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1. 发明申请

WO2011064606A2 MILL AND METHOD OF MILLING 审中-公开
标题翻译：铣刀和铣削方法
公开(公告)号：WO2011064606A2
公开(公告)日：2011-06-03
申请号：PCT/GB2011/000094
申请日：2011-01-25
申请人： BROWN, CHRISTOPHER JOHN , BROWN, Christopher, John
发明人： BROWN, Christopher, John
CPC分类号： B02C15/16
摘要： A milling apparatus in which at least two independently driven axiaily mounted elements are eccentrically mounted one within the other so as to define a processing chamber therebetween with the minimum radial gap between the elements at one position being diametrically opposite to the maximum radial gap. Stresses are applied to the material by passing it through the minimum radial gap, which is adjustable. The elements may be rotated in the same direction to apply compressive and extensional stresses to material within the minimum gap, or in opposite directions to apply shear stresses to the material within this gap. A third element may be incorporated within the chamber to provide heat transfer and distributive mixing to the stressed material.
摘要翻译：一种铣削装置，其中至少两个独立驱动的轴向安装的元件偏心地安装在另一个中，以便在其间限定一个处理室，其中一个位置处的元件之间的最小径向间隙与最大径向间隙完全相反。通过将材料通过可调节的最小径向间隙施加应力。元件可以沿相同的方向旋转，以将压缩和拉伸应力施加在最小间隙内的材料上，或者在相反方向上施加剪切应力到该间隙内的材料。第三元件可以并入室中以提供热应力材料的热传递和分配混合。

2. 发明专利

IL257537D0 Probes for imaging huntingtin protein 未知
公开(公告)号：IL257537D0
公开(公告)日：2018-04-30
申请号：IL25753718
申请日：2018-02-14
申请人： CHDI FOUNDATION INC , DOMINGUEZ CELIA , WITYAK JOHN , BARD JONATHAN , BROWN CHRISTOPHER JOHN , PRIME MICHAEL EDWARD , JOHNSON PETER DAVID , KRULLE THOMAS MARTIN , CLARK FREW DANIEL , HIGGINS DUANE , MILLS MATTHEW ROBERT , MARSTON RICHARD WALDRON , COE SAMUEL , GREEN SAMANTHA LOUISE JONES , HAYES SARAH
发明人： DOMINGUEZ CELIA , WITYAK JOHN , BARD JONATHAN , BROWN CHRISTOPHER JOHN , PRIME MICHAEL EDWARD , JOHNSON PETER DAVID , KRULLE THOMAS MARTIN , CLARK-FREW DANIEL , HIGGINS DUANE , MILLS MATTHEW ROBERT , MARSTON RICHARD WALDRON , COE SAMUEL , GREEN SAMANTHA LOUISE JONES , HAYES SARAH
IPC分类号： A61K20060101
摘要： Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use. (I).

3. 发明专利

GB2475680A Milling apparatus 未知
公开(公告)号：GB2475680A
公开(公告)日：2011-06-01
申请号：GB0920603
申请日：2009-11-25
申请人： BROWN CHRISTOPHER JOHN
发明人： BROWN CHRISTOPHER JOHN
IPC分类号： B02C19/08 , B02C17/00
摘要： A milling device has a shaft 27 within a cup 28, the outer wall of the shaft 27 proximate or in contact with the inner wall of the cup 28, both shaft 27 and cup 28 being rotatable in both the same, and opposite, directions to provide two different grinding actions for material, usually in a fluid medium, passed into the cup 28, and between the cup 28 and shaft 27 to be disintegrated.

4. 发明专利

IL257537A Probes for imaging huntingtin protein 未知
公开(公告)号：IL257537A
公开(公告)日：2020-08-31
申请号：IL25753718
申请日：2018-02-14
申请人： CHDI FOUNDATION INC , DOMINGUEZ CELIA , WITYAK JOHN , BARD JONATHAN , BROWN CHRISTOPHER JOHN , PRIME MICHAEL EDWARD , JOHNSON PETER DAVID , KRULLE THOMAS MARTIN , CLARK FREW DANIEL , HIGGINS DUANE , MILLS MATTHEW ROBERT , MARSTON RICHARD WALDRON , COE SAMUEL , GREEN SAMANTHA LOUISE JONES , HAYES SARAH
发明人： CLARK-FREW DANIEL , HIGGINS DUANE , DOMINGUEZ CELIA , WITYAK JOHN , BARD JONATHAN , BROWN CHRISTOPHER JOHN , PRIME MICHAEL EDWARD , JOHNSON PETER DAVID , KRULLE THOMAS MARTIN , MILLS MATTHEW ROBERT , MARSTON RICHARD WALDRON , COE SAMUEL , GREEN SAMANTHA LOUISE JONES , HAYES SARAH
IPC分类号： A61K51/04
摘要： Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use. (I).

5. 发明申请

WO2013033085A1 KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：吉非烯-3-MONOOXYGENASE抑制剂，药物组合物及其使用方法
公开(公告)号：WO2013033085A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052648
申请日：2012-08-28
申请人： COURTNEY, Stephen Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher John , DE AGUIAR PENA, Paula C. , JOHNSON, Peter , DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia M. , MUNOZ, Ignacio
发明人： COURTNEY, Stephen Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher John , DE AGUIAR PENA, Paula C. , JOHNSON, Peter , DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia M. , MUNOZ, Ignacio
IPC分类号： A61K31/44 , C07D401/00
CPC分类号： C07D239/28 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D491/048 , C07D491/052 , C07H13/10
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对KMO活性的抑制作用的某些疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症的体征或症状的化学实体。这些疾病包括神经变性疾病如亨廷顿氏病。还描述了治疗方法，包括给予至少一种作为单一活性剂的化学实体或与一种或多种其它治疗剂组合施用至少一种化学实体。还提供了用于筛选能够抑制KMO活性的化合物的方法。

6. 发明申请

WO2013033068A1 KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译： KUNURENINE-3-单硫酸酯酶抑制剂，药物组合物及其使用方法
公开(公告)号：WO2013033068A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052617
申请日：2012-08-28
申请人： COURTNEY, Stephen Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher John , DE AGUIAR PENA, Paula C. , JOHNSON, Peter , DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia M. , MUNOZ, Ignacio
发明人： COURTNEY, Stephen Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher John , DE AGUIAR PENA, Paula C. , JOHNSON, Peter , DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia M. , MUNOZ, Ignacio
IPC分类号： C07D239/47
CPC分类号： C07D239/28 , A61K31/506 , C07D239/42 , C07D239/52 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , Y02A50/401 , Y02A50/411 , Y02A50/465
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对抑制KMO活性有响应的某些疾病和病症的患者的方法，其包括向这些患者施用有效量的至少一种化学实体，以减轻疾病或病症的体征或症状。这些疾病包括神经退行性疾病，如亨廷顿病。还描述了治疗方法，包括施用至少一种化学实体作为单一活性剂或施用与一种或多种其他治疗剂组合的至少一种化学实体。还提供了筛选能够抑制KMO活性的化合物的方法。

7. 发明申请

WO2013016488A1 CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：某些京那奈因-3-MONOOXYGENASE抑制剂，药物组合物及其使用方法
公开(公告)号：WO2013016488A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/048254
申请日：2012-07-26
申请人： DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia, M. , COURTNEY, Stephen, Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher, John , DE AGUIAR PENA, Paula, C. , JOHNSON, Peter
发明人： DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia, M. , COURTNEY, Stephen, Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher, John , DE AGUIAR PENA, Paula, C. , JOHNSON, Peter
IPC分类号： A01N43/54 , C07D239/42 , C07D471/04
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/5377 , C07D239/26 , C07D239/28 , C07D239/42 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D491/044 , C07D491/048 , C07D491/052
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对KMO活性的抑制作用的某些疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症的体征或症状的化学实体。这些疾病包括神经变性疾病如亨廷顿氏病。还描述了治疗方法，包括给予至少一种作为单一活性剂的化学实体或与一种或多种其它治疗剂组合施用至少一种化学实体。还提供了用于筛选能够抑制KMO活性的化合物的方法。

8. 发明申请

WO2011064606A3 MILL AND METHOD OF MILLING 审中-公开
标题翻译：铣刀和铣削方法
公开(公告)号：WO2011064606A3
公开(公告)日：2011-09-09
申请号：PCT/GB2011000094
申请日：2011-01-25
申请人： BROWN CHRISTOPHER JOHN
发明人： BROWN CHRISTOPHER JOHN
IPC分类号： B02C2/02
CPC分类号： B02C15/16
摘要： A milling apparatus in which at least two independently driven axiaily mounted elements are eccentrically mounted one within the other so as to define a processing chamber (12) therebetween with the minimum radial gap between the elements at one position being diametrically opposite to the maximum radial gap. Stresses are applied to the material by passing it through the minimum radial gap, which is adjustable. The elements may be rotated in the same direction to apply compressive and extensional stresses to material within the minimum gap, or in opposite directions to apply shear stresses to the material within this gap. A third element may be incorporated within the chamber to provide heat transfer and distributive mixing to the stressed material.
摘要翻译：一种铣削装置，其中至少两个独立驱动的轴向安装的元件偏心地安装在另一个中，以便在其间限定一个处理室（12），其中一个位置处的元件之间的最小径向间隙在径向上与最大径向间隙。通过将材料通过可调节的最小径向间隙施加应力。元件可以沿相同的方向旋转，以将压缩和拉伸应力施加在最小间隙内的材料上，或者在相反方向上施加剪切应力到该间隙内的材料。第三元件可以并入室中以提供热应力材料的热传递和分配混合。

9. 发明申请

WO2010089320A1 DISTRIBUTIVE AND DISPERSIVE MIXING APPARATUS OF THE CDDM TYPE, AND ITS USE 审中-公开
标题翻译： CDDM类型的分布式和分散混合装置及其使用
公开(公告)号：WO2010089320A1
公开(公告)日：2010-08-12
申请号：PCT/EP2010/051292
申请日：2010-02-03
申请人： UNILEVER PLC , UNILEVER N.V. , HINDUSTAN UNILEVER LIMITED , BROWN, Christopher, John , IRVING, Graeme, Neil , KOWALSKI, Adam, Jan
发明人： BROWN, Christopher, John , IRVING, Graeme, Neil , KOWALSKI, Adam, Jan
IPC分类号： B01F7/00 , B01F3/08
CPC分类号： B01F7/00775 , B01F3/0807 , B01F7/00783 , B01F7/00816 , B01F7/00825
摘要： A distributive and dispersive mixing apparatus of the CDDM type comprising two confronting surfaces as being the inner surface of shell (4) and the outer surface of fixed cage (2)) and at least one cage-like member (3) disposed between the confronting surfaces said cage-like member (3) defining passages for fluid flow adjacent at least one of the confronting surfaces CHARACTERISED IN THAT the or at least one cage-like member (3) has a relative rotational movement but is not freely rotating relative to at least one of the confronting surfaces and/or at least one other cage-like member, and the bulk fluid flow within the mixing apparatus is in the plane of the surface of the or at least one cage-like member perpendicular to the direction of relative rotational movement.
摘要翻译：一种CDDM型分布式和分散混合装置，包括两个相对的表面作为壳体（4）的内表面和固定笼（2）的外表面）和至少一个笼状构件（3）表面所述笼状构件（3）限定用于流体流动的通道，其邻近表面中的至少一个表面，其特征在于，所述或至少一个笼状构件（3）具有相对旋转运动，但不相对于自由旋转至少一个相对的表面和/或至少一个其它笼状构件，并且混合装置内的主体流体流动在垂直于相对方向的该或该至少一个笼状构件的表面的平面中旋转运动。

10. 发明申请

WO1996035507A1 INTERNAL MIXERS 审中-公开
标题翻译：内部混合器
公开(公告)号：WO1996035507A1
公开(公告)日：1996-11-14
申请号：PCT/GB1996001128
申请日：1996-05-13
申请人： FRANCIS SHAW & COMPANY (MANCHESTER) LIMITED , BROWN, Christopher, John
发明人： FRANCIS SHAW & COMPANY (MANCHESTER) LIMITED
IPC分类号： B01F07/02
CPC分类号： B29B7/125 , B29B7/186 , B29B7/20
摘要： An internal mixer comprising at least one rotor supported to rotate about a predetermined axis within a mixing chamber, at least one projection mounted on the or each rotor and extending towards an internal wall of the chamber, and means for rotating the or each rotor about its axis, the said at least one rotor defining projection edges of different geometries and being rotated such that each of the said edges is a leading edge in at least part of a mixing cycle, whereby material within the chamber is subjected to different mixing actions by the edges of different geometries.
摘要翻译：一种内部混合器，包括至少一个转子，所述至少一个转子被支撑以在混合室内围绕预定轴线旋转，安装在所述转子上或每个转子上的至少一个突起并且朝向所述室的内壁延伸，以及用于围绕其旋转所述或每个转子的装置所述至少一个转子限定不同几何形状的突出边缘并且被旋转，使得每个所述边缘在混合循环的至少一部分中是前缘，由此室内的材料受到不同的混合动作不同几何的边缘。

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