13320749
申请日：2010-05-17
申请人： Craig B. Clark , John M. Gilker , Norbert D. Hagen , Tom R. Horn , Byron J. Knight , David Opalsky , Jason F. Rhubottom , Waldemar Lukhaub , Olaf Hörger
发明人： Craig B. Clark , John M. Gilker , Norbert D. Hagen , Tom R. Horn , Byron J. Knight , David Opalsky , Jason F. Rhubottom , Waldemar Lukhaub , Olaf Hörger
IPC分类号： G06K19/00 , G06Q10/08 , B01L9/06 , G01N35/10
CPC分类号： G06Q10/087 , B01L9/06 , B01L2200/023 , B01L2200/06 , B01L2200/141 , B01L2300/021 , G01N35/1004
摘要： A structure (10) for holding sample-containing receptacles includes a cover (40) with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element (44) adjacent each opening (42) engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element. A sample rack configured to hold receptacles and to be inserted into the structure below the cover includes a sample rack having receptacle-receiving pockets, each with a resilient element and a positioning feature for holding receptacles of varying sizes in a predetermined position within the receptacle receiving pocket, and a cover including features for preventing a receptacle from being pulled out of its receptacle-receiving pocket when the transfer mechanism is withdrawn from the receptacle.
摘要翻译：用于保持含有样品的容器的结构（10）包括其中形成有孔的盖（40），通过所述盖（40）可以用诸如机器人移液器的物质转移机构接近所述容器。当转移机构插入到容器中然后从容器中取出时，一串粘性材料可以悬挂在机构上。邻近每个开口（42）的粘性排除元件（44）与粘性材料串接合，并且当机构相对于去除元件以规定的路径移动时，将串从机构中移出。被配置成保持插座并插入到盖子下面的结构中的样品架包括具有插座容纳凹部的样品架，每个具有弹性元件和用于在插座接收中的预定位置保持不同尺寸的容器的定位特征口袋和盖子，其包括当传送机构从容器中取出时防止插座从其容器接收口袋中被拉出的特征。

23. 发明授权

US08368882B2 Systems and methods for detecting a signal and applying thermal energy to a signal transmission element 有权
标题翻译：用于检测信号并向信号传输元件施加热能的系统和方法
公开(公告)号：US08368882B2
公开(公告)日：2013-02-05
申请号：US12696406
申请日：2010-01-29
申请人： David Opalsky , George T. Walker , Norman C. Nelson , Richard S. Lee , Sara H. Fan
发明人： David Opalsky , George T. Walker , Norman C. Nelson , Richard S. Lee , Sara H. Fan
IPC分类号： G01N21/01
CPC分类号： G01N21/03 , B01L3/5027 , B01L3/505 , B01L7/52 , B01L9/527 , B01L2200/04 , B01L2200/146 , B01L2300/021 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/087 , B01L2300/1827 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0666 , G01N21/0332 , G01N2021/0328 , G01N2021/0346 , G01N2035/00346
摘要： A signal detection system configured for detecting a signal emitted by the contents of a reaction receptacle is also configured to apply thermal energy to a portion of the reaction receptacle to affect a reaction occurring within the reaction receptacle. More particularly, a system for detecting electromagnetic radiation emitted by the contents of a reaction receptacle includes a transmission element configured for transmitting electromagnetic radiation from the contents of the receptacle, a thermal element associated with the transmission element and configured to apply thermal energy to at least a portion of the receptacle, and a detector configured to receive electromagnetic radiation from the transmission element and to generate a signal corresponding to a characteristic of the electromagnetic radiation received by the detector.
摘要翻译：被配置为检测由反应容器的内容物发射的信号的信号检测系统还被配置为将热能施加到反应容器的一部分以影响在反应容器内发生的反应。更具体地，用于检测由反应容器的内容物发射的电磁辐射的系统包括传输元件，其被配置用于从容器的内容物传输电磁辐射，与传输元件相关联的热元件，并被配置为将热能施加到至少所述插座的一部分以及被配置为从所述传输元件接收电磁辐射并且产生对应于由所述检测器接收的电磁辐射的特性的信号的检测器。

24. 发明授权

US08315805B2 Systems and methods for testing a biological sample 有权
标题翻译：用于测试生物样品的系统和方法
公开(公告)号：US08315805B2
公开(公告)日：2012-11-20
申请号：US10128680
申请日：2002-04-22
申请人： David Opalsky , Ping Yip , Kishorchandra Bhakta
发明人： David Opalsky , Ping Yip , Kishorchandra Bhakta
IPC分类号： G06F19/00 , G01N24/00
CPC分类号： G06F19/18 , G06F19/28
摘要： Systems and methods for testing samples, particularly biological samples are provided. The system includes an instrument for detecting molecules in samples, and a processor that communicates with the instrument to provide results-based control of the instrument to effect assay-based judging. For example, a system, including software, is provided that directs and performs assays such as diagnostic assays that employ a mass spectrometer. The output of the system, rather than a mass spectrum or other raw data form, is the diagnostic outcome, such as a genotype.
摘要翻译：提供了用于测试样品，特别是生物样品的系统和方法。该系统包括用于检测样品中的分子的仪器，以及与仪器通信以提供仪器的基于结果的控制以进行基于测定的判断的处理器。例如，提供包括软件的系统，其指导和执行诸如使用质谱仪的诊断测定法的测定。系统的输出，而不是质谱或其他原始数据形式是诊断结果，如基因型。

25. 发明申请

US20120118954A1 SYSTEM AND METHOD FOR TRACKING ITEMS DURING A PROCESS 有权
标题翻译：在一个过程中追踪物品的系统和方法
公开(公告)号：US20120118954A1
公开(公告)日：2012-05-17
申请号：US13293529
申请日：2011-11-10
申请人： Norbert D. HAGEN , David OPALSKY
发明人： Norbert D. HAGEN , David OPALSKY
IPC分类号： G06Q90/00
CPC分类号： G06Q10/087 , G01N35/00732 , G01N2035/00752 , G01N2035/00782 , G01N2035/00801 , G01N2035/00831 , G01N2035/00841
摘要： A system and method for tracking items during a process employs a rack configured to hold one or more receptacles. Each receptacle includes a machine-readable label providing information regarding the receptacle, and each receptacle-receiving position of the rack has associated therewith a machine-readable label identifying the receptacle receiving location. The rack also includes a memory element to which electronic data may be written. A label reading device reads the machine-readable label on each receptacle and the position-indicating, machine-readable labels on the rack. Information obtained from the machine-readable labels is written to the memory element, so that for subsequent processing of the receptacles carried on the rack, information relating to each of the receptacles can be obtained by reading the information written to the memory element. A tamper prevention element provides an indication of whether the rack may have been tampered with after data is written to the memory element.
摘要翻译：用于在过程中跟踪物品的系统和方法采用配置成容纳一个或多个容器的架子。每个插座包括提供关于插座的信息的机器可读标签，并且机架的每个插座接收位置具有标识容器接收位置的机器可读标签。机架还包括可以写入电子数据的存储元件。标签读取装置读取每个插座上的机器可读标签和机架上的位置指示机器可读标签。从机器可读标签获得的信息被写入存储元件，因此为了随后处理在机架上承载的插座，可以通过读取写入存储元件的信息来获得与每个插座有关的信息。防篡改元件提供了在将数据写入存储器元件之后机架是否可能被篡改的指示。

26. 发明申请

US20120024055A1 Method, System and Apparatus for Incorporating Capacitive Proximity Sensing in an Automated Fluid Transfer Procedure 有权
标题翻译：用于在自动流体传输程序中引入电容接近感测的方法，系统和装置
公开(公告)号：US20120024055A1
公开(公告)日：2012-02-02
申请号：US13192828
申请日：2011-07-28
申请人： Byron J. KNIGHT , David OPALSKY , Brian SCHROETER
发明人： Byron J. KNIGHT , David OPALSKY , Brian SCHROETER
IPC分类号： G01F23/26 , G01F23/00
CPC分类号： G01N35/1011 , G01F23/263 , G01N2035/1013
摘要： A fluid transfer apparatus includes a fluid transfer probe, a fluid level detection system, and a tip detection system. The fluid level detection system is configured to detect contact by the fluid transfer probe with a fluid surface within a receptacle from a signal based on the capacitance of the fluid transfer probe. The tip detection system is configured to detect the presence or absence of a tip at a distal end of the fluid transfer probe from a signal based on the capacitance of the fluid transfer probe.
摘要翻译：液体输送装置包括流体转移探针，液位检测系统和尖端检测系统。流体液位检测系统配置成基于流体转移探针的电容从信号中检测流体转移探针与容器内的流体表面的接触。尖端检测系统被配置为基于流体转移探针的电容从信号中检测流体转移探针的远端处的尖端的存在或不存在。

27. 发明申请

US20100288395A1 Method and Apparatus for Effecting Automated Movement of a Magnet in an Instrument for Performing a Magnetic Separation Procedure 有权
标题翻译：用于实现磁选机的磁铁自动运动的方法和装置
公开(公告)号：US20100288395A1
公开(公告)日：2010-11-18
申请号：US12781390
申请日：2010-05-17
申请人： Norbert D. Hagen , Byron J. Knight , David Opalsky
发明人： Norbert D. Hagen , Byron J. Knight , David Opalsky
IPC分类号： B65B1/04
CPC分类号： B01L3/52 , B01L3/561 , B01L9/52 , B01L2300/0609 , B01L2300/12 , B03C1/0332 , B03C1/12 , B03C1/14 , B03C1/28 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , B25J11/00 , B65B3/04 , C12N15/1013 , G01N35/0098 , Y10T29/49815
摘要： Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a proton of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.
摘要翻译：提供了方法，系统和装置，用于自动分离来自样品的其它组分的选定的分析物，其中磁性响应性固体支持物被结合。用于执行自动磁分离程序的装置包括用于在相对于插座装置的操作位置和非操作位置之间实现磁体的线性移动的机构。在将容器移动到用于执行磁性分离的装置之前可以临时存储插座装置的容器保持站包括用于向保持在其中的插座装置施加磁场的磁体，从而至少吸取磁响应的质子在插座装置移动到磁选分离台之前，固体支撑体不能悬挂。自动插座传送机构使插座装置在用于执行磁分离的装置和插座保持台之间移动。

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