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21. 发明申请

WO2011037619A1 POLYMERIC DYE FOR OPTICAL POWER LIMITING 审中-公开
标题翻译：用于光功率限制的聚合染料
公开(公告)号：WO2011037619A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/002586
申请日：2010-09-22
申请人： OXAZOGEN, INC. , SARKAR, Abhijit , DVORNIC, Petar, R. , GODSCHALX, James, P.
发明人： SARKAR, Abhijit , DVORNIC, Petar, R. , GODSCHALX, James, P.
IPC分类号： B01J19/10 , B05D3/06
CPC分类号： G02B5/223 , B82Y20/00 , C09B47/0675 , C09B69/108 , Y10S977/742 , Y10S977/75 , Y10S977/752 , Y10S977/753
摘要： This invention concerns a polymer coating composition for use as non-focal optical power limiting dye containing polymeric materials. This composition contains: (1) one or more Modified Polymers comprising a Polymer, such as a hyperbranched polymer family, especially HB-PCS, HB-PU, HB-PUSOX or PC with one or more of: a) reverse saturable dye (RSA), b) multi-photon absorption dye (MPA), c) an azo dye, or d) absorption dye, which dye is chemically bonded to the pendant groups of the Polymer (along its chain and/or termini) or which forms a part of the backbone of the Polymer; (2) carbon nanotubes (CNT) as optical power limiters (OPL); and (3) a self-focusing component. This Modified Polymer composition contains the dye incorporated into the polymer chain backbone or chemically bonded to the terminal groups at the ends or along the chain of the polymer, which provides efficient protection from laser beam damage along with its self-focusing mechanism.
摘要翻译：本发明涉及一种聚合物涂料组合物，其用作含有聚合物材料的非焦点光学功率限制性染料。该组合物包含：（1）一种或多种包含聚合物的改性聚合物，例如超支化聚合物族，特别是HB-PCS，HB-PU，HB-PUSOX或具有以下一种或多种的PC：a）反向可饱和染料（RSA ），b）多光子吸收染料（MPA），c）偶氮染料或d）吸收染料，该染料与聚合物（沿其链和/或末端）的侧基化学键合，或形成聚合物骨架的一部分; （2）碳纳米管（CNT）作为光功率限制器（OPL）; 和（3）自聚焦部件。该改性聚合物组合物含有掺入聚合物链骨架中的化学键或化学键合在聚合物端部或沿着链的端基，其提供了与激光束损伤及其自聚焦机制的有效保护。

22. 发明申请

WO2009110971A3 PROCESS FOR CONVERTING MULTIFUNCTIONAL ALIPHATIC ALCOHOLS 审中-公开
公开(公告)号：WO2009110971A3
公开(公告)日：2009-09-11
申请号：PCT/US2009/001163
申请日：2009-02-25
申请人： DENDRITIC NANOTECHNOLOGIES, INC. , PULGAM, Veera, Reddy , SVENSON, Sonke , ZHURAVEL, Michael, A.
发明人： PULGAM, Veera, Reddy , SVENSON, Sonke , ZHURAVEL, Michael, A.
IPC分类号： C07D301/00
摘要： The present invention describes a single-stage process for preparing multifunctional epoxides having at least three hydroxyl groups using epichlorohydrin in the presence of freshly ground KOH, at a temperature between 10-25°C.

23. 发明申请

WO2009045230A1 COMPOSITIONS FOR TREATMENT OF TUMORS BY DIRECT ADMINISTRATION OF A RADIOISOTOPE 审中-公开
标题翻译：通过直接管理放射治疗来治疗肿瘤的组合物
公开(公告)号：WO2009045230A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/002026
申请日：2008-02-15
申请人： ISO THERAPEUTICS GROUP LLC , GABRIEL INSTITUTE, INC. , FRANK, R., Keith , MCMILLAN, Kenneth , SIMON, Jaime , LOY, H., Max , STEARNS, Stanley, D.
发明人： FRANK, R., Keith , MCMILLAN, Kenneth , SIMON, Jaime , LOY, H., Max , STEARNS, Stanley, D.
IPC分类号： A61K51/02 , A61M36/06
CPC分类号： A61K51/0478 , A61K51/025 , A61K51/048 , A61K51/0489
摘要： This invention provides a safer and more effective treatment for undesirable tissue masses, especially bone cancer and soft tissue tumors. The method involves a composition for direct administration of a therapeutic, radioisotope formulation nearby or directly into the tissue mass. Administration of the dose for bone cancer may be done through a hole created in the bone using a miniature drill. Delivery of the dose directly into a tumor may be accomplished using microsyringe or a miniature pump capable of accurately delivering microliter amounts of material. A chelating agent capable of removing activity from the bloodstream is also an aspect of this invention.
摘要翻译：本发明为不希望的组织块，特别是骨癌和软组织肿瘤提供更安全和更有效的治疗。该方法包括用于在组织块附近或直接施用治疗性放射性同位素制剂的组合物。可以通过使用微型钻头在骨头中产生的孔来进行骨癌剂量的施用。可以使用微量注射器或能够精确地递送微量的材料的微型泵来将剂量直接递送到肿瘤中。能够从血液中除去活性的螯合剂也是本发明的一个方面。

24. 发明申请

WO2008082627A1 DIVERGENT SYNTHESIS OF LOOPED POLY (ESTER)-AND POLY (ETHER)- SUBSTITUTED DENDRONS AND DENDRIMERS 审中-公开
标题翻译：循环聚合（ESTER）和聚（醚） - 取代的DENDRONS和DENDRIMERS的多重合成
公开(公告)号：WO2008082627A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/026445
申请日：2007-12-27
申请人： DENDRITIC NANOTECHNOLOGIES, INC. , TOMALIA, Donald, A. , SWANSON, Douglas, R. , HUANG, Baohua , PULGAM, Veera, Reddy
发明人： TOMALIA, Donald, A. , SWANSON, Douglas, R. , HUANG, Baohua , PULGAM, Veera, Reddy
IPC分类号： A61B5/055
CPC分类号： C08G83/003 , Y10T436/143333
摘要： The present invention describes a process for preparing new looped dendrimer and dendron compounds by controlling the molar amount of branch cell reagent monomer that is combined with various cores bearing core- XR functionalities (e.g., primary, or secondary amines, thiol, or epoxy functionalities). These looped, macrocyclic structures are more robust to various conditions, with greater resistance to acid/base hydrolysis. Alternatively, the looped, macrocyclic structure may offer new orientations that would qualify it as a better chelation ligand for metals, and other similar uses.
摘要翻译：本发明描述了通过控制与具有核-XR官能团的各种核心（例如伯，仲胺，硫醇或环氧官能团）组合的分支细胞试剂单体的摩尔量来制备新的环状树枝状聚合物和树枝状化合物的方法，。这些环状的大环结构对各种条件更加坚固，具有较强的抗酸/碱水解的能力。或者，环状的大环结构可以提供新的取向，其将其作为金属的更好的螯合配体和其它类似的用途。

25. 发明申请

WO2008060393A2 THE USE OF MATERIALS AND EXTERNAL STIMULI FOR SYNOVECTOMY 审中-公开
标题翻译：材料的使用和外部刺激的概要
公开(公告)号：WO2008060393A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/022536
申请日：2007-10-24
申请人： ISO THERAPEUTICS GROUP LLC , FRANK, R., Keith , McMILLAN, Kenneth , SIMON, Jaime , STRICKLAND, Alan, D.
发明人： FRANK, R., Keith , McMILLAN, Kenneth , SIMON, Jaime , STRICKLAND, Alan, D.
IPC分类号： A61K51/00
CPC分类号： A61K51/1244 , A61K41/0052 , A61K47/6849
摘要： This invention has as one of its aspects a method to provide a safe an effective treatment for synovectomy. The method involves the administration a material to the affected joint, allowing the material to localize in the synovial membrane, and then applying an external stimulus that interacts with the material to provide therapy. The materials of this invention are preferably particles, which are either magnetic or contain a heavy element. The external stimuli of this invention includes an alternating magnetic field to heat magnetic particles, infrared laser to heat heavy elements, or electromagnetic ionizing radiation (X- or gamma-radiation) that interacts with heavy elements to produce a localized radiation dose.
摘要翻译：本发明的一个方面是提供一种安全有效的滑膜切除治疗方法。该方法包括向受影响的关节施用材料，允许材料定位在滑膜中，然后施加与材料相互作用以提供治疗的外部刺激。本发明的材料优选是磁性的或含有重元素的颗粒。本发明的外部刺激包括用于加热磁性颗粒的交变磁场，加热重元素的红外激光或与重元素相互作用以产生局部辐射剂量的电磁离子辐射（X-或γ-辐射）。

26. 发明申请

WO2007149501A2 PROCESS FOR PREPARING DENDRITIC POLYMERS USING MICROWAVE ASSISTED SYNTHESIS 审中-公开
标题翻译：使用微波辅助合成法制备聚合物的方法
公开(公告)号：WO2007149501A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/014403
申请日：2007-06-20
申请人： DENDRITIC NANO TECHNOLOGIES, INC. , HUANG, Baohua , SWANSON, Douglas, R. , PULGAM, Veera, Reddy , TOMALIA, Donald, A.
发明人： HUANG, Baohua , SWANSON, Douglas, R. , PULGAM, Veera, Reddy , TOMALIA, Donald, A.
IPC分类号： C08L79/04
CPC分类号： C08G73/028 , C08G73/024 , C08G73/1046 , C08G83/003
摘要： The present invention provides an improved process for preparing dendritic polymers where a core is reacted with a branch cell reagent (BR) and/or an extender using microwave radiation wherein, compared with prior processes, the amount of (BR) required is not in large excessive amounts, the time of the reaction is greatly reduced, and the purity of the final dendritic polymer is increased.
摘要翻译：本发明提供了一种制备树突状聚合物的改进方法，其中芯与分支细胞试剂（BR）和/或使用微波辐射的增量剂反应，其中与现有方法相比，所需量（BR）不大过量，反应时间大大降低，最终树枝状聚合物的纯度提高。

27. 发明申请

WO2007149500A3 FORMULATIONS CONTAINING HYBRID DENDRIMERS 审中-公开
公开(公告)号：WO2007149500A3
公开(公告)日：2007-12-27
申请号：PCT/US2007/014402
申请日：2007-06-20
申请人： DENDRITIC NANOTECHNOLOGIES, INC. , CHAUHAN, Abhay, Singh , SVENSON, Sonke
发明人： CHAUHAN, Abhay, Singh , SVENSON, Sonke
IPC分类号： A61K31/74 , A61K47/48
摘要： The present invention concerns hybrid dendrimers comprising a mixture, at the same or different ratios, of at least two dendritic polymers or dendronized polymers that have at least one difference between them. The surfaces of the dendritic polymer or dendronized polymer may be further modified by known methods. Also included are formulations of hybrid dendrimers wherein the dendritic polymers have the same drug present at either identical or different loading concentrations but have different release profiles. Such formulations of hybrid dendrimers may have different guest molecules present at either identical or different loading concentrations but have different release profiles. Additionally a method of using a hybrid dendrimer for delivery of a drug or guest moiety in order to provide increased solubility to poorly soluble drugs or guest moieties is provided.

28. 发明申请

WO2003068948A1 OVER-EXPRESSION OF EXTREMOZYME GENES IN PSEUDOMONADS AND CLOSELY RELATED BACTERIA 审中-公开
标题翻译：超微结构基因在超微结构和封闭相关细菌中的超表达
公开(公告)号：WO2003068948A1
公开(公告)日：2003-08-21
申请号：PCT/US2002/004294
申请日：2002-02-13
申请人： DOW GLOBAL TECHNOLOGIES INC. , CHEW, Lawrence, C. , TALBOT, Henry, W.
发明人： CHEW, Lawrence, C. , TALBOT, Henry, W.
IPC分类号： C12N9/00
CPC分类号： C12N9/00 , C12N9/10 , C12N9/14 , C12N9/2417 , C12N9/2437 , C12N15/78 , C12P21/00 , C12Y302/01004
摘要： An extremozyme over-expression system in which Pseudomonads and closely related bacteria are used as host cells, and methods and kits for use thereof, extremozymes expressed therefrom.
摘要翻译：使用假单胞菌和密切相关的细菌作为宿主细胞的extremozyme过表达系统，及其使用的方法和试剂盒，由其表达的extremozymes。

29. 发明申请

WO2021257626A1 EXCIPIENTS PROVIDING STABILIZATION AND ENHANCED WATER SOLUBILIZATION AND THEIR USES 审中-公开
公开(公告)号：WO2021257626A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037513
申请日：2021-06-15
申请人： NANOSYNTHONS LLC
发明人： TOMALIA, Donald, A. , HEDSTRAND, David, M. , SINGH, Mayank, K. , NIXON, Linda, S.
IPC分类号： A61K31/724 , A61K47/40 , C08B37/16
摘要： Four major polymeric architectures, namely: (a) linear, (b) branched, (c) hyperbranched/dendritic and (d) cross-linked polymers, when formed by reaction of multifunctional alcohols, such as sugar-based alpha-, beta- or gamma-cyclodextrins, with multi-carboxylic acids form unique polyester copolymers. These copolymers have been demonstrated to substantially enhance the water-solubility properties of water insoluble compounds for a wide variety of uses.

30. 发明申请

WO2021216029A1 PROCESS FOR PREPARING DTEA HCI 审中-公开
公开(公告)号：WO2021216029A1
公开(公告)日：2021-10-28
申请号：PCT/US2020/028897
申请日：2020-04-19
申请人： AMSA, INC.
发明人： HAAG, Anthony, P. , THOMAS, Pulikkottil, Jacob
IPC分类号： C07C319/18 , C07C319/26 , C07C323/25
摘要： The present invention provides an improved process for preparing DTEA HCl from decene and cysteamine HCl by using a catalyst, solvent and a Co- solvent to aid the reaction and provide low temperature stabilization of the resulting product solution.

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