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21. 发明申请

WO2006002336A3 METHOD FOR RESPONDING TO CUSTOMER QUERIES 审中-公开
标题翻译：用于客户查询的方法
公开(公告)号：WO2006002336A3
公开(公告)日：2009-04-30
申请号：PCT/US2005022371
申请日：2005-06-23
申请人： COHEN DARRYL R , COHEN MARK I , PALAZOTTO DAN M , BURNS STEPHEN S
发明人： COHEN DARRYL R , COHEN MARK I , PALAZOTTO DAN M , BURNS STEPHEN S
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： H04M3/51 , G06F17/30905 , H04M3/5175
摘要： A method for responding to customer queries using a communication network includes receiving one or more verbal queries from a customer via a customer communication device, digitizing and storing the verbal query, retrieving the stored query and transcribing the query by a human transcriber, spot-checking by a quality assurance operator of the transcribed query, and routing the transcribed query to a human researcher. The researcher than performs research using search engines, databases, and/or knowledge-bases to obtain an answer to the query. The researcher's answer may also be spot-checked by a quality assurance operator. The answer is then transmitted to the customer communication device in text format.
摘要翻译：使用通信网络来响应客户查询的方法包括经由客户通信设备接收来自客户的一个或多个口头查询，数字化和存储语言查询，检索所存储的查询并由人类抄录员转录查询，点检通过转录查询的质量保证运算符，并将转录的查询路由到人类研究者。研究人员使用搜索引擎，数据库和/或知识库进行研究，以获得查询的答案。研究人员的答案也可能由质量保证经营者进行检查。然后将答案以文本格式发送给客户通信设备。

22. 发明申请

WO2008008447A3 PORTABLE DEVICE FOR ULTRA-LOW FIELD MAGNETIC RESONANCE IMAGING (ULF-MRI) 审中-公开
标题翻译：用于超低场磁共振成像的便携式装置（ULF-MRI）
公开(公告)号：WO2008008447A3
公开(公告)日：2008-09-18
申请号：PCT/US2007015915
申请日：2007-07-12
申请人： UNIV CALIFORNIA , COHEN MARK
发明人： COHEN MARK
IPC分类号： G01V3/00
CPC分类号： G01R33/3415 , G01R33/28 , G01R33/445
摘要： A portable device for ultra-low field magnetic resonance imaging (ULF-MRI). This portable ULF-MRI device has applications for emergency care, surgery, battlefield care and other trauma applications. The portable ULF-MRI device includes multiple receiver channels, imaging coils and times, and provides enhanced contrast behavior of ultra low field imaging and pulse sequence optimization. Using the additional spatial information that derives from the use of multiple receiver coil, the invention discloses a novel means of MRI signal spatial encoding.
摘要翻译：用于超低场磁共振成像（ULF-MRI）的便携式设备。这种便携式ULF-MRI设备可用于紧急护理，手术，战场护理和其他创伤应用。便携式ULF-MRI设备包括多个接收器通道，成像线圈和时间，并且提供增强的超低场成像和脉冲序列优化的对比行为。使用从使用多个接收器线圈导出的附加空间信息，本发明公开了一种MRI信号空间编码的新颖方法。

23. 发明申请

WO2012106393A2 WITHANOLIDE ISOLATED FROM PHYSALIS LONGIFOLIA AND ANALOGS AND METHODS OF USE THEREOF 审中-公开
标题翻译：来自PHYSALIS LONGIFOLIA和模拟物分离的非芳香化合物及其使用方法
公开(公告)号：WO2012106393A2
公开(公告)日：2012-08-09
申请号：PCT/US2012/023431
申请日：2012-02-01
申请人： UNIVERSITY OF KANSAS , TIMMERMANN, Barbara, N. , AUBE, Jeffrey , ZHANG, Huaping , GOLLAPUDI, Rao , COHEN, Mark, S. , SAMADI, Abbas , MOTIWALA, Hashim, Fakruddin
发明人： TIMMERMANN, Barbara, N. , AUBE, Jeffrey , ZHANG, Huaping , GOLLAPUDI, Rao , COHEN, Mark, S. , SAMADI, Abbas , MOTIWALA, Hashim, Fakruddin
IPC分类号： A61K31/704 , C07J71/00 , C07G3/00 , A61K31/58 , A61P35/00 , A61P9/12 , A61P9/10 , A61P25/16 , A61P25/28 , A61P25/00 , A61P11/06 , A61P19/02 , C12N5/07
CPC分类号： C07J71/001 , C07J17/00 , C07J17/005 , C07J41/0055 , C07J61/00
摘要： The present invention features novel withanolides, as well as analogs and salts thereof, for use in the treatment of proliferative disease, cardiovascular disease, neurodegenerative disease and inflammatory disease.
摘要翻译：本发明的特征在于用于治疗增殖性疾病，心血管疾病，神经退行性疾病和炎症性疾病的新颖的脱乙酰壳多糖及其类似物和盐。

24. 发明申请

WO2005076772A2 SYSTEMS AND METHODS FOR CONTEXT RELEVANT INFORMATION MANAGEMENT AND DISPLAY 审中-公开
标题翻译：系统与方法相关的信息管理和显示
公开(公告)号：WO2005076772A2
公开(公告)日：2005-08-25
申请号：PCT/US2004022979
申请日：2004-07-16
申请人： CONTEXTUAL INFORMATION INC , COHEN MARK , COHEN JANE
发明人： COHEN MARK , COHEN JANE
IPC分类号： G06Q30/00 , H04L29/08 , H04W4/02
CPC分类号： G06Q30/02 , G06Q50/22 , G06Q50/24 , G16H40/20 , G16H40/63 , H04L67/18 , H04L67/306 , H04W4/02
摘要： A wireless information device provides a user with context relevant information. The precise location of the wireless device is monitored by a tracking system. Using the location of the wireless device and the identity of the user, context relevant information is transmitted to the device, where the context relevant information is pre-defined, at least in part, by the user. Context relevant information served to the device depends on the identity of the user, the location of the device, and the proximity of the device to persons or objects. The wireless information device may be used by healthcare workers, such as physicians, in hospitals, although other environments are contemplated, such as hotels, airports, zoos, theme parks, and the like.
摘要翻译：无线信息设备向用户提供上下文相关信息。无线设备的精确位置由跟踪系统监控。使用无线设备的位置和用户的身份，上下文相关信息被传送到设备，其中上下文相关信息至少部分由用户预定义。服务于设备的上下文相关信息取决于用户的身份，设备的位置以及设备对人或物体的接近程度。无线信息设备可以由卫生保健工作者（例如医生）在医院中使用，但是可以考虑其他环境，例如酒店，机场，动物园，主题公园等。

25. 发明申请

WO0213689A3 METHOD AND APPARATUS FOR REDUCING CONTAMINATION OF AN ELECTRICAL SIGNAL 审中-公开
标题翻译：减少电子信号污染的方法和装置
公开(公告)号：WO0213689A3
公开(公告)日：2003-08-21
申请号：PCT/US0125480
申请日：2001-08-15
申请人： UNIV CALIFORNIA , COHEN MARK S
发明人： COHEN MARK S
IPC分类号： G01R33/28 , A61B5/04 , A61B5/0476 , A61B5/055 , G06F17/00
CPC分类号： A61B5/04004 , A61B5/04017 , A61B5/4094
摘要： The method of reducing contamination of electrical signals recorded in the presence of repeated interference contamination comprises obtaining an electrical signal recorded in the presence of a contaminating signal, and detecting a timing signal that occurs at a fixed time point during the electrical signal relative to the onset of the contaminating signal. The electrical signal is digitized, wherein the digitizing begins with the timing signal. A plurality of digitized electrical signals is analyzed, wherein the electrical signals are synchronized with respect to the timing signal, to obtain an estimated contaminating signal that is subtracted from the digitized electrical signal. This method can be used with electrophysiological signals, such as EEG, ECG, EMG and galvanic skin response, and for elimination of noise associated with concurrently used methods such as MRI. The method of noise reduction is applicable to recordings of other electrical signals, including audio recordings.
摘要翻译：在存在重复的干扰污染的情况下减少记录的电信号的污染的方法包括获得在存在污染信号的情况下记录的电信号，以及检测在电信号期间相对于发生的固定时间点发生的定时信号的污染信号。电信号被数字化，其中数字化以定时信号开始。分析多个数字化电信号，其中电信号相对于定时信号同步，以获得从数字化电信号中减去的估计污染信号。该方法可用于电生理信号，如EEG，ECG，EMG和电流皮肤反应，以及消除与同时使用的方法如MRI相关的噪声。噪声降低的方法适用于包括音频记录在内的其他电信号的记录。

26. 发明申请

WO2016011049A3 COMPOSITIONS AND METHODS FOR DISEASE TREATMENT USING NANOPARTICLE DELIVERED COMPOUNDS 审中-公开
标题翻译：使用纳米颗粒递送化合物进行疾病治疗的组合物和方法
公开(公告)号：WO2016011049A3
公开(公告)日：2016-04-14
申请号：PCT/US2015040404
申请日：2015-07-14
申请人： SCHWENDEMAN ANNA , COHEN MARK , SUBRAMANIAN CHITRA , KUAI RUI , LI DAN , WHITE PETER , MOON JAMES
发明人： SCHWENDEMAN ANNA , COHEN MARK , SUBRAMANIAN CHITRA , KUAI RUI , LI DAN , WHITE PETER , MOON JAMES
IPC分类号： A61K9/127 , A61K39/00
CPC分类号： A61K31/585 , A61K9/16 , A61K9/5123 , A61K31/58 , A61K38/1709
摘要： Provided herein are compositions and methods for the treatment of diseases, such as hyperproliferative diseases, employing compounds formulated for pharmaceutical and research use via nanoparticles.
摘要翻译：本文提供了用于治疗诸如过度增殖性疾病的疾病的组合物和方法，其使用通过纳米颗粒配制用于药物和研究用途的化合物。

27. 发明申请

WO2011019849A1 MAGNETIC RESONANCE MICROCOIL AND METHOD OF USE 审中-公开
标题翻译：磁共振微球及其使用方法
公开(公告)号：WO2011019849A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/045219
申请日：2010-08-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , STRICK RIVERA, Debra , JUDY, Jack, W. , COHEN, Mark, S. , MILLS, Dixie, J.
发明人： STRICK RIVERA, Debra , JUDY, Jack, W. , COHEN, Mark, S. , MILLS, Dixie, J.
IPC分类号： A61M5/178
CPC分类号： A61B5/055 , A61B5/4094 , A61B5/6846 , G01R33/287 , G01R33/34084
摘要： A magnetic resonance imaging device includes an elongate flexible member having a proximal end, a distal end, and a lumen extending between the proximal end and the distal end and a solenoid coil affixed to the distal end of the elongate flexible member, the solenoid coil having a plurality of wire turns, the solenoid coil connected to a twisted-pair of leads extending proximally along the length of the flexible member. A connector is disposed at the proximal end of the elongate flexible member, the connector operatively coupled to the twisted-pair of leads. In an alternative embodiment, a coaxial cable substitutes for the lumen-containing elongate flexible member.
摘要翻译：磁共振成像装置包括具有近端，远端和在近端和远端之间延伸的内腔的细长柔性构件和固定到细长柔性构件的远端的螺线管线圈，螺线管线圈具有多个线圈，螺线管线圈连接到沿着柔性构件的长度向近侧延伸的双绞线。连接器设置在细长柔性构件的近端处，连接器可操作地连接到双绞线引线。在替代实施例中，同轴电缆代替含内腔的细长柔性构件。

28. 发明申请

WO2010053655A3 THERAPEUTIC METHODS WITH WITHAFERIN A AND ANALOGS 审中-公开
标题翻译： WATHAFERIN A和ANALOGS的治疗方法
公开(公告)号：WO2010053655A3
公开(公告)日：2010-07-15
申请号：PCT/US2009060056
申请日：2009-10-08
申请人： UNIV KANSAS , COHEN MARK S , SAMADI ABBAS , TIMERMAN BARBARA N
发明人： COHEN MARK S , SAMADI ABBAS , TIMERMAN BARBARA N
IPC分类号： A61K31/56 , A61P25/28 , A61P35/00
CPC分类号： A61K31/56
摘要： Compounds of Formulas 1 (withaferin A, also referred to as D004), 2 (viscosalactone B, also referred to as E002), and 3 (22R-5ß-formyl-6ß,27-dihydroxyl-l -oxo-4-norwith-24- enolide, also referred to as O010), as well as salts, prodrugs, analogs, and derivatives thereof are biologically active for modulating Hsp70, Hsp90, and/or HSFl. Also, these compounds can be included in pharmaceutical compositions for administration to a subject for modulating the expression or activity of Hsp70, Hsp90, and/or HSFl in order to produce a therapeutic effect.
摘要翻译：式1的化合物（含有铁蛋白A，也称为D004），2（粘内酯B，也称为E002）和3（22R-5β-甲酰基-6β，27-二羟基-1-氧代-4-去甲基 - 24-烯醇化物，也称为O010），以及其盐，前药，类似物和衍生物在调节Hsp70，Hsp90和/或HSF1方面具有生物活性。此外，为了产生治疗效果，这些化合物可以包括在用于给受试者施用以调节Hsp70，Hsp90和/或HSF1的表达或活性的药物组合物中。

29. 发明申请

WO2008091712A3 LOW FIELD ELECTRON PARAMAGNETIC RESONANCE IMAGING WITH SQUID DETECTION 审中-公开
标题翻译：低场电子参考谐波成像与检测
公开(公告)号：WO2008091712A3
公开(公告)日：2008-11-06
申请号：PCT/US2008001136
申请日：2008-01-28
申请人： CALIFORNIA INST OF TECHN , HANH INSEOB , DAY PETER , PENANEN KONSTANTIN I , EOM BYEONG H , COHEN MARK S
发明人： HANH INSEOB , DAY PETER , PENANEN KONSTANTIN I , EOM BYEONG H , COHEN MARK S
IPC分类号： G01N24/10 , G01R33/035 , G01R33/36 , G01R33/48
CPC分类号： G01R33/326 , G01N24/10 , G01R33/0354 , G01R33/0358 , G01R33/445
摘要： A flux transformer is magnetically coupled to a SQUID (112), and a plurality of SQUIDs (114B1 115B, 116B, 117B), connected in series, is magnetically coupled to the output of the SQUID. Alternatively, a flux transformer (108, 110) and a modulating coil (330) are magnetically coupled to a SQUID and an oscillator drives the modulating coil (230) at a frequency f. A processing system (306) mixes the output signal of the SQUID with sin(wt) and cos(2wt), where w = 2TT.f.
摘要翻译：磁通变压器磁耦合到SQUID（112），并且串联连接的多个SQUID（114B1 115B，116B，117B）磁耦合到SQUID的输出端。或者，磁通变压器（108,110）和调制线圈（330）磁耦合到SQUID并且振荡器以频率f驱动调制线圈（230）。处理系统（306）将SQUID的输出信号与sin（wt）和cos（2wt）混合，其中w = 2TT.f。

30. 发明申请

WO2008091712A2 LOW FIELD ELECTRON PARAMAGNETIC RESONANCE IMAGING WITH SQUID DETECTION 审中-公开
标题翻译：低场电子参考谐波成像与检测
公开(公告)号：WO2008091712A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/001136
申请日：2008-01-28
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , HANH, Inseob , DAY, Peter , PENANEN, Konstantin, I. , EOM, Byeong, H. , COHEN, Mark, S.
发明人： HANH, Inseob , DAY, Peter , PENANEN, Konstantin, I. , EOM, Byeong, H. , COHEN, Mark, S.
IPC分类号： G01N24/10 , G01R33/36 , G01R33/48 , G01R33/035
CPC分类号： G01R33/326 , G01N24/10 , G01R33/0354 , G01R33/0358 , G01R33/445
摘要： In one embodiment, a flux transformer is magnetically coupled to a SQUID, and a plurality of SQUIDs, connected in series, is magnetically coupled to the output of the SQUID. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，磁通变换器磁耦合到SQUID，并且串联连接的多个SQUID磁耦合到SQUID的输出端。描述和要求保护其他实施例。

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