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11. 发明授权

US12076524B2 Compounding device, system, kit, software, and method 有权
公开(公告)号：US12076524B2
公开(公告)日：2024-09-03
申请号：US17829450
申请日：2022-06-01
申请人： B. Braun Medical Inc.
发明人： Michael Y. Brown , Mariano Mumpower , Jake A. Cowperthwaite , Jamie Kendall , Jeremy C. Savage , Chet B. Larrow , Alex K. Flamm , Dave E. Hershey , Aaron S. Pearl , Benjamin R. Lane , Karl Konrad, Jr. , Joel Bartholomew , Mike Janders , Edwin Burnard
IPC分类号： A61M39/22 , A61J3/00 , A61M39/24 , B01F23/45 , B01F23/451 , B01F25/00 , B01F25/30 , B01F25/31 , B01F33/30 , B01F33/301 , B01F33/84 , B01F35/71 , B01F101/06 , B01F101/22 , B65B3/12 , F16K5/04 , F16K11/085 , F16K11/22 , F16K31/04 , F16K99/00 , B01F101/00
CPC分类号： A61M39/223 , A61J3/002 , A61M39/24 , B01F23/45 , B01F23/451 , B01F25/1051 , B01F25/30 , B01F25/31 , B01F33/30 , B01F33/3017 , B01F33/84 , B01F33/846 , B01F35/7176 , B01F35/717611 , B01F35/71805 , B65B3/12 , F16K5/04 , F16K5/0407 , F16K5/0414 , F16K11/085 , F16K11/22 , F16K31/041 , F16K99/0013 , F16K99/0042 , A61J2200/70 , A61M39/22 , A61M2039/229 , B01F2101/06 , B01F2101/22 , B01F2101/2202 , B01F2101/2204 , F16K11/0856 , F16K2099/0084
摘要： An exemplary compounding system and method can include two pump heads for simultaneously drawing two different fluids from at least two separate input containers such that the at least two different fluids are mixed and distributed to an output container. The system can include a manifold that maintains separation of certain of the different fluids until after passing by a first pump and a second pump and/or additional pumps. A junction can be placed in the fluid line downstream of the first and second pumps and/or additional pumps such that all or some of the fluids are mixed prior to output to the output container. The method of using the system can include incorporating software that selects various fluids at certain times and sequences to ensure optimum efficiency and safety for the system, and can continue compounding actions even when an input supply container runs out or otherwise fails to supply a particular fluid/material. The method of use also includes connection of a transfer set to a housing in a manner that further ensures optimum efficiency and safety.

12. 发明授权

US11975298B2 Fluid controller and fluid mixer 有权
公开(公告)号：US11975298B2
公开(公告)日：2024-05-07
申请号：US17249358
申请日：2021-02-26
申请人： KABUSHIKI KAISHA TOSHIBA
发明人： Mitsuaki Kato , Masato Akita , Hideaki Okano
IPC分类号： B01F33/3012 , B01F33/301
CPC分类号： B01F33/3017 , B01F33/3012 , B01F2215/0409 , B01F2215/0431
摘要： According to one embodiment, a fluid controller includes a fluid channel deforming portion and a mixing portion provided downstream from the fluid channel deforming portion. The fluid channel deforming portion includes an upstream end portion, a first channel, a second channel and a channel terminating portion. At least one of the first and second channels is deformed between the upstream end portion and the channel terminating portion. A region of the second channel in a second cross-section, is increased more than a region of the second channel in the first cross-section, between the upstream end portion ad the channel terminating portion. The mixing portion mixes a plurality of fluids flowing through the fluid channel deforming portion.

13. 发明授权

US11873173B2 Multilayer hydrodynamic sheath flow structure 有权
公开(公告)号：US11873173B2
公开(公告)日：2024-01-16
申请号：US18136126
申请日：2023-04-18
申请人： CYTONOME/ST, LLC
发明人： John R. Gilbert , Manish Deshpande , Bernard Bunner
IPC分类号： B65G51/08 , B01L3/00 , G01N15/14 , B07C5/00 , B07C5/34 , B01F33/301 , B65G51/00 , B01F33/3011
CPC分类号： B65G51/08 , B01F33/3017 , B01L3/502776 , B07C5/00 , B07C5/34 , G01N15/1404 , G01N15/1484 , B01F33/3011 , B01J2219/0086 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00891 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N2015/1409
摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

14. 发明公开

US20230381721A1 APPARATUS FOR MANUFACTURING COSMETICS 审中-公开
公开(公告)号：US20230381721A1
公开(公告)日：2023-11-30
申请号：US18200005
申请日：2023-05-22
申请人： AMOREPACIFIC CORPORATION
发明人： Soojung OH , Kyungsup HAN , Hyeungsoo BAEK , Jeongin LEE
IPC分类号： B01F21/20 , B01F35/221 , B01F23/41 , B01F25/10 , B01F33/301
CPC分类号： B01F21/20 , B01F35/2213 , B01F23/4143 , B01F25/103 , B01F33/3017 , B01F2101/21
摘要： An aspect of the present disclosure may provide an apparatus for manufacturing cosmetics includes a storage part capable of storing at least one fluid; and a main body capable of accommodating a microfluidic chip with a micro flow path formed therein, wherein the microfluidic chip is provided with at least one formulation to be dissolved by the fluid, wherein the fluid flows along the micro flow path formed in the microfluidic chip and dissolves the formulation, and the fluid and the dissolved formulation are mixed in the microfluidic chip to form a cosmetic, and then discharged to the outside of the microfluidic chip.

15. 发明公开

US20230271793A1 MULTILAYER HYDRODYNAMIC SHEATH FLOW STRUCTURE 审中-公开
公开(公告)号：US20230271793A1
公开(公告)日：2023-08-31
申请号：US18136126
申请日：2023-04-18
申请人： CYTONOME/ST, LLC
发明人： John R. Gilbert , Manish Deshpande , Bernard Bunner
IPC分类号： B65G51/08 , B01L3/00 , G01N15/14 , B07C5/00 , B07C5/34 , B01F33/301
CPC分类号： B65G51/08 , B01L3/502776 , G01N15/1404 , G01N15/1484 , B07C5/00 , B07C5/34 , B01F33/3017 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L2200/0636 , B01L2300/0816 , B01L2300/0887 , B01L2400/0487 , B65G51/00
摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

16. 发明公开

US20230249180A1 A multifunctional microfluidic detection chip 审中-公开
公开(公告)号：US20230249180A1
公开(公告)日：2023-08-10
申请号：US18012653
申请日：2021-11-01
申请人： LANSION BIOTECHNOLOGY CO., LTD.
发明人： Xingshang Xu , Jeffery Chen
IPC分类号： B01L3/00 , B01F33/301 , B01F23/451 , B01F23/40 , B01F35/83
CPC分类号： B01L3/502723 , B01F33/3017 , B01F23/451 , B01F23/483 , B01F35/83 , B01F2101/23
摘要： The invention discloses a multifunctional microfluidic detection chip. The detection chip comprises a chip body, on which a sample injection chamber, a sample quantitative chamber, a sample overflow chamber, a diluent storage chamber, a diluent quantitative chamber, a diluent overflow chamber, a quantitative mixing chamber, a reaction chamber and vent holes are disposed; a sample to be detected is injected into the sample injection chamber, and enters the sample quantitative chamber through a microfluidic channel, and the excess reaction sample enters the sample overflow chamber, a diluent in the diluent storage chamber enters the diluent quantitative chamber through a microfluidic channel, and the excess diluent enters the diluent overflow chamber; the reaction chamber includes one or more reaction cavities and a sample blank cavity; after the sample in the sample quantitative chamber is mixed with the diluent in the diluent quantitative chamber uniformly in the quantitative mixing chamber, mixed liquid enters the reaction cavities through microfluidic channels and reacts with a reaction reagent for detection, and enters the sample blank cavity at the same time as a sample blank for detection. The invention can effectively reduce the sample consumption, improve the accuracy of the detection results, and simultaneously detect multiple indicators.

17. 发明公开

US20240293538A1 NOVEL METHODS FOR MANUFACTURING AN ADJUVANT 审中-公开
公开(公告)号：US20240293538A1
公开(公告)日：2024-09-05
申请号：US18662744
申请日：2024-05-13
申请人： GLAXOSMITHKLINE BIOLOGICALS SA
发明人： Pol HARVENGT , Philippe JEHOULET , Loic LE GOURRIEREC , Demostene SIFAKAKIS , Laurent STRODIOT
IPC分类号： A61K39/39 , A61K39/00 , B01F23/41 , B01F25/433 , B01F33/301 , B01F101/22
CPC分类号： A61K39/39 , B01F23/4105 , B01F25/4334 , B01F33/3017 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , B01F23/4143 , B01F2101/22 , B01F2215/0431 , B01F2215/044 , B01F2215/045
摘要： The present invention relates to compositions and methods for manufacturing an adjuvant comprising a saponin using a microfluidic device and to aspects thereof.

18. 发明授权

US11982602B2 Fluidic device, system, and mixing method 有权
公开(公告)号：US11982602B2
公开(公告)日：2024-05-14
申请号：US17256151
申请日：2018-06-29
申请人： NIKON CORPORATION
发明人： Ryo Kobayashi , Hirofumi Shiono
IPC分类号： G01N1/38 , B01F33/301 , G01N35/08
CPC分类号： G01N1/38 , B01F33/3017 , G01N35/085 , G01N2001/383
摘要： The present invention provides a fluidic device in which solutions of different concentrations can be easily obtained. The fluidic device includes: a first substrate and a second substrate which are stacked in a thickness direction; an undiluted solution introduction flow path which has an undiluted solution introduction port and which is constituted of a groove part provided on at least one of the first substrate and the second substrate; a first circulation flow path which is constituted of a groove part having an annular shape and having a shared part that shares part of a flow path with the undiluted solution introduction flow path and a non-shared part which is not shared with the undiluted solution introduction flow path and which is connected to a diluting solution introduction port; a second circulation flow path which is provided independently of the first circulation flow path and which is constituted of a groove part having an annular shape and having a shared part that shares some flow path with the undiluted solution introduction flow path and a non-shared part which is not shared with the undiluted solution introduction flow path and which is connected to a diluting solution introduction port; and/or a third circulation flow path which is constituted of a groove part having an annular shape and having a shared flow path that shares part of a flow path with the first circulation flow path and a non-shared flow path which is not shared with the first circulation flow path and which is connected to a diluting solution introduction port, wherein the undiluted solution introduction flow path includes a valve at both ends of the shared part.

19. 发明授权

US11969480B2 Processes of preparing mRNA-loaded lipid nanoparticles 有权
公开(公告)号：US11969480B2
公开(公告)日：2024-04-30
申请号：US17185587
申请日：2021-02-25
申请人： Translate Bio, Inc.
发明人： Shrirang Karve , Ashish Sarode , Frank DeRosa
IPC分类号： C07H21/02 , A61K9/51 , A61K47/60 , A61K47/69 , A61K48/00 , B01F23/451 , B01F33/301 , B01J13/20 , B01F101/22
CPC分类号： A61K48/0091 , A61K9/5123 , A61K47/60 , A61K47/6925 , A61K48/0033 , B01F23/451 , B01F33/3017 , B01J13/203 , B01F2101/22
摘要： The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.

20. 发明公开

US20230356221A1 MIXING AND MICROFLUIDIC APPARATUSES RELATED THERETO 审中-公开
公开(公告)号：US20230356221A1
公开(公告)日：2023-11-09
申请号：US18199521
申请日：2023-05-19
申请人： Nutcracker Therapeutics, Inc.
发明人： Benjamin Eldridge , Ximiao Wen
IPC分类号： B01L3/00 , A61K31/7105 , B01F23/40 , B01F33/301
CPC分类号： B01L3/50273 , B01L3/502738 , A61K31/7105 , B01F23/405 , B01F33/3017 , B01L2300/0854 , B01L2300/0858 , B01L2300/0867 , B01L2300/0877 , B01L2300/0883 , B01L2400/0478 , B01L2400/0487 , B01L2400/06 , B01F2215/0472 , B01F2101/22
摘要： The application relates to microfluidic apparatus and methods of use thereof. Provided in one example is a microfluidic device comprising: a first fluidic input and a second fluidic input; and a fluidic intersection channel to receive fluid from the first fluidic input and the second fluidic input, wherein the fluidic intersection channel opens into a first mixing chamber on an upper region of a first side of the first mixing chamber, wherein the first mixing chamber has a length, a width, and a depth, wherein the depth is greater than about 1.5 times a depth of the fluidic intersection channel; an outlet channel on an upper region of a second side of the first mixing chamber, wherein the outlet channel has a depth that is less than the depth of the first mixing chamber, and wherein an opening of the outlet channel is offset along a width of the second side of the first mixing chamber relative to the fluidic intersection.

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