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21. 发明申请

US20040137554A1 Diagnosis and treatment of bacterial infections 审中-公开
标题翻译：细菌感染的诊断和治疗
公开(公告)号：US20040137554A1
公开(公告)日：2004-07-15
申请号：US10751947
申请日：2004-01-07
申请人： Oxoid Limited
发明人： Peter A. Lambert , Thomas S.J. Elliott
IPC分类号： C12Q001/04 , C07K009/00
CPC分类号： A61K31/70 , A61K39/085 , C07H3/04 , C07K1/00 , C07K16/1271 , C12N1/20
摘要： Disclosed is an isolated compound having the structure shown in FIG. 2, wherein n is an integer between 3 and 10 (inclusive) and X may be H, OH, alkyl, aryl, amyl, or an amino acid residue (optionally substituted) or a sugar residue (optionally substituted), and wherein R and R1 are hydrophobic hydrocarbon or fatty acid chains (R may be the same as R1 or different), a method of preparing compositions comprising the compound, and a diagnostic method comprising use of the composition.
摘要翻译：公开了具有图1所示结构的分离化合物。 2，其中n是3至10（包括端值）的整数，X可以是H，OH，烷基，芳基，戊基或氨基酸残基（任选取代的）或糖残基（任选取代的），其中R和 R 1是疏水性烃或脂肪酸链（R可以与R 1相同或不同），制备包含该化合物的组合物的方法和包括使用该组合物的诊断方法。

22. 发明授权

US5888825A Method and device for monitoring changes in an array of sensor containing bottles 失效
标题翻译：用于监测包含瓶子的传感器阵列变化的方法和装置
公开(公告)号：US5888825A
公开(公告)日：1999-03-30
申请号：US917805
申请日：1997-08-27
申请人： Anthony Hugh Carr , Kenneth Cherry , Simon Edward Jackson
发明人： Anthony Hugh Carr , Kenneth Cherry , Simon Edward Jackson
IPC分类号： C12M1/34 , G01N7/20 , G01N35/00 , G01N35/02 , G01N35/04 , C12Q1/04
CPC分类号： C12M41/40 , C12M23/08 , G01N35/0092 , G01N35/026 , G01N2035/00752 , G01N2035/042 , G01N2035/0465 , G01N2035/0498 , Y10T436/11 , Y10T436/114165
摘要： Monitoring apparatus comprises a support device for receiving a plurality of items to be monitored in an array, each item having a unique machine-readable identifying reference associated therewith, the arrangement being such that the items are movable to different positions in the array; a sensor device for intermittently and repeatedly monitoring each item in the array to monitor changes in a variable associated with each item and to read the reference associated with each item; device for supplying data to the monitored variable and machine-readable reference of each item to a computer, wherein the computer relates the monitored variable to the reference to each item independently of the position of the item in the array.
摘要翻译： PCT No.PCT / GB94 / 00253 Sec。 371日期：1995年11月27日 102（e）日期1995年11月27日PCT 1994年2月9日PCT PCT。公开号WO94 / 19698 日期1994年9月1日监视装置包括用于以阵列方式接收要监视的多个项目的支持装置，每个物品具有与之相关联的独特的机器可读标识参考，该装置使得物品可移动到不同位置阵列用于间歇地和重复地监视阵列中的每个物品的传感器装置，以监测与每个物品相关联的变量的变化并读取与每个物品相关的参考; 用于将数据提供给每个项目的监视变量和机器可读参考的计算机的设备，其中计算机将所监视的变量与每个项目的引用相关联，而与项目在阵列中的位置无关。

23. 发明授权

US5863752A Methods and apparatus for monitoring the growth of microorganisms in liquid culture 失效
标题翻译：监测液体培养微生物生长的方法和装置
公开(公告)号：US5863752A
公开(公告)日：1999-01-26
申请号：US30488
申请日：1993-06-02
申请人： Nigel Timothy Court , Richard Paul Hayes-Pankhurst , Neil Laurence Evans , Judith Marjorie Anderson , Roy Holbrook , Peter Richard Stephenson , Arthur Maurice Weightman
发明人： Nigel Timothy Court , Richard Paul Hayes-Pankhurst , Neil Laurence Evans , Judith Marjorie Anderson , Roy Holbrook , Peter Richard Stephenson , Arthur Maurice Weightman
IPC分类号： C12M1/24 , C12M1/34 , C12Q1/02 , C12Q1/06 , C12Q1/04
CPC分类号： C12Q1/06 , C12M23/08 , C12M23/38 , C12M23/48 , C12M41/36 , C12M41/40 , C12Q1/02
摘要： A method of monitoring the growth of microorganisms in liquid culture involving the detection of pressure change in a gas-tight container such as a blood culture bottle incorporating a flexible diaphragm (septum) by detecting displacement of the septum, is characterised by the position or conformation of the diaphragm being repeatedly sensed using a distance-measuring means, such as a laser, preferably capable of detecting a variation in the position or conformation of the diaphragm to an accuracy of 200.mu. or better, with a portion of the container adjacent the diaphragm conveniently being used as a reference to detect any relative positional or conformational change of the diaphragm. Preferably the laser repeatedly scans a plurality of containers mounted in a holder such as a flat bed or a carousel.
摘要翻译： PCT No.PCT / GB92 / 01327 Sec。 371日期：1993年6月2日 102（e）日期1993年6月2日PCT提交1992年7月20日PCT公布。公开号WO93 / 03178 日期：1993年2月18日一种监测液体培养物中微生物生长的方法，涉及通过检测隔膜位移来检测包含柔性隔膜（隔膜）的血培养瓶的气密容器中的压力变化的压力变化。通过使用诸如激光器的距离测量装置重复感测隔膜的位置或构造，优选地能够检测膜片的位置或构象的变化，使其具有200μm或更好的精度，其中一部分邻近隔膜的容器方便地用作参考以检测隔膜的任何相对位置或构象变化。优选地，激光器重复地扫描安装在诸如平板床或转盘中的保持器中的多个容器。

24. 发明授权

US4692417A Immunological identification test for group D streptococci using achromopeptidase 失效
标题翻译：使用无色肽酶对D组链球菌进行免疫鉴定试验
公开(公告)号：US4692417A
公开(公告)日：1987-09-08
申请号：US739462
申请日：1985-05-30
申请人： Martyn F. Webster
发明人： Martyn F. Webster
IPC分类号： C12Q1/14 , C12Q1/37 , G01N33/569 , G01N33/53 , C12Q1/38
CPC分类号： C12Q1/14 , C12Q1/37 , G01N33/56944 , G01N2333/315 , Y10S435/975
摘要： The grouping of a sample of a streptococcus is identified by treating the sample with achromopeptidase prior to contacting the sample with a group-specific antibody bound to minute, insoluble carrier particles. A positive identification is indicated by agglutination of the carrier particles.
摘要翻译：通过在将样品与结合到微小的不溶性载体颗粒的组特异性抗体接触之前用无色肽酶处理样品来鉴定链球菌样品的分组。阳性鉴定由载体颗粒的凝集指示。

25. 发明授权

US4289855A Safety catalyst systems 失效
标题翻译：安全催化剂体系
公开(公告)号：US4289855A
公开(公告)日：1981-09-15
申请号：US971830
申请日：1978-12-19
申请人： Donald C. Whitley
发明人： Donald C. Whitley
IPC分类号： B01J35/02 , C01B5/00 , C12M1/04 , B01J8/02 , B01J35/04
CPC分类号： C01B5/00 , B01J35/02 , C12M41/34 , Y10S435/801
摘要： Safety catalyst systems and their use in chemical reactions carried out in the gas phase, wherein the safety catalyst system comprises pelleted catalyst held loose in and throughout the holes and folds of a folded or rolled up metal foil net which is inside a container having holes for the inflow and outflow of gases. The safety catalyst system of the invention does not allow the formation of localized hot-spots or allow free catalyst dust to escape from the system, both of which are known disadvantages of prior art systems.
摘要翻译：安全催化剂体系及其在气相中进行的化学反应中的应用，其中安全催化剂体系包括沉淀的催化剂体系，该催化剂体系包含在折叠或卷起的金属箔网中的整个孔中的整个孔和折叠物，气体的流入和流出。本发明的安全催化剂体系不允许形成局部热点或允许游离催化剂粉尘从系统逸出，这两者都是现有技术系统的已知缺点。

26. 外观设计

USD221426S Dip inoculum slide 未知
公开(公告)号：USD221426S
公开(公告)日：1971-08-17
申请日：1969-07-11
申请人： Oxoid Limited
设计人： Arnold Brecker

27. 发明申请

US20220266243A1 Swab Collection Kit 有权
公开(公告)号：US20220266243A1
公开(公告)日：2022-08-25
申请号：US17737232
申请日：2022-05-05
申请人： Oxoid Limited
发明人： John Marshall STATON
IPC分类号： B01L3/00 , A61F13/38 , B65D1/36 , A61B50/33 , A61B10/02 , A61B10/00 , A61B50/30 , C12M1/12 , C12M1/00 , C12M3/00
摘要： A collection system including a storage tray and a swab positioned in the storage tray, wherein the swab is configured to collect a sample comprising one or more microorganisms. The system further includes a generally elongate storage device positioned in the tray. The storage device is configured to contain a culture medium therein and configured to receive therein at least part of the one or more microorganisms collected by the swab. The storage tray includes a first recess configured to receive the storage device in a longitudinal configuration, and a second recess configured to receive the storage device in an axial configuration oriented generally perpendicular to the longitudinal configuration.

28. 发明授权

US09090929B2 Medium for detecting and differentiating vancomycin-resistant enterococci 有权
标题翻译：用于检测和分化耐万古霉素肠球菌的培养基
公开(公告)号：US09090929B2
公开(公告)日：2015-07-28
申请号：US12613834
申请日：2009-11-06
申请人： Stephen Dimmer , Dagmara Klein
发明人： Stephen Dimmer , Dagmara Klein
IPC分类号： C12N1/20 , C12Q1/20 , C12Q1/04
CPC分类号： C12Q1/045 , C12N1/20
摘要： A medium for the growth of vancomycin-resistant Enterococci comprising:— (i) a nutrient medium with an energy source effective to support growth and reproduction of vancomycin-resistant Enterococci; (ii) an effective amount of one or more selective agents to inhibit the growth of microorganisms other than vancomycin-resistant Enterococci; (iii) a Krebs cycle intermediate.
摘要翻译：用于万古霉素耐药性肠球菌生长的培养基包括：（i）具有有效支持万古霉素耐药性肠球菌生长和繁殖的能量源的营养培养基; （ii）有效量的一种或多种选择剂以抑制非万古霉素肠球菌以外的微生物的生长; （iii）克雷布斯循环中间体。

29. 发明授权

US07704706B2 L-alanyl-L-1-aminoethylphosphonic acid (alaphosphin) for selective inhibition of cell growth 有权
标题翻译：用于选择性抑制细胞生长的L-丙氨酰-L- 1-氨基乙基膦酸（alaphosphin）
公开(公告)号：US07704706B2
公开(公告)日：2010-04-27
申请号：US10380330
申请日：2001-09-14
申请人： Patrick Druggan
发明人： Patrick Druggan
IPC分类号： C12Q1/04
CPC分类号： C12N1/38 , C12N1/20
摘要： Disclosed is a method of selectively inhibiting for growth of non-target cells in a mixed population of target and non-target cells, the method comprising the steps of: (a) contacting the mixed population with a selective agent which comprises a carrier moiety linked by a scissile linkage to a toxic moiety; wherein the selective agent is able to enter non-target cells in which the scissile linkage is cleaved, releasing the toxic moiety to exert a toxic effect on the non-target cells causing inhibition of the growth of the non-target cells, whereas the selective agent is unable to enter target cells and/or the scissile linkage is not cleaved in target cells and/or toxic moiety, if released from the selective agent, does not exert a toxic effect on the target cell; and (b) culturing the cells in conditions which allow for growth of non-inhibited cells.
摘要翻译：公开了一种选择性抑制靶和非靶细胞混合群体中非靶细胞生长的方法，所述方法包括以下步骤：（a）使混合群体与包含载体部分连接的选择剂接触通过与毒性部分的剪切连接; 其中所述选择剂能够进入其中所述剪切连接被切割的非靶细胞，释放所述毒性部分以对非靶细胞产生毒性作用，从而导致非靶细胞生长的抑制，而所述选择性药剂不能进入靶细胞和/或染色体连接不会在靶细胞和/或毒性部分中被切割，如果从选择剂释放，则不会对靶细胞发挥毒性作用; 和（b）在允许非抑制细胞生长的条件下培养细胞。

30. 发明授权

US07514235B2 Medium for identification of Candida 有权
标题翻译：用于鉴定假丝酵母的培养基
公开(公告)号：US07514235B2
公开(公告)日：2009-04-07
申请号：US10582335
申请日：2004-12-10
申请人： Bryan Stevon De Caux
发明人： Bryan Stevon De Caux
IPC分类号： C12Q1/04 , C12N1/00
CPC分类号： C12Q1/045
摘要： Disclosed is a medium for the detection and/or identification of a Candida yeast, the medium comprising: a chromogen; carbohydrate in the range 1-5 gms/liter; and an alcohol; the medium being such that growth of the Candida yeast under appropriate conditions results in hydrolysis of the chromogen to generate a chromophore of a derived color which is a different color from that generated by hydrolysis of the chromogen in a standard medium.
摘要翻译：公开了用于检测和/或鉴定假丝酵母酵母的培养基，所述培养基包括：色原; 碳水化合物，范围为1-5 gms / l; 和酒精; 培养基使得假丝酵母在合适条件下的生长导致色原体的水解，从而产生与标准培养基中色原水解产生的颜色不同的衍生颜色的发色团。

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