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21. 发明申请

WO2005060986A1 GLP-1 (9-36) METHODS AND COMPOSITIONS 审中-公开
标题翻译： GLP-1（9-36）方法和组合物
公开(公告)号：WO2005060986A1
公开(公告)日：2005-07-07
申请号：PCT/US2004/040852
申请日：2004-12-07
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , BROWNLEE, Michael, A.
发明人： BROWNLEE, Michael, A.
IPC分类号： A61K38/00
CPC分类号： C07K14/605 , A61K38/26
摘要： Methods of inhibiting hyperglycemia-induced or free fatty acid-induced reactive oxygen formation in mammalian cells and mammals using the degradation product of glucagon-like peptide 1, GLP-1 (9-36) are provided. Various GLP-1 (9-36) compositions are also provided.
摘要翻译：提供了使用胰高血糖素样肽1，GLP-1（9-36）的降解产物抑制哺乳动物细胞和哺乳动物中高血糖诱导或游离脂肪酸诱导的活性氧形成的方法。还提供了各种GLP-1（9-36）组合物。

22. 发明申请

WO2005044077A2 ASSAY FOR ACETYLTRANSFERASES AND ACETYLTRANSFERASE SUBSTRATES 审中-公开
标题翻译：乙炔基酯和乙酰基酯基质的测定
公开(公告)号：WO2005044077A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/032356
申请日：2004-10-01
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , BLANCHARD, John, S.
发明人： BLANCHARD, John, S.
IPC分类号： A61B
CPC分类号： C12Q1/48 , G01N2333/91051
摘要： Methods of identifying an acetyltransferase substrate in a sample are provided. Also provided are methods of localizing acetylation of an acetyltransferase substrate in a cell. Additionally, methods of labeling a protein substrate of an acetyltransferase are provided, as are methods of assaying an acetyltransferase in a sample. Methods of quantifying acetyltransferase activity in a sample are further provided. Compositions provided include halo-acetyl-pantetheine, halo-acetyl-pantetheine with a label, and halo-acetyl-CoA with a label on the adenine of the CoA.
摘要翻译：提供了在样品中鉴定乙酰转移酶底物的方法。还提供了定位细胞中乙酰转移酶底物的乙酰化的方法。此外，提供了标记乙酰转移酶的蛋白质底物的方法，以及测定样品中的乙酰转移酶的方法。还提供了定量样品中乙酰转移酶活性的方法。所提供的组合物包括卤代 - 乙酰 - 泛et啶，具有标记的卤代 - 乙酰 - 泛菌碱和在CoA的腺嘌呤上具有标记的卤代 - 乙酰辅酶A。

23. 发明申请

WO2004083383A2 GLOBIN VARIANT GENE METHODS AND COMPOSITIONS 审中-公开
标题翻译： GLOBIN变体基因方法和组合物
公开(公告)号：WO2004083383A2
公开(公告)日：2004-09-30
申请号：PCT/US2004/007325
申请日：2004-03-12
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, A DIVISION OF YESHIVA UNIVERSITY , NAGEL, Ronald, L.
发明人： NAGEL, Ronald, L.
IPC分类号： C12N
CPC分类号： C07K14/805 , A61K38/00 , A61K48/00
摘要： Methods are provided for treating a mammal having a disease, where the disease is caused by a globin disease mutation or a mutation in globin regulation, and where the globin disease mutation or the mutation in globin regulation causes production of a deleterious globin chain or production of insufficient quantities of a globin chain. The methods include transfecting the mammal with a vector comprising a mutant globin gene encoding the same globin chain as the deleterious of insufficient globin chain, where the vector is transfected under conditions where the mutant globin gene is expressed in the mammal, and where the mutant globin gene encodes a globin chain that has lower oxygen affinity and similar stability in hemoglobin when compared to the wild-type of the same globin chain. Also provided are methods of improving hemoglobin oxygen exchange in a mammal. The methods include transfecting the mammal with a vector comprising a mutant globin gene under conditions where the mutant globin gene is exp0ressed in the mammal, where the mutant globin gene encodes a globin chain that has lower oxygen affinity and similar stability in hemoglobin when compared to the same globin chain when unmutated.
摘要翻译：提供了用于治疗患有疾病由珠蛋白病突变或珠蛋白调节突变引起的疾病的哺乳动物的方法，并且其中球蛋白疾病突变或珠蛋白调节突变引起有害珠蛋白链的产生或产生球蛋白链数量不足。所述方法包括用包含编码与不充分球蛋白链有害的相同珠蛋白链的突变珠蛋白基因的载体转染哺乳动物，其中载体在突变型球蛋白基因在哺乳动物中表达的条件下转染，并且其中突变球蛋白与野生型相同的珠蛋白链相比，基因编码具有较低氧亲和力和血红蛋白相似稳定性的珠蛋白链。还提供了改善哺乳动物血红蛋白氧交换的方法。所述方法包括在突变型球蛋白基因在哺乳动物中进行突变的条件下用包含突变型珠蛋白基因的载体转染哺乳动物，其中突变型球蛋白基因编码与血红蛋白相比具有较低的氧亲合力和相似的稳定性的球蛋白链相同的球蛋白链未突变。

24. 发明申请

WO2004066928A2 USE OF MYCOBACTERIAL VACCINES IN CD4+ OR CD8+ LYMPHOCYTE-DEFICIENT MAMMALS 审中-公开
标题翻译：在CD4 +或CD8 +淋巴细胞缺乏的哺乳动物中使用MYCOBACTERIAL VACCINES
公开(公告)号：WO2004066928A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/001773
申请日：2004-01-23
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , JACOBS, William, R., Jr. , HSU, Tsungda , SAMBANDAMURTHY, Vasan , MORRIS, Sheldon
发明人： JACOBS, William, R., Jr. , HSU, Tsungda , SAMBANDAMURTHY, Vasan , MORRIS, Sheldon
IPC分类号： A61K
CPC分类号： A61K39/04 , A61K2039/522
摘要： Methods of treating a mammal that is deficient in CD4 + and/or CD8 + lymphocytes are provided. The methods comprise inoculating the mammal with an attenuated mycobacterium in the M. tuberculosis complex. In these methods, the mycobacterium comprises two deletions, wherein a virulent mycobacterium in the M. tuberculosis complex having either deletion exhibits attenuated virulence. Use of these mycobacteria for the manufacture of a medicament for the treatment of mammals deficient in CD4 + and/or CD8 + lymphocytes is also provided.
摘要翻译：提供了治疗缺乏CD4 +和/或CD8 +淋巴细胞的哺乳动物的方法。所述方法包括在结核分枝杆菌复合物中用减毒的分枝杆菌接种哺乳动物。在这些方法中，分枝杆菌包含两个缺失，其中具有任一缺失的结核分枝杆菌复合体中的有毒分枝杆菌表现出减毒的毒力。还提供了这些分枝杆菌用于制备用于治疗缺乏CD4 +和/或CD8 +淋巴细胞的哺乳动物的药物的用途。

25. 发明申请

WO2004041115A2 NOVEL HUMAN ELASTASES AND STRESS URINARY INCONTINENCE 审中-公开
标题翻译：新的人类弹性和压力不均匀性
公开(公告)号：WO2004041115A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/018696
申请日：2003-06-12
申请人： NORTH SHORE - LONG ISLAND JEWISH RESEARCH INSTITUTE , KUSHNER, Leslie , MATHRUBUTHAM, Mahesh , RAO, Srinivasa, K.
发明人： KUSHNER, Leslie , MATHRUBUTHAM, Mahesh , RAO, Srinivasa, K.
IPC分类号： A61F
CPC分类号： C12N9/6448 , A61K38/482 , C12Q1/37 , G01N2333/966
摘要： Novel elastases are provided that are associated with stress urinary incontinence. Also provided are methods for determining whether a woman has stress urinary incontinence, and methods for treating or preventing stress urinary incontinence.
摘要翻译：提供与压力性尿失禁相关的新型弹性蛋白酶。还提供了用于确定女性是否具有压力性尿失禁的方法，以及用于治疗或预防压力性尿失禁的方法。

26. 发明申请

WO2004037983A2 CAGED LIGANDS AND USES THEREOF 审中-公开
标题翻译： CAGED配偶及其用途
公开(公告)号：WO2004037983A2
公开(公告)日：2004-05-06
申请号：PCT/US2003/033438
申请日：2003-10-22
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , LAWRENCE, David , PESTELL, Richard , ALBANESE, Christopher
发明人： LAWRENCE, David , PESTELL, Richard , ALBANESE, Christopher
IPC分类号： C12N
CPC分类号： B82Y5/00 , A61K31/56 , A61K41/0042 , A61K47/554 , A61K47/6949 , A61K48/005 , A61K48/0058 , C12N15/67
摘要： Provided are caged compounds comprising a ligand that specifically reacts with a receptor not naturally present in mammals. The cage is released from the ligand upon illumination of the compound with light. Also provided are cells transfected with a gene of interest and a gene encoding a receptor, the gene of interest operably linked to a genetic element capable of being induced by the receptor when bound to a ligand, and the receptor not naturally present in the species of the cell. The cells also comprise a caged ligand of the receptor. Additionally provided are methods of inducing a gene of interest in the above cells. Also provided are methods of repressing a gene of interest in a cell using caged ligands of receptors. Methods are additionally provided for inducing elimination of a target sequence in a cell of a species, using a caged ligand and a recombinase.
摘要翻译：提供了包含与哺乳动物中天然存在的受体特异性反应的配体的笼养化合物。在用光照射化合物时，笼从配体释放出来。还提供了用感兴趣的基因转染的细胞和编码受体的基因，该靶基因可操作地连接到当与配体结合时能够被受体诱导的遗传元件，以及不是天然存在于细胞。细胞还包含受体的笼状配体。另外提供了在上述细胞中诱导目的基因的方法。还提供了使用笼式受体配体抑制细胞中目的基因的方法。另外提供了使用笼式配体和重组酶诱导物种细胞中靶序列的消除的方法。

27. 发明申请

WO2004012695A1 THE USE OF ALKYLUREAS FOR TREATING ACNE 审中-公开
标题翻译：用于治疗ACNE的ALKYLUREAS的使用
公开(公告)号：WO2004012695A1
公开(公告)日：2004-02-12
申请号：PCT/US2003/023916
申请日：2003-07-31
申请人： RUBINSTEIN, Arye
发明人： RUBINSTEIN, Arye
IPC分类号： A61K7/42
CPC分类号： A61K8/42 , A61K31/17 , A61Q19/00
摘要： Methods of treating acne are provided. The methods involve applying to the acne an alkyl urea in a pharmaceutically acceptable carrier. The use of an alkyl urea in the manufacture of a medicament for the treatment of acne is also provided. Compositions of alkyl ureas in a pharmaceutically acceptable carrier are additionally provided.
摘要翻译：提供治疗痤疮的方法。所述方法包括在药学上可接受的载体中向痤疮施用烷基脲。还提供了在制备用于治疗痤疮的药物中使用烷基脲的方法。另外提供药学上可接受的载体中烷基脲的组合物。

28. 发明申请

WO2003102146A3 APTAMER CONSTRUCTS 审中-公开
公开(公告)号：WO2003102146A3
公开(公告)日：2003-12-11
申请号：PCT/US2003/017182
申请日：2003-05-29
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , PRASAD, Vinayaka, R. , JOSHI, Pheroze
发明人： PRASAD, Vinayaka, R. , JOSHI, Pheroze
IPC分类号： A61K48/00
摘要： Provided are RNA oligonucleotides having an aptamer flanked by two self-cleaving ribozymes. Vectors encoding the oligonucleotides, and cells transfected with these vectors are also provided. Additionally, methods of inhibiting replication of a virus in a cell, methods of treating an organism with an aptamer, methods of determining whether a test aptamer is effective in inhibiting the function of a target of the aptamer in a cell, and methods of expressing an RNA aptamer in a cell are provided.

29. 发明申请

WO2003102146A2 APTAMER CONSTRUCTS 审中-公开
标题翻译： APTAMER建筑
公开(公告)号：WO2003102146A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/017182
申请日：2003-05-29
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , PRASAD, Vinayaka, R. , JOSHI, Pheroze
发明人： PRASAD, Vinayaka, R. , JOSHI, Pheroze
IPC分类号： C12N
CPC分类号： C12N15/115 , C12N15/1132 , C12N2310/111 , C12N2310/121 , C12N2310/127 , C12N2310/16 , C12Y207/07049
摘要： Provided are RNA oligonucleotides having an aptamer flanked by two self-cleaving ribozymes. Vectors encoding the oligonucleotides, and cells transfected with these vectors are also provided. Additionally, methods of inhibiting replication of a virus in a cell, methods of treating an organism with an aptamer, methods of determining whether a test aptamer is effective in inhibiting the function of a target of the aptamer in a cell, and methods of expressing an RNA aptamer in a cell are provided.
摘要翻译：提供的是具有两个自切割核酶侧翼的适体的RNA寡核苷酸。还提供了编码寡核苷酸的载体和用这些载体转染的细胞。此外，抑制细胞中病毒复制的方法，用适体治疗生物体的方法，确定测试适体是否有效抑制细胞中适体靶标功能的方法，以及表达提供细胞中的RNA适体。

30. 发明申请

WO2003068914A2 SOLUTION STRUCTURE OF RIP DD AND USES THEROF 审中-公开
标题翻译： RIP DD的解决方案结构及其用途
公开(公告)号：WO2003068914A2
公开(公告)日：2003-08-21
申请号：PCT/US2003/003589
申请日：2003-02-06
申请人： WYETH
发明人： SUKITS, Steven, F. , TELLIEZ, Jean-Baptiste , LIH-LING, Lin , XU, Guang-Yi
IPC分类号： C12N
CPC分类号： C12N9/1205 , C07K2299/00 , G01N33/54353 , G01N33/552 , G06F19/16 , G06F19/706
摘要： The present invention relates to the three dimensional solution structure of receptor interacting protein dead domain (RIP DD), as well as the identification and characterization of various binding active sites of RIP DD. Also provided for by the present invention are methods of utilizing the three dimensional structure for the design and selection of potent and selective inihbitors of TNF signaling pathways.
摘要翻译：本发明涉及受体相互作用蛋白死区（RIP DD）的三维解决方案结构，以及RIP DD各种结合活性位点的鉴定和表征。本发明还提供了利用三维结构设计和选择TNF信号通路的有效和选择性抑制剂的方法。

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