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11. 发明申请

US20040142341A1 System for measuring membrane permeation 审中-公开
标题翻译：膜渗透测量系统
公开(公告)号：US20040142341A1
公开(公告)日：2004-07-22
申请号：US10475888
申请日：2004-03-17
发明人： Johannes Schmitt , Joachim Noller
IPC分类号： C12Q001/68 , C08G063/48 , C08G063/91 , B32B005/16
CPC分类号： G01N33/5432 , Y10T428/2991
摘要： The invention relates to a system, which can be used for measuring membrane permeation in substances. Said system comprises, essentially, porous particles with an inner surface formed within the pores, and another outer surface. Essentially, only the outer surface is fully covered by a lipid layer, said lipid layer extending over the openings of the pores on the outer surface. Preferably, an intermediate layer is arranged between the outer surface and the lipid layer. Said intermediate layer is embodied, more particularly, in the form a polymer network.
摘要翻译：本发明涉及一种可用于测量物质中膜渗透性的系统。所述系统基本上包括在孔内形成有内表面的多孔颗粒和另一外表面。基本上，只有外表面被脂质层完全覆盖，所述脂质层在外表面上的孔的开口上延伸。优选地，在外表面和脂质层之间布置中间层。所述中间层更具体地体现为聚合物网络的形式。

12. 发明申请

US20040141944A1 Inhibition of xenoreactive antibodies 审中-公开
标题翻译：抑制异反应性抗体
公开(公告)号：US20040141944A1
公开(公告)日：2004-07-22
申请号：US10402845
申请日：2003-03-28
发明人： Alexander Schwarz , Guerard W. Byrne , Thomas A. Davis , Lisa E. Diamond , John S. Logan
IPC分类号： A61K039/00 , C08G063/48 , C08G063/91
CPC分类号： C07K16/00 , A61K39/001 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/645 , A61K2039/6093
摘要： One aspect of the present invention relates to methods and compositions for attenuating xenograft rejection by administering, to an animal receiving the xenograft, an amount of a polymer-derivatized xenoantigen (hereinafter nullxenopolymernull) effective for inhibiting or lessening the severity of hyperacute rejection response (HAR), or other immunological response to the graft, that is dependent on the presence of the xenoantigen on the grafted tissues or cells. In certain embodiments, the xenopolymer is administered in an amount sufficient to neutralize host antibodies (nullxenoreactive antibodiesnull or nullXNAnull) immunoreactive with the xenoantigen. The xenopolymer may additionally, or alternatively, be used as a tolerogen (or anergen) for the xenoantigen, e.g., able to suppress, to some degree, the production/secretion of XNAs by the immune system of the host.
摘要翻译：本发明的一个方面涉及通过向接受异种移植物的动物施用一定量的有效抑制或减轻超急性排斥反应严重性的聚合物衍生的异种抗原（以下称为“异戊烯”）来减弱异种移植排斥的方法和组合物（HAR）或其他对移植物的免疫应答，这取决于移植组织或细胞上异种抗原的存在。在某些实施方案中，以足以中和与异种抗原免疫反应的宿主抗体（“异反应性抗体”或“XNA”）的量施用异种聚合物。异源聚合物可以另外地或替代地用作异种抗原的耐受原（或过敏原），例如能够在一定程度上抑制宿主的免疫系统产生/分泌XNA。

13. 发明申请

US20040106728A1 Reagents and methods for solid phase synthesis and display 审中-公开
标题翻译：用于固相合成和显示的试剂和方法
公开(公告)号：US20040106728A1
公开(公告)日：2004-06-03
申请号：US10619799
申请日：2003-07-14
申请人： Affymetrix, Inc.
发明人： Glenn H. McGall , Anthony D. Barone , Martin Diggelmann
IPC分类号： C08G063/48 , C08G063/91 , C07F009/02
CPC分类号： C07F9/2408 , B01J2219/00722 , B01J2219/00725 , C07D493/10 , C07H21/00 , C40B40/06 , C40B40/10
摘要： New compounds, compositions and methods which find application in solid phase synthesis including the preparation of high-density arrays of diverse polymer sequences such as diverse peptides and oligonucleotides as well as in preparation of arrays of small ligand molecules. The compounds of the present invention are those which are typically referred to as linking groups, linkers or spacers and include unsymmetrical disulfide linking groups, and 1,3-diol derivatives capable of providing a triggered release of an attached compound from a solid support under mild conditions. Additional new compounds are labels which can be incorporated into either the 3null or 5null terminus of a DNA oligomer.
摘要翻译：可用于固相合成的新化合物，组合物和方法，包括制备不同聚合物序列的高密度阵列，例如多种肽和寡核苷酸，以及制备小配体分子的阵列。本发明的化合物是通常称为连接基团，接头或间隔基并且包括不对称二硫键连接基团的化合物，以及能够在温和的条件下从固体支持物引发附着化合物的触发释放的1,3-二醇衍生物条件。另外的新化合物是可掺入DNA寡聚体的3'或5'末端的标记。

14. 发明申请

US20040101941A1 Intracellular delivery system for protein phosphatases 审中-公开
标题翻译：蛋白磷酸酶的细胞内递送系统
公开(公告)号：US20040101941A1
公开(公告)日：2004-05-27
申请号：US10343094
申请日：2003-07-07
发明人： Sara Lavi , Roni Sutchi-Painaro
IPC分类号： C12N009/16 , C08G063/48 , C08G063/91
CPC分类号： C12N11/08 , A61K38/00 , A61K47/65 , C12N9/16 , C12Y301/03016
摘要： The subject invention relates to a polymer-based intracellular delivery system for protein phosphatases. This delivery system can be used to deliver protein phosphatases for any disease or disorder in which it is desirable to elevate protein phosphatase activity, particularly for tumor therapy. Novel protein phosphatases are also disclosed.
摘要翻译：本发明涉及蛋白磷酸酶的基于聚合物的细胞内递送系统。该递送系统可用于递送蛋白质磷酸酶用于任何疾病或病症，其中期望提高蛋白质磷酸酶活性，特别是用于肿瘤治疗。还公开了新的蛋白磷酸酶。

15. 发明申请

US20040091451A1 Biocompatible polymer for fixing biological ligands 审中-公开
标题翻译：用于固定生物配体的生物相容性聚合物
公开(公告)号：US20040091451A1
公开(公告)日：2004-05-13
申请号：US10296889
申请日：2003-01-27
发明人： Marie-Therese Charreyre , Franck D'Agosto , Arnaud Favier , Christian Pichot , Bernad Mandrand
IPC分类号： A61K031/765 , C08G063/48 , C08G063/91
CPC分类号： C08L53/00 , C08F293/005
摘要： The invention concerns a biocompatible polymer having a mole weight more than 50000 g/mole, preferably 90000 g/mole for fixing biological ligands comprising at least a first linear segment consisting of a hydrophobic homopolymer derived from polymerisation of a hydrophobic monomer A; a second linear segment consisting of a hydrophilic polymer derived from copolymerisation of a monomer B bearing a reactive function X and a hydrophilic monomer C not bearing any reactive function, said second segment being covalently bound to one end of the first segment. The invention also concerns a biological polymer-ligand-conjugate, a device for capturing a target molecule comprising a solid support whereon is immobilised a biological polymer-ligand conjugate and methods for preparing said polymer. The invention is mainly applicable in the field of diagnosis.
摘要翻译：本发明涉及摩尔重量大于50000克/摩尔，优选90000克/摩尔的生物相容性聚合物，用于固定生物配体，其包含至少一种由衍生自疏水性单体A的聚合的疏水性均聚物组成的第一线性区段; 第二线性区段由亲水性聚合物组成，所述亲水性聚合物衍生自携带反应性官能团X的单体B与不具有任何反应性功能的亲水性单体C的共聚，所述第二区段共价结合到第一区段的一端。本发明还涉及生物聚合物 - 配体 - 缀合物，用于捕获包含其中固定有生物聚合物 - 配体缀合物的固体支持物的靶分子的装置和用于制备所述聚合物的方法。本发明主要适用于诊断领域。

16. 发明申请

US20040077595A1 Cyclodextrin-based polymers for therapeutics delivery 有权
标题翻译：用于治疗输送的基于环糊精的聚合物
公开(公告)号：US20040077595A1
公开(公告)日：2004-04-22
申请号：US10656838
申请日：2003-09-05
申请人： Insert Therapeutics, Inc.
发明人： Jianjun Cheng , Mark E. Davis , Kay T. Khin
IPC分类号： A61K031/724 , C08G063/48 , C08G063/91
CPC分类号： C08G69/44 , A61K31/337 , A61K31/7048 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48215 , A61K47/4823 , A61K47/48338 , A61K47/48969 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/6951 , B82Y5/00 , C08B30/00 , C08B31/00 , C08B37/0012 , C08F220/28 , C08F220/58 , C08F222/22 , C08F2220/282 , C08G81/02 , G06F19/00 , G06F19/3456 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
摘要翻译：本发明涉及设计为小分子治疗剂递送载体的治疗性环糊精含有聚合物的组合物及其药物组合物。这些含环糊精的聚合物改善药物稳定性和溶解性，并且在体内使用时降低小分子治疗剂的毒性。此外，通过从各种接头基团和靶向配体中选择，聚合物呈现用于治疗剂的受控递送的方法。本发明还涉及用本文所述的治疗组合物治疗受试者的方法。本发明还涉及用于进行药物业务的方法，包括制造，许可或分发包含或涉及本文所述的聚合物的试剂盒。

17. 发明申请

US20040039177A1 Stimulus responsive affinity chromatographic material and separation/purification method 失效
标题翻译：刺激响应亲和层析材料和分离/纯化方法
公开(公告)号：US20040039177A1
公开(公告)日：2004-02-26
申请号：US10381120
申请日：2003-07-07
发明人： Hidenori Yamanaka , Yukio Hasegawa
IPC分类号： C08G063/48 , C07K014/47
CPC分类号： B01D15/3861 , B01D15/20 , B01D15/3804 , B01D15/3876 , B01J20/261 , B01J20/262 , B01J20/267 , B01J20/285 , B01J20/286 , B01J20/3092 , B01J20/3212 , B01J20/3217 , B01J20/327 , B01J20/3282 , B01J20/3425 , B01J20/3483 , B01J2220/54 , B01J2220/58 , G01N30/54
摘要： A separation material characterized by supporting, in its surface, a linear or crosslinked stimulus responsive polymer to which a substance A having specific affinity for a target substance and a low-molecular substance B having specific affinity for the substance A have been bonded. Such a separation material can increase the recovery of a target substance to be purified and do not require desalting and hapten sugar-eliminating operations and, in addition, have high productivity.
摘要翻译：一种分离材料，其特征在于在其表面上支持线性或交联的刺激响应性聚合物，对物质A具有特异性亲和性的物质A与对物质A具有特异性亲和力的低分子物质B已经结合。这样的分离材料可以提高要纯化的目标物质的回收率，并且不需要脱盐和半抗原糖消除操作，并且另外具有高生产率。

18. 发明申请

US20040023304A1 Biomimetic systems consisting of lipid membranes bound to a substrate 审中-公开
标题翻译：由与膜结合的脂质膜组成的生物模拟系统
公开(公告)号：US20040023304A1
公开(公告)日：2004-02-05
申请号：US10443659
申请日：2003-05-22
发明人： Schiller Stefan , Naumann Renate , Knoll Wolfgang
IPC分类号： G01N033/53 , C08G063/91 , C08G063/48
CPC分类号： B82Y10/00 , C07D339/04 , C07F9/10 , C08G65/334 , C08L2203/02 , G01N33/54353 , G01N33/5438 , G01N2610/00 , G06N3/002
摘要： The invention concerns lipids functionalized with a hydrophilic linker which contain a tethering group for binding to a surface. The invention also concerns self-assembled monolayers of lipids on substrates in particular on ultrasmooth gold substrates. The lipids and the lipid monolayers or bilayers containing these lipids can be used to produce biomimetic supported membrane systems. After the optional incorporation of functional molecules such as membrane-associated proteins, these systems can be used for applications such as model systems for examining biological membranes, screening methods, sensors and bioelectronic devices such as biocomputers.
摘要翻译：本发明涉及用亲水接头官能化的脂质，其包含用于结合表面的束缚基团。本发明还涉及基质上特别是在超光滑金底物上的脂质的自组装单层。含有这些脂质的脂质和脂质单层或双层可用于产生仿生支持的膜系统。在功能分子如膜相关蛋白的任选引入之后，这些系统可用于诸如用于检查生物膜的模型系统，筛选方法，传感器和诸如生物计算机的生物电子装置之类的应用。

19. 发明申请

US20030232922A1 Perfluoropolyethers comprising repeating units obtained from oxidation of perfluorodioxoles 失效
标题翻译：全氟聚醚包含由全氟二氧杂环己烯氧化获得的重复单元
公开(公告)号：US20030232922A1
公开(公告)日：2003-12-18
申请号：US10458308
申请日：2003-06-11
申请人： SOLVAY SOLEXIS S.p.A.
发明人： Giuseppe Marchionni , Ugo De Patto
IPC分类号： C08G063/48 , C08G063/91 , C07D317/44
CPC分类号： C08G65/007 , C08G65/322 , C08G2650/10
摘要： Perfluoropolyethers obtained by oxidation of perfluorodioxoles of formula (I) 1 wherein RfnullnullF, null(O)yCnF2nnull1 with ynull0, 1 and nnull1, 2, 3, 4, 5, and with WnullnullF, nullCnF2nnull1, optionally in the presence of tetrafluoroethylene and/or hexafluoropropene, and subsequent reduction of the obtained peroxidic perfluoropolyethers.
摘要翻译：通过氧化式（I）的全氟二氧杂环己烷得到的全氟聚醚，其中Rf = -F， - （O）yCnF 2 n + 1，其中y = 0,1和n = 1,2,3,4,5，并且W = -F， -C n F 2n + 1，任选在四氟乙烯和/或六氟丙烯的存在下，随后还原所得的过氧化全氟聚醚。

20. 发明申请

US20030215853A1 Template-drive processes for synthesizing polymers and components related to such processes 有权
标题翻译：用于合成与这些方法相关的聚合物和组分的模板驱动方法
公开(公告)号：US20030215853A1
公开(公告)日：2003-11-20
申请号：US10396001
申请日：2003-03-24
发明人： David Lynn , Xiaoyu Li
IPC分类号： C12Q001/68 , C07H021/04 , C08G063/48
CPC分类号： B82Y30/00 , C12Q1/6837 , C12Q2565/518 , C12Q2533/101 , C12Q2525/101
摘要： Template-directed processes for synthesizing polymers are presented in which a sequence-specific polymer is generated from a corresponding sequence-specific template. The generated polymer has a chain length that corresponds to the chain length of the template.
摘要翻译：提出了用于合成聚合物的模板导向方法，其中从相应的序列特异性模板产生序列特异性聚合物。产生的聚合物具有对应于模板的链长度的链长度。

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