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21. 发明申请

WO2013033068A1 KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译： KUNURENINE-3-单硫酸酯酶抑制剂，药物组合物及其使用方法
公开(公告)号：WO2013033068A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052617
申请日：2012-08-28
申请人： COURTNEY, Stephen Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher John , DE AGUIAR PENA, Paula C. , JOHNSON, Peter , DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia M. , MUNOZ, Ignacio
发明人： COURTNEY, Stephen Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher John , DE AGUIAR PENA, Paula C. , JOHNSON, Peter , DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia M. , MUNOZ, Ignacio
IPC分类号： C07D239/47
CPC分类号： C07D239/28 , A61K31/506 , C07D239/42 , C07D239/52 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , Y02A50/401 , Y02A50/411 , Y02A50/465
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对抑制KMO活性有响应的某些疾病和病症的患者的方法，其包括向这些患者施用有效量的至少一种化学实体，以减轻疾病或病症的体征或症状。这些疾病包括神经退行性疾病，如亨廷顿病。还描述了治疗方法，包括施用至少一种化学实体作为单一活性剂或施用与一种或多种其他治疗剂组合的至少一种化学实体。还提供了筛选能够抑制KMO活性的化合物的方法。

22. 发明申请

WO2013016488A1 CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：某些京那奈因-3-MONOOXYGENASE抑制剂，药物组合物及其使用方法
公开(公告)号：WO2013016488A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/048254
申请日：2012-07-26
申请人： DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia, M. , COURTNEY, Stephen, Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher, John , DE AGUIAR PENA, Paula, C. , JOHNSON, Peter
发明人： DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia, M. , COURTNEY, Stephen, Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher, John , DE AGUIAR PENA, Paula, C. , JOHNSON, Peter
IPC分类号： A01N43/54 , C07D239/42 , C07D471/04
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/5377 , C07D239/26 , C07D239/28 , C07D239/42 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D491/044 , C07D491/048 , C07D491/052
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对KMO活性的抑制作用的某些疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症的体征或症状的化学实体。这些疾病包括神经变性疾病如亨廷顿氏病。还描述了治疗方法，包括给予至少一种作为单一活性剂的化学实体或与一种或多种其它治疗剂组合施用至少一种化学实体。还提供了用于筛选能够抑制KMO活性的化合物的方法。

23. 发明申请

WO2011071951A2 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES 审中-公开
标题翻译： N-羟基甲酰胺和N-羟基-N-亚磺酰胺衍生物
公开(公告)号：WO2011071951A2
公开(公告)日：2011-06-16
申请号：PCT/US2010/059335
申请日：2010-12-07
申请人： JOHNS HOPKINS UNIVERSITY , CARDIOXYL PHARMACEUTICALS, INC. , TOSCANO, John P. , SUTTON, Art , KALISH, Vincent J. , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie
发明人： TOSCANO, John P. , SUTTON, Art , KALISH, Vincent J. , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie
IPC分类号： C07C311/48
CPC分类号： C07C311/48 , C07C311/51 , C07C317/14 , C07C317/32 , C07C2601/14 , C07D207/06 , C07D207/16 , C07D209/48 , C07D211/46 , C07D211/58 , C07D211/62 , C07D213/40 , C07D213/46 , C07D213/59 , C07D213/71 , C07D213/74 , C07D233/38 , C07D241/04 , C07D241/08 , C07D295/192 , C07D295/195 , C07D295/205 , C07D307/82 , C07D309/12 , C07D317/30 , C07D333/34 , C07D401/04 , C07D413/04
摘要： The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.
摘要翻译：本发明提供某些N-酰氧基亚磺酰胺和N-羟基-N-酰基磺酰胺衍生物化合物，包含这些化合物的药物组合物和试剂盒，以及使用这些化合物或药物组合物的方法。特别地，本发明提供了使用这些化合物或药物组合物治疗，预防或延缓疾病或病症发作和/或发展的方法。在一些实施方案中，疾病或病症选自心血管疾病，缺血，再灌注损伤，癌性疾病，肺动脉高压和对硝酰基治疗有反应的病症。

24. 发明申请

WO2010142970A1 A CLEANER HEAD 审中-公开
标题翻译：清洁头
公开(公告)号：WO2010142970A1
公开(公告)日：2010-12-16
申请号：PCT/GB2010/050853
申请日：2010-05-25
申请人： DYSON TECHNOLOGY LIMITED , FOLLOWS, Thomas , COURTNEY, Stephen
发明人： FOLLOWS, Thomas , COURTNEY, Stephen
IPC分类号： A47L9/04
CPC分类号： A47L9/0477
摘要： Agitating apparatus (40) for a surface treating appliance comprises a rotatable body(50) having a plurality of grooves (58) formed therein, an agitating member (56) located within each groove so that at least one side edge of the agitating member protrudes outwardly from the body, and a connecting member (60) located within each groove for connecting the agitating member to the body.
摘要翻译：用于表面处理装置的搅拌装置（40）包括：旋转体（50），其具有形成在其中的多个凹槽（58），位于每个凹槽内的搅拌构件（56），使得搅拌构件的至少一个侧边缘突出以及位于每个凹槽内的连接构件（60），用于将搅拌构件连接到主体。

25. 发明申请

WO2010017179A1 CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：某些喹喔啉-3-单氧核糖核酸酶抑制剂，药物组合物及其使用方法
公开(公告)号：WO2010017179A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/052667
申请日：2009-08-04
申请人： CHDI, INC. , WITYAK, John , TOLEDO-SHERMAN, Leticia, M. , LEEDS, Janet , DOMINGUEZ, Cella , COURTNEY, Stephen, Martin , YARNOLD, Christopher, John , DE AGUIAR PENA, Paula, Cristina , SCHEEL, Andreas , WINKLER, Dirk
发明人： WITYAK, John , TOLEDO-SHERMAN, Leticia, M. , LEEDS, Janet , DOMINGUEZ, Cella , COURTNEY, Stephen, Martin , YARNOLD, Christopher, John , DE AGUIAR PENA, Paula, Cristina , SCHEEL, Andreas , WINKLER, Dirk
IPC分类号： A61K31/426 , A61K31/4453
CPC分类号： C07D239/52 , A61K31/505 , A61K31/506 , C07D213/79 , C07D213/81 , C07D239/28 , C07D239/38 , C07D239/42 , C07D239/69 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , Y02A50/401 , Y02A50/411 , Y02A50/465
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对抑制KMO活性有响应的某些疾病和病症的患者的方法，其包括向这些患者施用有效量的至少一种化学实体，以减轻疾病或病症的体征或症状。这些疾病包括神经退行性疾病，如亨廷顿病。还描述了治疗方法，包括施用至少一种化学实体作为单一活性剂或施用与一种或多种其他治疗剂组合的至少一种化学实体。还提供了筛选能够抑制KMO活性的化合物的方法。

26. 发明申请

WO2009053676A3 A CLEANING APPLIANCE 审中-公开
标题翻译：清洁器具
公开(公告)号：WO2009053676A3
公开(公告)日：2009-06-25
申请号：PCT/GB2008003530
申请日：2008-10-17
申请人： DYSON TECHNOLOGY LTD , COURTNEY STEPHEN BENJAMIN
发明人： COURTNEY STEPHEN BENJAMIN
IPC分类号： A47L9/14
CPC分类号： A47L9/1481
摘要： The invention provides a filter assembly (20) for a cleaning appliance (10). The cleaning appliance comprises a main body (12), including a motor and fan unit (30) for generating an airflow, separating apparatus (100) for separating dirt and dust from the airflow and a passageway (114) for receiving a filter. The passageway and a filter may be located downstream of the separating apparatus (100) and upstream of the motor, and the filter may have an at least partially curved filter surface. The filter is arranged around at least a part of the motor and fan unit (30). The filter is removable through a side, and through a wheel (14), of the appliance (12). The arrangement facilitates ease of removal of the filter (20) from the cleaning appliance (10).
摘要翻译：本发明提供一种用于清洁器具（10）的过滤组件（20）。清洁器具包括主体（12），其包括用于产生气流的马达和风扇单元（30），用于从空气流中分离污物和灰尘的分离设备（100）和用于接收过滤器的通道（114）。通道和过滤器可以位于分离装置（100）的下游和电动机的上游，并且过滤器可以具有至少部分弯曲的过滤器表面。过滤器布置在马达和风扇单元（30）的至少一部分周围。该过滤器可通过一侧移动并穿过该设备（12）的一个轮（14）。该装置有助于从清洁器具（10）移除过滤器（20）。

27. 发明申请

WO1995003315A2 SACCHARIDES, THEIR SYNTHESIS AND USE 审中-公开
标题翻译： SACCHARIDES，他们的合成和使用
公开(公告)号：WO1995003315A2
公开(公告)日：1995-02-02
申请号：PCT/GB1994001575
申请日：1994-07-21
申请人： OXFORD GLYCOSYSTEMS LTD , CAMPION, Colin , ALI, Mezher, Hussein , ORCHARD, Michael, Glen , COURTNEY, Stephen, Martin , PAREKH, Rajesh, Bhikhu
发明人： OXFORD GLYCOSYSTEMS LTD
IPC分类号： C07H03/06
CPC分类号： C07H3/06 , A61K47/56 , A61K47/62 , G01N33/66 , G01N33/68
摘要： A library comprises at least six different sugar-containing molecules selected from (i) carbohydrates each derived from at least two saccharide monomers, and (ii) glycoconjugates. Such a library may comprise disaccharides or linear or branched trisaccharides. It may be prepared from a compound having at least two OH groups which are modified by independently-removable blocking groups. A novel process comprises synthesising a polysaccharide of the formula sugarn, n representing the number of mono- and/or oligo-saccharide units from which the polysaccharide may be derived, comprises the steps of coupling sugar2 with a conjugate of the formula Q-sugar1, Q being a removable lipophilic or polymeric material, in a solvent for the conjugate; adding a non-solvent for the resultant conjugate Q-sugar1-sugar2; repeating the said steps n-2 times, as necessary, selecting the sugar to be coupled independently each time; and removing Q from the resultant coupled conjugate.
摘要翻译：文库包含至少六种不同的含糖分子，其选自（i）各自衍生自至少两种糖单体的碳水化合物，和（ii）糖缀合物。这样的文库可以包含二糖或直链或支链三糖。它可以由具有至少两个OH基团的化合物制备，所述OH基团可通过独立取代的封闭基团改性。一种新方法包括合成式糖的多糖，n代表可衍生多糖的单糖和/或寡糖单元的数目，包括以下步骤：将糖2与式Q-糖1的共轭物偶联， Q为可移除的亲脂性或聚合物材料，用于缀合物的溶剂中; 加入所得偶联物Q-sugar1-sugar2的非溶剂; 根据需要重复所述步骤n-2次，每次选择要独立耦合的糖; 并从所得偶联的偶联物中除去Q。

28. 发明申请

WO2013186510A1 ARRANGEMENT COMPRISING SINK AND FIXTURE, SAID FIXTURE COMPRISING A WATER SPOUT AND AN ELONGATE AIR -KNIFE DISCHARGE OUTLET 审中-公开
标题翻译：包括水槽和固定装置的装置，包括水分离器和最终空气灭火器出口的固定装置
公开(公告)号：WO2013186510A1
公开(公告)日：2013-12-19
申请号：PCT/GB2012/051373
申请日：2012-06-14
申请人： DYSON TECHNOLOGY LIMITED , COURTNEY, Stephen
发明人： COURTNEY, Stephen
IPC分类号： A47K10/48
CPC分类号： A47K10/00 , A47K10/48 , A47K2210/00 , F26B21/004
摘要： The invention relates to an arrangement comprising a sink and a sink fixture. The fixture has a water spout arranged to project over the basin of the sink, the water spout having a water nozzle arranged for connection through the spout to a water supply. The fixture also incorporates an elongate air-knife discharge outlet connected to an air supply for discharging an air-knife onto a users hand. The air-knife discharge outlet is angled downwards so that the air-knife is directed down into the basin of the sink.
摘要翻译：本发明涉及一种包括水槽和水槽固定装置的装置。固定装置具有排水口，其突出在水槽的水池上，水口具有布置成通过喷口连接到水源的水嘴。固定装置还包括连接到空气供应器的细长气刀排出口，用于将气刀排放到使用者手上。气刀排出口向下倾斜，使得气刀被引导到水槽的盆中。

29. 发明申请

WO2013024254A1 A HAND DRYER 审中-公开
标题翻译：手提干衣机
公开(公告)号：WO2013024254A1
公开(公告)日：2013-02-21
申请号：PCT/GB2012/051831
申请日：2012-07-27
申请人： DYSON TECHNOLOGY LIMITED , COURTNEY, Stephen , GAMMACK, Peter , RYAN, Leigh
发明人： COURTNEY, Stephen , GAMMACK, Peter , RYAN, Leigh
IPC分类号： A47K10/48
CPC分类号： A47K10/48
摘要： A wall-mountable hand dryer for drying one side of a user's hands at a time, the dryer having two nozzle sections - one for each hand - which nozzle sections are positioned towards the front of the dryer so that they are spaced away from the wall in use, the nozzle sections each extending to span the width of a user's open hand and being arranged for directing drying air down onto the front or back of said hand as it is inserted lengthwise underneath the nozzle sections from the front of the dryer, wherein the dryer comprises a downwardly pitched guide part positioned behind each nozzle section for guiding the pitch of the user's hands underneath the nozzle sections.
摘要翻译：一次用于干燥使用者手的一侧的壁挂式干手器，干燥器具有两个喷嘴部分 - 每个手一个 - 这些喷嘴部分朝向干燥器的前部定位，使得它们与壁间隔开在使用中，喷嘴部分各自延伸以跨越使用者的开放手的宽度，并且布置成当干燥空气从烘干机的前部沿喷嘴部分的纵向插入时将干燥空气向下引导到所述手的前部或后部，其中干燥机包括位于每个喷嘴部分后面的向下倾斜的引导部分，用于将使用者的手的俯仰引导到喷嘴部分下方。

30. 发明申请

WO2013024253A2 A HAND DRYER 审中-公开
标题翻译：干手器
公开(公告)号：WO2013024253A2
公开(公告)日：2013-02-21
申请号：PCT/GB2012/051830
申请日：2012-07-27
申请人： DYSON TECHNOLOGY LIMITED , RYAN, Leigh , GAMMACK, Peter , COURTNEY, Stephen
发明人： RYAN, Leigh , GAMMACK, Peter , COURTNEY, Stephen
IPC分类号： A47K10/48
CPC分类号： A47K10/48 , F26B25/06
摘要： A hand dryer having a left-hand nozzle section which, in normal use, is used to dry a user's left hand and a right-hand nozzle section which, in normal use, is used separately to dry the user's right hand, the left-hand nozzle section being arranged to emit drying air along a first direction - outwardly to the left of the dryer - and the right-hand nozzle section being arranged to emit drying air in a second direction - outwardly to the right of the dryer - said first and second directions having a downward and/or forward component.
摘要翻译：具有左侧喷嘴部分的干手器，其在正常使用中用于干燥使用者的左手和右手嘴部分，所述左手部分和右手部分在正常使用中单独使用以干燥使用者的右手，左侧喷嘴部分布置成沿第一方向喷出干燥空气 - 向外至干燥器的左侧 - 并且右侧喷嘴部分布置成沿第二方向喷出干燥空气 - 向外至干衣机的右侧 - 所述第一和第二方向具有向下和/或向前的分量。

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