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191. 发明申请

WO1995008642A1 NUCLEIC ACID DETECTION WITH ENERGY TRANSFER 审中-公开
标题翻译：具有能量转移的核酸检测
公开(公告)号：WO1995008642A1
公开(公告)日：1995-03-30
申请号：PCT/GB1994002068
申请日：1994-09-23
申请人： ZENECA LIMITED , SAMMES, Peter, George , GARMAN, Andrew, John
发明人： ZENECA LIMITED
IPC分类号： C12Q01/68
CPC分类号： C07D471/04 , C07H21/00 , C12Q1/6818 , G01N2458/40 , Y10S435/81 , Y10S436/805 , C12Q2563/137 , C12Q2563/103
摘要： A method for the detection of a nucleic acid analyte by complementary probe hybridisation and formation of a chelated lanthanide complex which, upon irradiation by light, results in a characteristic delayed luminescence emission.
摘要翻译：用于通过互补探针杂交和螯合镧系元素络合物的形成来检测核酸分析物的方法，其在光照射时导致特征延迟的发光发射。

192. 发明申请

WO1995004718A1 4-METHYLENEPROLINE DERIVATIVES AS FUNGICIDES 审中-公开
标题翻译： 4-甲基吡咯烷酮衍生物作为防腐剂
公开(公告)号：WO1995004718A1
公开(公告)日：1995-02-16
申请号：PCT/GB1994001497
申请日：1994-07-11
申请人： ZENECA LIMITED , COX, John, Michael , PEARSON, David, Philip, John , KOZAKIEWICZ, Anthony, Marian , YOULE, David , WHITTINGHAM, William, Guy , HEANEY, Stephen, Paul
发明人： ZENECA LIMITED
IPC分类号： C07D207/22
CPC分类号： C07K7/06 , A01N43/36 , C07D207/22 , C07K5/06139 , C07K5/0821 , C07K5/1024
摘要： A fungicidal composition comprising a fungicidally effective amount of a compound of formula (I), wherein R is OH, optionally substituted alkoxy, optionally substituted phenoxy, optionally substituted phenylalkoxy, alkenyloxy, NR R (wherein R and R are, independently, hydrogen, optionally substituted alkyl, optionally substituted phenyl or optionally substituted phenylalkyl) or a nitrogen atom which is included in a peptide residue; or a salt thereof, and a fungicidally acceptable carrier or diluent therefor.
摘要翻译：一种杀真菌组合物，其包含杀真菌有效量的式（I）化合物，其中R是OH，任选取代的烷氧基，任选取代的苯氧基，任选取代的苯基烷氧基，烯氧基，NR 5 R 6（其中R 5）和R 6独立地是氢，任选取代的烷基，任选取代的苯基或任选取代的苯基烷基）或包含在肽残基中的氮原子; 或其盐，以及杀真菌可接受的载体或稀释剂。

193. 发明申请

WO1995003395A1 IMPROVING VIABILITY OF BACTERIAL DRIED CELLS 审中-公开
标题翻译：改善细菌干细胞的可行性
公开(公告)号：WO1995003395A1
公开(公告)日：1995-02-02
申请号：PCT/GB1994001556
申请日：1994-07-19
申请人： ZENECA LIMITED , LEGG, Michael, Jeremy
发明人： ZENECA LIMITED
IPC分类号： C12N01/04
CPC分类号： C12N1/04
摘要： The viability of bacterial cells after drying is improved by ageing the culture in the stationary phase for periods of around six hours prior to drying. Further improvement may be obtained by culturing in a nitrogen deficient medium.
摘要翻译：干燥后细菌细胞的活力可以通过在干燥前约6小时使固定相的培养物老化而得到改善。通过在氮缺乏培养基中培养可以进一步改善。

194. 发明申请

WO1995002579A1 SUBSTITUTED AZETIDINONE AMIDE DERIVATIVES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS 审中-公开
标题翻译：作为抗炎和抗感染药物的替扎唑胺类衍生物
公开(公告)号：WO1995002579A1
公开(公告)日：1995-01-26
申请号：PCT/GB1994001466
申请日：1994-07-07
申请人： ZENECA LIMITED , CRAWLEY, Graham, Charles
发明人： ZENECA LIMITED
IPC分类号： C07D205/09
CPC分类号： C07D205/09
摘要： Azetidinone compounds pharmaceutically useful as inhibitors of tumour necrosis factor (TNF) production are disclosed of general formula (I) wherein Y is H, (1-4C)alkyl or (a) and X is thio, sulphinyl or sulphonyl.
摘要翻译：通式（I）公开了作为肿瘤坏死因子（TNF）产生抑制剂药用的氮杂环丁酮化合物，其中Y为H，（1-4C）烷基或（a），X为硫代，亚磺酰基或磺酰基。

195. 发明申请

WO1995002327A1 HERBICIDAL FORMULATIONS CONTAINING N-PHOSPHONOMETHYLGLYCINE AND ALKYL PHENOL POLYOXYALKYLENE CARBOXYLIC ACID SURFACTANT 审中-公开
标题翻译：含有N-磷酰基乙二胺和烷基酚的杀草剂配方聚氧乙烯羧酸表面活性剂
公开(公告)号：WO1995002327A1
公开(公告)日：1995-01-26
申请号：PCT/GB1994001157
申请日：1994-05-27
申请人： ZENECA LIMITED
发明人： ZENECA LIMITED , MOUCHARAFIEH, Nadim, C. , LIN, Kang-Chi , AHLE, James, L.
IPC分类号： A01N25/30
CPC分类号： A01N57/20 , A01N25/30 , A01N25/02 , A01N2300/00
摘要： Herbicidal compositions contain N-phosphonomethylglycine and alkyl phenol polyoxyalkylene surfactant which contains from about 50 to about 90 weight percent of alkyl phenol polyoxyethylene carboxylic acid.
摘要翻译：除草组合物含有N-膦酰甲基甘氨酸和烷基酚聚氧化烯表面活性剂，其含有约50至约90重量％的烷基酚聚氧乙烯羧酸。

196. 发明申请

WO1995001951A1 PROCESS FOR THE PREPARATION OF 2-HYDROXYARYLALDEHYDES 审中-公开
标题翻译：制备2-羟基胆碱的方法
公开(公告)号：WO1995001951A1
公开(公告)日：1995-01-19
申请号：PCT/GB1994001227
申请日：1994-06-06
申请人： ZENECA LIMITED , LEVIN, Daniel
发明人： ZENECA LIMITED
IPC分类号： C07C45/68
CPC分类号： C07C45/68 , C07C47/565
摘要： A method for the preparation of a 2-hydroxyarylaldehyde which comprises reacting a magnesium bis-hydrocarbyloxide, derived at least in part from a hydroxyaromatic compound having at least one free position ortho to the hydroxyl group, with formaldehyde or a formaldehyde-liberating compound under substantially anhydrous conditions at a pressure of from 50 to 700 mm Hg absolute.
摘要翻译：一种制备2-羟基芳基醛的方法，其包括将至少部分衍生自羟基芳族化合物的羟基氧化镁与至少一个羟基邻位的游离位置与甲醛或释放甲醛的化合物基本上反应无水条件下的绝对压力为50至700毫米汞柱。

197. 发明申请

WO1995000592A1 DISAZO DYES 审中-公开
公开(公告)号：WO1995000592A1
公开(公告)日：1995-01-05
申请号：PCT/GB1994001226
申请日：1994-06-06
申请人： ZENECA LIMITED , GREGORY, Peter , KENYON, Ronald, Wynford
发明人： ZENECA LIMITED
IPC分类号： C09B31/08
CPC分类号： C09D11/328 , C09B31/08
摘要： Compounds of formula (1) and salts thereof, wherein: T and T each independently is H, acyl or optionally substituted alkyl or aryl; or T and T together represent an optionally substituted hydrocarbylene optionally interrupted by oxygen; D is optionally substituted phenylene or naphthylene; E is optionally substituted naphthylene or quinolinylene; Z is H or optionally substituted aryl; and n has a value of 0 or 1; provided that T , T and Z are not all H when n has a value of 0 and their use in inks, especially ink jet printing inks, for paper.
摘要翻译：式（1）化合物及其盐，其中：T 1和T 2各自独立地为H，酰基或任选取代的烷基或芳基; 或T 1和T 2一起代表任选被氧中断的任选取代的亚烃基; D是任选取代的亚苯基或亚萘基; E是任选取代的亚萘基或喹啉基; Z是H或任选取代的芳基; 并且n的值为0或1; 条件是当n值为0时，T 1，T 2和Z不全都为H，并且它们在油墨，特别是喷墨印刷油墨中用于纸。

198. 发明申请

WO1994025564A1 VIABLE BACTERIA 审中-公开
标题翻译：可视细菌
公开(公告)号：WO1994025564A1
公开(公告)日：1994-11-10
申请号：PCT/GB1994000811
申请日：1994-04-18
申请人： ZENECA LIMITED , RODHAM, David, Kirk , CANTWELL, John, Burnett
发明人： ZENECA LIMITED
IPC分类号： C12N01/04
CPC分类号： C12N1/04 , C12N11/04
摘要： Microbial cells are stabilised for storage in the form of a dried composition in a stasis state suspended in a collapsed matrix. The composition is prepared by mixing the microbial cells, for example Gram-negative bacterial cells such as Pseudomonas fluorescens, with an aqueous composition comprising a polyhydroxy compound, preferably a saccharide, from which the matrix will be derived, and drying the mixture under conditions such that viscous flow of the polyhydroxy compound occurs and the matrix collapses but does not unduly damage the cells. The glass transition temperature of the matrix is ideally above the temperature at which the composition is stored.
摘要翻译：稳定的微生物细胞以悬浮在收缩基质中的停滞状态的干燥组合物的形式存储。通过将微生物细胞，例如革兰氏阴性细菌细胞，例如荧光假单胞菌（Pseudomonas fluorescens）与包含多羟基化合物（优选糖）的水性组合物混合来制备组合物，从其中衍生基质，并在下列条件下干燥该混合物：发生多羟基化合物的粘性流动，并且基质崩溃，但不会不适当地损伤细胞。基质的玻璃化转变温度理想地高于组合物储存温度。

199. 发明申请

WO1994025459A1 HETEROCYCLIC DERIVATIVES 审中-公开
标题翻译：杂环衍生物
公开(公告)号：WO1994025459A1
公开(公告)日：1994-11-10
申请号：PCT/GB1994000910
申请日：1994-04-28
申请人： ZENECA LIMITED , BROWN, George, Robert , WHITTAMORE, Paul, Robert, Owen , BRITTAIN, David, Robert
发明人： ZENECA LIMITED
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： Compounds of formula (I) wherein R is hydrogen or hydroxy; R is hydrogen; or R and R are joined together so that CR -CR is a double bond; X is selected from -CH2CH2-, -CH=CH-, -CC-, -CH2O-, -OCH2-, CH2NH-, -NHCH2-, -CH2CO-, -COCH2-, -CH2S(O)n- and -S(O)nCH2- (wherein n is 0, 1 or 2); Ar is phenyl which bears one or more substituents independently selected from the groups (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (1-6C)alkoxy, (1-6C)alkoxycarbonyl, (1-6C)alkoxycarbonyl(1-6C)alkyl, (1-6C)alkoxy(1-6C)alkyl, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, carbamoyl, (1-6C) alkylcarbamoyl, di-[(1-6C)alkyl]carbamoyl, (1-6C)alkanoyl and oxime derivatives thereof and O-(1-6C)alkyl ethers of said oximes, (1-6C)alkylthio, (1-6C)alkylsulphinyl and (1-6C)alkylsulphonyl when substituted by one or more groups selected from (1-6C)alkoxycarbonyl, (1-6C)alkanoyl and oxime derivatives thereof and O-(1-6C)alkyl ethers of said oxime derivatives, (1-6C)alkanoylamino, (1-6C)alkanoyloxy, (1-6C)alkanoyloxy(1-6C)alkyl, carbamoyl, N-(1-6C)alkylcarbamoyl, N,N-di[(1-6C)alkyl]carbamoyl, amino, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, (1-6C)alkoxy, (2-6C)alkenyloxy, (1-6C)alkylthio, (1-6C)alkylsulphinyl, (1-6C)alkylsulphonyl, halogeno(1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, phenyl, phenoxy, cyano, nitro, hydroxy and carboxy; and wherein Ar may bear further substituents; and their pharmaceutically acceptable salts inhibit squalene synthese and are hence useful in lowering cholesterol levels in blood plasma. Processes for preparing compounds of formula (I) are also referred to as well as pharmaceutical compositions containing them and their use in medicine.
摘要翻译：式（I）的化合物，其中R 1是氢或羟基; R 2是氢; 或R 1和R 2连接在一起，使得CR 1 -CR 2是双键; X选自-CH 2 CH 2 - ， - CH = CH - ， - C - ， - CH 2 O - ， - OCH 2 - ，CH 2 NH-，-NHCH 2 - ， - CH 2 CO-，-COCH 2 - ， - CH 2 S（O） S（O）n CH 2 - （其中n为0,1或2）; Ar是含有一个或多个独立地选自（1-6C）烷基，（2-6C）烯基，（2-6C）炔基，（1-6C）烷氧基，（1-6C）烷氧羰基，（1-6C）（1-6C）烷基，（1-6C）烷氧基（1-6C）烷基，（1-6C）烷基氨基，二 - [（1-6C）烷基]氨基，氨基甲酰基，（1-6C ）烷基氨基甲酰基，二 - [（1-6C）烷基]氨基甲酰基，（1-6C）烷酰基和肟衍生物和所述肟的（1-6C）烷基醚，（1-6C）烷硫基，（1-6C ）（1-6C）烷氧基羰基，（1-6C）烷酰基及其肟衍生物和所述肟衍生物的O-（1-6C）烷基醚取代的（1-6C）烷基磺酰基，（1-6C）烷酰氨基，（1-6C）烷酰氧基，（1-6C）烷酰氧基（1-6C）烷基，氨基甲酰基，N-（1-6C）烷基氨基甲酰基，N，N-二[（1-6C）氨基，（1-6C）烷基氨基，二 - [（1-6C）烷基]氨基，（1-6C）烷氧基，（2-6C）烯氧基，（1-6C）烷硫基，（1-6C）烷基亚磺酰基，（1-6C）烷基磺酰基，卤代（1-6C）烷基，（2-6C）烯基，（2-6C）炔基，苯基，苯氧基，氰基，硝基，羟基和羧基; 并且其中Ar可以带有其它取代基; 其药学上可接受的盐抑制角鲨烯合成物，因此可用于降低血浆中的胆固醇水平。制备式（I）化合物的方法也被称为含有它们的药物组合物及其在医药中的用途。

200. 发明申请

WO1994025453A1 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS 审中-公开
标题翻译： 4-亚氨基-4-羟基四氢吡喃酮和3-氰基-3-羟基四氢呋喃作为5-LIPOXYGENASE抑制剂
公开(公告)号：WO1994025453A1
公开(公告)日：1994-11-10
申请号：PCT/EP1994001277
申请日：1994-04-25
申请人： ZENECA LIMITED , ZENECA-PHARMA S.A.
发明人： ZENECA LIMITED , ZENECA-PHARMA S.A. , BIRD, Thomas, Geoffrey, Colerick , CRAWLEY, Graham, Charles , LARGE, Michael, Stewart , PLE, Patrick
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , C07D409/14 , C07D417/14 , C07D493/08
摘要： The invention concerns ether derivatives of the formula (I): Q -X-Ar-Q , wherein Q is an optionally substituted 9-, 10- or 11-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur; X is oxy, thio, sulphinyl or sulphonyl; Ar is optionally substituted phenylene, pyridinediyl, pyrimidinediyl, thiophenediyl, furandiyl, thiazolediyl, oxazolediyl, thiadiazolediyl or oxadiazolediyl; and Q is selected from the groups of formulae (II) and (III), wherein R is hydrogen, (2-5C)alkanoyl or optionally substituted benzoyl; R is (1-4C)alkyl; and R is hydrogen or (1-4C)alkyl; or R and R are linked to form a methylene, vinylene, ethylene or trimethylene group; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
摘要翻译：本发明涉及式（I）的醚衍生物：Q 1 -X-Ar -Q 2，其中Q 1是任选取代的9,10或11元双环杂环部分，其含有一个或多个两个氮杂原子和任选地含有另外的选自氮，氧和硫的杂原子; X是氧基，硫基，亚磺酰基或磺酰基; Ar是任选取代的亚苯基，吡啶二基，嘧啶二基，噻吩二基，呋喃二基，噻唑二基，恶唑二基，噻二唑二基或恶二唑二基。和Q 2选自式（II）和（III）的基团，其中R 1是氢，（2-5C）烷酰基或任选取代的苯甲酰基; R 2是（1-4C）烷基; 和R 3是氢或（1-4C）烷基; 或R 2和R 3连接形成亚甲基，亚乙烯基，亚乙基或三亚甲基; 或其药学上可接受的盐; 其准备过程; 含有它们的药物组合物及其作为5-脂肪氧合酶抑制剂的用途。

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