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21. 发明申请

WO2021001661A1 ANTIBACTERIAL AND ANTIPARASITIC QUINOXALINE-2,3-DIAMINE DERIVATIVES 审中-公开
公开(公告)号：WO2021001661A1
公开(公告)日：2021-01-07
申请号：PCT/GB2020/051610
申请日：2020-07-03
申请人： ABERYSTWYTH UNIVERSITY , UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED
发明人： BRANCALE, Andrea , PADALINO, Gilda , HOFFMANN, Karl
IPC分类号： A61K31/382 , A61K31/498 , A61K45/06 , A61P31/04 , A61P33/06 , A61P33/12 , C07D241/44
摘要： A compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, for use in the treatment of a patient infected with pathogenic organisms; wherein X and Y are each independently selected from C, N, O and S, provided at least one of X and Y is N, O or S; wherein R 1 and R 2 are each independently selected from an optionally substituted C 1 -C 8 alkyl, C 1 -C 8 alkenyl, aryl, heteroaryl or alkylaryl group; and wherein Z is selected from H, -CN, -NO 2 , -NR 3 R 4 , -NR 5 (CO)R 6 ; C 1 -C 4 alkyl, C 1 -C 4 alkoxy, -(CO)WR 12 , hydroxy, amino, thiol, chloro, fluoro, CF 3 , CHF 2 or CH 2 F groups. The compounds may be effective in treating patients/animals infected with parasites selected from Schistosoma, Haemonchus, Eimeria, Echinococcus, Dirofilaria, Fasciola or Plasmodium parasites. Additionally or alternatively, the compounds of formula (I) may be effective in treating patients infected with pathogenic bacteria selected from S. aureus , MRSA and Enterococcus faecalis.

22. 发明申请

WO2018115877A2 COMPOSITIONS AND METHODS OF TREATMENT 审中-公开
公开(公告)号：WO2018115877A2
公开(公告)日：2018-06-28
申请号：PCT/GB2017/053847
申请日：2017-12-20
申请人： ABERYSTWYTH UNIVERSITY
发明人： HUWS, Sharon Ann , OYAMA, Linda
IPC分类号： A61K38/10 , C07K7/08 , A61P31/00 , A61P31/04
CPC分类号： A61K38/10 , A61L15/44 , A61L15/46 , A61L2300/404 , A61P31/00 , A61P31/04 , C07K7/08 , C07K14/195 , G01N33/6842 , G01N2500/10 , Y02A50/47 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to a composition comprising rumen microbe derived peptides which have particular uses as antimicrobial agents.

23. 发明申请

WO2018100386A1 METHODS AND COMPOSITIONS FOR IMPROVING FEED OUTCOMES 审中-公开
公开(公告)号：WO2018100386A1
公开(公告)日：2018-06-07
申请号：PCT/GB2017/053622
申请日：2017-11-30
申请人： BANGOR UNIVERSITY , ABERYSTWYTH UNIVERSITY
发明人： BRAGANCA, Radek Messias , NEWBOLD, Charles James , MORALES, Eva Ramos , NASH, Robert James
IPC分类号： A23K50/10 , A23K20/132
摘要： The present invention relates to a method for improving outcomes in ruminant feeding, the method comprising administering a composition to the ruminant, the composition comprising a glycosidase inhibiting iminosugar; wherein the improved outcome is selected from one or more of: inhibiting protozoal activity in the rumen of a ruminant; and/or improving ruminant feed efficiency; and/or improving growth performance of a ruminant; and/or reducing greenhouse gas emissions. The invention also relates to a composition comprising a saponin and a glycosidase inhibitor, preferably a glycosidase inhibiting iminosugar.

24. 发明申请

WO2012101416A1 COMPOSITION AND METHOD FOR IMPROVING THE QUALITY OF MILK 审中-公开
标题翻译：用于改善奶粉质量的组合物和方法
公开(公告)号：WO2012101416A1
公开(公告)日：2012-08-02
申请号：PCT/GB2012/000092
申请日：2012-01-30
申请人： ABERYSTWYTH UNIVERSITY , LEE, Michael R.F. , HUWS, Sharon A.
发明人： LEE, Michael R.F. , HUWS, Sharon A.
IPC分类号： A23K1/16
CPC分类号： A23K50/10 , A23K20/10 , A23K20/105 , A23K20/158
摘要： The quality of milk can be improved by feeding to ruminants a nutritional composition comprising one or more green odour compounds or one or more derivatives, analogues or homologues thereof. In particularly preferred embodiments, the green odour compounds comprise one or more of hydroperoxides and jasmonates.
摘要翻译：可以通过向反刍动物喂养包含一种或多种绿色气味化合物或其一种或多种衍生物，类似物或同系物的营养组合物来改善牛奶的质量。在特别优选的实施方案中，绿色气味化合物包含一种或多种氢过氧化物和茉莉酮酸酯。

25. 发明申请

WO2012001370A1 METHOD FOR DIAGNOSING LUNG CANCER 审中-公开
标题翻译：诊断肺癌的方法
公开(公告)号：WO2012001370A1
公开(公告)日：2012-01-05
申请号：PCT/GB2011/000997
申请日：2011-07-01
申请人： ABERYSTWYTH UNIVERSITY , SWANSEA UNIVERSITY , LEWIS, Paul David , MUR, Luis Alejandro Jose
发明人： LEWIS, Paul David , MUR, Luis Alejandro Jose
IPC分类号： G01N21/35 , G01N33/574
CPC分类号： G01N21/35 , G01N2021/3595
摘要： Provided are methods for diagnosing lung cancer in a subject or for identifying a subject at risk of developing lung cancer, the method comprising performing FTIR spectral analysis of a sputum sample obtained from the subject and comparing the spectrum produced from the sample with an FTIR spectrum from a normal control. Also provided are methods for detecting early and late stage cancer, methods for monitoring the progression of lung cancer in a subject and kits for use in the described methods.
摘要翻译：提供了用于诊断受试者中的肺癌或用于鉴定患有肺癌风险的受试者的方法，所述方法包括对从受试者获得的痰样品进行FTIR光谱分析，并将样品产生的光谱与FTIR光谱一个正常的控制。还提供了用于检测早期和晚期癌症的方法，用于监测受试者中肺癌进展的方法和用于所述方法的试剂盒。

26. 发明申请

WO2009030889A1 IMAGING ELLIPSOMETER 审中-公开
标题翻译：成像ELLIPSOMETER
公开(公告)号：WO2009030889A1
公开(公告)日：2009-03-12
申请号：PCT/GB2008/002966
申请日：2008-09-02
申请人： ABERYSTWYTH UNIVERSITY , GUNN, Matthew, David , JENKINS, Tudor, Emlyn
发明人： GUNN, Matthew, David , JENKINS, Tudor, Emlyn
IPC分类号： G01B11/06 , G01N21/21
CPC分类号： G01B11/0641 , G01J1/0411 , G01N21/211
摘要： An imaging ellipsometer for imaging a substantially planar reflecting surface, the surface defining a surface plane. The ellipsometer comprises: a focussing element for focusing electromagnetic radiation specularly reflected from said surface, the focussing element having a focussing element plane; a detector for detecting specularly reflected electromagnetic radiation focussed by the focussing element at a detector plane; and a stage for supporting said surface; at least one constraining device for constraining the movement of the ellipsometer such that: the detector plane, the focussing element plane and said surface plane are arranged either to intersect along a single line or to be parallel to one another. Furthermore, the focussing element is arranged such that it is tiltable with respect to a principal axis such that the magnitude of an angle between a focussing element axis and the principal axis is able to be greater than 0 radians.
摘要翻译：一种成像椭偏仪，用于对基本上平面的反射表面进行成像，所述表面限定表面平面。所述椭偏仪包括：用于聚焦从所述表面镜面反射的电磁辐射的聚焦元件，所述聚焦元件具有聚焦元件平面; 检测器，用于检测由检测器平面上的聚焦元件聚焦的镜面反射的电磁辐射; 以及用于支撑所述表面的台阶; 至少一个约束装置，用于限制椭圆计的运动，使得：检测器平面，聚焦元件平面和所述表面平面布置成沿着单个线相交或者彼此平行。此外，聚焦元件布置成使得其可相对于主轴倾斜，使得聚焦元件轴线和主轴线之间的角度的大小能够大于0弧度。

27. 发明公开

EP4288038A2 A CANNABINOID MIXTURE 审中-实审
公开(公告)号：EP4288038A2
公开(公告)日：2023-12-13
申请号：EP22705099.4
申请日：2022-02-08
申请人： TTS Pharma Ltd , Aberystwyth University
发明人： WALTON, Robert , TUCKER, Mark , NASH, Debbie , ALLEN, Nathan , WONFOR, Ruth , SHAH, Ifat
IPC分类号： A61K31/015 , A61K31/05 , A61K31/192 , A61K45/06 , A61P29/00 , A23L33/00

28. 发明公开

EP2895604A1 LIPASES, POLYNUCLEOTIDES ENCODING THEM AND THEIR USES 审中-公开
标题翻译：脂肪酶，多核苷酸其编码及其用途
公开(公告)号：EP2895604A1
公开(公告)日：2015-07-22
申请号：EP13773313.5
申请日：2013-09-16
申请人： Aberystwyth University
发明人： PRIVÉ, Florence , NEWBOLD, Charles Jamie , HUWS, Sharon , SCOLLEN, Nigel
IPC分类号： C12N9/20 , C12N9/18 , C07K16/12 , C12P7/64 , G01N33/48 , G01N33/50 , A61K38/46 , C12P41/00 , C07K14/405
CPC分类号： C12N9/20 , A61K38/465 , A61K39/3955 , C07K16/40 , C07K2317/21 , C07K2317/76 , C12N9/18 , C12P7/64 , C12Y301/01003 , Y02E50/13
摘要： A lipase comprising a polypeptide or peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-19 and the polynucleotides encoding the lipases is disclosed. The lipases and nucleic acid sequences encoding these lipases can be used in the preparation of polymers, in formulations which may comprise detergents, as catalysts, in the preparation of bioplastics, as part of diagnostic kits, in the preparation of biofuels and for the prevention and/or treatment of a disease.

29. 发明公开

EP2478370A2 DUAL FLUORESCENCE ASSAY FOR DETERMINING VIABILITY OF PARASITIC OR NON-PARASITIC WORMS 审中-公开
标题翻译：双荧光试验测定寄生或非寄生虫的存活
公开(公告)号：EP2478370A2
公开(公告)日：2012-07-25
申请号：EP10763844.7
申请日：2010-09-13
申请人： Aberystwyth University
发明人： PEAK, Emily , HOFFMANN, Karl Francis
IPC分类号： G01N33/569 , G01N33/53
CPC分类号： G01N33/5308 , G01N33/5085 , G01N2021/6441 , G01N2333/43526
摘要： A two colour fluorescent assay and a kit are described that permit the determination of live and dead parasitic or non-parasitic worms, for example helminths. The assay permits screening for the effect of one or more agents or an event on the viability of a parasitic or non-parasitic worm, In one example, the assay comprises (a) providing a sample comprising one or more parasitic or non-parasitic worms; (b) contacting the parasitic or non-parasitic worms with a concentration of fluorescein diacetate sufficient to yield detectable green fluorescence in any live parasitic or non-parasitic worms present in the sample and a concentration of propidium iodide sufficient to yield detectable red fluorescence in any dead parasitic or non-parasitic worms present in the sample; and (c) detecting the red and green fluorescence of the parasitic or non-parasitic worms. The assay further comprises contacting the parasitic or non-parasitic worms with one or more test agents, or subjecting the parasitic or non-parasitic worms to an event. The assay allows for a rapid and objective score of parasitic or non-parasitic worm death and survival and enables the performance of high- throughput screens for the identification of potential agents against diseases such as schistosomiasis. Also described are methods and kits for discriminatory analysis of parasitic or non-parasitic worm phenotype and/or metabolics using FTIR analysis.

30. 发明申请

WO2022112763A1 BIOMARKERS FOR MYCOBACTERIUM AVIUM PARATUBERCULOSIS 审中-公开
公开(公告)号：WO2022112763A1
公开(公告)日：2022-06-02
申请号：PCT/GB2021/053054
申请日：2021-11-24
申请人： ABERYSTWYTH UNIVERSITY
发明人： MUR, Luis Alejandro Jose , TAYLOR, Emma Nicole , ROOKE, David John , KOETS, Adriaan Peter
IPC分类号： G01N33/569 , G01N33/543
摘要： The present invention relates to a method for determining the presence of Mycobacterium avium paratuberculosis in a subject. The method comprises: (i) determining the level of one or more metabolites in a sample from the subject; and (ii) comparing the level of said one or more metabolites with the level of said one or more metabolites in a control sample to determine whether Mycobacterium avium paratuberculosis is present in the subject. The metabolites are selected from: 2- hydroxyglutaric acid; leukotriene B4; itaconic acid; bicyclo-prostaglandin E2; N6-acetyl- L-lysine; guanidinobutanoic acid; creatine; docosahexaenoic acid; cis-10- nonadecenoic acid; creatinine; 5-hydroxyeicosapentaenoic acid, 17-hydroxy docosahexaenoic acid, palmitoleic acid; R-3-hydroxy-octadecanoic acid; 8,11,14- eicosatrienoic acid; nonadecanoic acid; stearic acid; eicosapentaenoic acid; 16- methylheptadecanoic acid; phytanic acid; arachidonic acid; 9,10-dihydroxy-12- octadecenoic acid, 8,11,14, 17-eicosatetraenoic acid; palmitic acid; pyruvic acid; and p- cresol.

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