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21. 发明申请

US20130028867A1 LONG-ACTING INTERFERON BETA FORMULATION USING IMMUNOGLOBULIN FRAGMENT 有权
标题翻译：使用免疫抑制蛋白片段的长效干扰素制剂
公开(公告)号：US20130028867A1
公开(公告)日：2013-01-31
申请号：US13638821
申请日：2011-04-04
申请人： Dae Jin Kim , Min Young Kim , Jin Sun Kim , Sung Hee Hong , Sung Youb Jung , Se Chang Kwon
发明人： Dae Jin Kim , Min Young Kim , Jin Sun Kim , Sung Hee Hong , Sung Youb Jung , Se Chang Kwon
IPC分类号： A61K38/21 , A61P25/28 , A61P37/06 , A61P35/00 , C07K14/565 , A61P31/12
CPC分类号： A61K38/215 , A61K47/68 , A61K47/6813 , A61K47/6835 , C07K14/565 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： The present invention relates to a long-acting interferon beta formulation having improved in vivo duration and stability, comprising an interferon beta conjugate that is prepared by covalently linking interferon beta with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting interferon beta formulation of the present invention maintains in vivo activity of interferon beta at a relatively high level and remarkably increases the serum half-life thereof, thereby being used for various diseases, for which interferon is efficacious.
摘要翻译：本发明涉及具有改善的体内持续时间和稳定性的长效型干扰素β制剂，其包含通过非肽基聚合物共价连接干扰素β与免疫球蛋白Fc区制备的干扰素β偶联物及其制备方法。本发明的长效干扰素β配方维持干扰素β的体内活性在相当高的水平，并显着提高其血清半衰期，从而被用于干扰素有效的各种疾病。

22. 发明授权

US08282340B2 Turbo-machine having bellows unit for automatic axial thrust control 有权
标题翻译：涡轮机具有用于自动轴向推力控制的波纹管单元
公开(公告)号：US08282340B2
公开(公告)日：2012-10-09
申请号：US12493353
申请日：2009-06-29
申请人： Dae-Jin Kim , Jinhan Kim
发明人： Dae-Jin Kim , Jinhan Kim
IPC分类号： F01D3/00
CPC分类号： F01D3/04 , F05D2240/52
摘要： A turbo-machine including a volute casing, a rotating shaft, an impeller, seals, an axial thrust control member and a bellows unit. The volute casing defines therein a fluid passage. The rotating shaft is rotatably provided in the volute casing. The impeller is coupled to the rotating shaft to draw fluid using centrifugal force. The seals are provided around the front and rear ends of the impeller to prevent leakage of fluid. The axial thrust control member is installed in the volute casing behind the impeller. The bellows unit includes the piston installed in the volute casing in a shape surrounding a circumferential outer surface of the axial thrust control member; and a bellows connected with one surface of the piston, the bellows having the predetermined elasticity; and an internal space, between the piston and the volute casing, isolated from the fluid drawn behind the impeller.
摘要翻译：涡轮机包括蜗壳，旋转轴，叶轮，密封件，轴向推力控制构件和波纹管单元。蜗壳在其中限定有流体通道。旋转轴可旋转地设置在蜗壳中。叶轮联接到旋转轴以使用离心力抽取流体。密封件围绕叶轮的前端和后端设置以防止流体泄漏。轴向推力控制构件安装在叶轮后面的蜗壳中。波纹管单元包括安装在蜗壳中的活塞，其形状围绕轴向推力控制构件的周向外表面; 以及与活塞的一个表面连接的波纹管，波纹管具有预定的弹性; 以及活塞和蜗壳之间的内部空间，与从叶轮后面吸取的流体分离。

23. 发明申请

US20100329845A1 TURBO-MACHINE HAVING BELLOWS UNIT FOR AUTOMATIC AXIAL THRUST CONTROL 有权
标题翻译：涡轮机具有自动轴向控制的BELLOWS单元
公开(公告)号：US20100329845A1
公开(公告)日：2010-12-30
申请号：US12493353
申请日：2009-06-29
申请人： Dae-Jin KIM , Jinhan Kim
发明人： Dae-Jin KIM , Jinhan Kim
IPC分类号： F01D3/04
CPC分类号： F01D3/04 , F05D2240/52
摘要： The turbo-machine of the present invention includes a volute casing, a rotating shaft, an impeller, seals, an axial thrust control member and a bellows unit. The volute casing defines therein a fluid passage. The rotating shaft is rotatably provided in the volute casing. The impeller is coupled to the rotating shaft to draw fluid using centrifugal force. The seals are provided around the front and rear ends of the impeller to prevent leakage of fluid. The axial thrust control member is installed in the volute casing behind the impeller. The bellows unit includes the piston installed in the volute casing in a shape surrounding a circumferential outer surface of the axial thrust control member; and a bellows connected with one surface of the piston, the bellows having the predetermined elasticity; and an internal space, between the piston and the volute casing, isolated from the fluid drawn behind the impeller.
摘要翻译：本发明的涡轮机包括蜗壳，旋转轴，叶轮，密封件，轴向推力控制构件和波纹管单元。蜗壳在其中限定有流体通道。旋转轴可旋转地设置在蜗壳中。叶轮联接到旋转轴以使用离心力抽取流体。密封件围绕叶轮的前端和后端设置以防止流体泄漏。轴向推力控制构件安装在叶轮后面的蜗壳中。波纹管单元包括安装在蜗壳中的活塞，其形状围绕轴向推力控制构件的周向外表面; 以及与活塞的一个表面连接的波纹管，波纹管具有预定的弹性; 以及活塞和蜗壳之间的内部空间，与从叶轮后面吸取的流体分离。

24. 发明授权

US07737260B2 Protein complex using an immunoglobulin fragment and method for the preparation thereof 有权
标题翻译：使用免疫球蛋白片段的蛋白质复合物及其制备方法
公开(公告)号：US07737260B2
公开(公告)日：2010-06-15
申请号：US10535232
申请日：2004-11-13
申请人： Young Min Kim , Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee
发明人： Young Min Kim , Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee
IPC分类号： C07K16/00
CPC分类号： A61K47/68 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment. Since the three components are covalently linked, the protein conjugate has extended in vivo duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains the in vivo activity at relatively high levels and remarkably increases the serum half-life for the physiologically active polypeptide, with less risk of inducing undesirable immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs.
摘要翻译：公开了具有改善的体内持续时间和稳定性的蛋白质缀合物及其用途。蛋白质缀合物包括生理活性多肽，非肽聚合物和免疫球蛋白Fc片段。由于三种成分共价连接，因此蛋白质缀合物延长了生理活性多肽的体内持续时间和增强的稳定性。蛋白质缀合物以较高的水平保持体内活性，并显着增加生理活性多肽的血清半衰期，具有诱导不良免疫反应的风险较小。因此，蛋白质缀合物可用于开发各种多肽药物的长效制剂。

25. 发明授权

US07164827B2 Optical module with accurate axial alignment using a platform 有权
标题翻译：使用平台精确轴向对准的光学模块
公开(公告)号：US07164827B2
公开(公告)日：2007-01-16
申请号：US10999444
申请日：2004-11-29
申请人： Kwang Jin Yang , Dae Jin Kim , Do Ik Kim
发明人： Kwang Jin Yang , Dae Jin Kim , Do Ik Kim
IPC分类号： G02B6/42 , G02B6/36
CPC分类号： G02B6/423 , G02B6/4239 , G02B6/4246
摘要： An optical communication module is provided with a platform to provide an accurate axial alignment with optical transceiving subassemblies. In the optical communication module, axes of the optical transceiving sub-assemblies are aligned by virtue of previously established axial alignment of the platform, and the platform is fixed to a main body by inserting an insertion jaw of a cover into an insertion groove formed on an upper surface of the platform. After the optical transceiving subassemblies are inserted into the platform having the axial alignment required for a system, a bonding agent is filled into spaces defined in the platform, thereby preventing the axes from deviated by an external force. The optical communication module allows for easier and more accurate guidance of a connection between the optical transceiving sub-assemblies and the optical connector, thereby minimizing the optical loss, and preventing the patterns on the printed circuit board from being damaged due to the insertion and disconnection of the optical connector.
摘要翻译：光通信模块设置有平台以提供与光收发子组件的精确轴向对准。在光通信模块中，通过先前建立的平台的轴向对准，光收发子组件的轴线对准，并且平台通过将盖的插入爪插入到形成在其上的插入槽中而固定到主体上平台的上表面。在将光学收发组件插入到具有系统所需的轴向对准的平台中之后，将粘合剂填充到平台中限定的空间中，从而防止轴由于外力而偏离。光通信模块允许更容易且更精确地引导光学收发子组件和光学连接器之间的连接，从而最小化光学损耗，并且防止印刷电路板上的图案由于插入和断开而被损坏的光连接器。

26. 发明申请

US20050056686A1 Hydrogen gas brazing method for manufacturing a diamond tool and arch-shaped hydrogen gas brazing apparatus for performing the same 审中-公开
标题翻译：用于制造金刚石工具的氢气钎焊方法和用于执行该金刚石工具的拱形氢气钎焊装置
公开(公告)号：US20050056686A1
公开(公告)日：2005-03-17
申请号：US10835357
申请日：2004-04-28
申请人： Jong-Hoon Kim , Dae-Jin Kim
发明人： Jong-Hoon Kim , Dae-Jin Kim
IPC分类号： B23K1/00 , B23K1/008 , B23K1/012 , B23K1/19 , B23K31/02 , B23K101/20 , B24D18/00 , F27B9/02 , F27B9/20 , F27B9/24 , F27B9/36 , F27B17/00 , F27D7/06 , F27D9/00 , F27D11/02 , F27D19/00 , F27D21/00
CPC分类号： B23K1/008 , B23K1/0008 , B23K1/012 , B23K1/19 , B23K31/025 , B24D18/00 , F27B9/028 , F27B9/20 , F27B9/243 , F27B9/36 , F27D7/06 , F27D19/00
摘要： To prevent oxidation and carbonization of a diamond, a heating unit includes an outside wall, a second furnace core tube coupled from an inlet to an outlet, and a heating device for heating a brazing object moved from the inlet into the outlet. A supplying unit includes a first furnace core tube to move the brazing object into the inlet, wherein the first furnace core tube is extended from the inlet. A cooling unit includes a third furnace core tube and a cooling device for cooling the brazing object moved from the outlet through the third furnace core tube, wherein the third furnace core tube is extended from the outlet. A moving unit moves the brazing object using a conveyer set to the inside of the first, second, and third furnace core tubes. A hydrogen gas supplying unit supplies hydrogen gas to the first, second, and third furnace core tubes.
摘要翻译：为了防止金刚石的氧化和碳化，加热单元包括外壁，从入口到出口连接的第二炉芯管和用于加热从入口移动到出口的钎焊物体的加热装置。供给单元包括将钎焊物移动到入口的第一炉芯管，其中，第一炉芯管从入口延伸。冷却单元包括第三炉芯管和用于冷却从出口经过第三炉芯管移动的钎焊物体的冷却装置，其中第三炉芯管从出口延伸。移动单元使用设置在第一，第二和第三炉芯管的内部的传送装置来移动钎焊物体。氢气供给单元向第一，第二和第三炉芯管供给氢气。

27. 发明授权

US5654765A Channel equalizer for digital television receiver having an initial coefficient storage unit 失效
标题翻译：具有初始系数存储单元的数字电视接收机的信道均衡器
公开(公告)号：US5654765A
公开(公告)日：1997-08-05
申请号：US341178
申请日：1994-11-18
申请人： Dae Jin Kim
发明人： Dae Jin Kim
IPC分类号： H04N5/21 , H04N5/44 , H04N5/213
CPC分类号： H04N5/211 , H04L25/03057 , H04N5/4401 , H04L2025/0349 , H04L2025/03662 , Y10S348/909
摘要： A channel equalizer for a digital television receiver which filters an input signal to remove a noise component mixed therewith during transmission. The channel equalizer comprises an initial coefficient storage unit for outputting a predetermined coefficient to channel equalizer circuit when a certain channel is firstly selected. The predetermined coefficient is used as an initial filtering value for allowing the channel equalizer circuit to update a filtering coefficient so that it can converge on an optimum value. The stored filtering coefficient is output to the channel equalizer circuit when the firstly selected channel is again selected, so that it can be used as the initial filtering value.
摘要翻译：一种用于数字电视接收机的信道均衡器，其对输入信号进行滤波以去除在传输期间与其混合的噪声分量。信道均衡器包括初始系数存储单元，用于当首先选择某个信道时，向信道均衡器电路输出预定系数。将预定系数用作初始滤波值，以允许信道均衡器电路更新滤波系数，使得其可以收敛于最佳值。当首次选择的频道再次被选择时，将存储的滤波系数输出到信道均衡器电路，从而可以将其用作初始滤波值。

28. 发明申请

US20140212440A1 CONJUGATE COMPRISING OXYNTOMODULIN AND AN IMMUNOGLOBULIN FRAGMENT, AND USE THEREOF 有权
标题翻译：包含氧自由基蛋白和免疫球蛋白片段的连接及其用途
公开(公告)号：US20140212440A1
公开(公告)日：2014-07-31
申请号：US14126914
申请日：2012-06-15
申请人： Sung Youb Jung , Dae Jin Kim , Sung Hee Park , Young Eun Woo , In Young Choi , Se Chang Kwon
发明人： Sung Youb Jung , Dae Jin Kim , Sung Hee Park , Young Eun Woo , In Young Choi , Se Chang Kwon
IPC分类号： A61K47/48 , A61K38/26
CPC分类号： A61K47/6889 , A61K38/00 , A61K38/26 , A61K45/06 , A61K47/60 , A61K47/68 , A61K47/6801 , A61K47/6811 , C07K14/575 , C07K2319/30
摘要： The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
摘要翻译：本发明涉及包含胃泌酸调节蛋白，免疫球蛋白Fc区和非肽基聚合物的缀合物，其中通过非肽基聚合物共价连接胃泌酸调节蛋白与免疫球蛋白Fc区域可获得的缀合物和用于预防或治疗肥胖症的药物组合物包括缀合物。与天然胃泌酸调节蛋白不同，包含胃泌酸调节蛋白和本发明的免疫球蛋白Fc的缀合物减少食物摄入，抑制胃排空，并且促进脂肪分解而不具有副作用，并且与天然胃泌酸调节素相比也显示出优异的受体激活作用和长期可持续性。因此，可广泛用于治疗肥胖症的安全性和有效性。

29. 发明授权

US08717421B2 System and method for automatic calibration of stereo images 失效
标题翻译：用于立体图像自动校准的系统和方法
公开(公告)号：US08717421B2
公开(公告)日：2014-05-06
申请号：US12838885
申请日：2010-07-19
申请人： Richard Alan Peters, II , Shawn Atkins , Dae Jin Kim , Aditya Nawab
发明人： Richard Alan Peters, II , Shawn Atkins , Dae Jin Kim , Aditya Nawab
IPC分类号： H04N15/00 , H04N13/02
CPC分类号： G06T7/85 , G06T2207/10012 , G06T2207/20224 , G06T2207/30204
摘要： A method and system to enable a computer to estimate calibration parameters autonomously so that accurate stereopsis can be performed. The present invention automatically calibrates two or more cameras with unknown parameters with respect to a robot or robotic appendage (e.g., articulated robot arm) with a light source that can be turned on and off at one end. A pair of cameras (e.g., digital cameras) are positioned and aimed so as to give stereoptic coverage of the robot's workspace. The procedure determines the positions and orientations of the pair of cameras with respect to a robot (i.e., exterior orientations) and the focal lengths, optical centers, and distortion coefficients of each camera (i.e., intrinsic parameters) automatically from a set of known positions of the robot arm, and a set of images from the right and left cameras of the robot arm in each position as the light is turned on and off.
摘要翻译：一种使计算机能够自主地估计校准参数以便能够执行准确的立体视觉的方法和系统。本发明相对于机器人或机器人附肢（例如，关节式机器人手臂）自动校准具有未知参数的两个或更多个相机，其具有可以在一端被打开和关闭的光源。定位和瞄准一对相机（例如，数码相机），以便给予机器人工作空间的立体声覆盖。该过程从一组已知位置自动确定相机相对于机器人（即，外部取向）和每个照相机的焦距，光学中心和失真系数的位置和取向（即固有参数）的机器人手臂，以及一组来自机器人手臂的左右照相机的图像，在每个位置打开和关闭光。

30. 发明授权

US08588530B2 Method and camera for detecting a region having a specific shape 有权
标题翻译：用于检测具有特定形状的区域的方法和相机
公开(公告)号：US08588530B2
公开(公告)日：2013-11-19
申请号：US13183726
申请日：2011-07-15
申请人： Seoung-seon Jeson , Dae-Jin Kim , Bong-jin Jun , Jong-min Yun
发明人： Seoung-seon Jeson , Dae-Jin Kim , Bong-jin Jun , Jong-min Yun
IPC分类号： G06K9/46
CPC分类号： H04N5/23219 , G06K9/4642 , G06K2009/4666
摘要： A method of detecting a region having a specific shape in a camera is provided. The method includes processing input image data in a camera and detecting the region having the specific shape. The method includes calculating gradation differences between a central pixel and respective peripheral pixels in each of local regions of an image frame, comparing an average gradation difference with each of the gradation differences and obtaining local gradient pattern (LGP) values based on a comparison result in each of the local regions, and detecting the region having the specific shape from the image frame using the LGP values obtained from the respective local regions.
摘要翻译：提供了一种在相机中检测具有特定形状的区域的方法。该方法包括处理相机中的输入图像数据并检测具有特定形状的区域。该方法包括：计算图像帧的每个局部区域中的中心像素与相应周边像素之间的灰度差，将平均灰度差与每个灰度差进行比较，并根据比较结果获得局部梯度图（LGP）值每个局部区域，并且使用从各个局部区域获得的LGP值从图像帧检测具有特定形状的区域。

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