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11. 发明申请

WO2018195468A3 DISPOSABLE SYSTEM FOR ANALYSIS OF HEMOSTATIC FUNCTION 审中-公开
公开(公告)号：WO2018195468A3
公开(公告)日：2018-10-25
申请号：PCT/US2018/028630
申请日：2018-04-20
申请人： HEMOSONICS, LLC , VIOLA, Francesco , HIGGINS, Timothy , HOMYK, Andrew , COREY, F. Scott , REGAN, Frank , WALKER, William F. , BRYANT, David , GIVENS, Thomas
发明人： VIOLA, Francesco , HIGGINS, Timothy , HOMYK, Andrew , COREY, F. Scott , REGAN, Frank , WALKER, William F. , BRYANT, David , GIVENS, Thomas
IPC分类号： G01N33/49
摘要： A disposable system, in some embodiments, includes a multi-channel or multi-chamber test cartridge device configured to operate with a testing system for evaluation of hemostasis in a subject by in vitro evaluation of a test sample from the subject. The disposable system, in some embodiments, is configured to interrogate the test sample to evaluate clot stiffness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes occur during coagulation and/or dissolution of the resulting clot.

12. 发明申请

WO2016149480A1 DETERMINING MECHANICAL PROPERTIES VIA ULTRASOUND-INDUCED RESONANCE 审中-公开
标题翻译：通过超声波感应谐振测定机械性能
公开(公告)号：WO2016149480A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/022844
申请日：2016-03-17
申请人： HEMOSONICS, LLC
发明人： WALKER, William F. , COREY, F. Scott , HOMYK, Andrew , HIGGINS, Tim , VIOLA, Francesco , REGAN, Frank , FERRANTE, Elisa
IPC分类号： G01N29/34 , G01R13/34
CPC分类号： G01N29/4418 , G01N29/036 , G01N29/4436 , G01N29/4472 , G01N2291/014 , G01N2291/02466 , G01N2291/02818 , G01N2291/02827
摘要： A device for estimating a mechanical property of a sample is disclosed herein. The device may include a chamber configured to hold the sample; a transmitter configured to transmit a plurality of waveforms, including at least one forcing waveform; and a transducer assembly operatively connected to the transmitter and configured to transform the transmit waveforms into ultrasound waveforms. The transducer assembly can also transmit and receive ultrasound waveforms into and out of the chamber, as well as transform at least two received ultrasound waveforms into received electrical waveforms. The device also includes a data processor that can receive the received electrical waveforms; estimate a difference in the received electrical waveforms that results at least partially from movement of the sample; and estimate a mechanical property of the sample by comparing at least one feature of the estimated difference to at least one predicted feature, wherein the at least one predicted feature is based on a model of an effect of the chamber wall. Finally, the device can also include a controller configured to control the timing of the ultrasound transmitter and data processor.
摘要翻译：这里公开了用于估计样品的机械性能的装置。该装置可以包括配置成保持样品的腔室; 发射机，被配置为发送包括至少一个强制波形的多个波形; 以及可操作地连接到所述发射器并且被配置为将所述发射波形变换成超声波形的换能器组件换能器组件还可以将超声波波形发送和接收到腔室中，并且将至少两个接收到的超声波形变换为接收的电波形。该装置还包括可以接收所接收的电波形的数据处理器; 估计至少部分地导致样品移动的接收电波形的差异; 并且通过将所估计的差异的至少一个特征与至少一个预测特征进行比较来估计样本的机械性质，其中所述至少一个预测特征基于所述室壁的效应的模型。最后，设备还可以包括配置成控制超声波发射器和数据处理器的定时的控制器。

13. 发明申请

WO2013105986A2 DEVICES, SYSTEMS AND METHODS FOR EVALUATION OF HEMOSTASIS 审中-公开
标题翻译：装置，系统和方法评估回声
公开(公告)号：WO2013105986A2
公开(公告)日：2013-07-18
申请号：PCT/US2012/025270
申请日：2012-02-15
申请人： HEMOSONICS, LLC , VIOLA, Francesco , WALKER, William H. , BROWNE, Gregory V. , MAGYAR, Robert S. , HANSEN, Bjarne , PLATT, Karen
发明人： VIOLA, Francesco , WALKER, William H. , BROWNE, Gregory V. , MAGYAR, Robert S. , HANSEN, Bjarne
IPC分类号： G01N33/50 , G01N33/48
CPC分类号： G01N33/86 , B01L3/5027 , B01L3/502761 , B01L3/527 , B01L2200/04 , B01L2200/0647 , B01L2300/02 , B01L2300/024 , B01L2300/027 , B01L2300/0627 , B01L2300/0654 , B01L2300/0681 , B01L2300/0816 , B01L2300/0829 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/123 , B01L2300/14 , B01L2300/16 , B01L2300/1805 , B01L2400/0436 , B01L2400/0439 , B01L2400/0487 , B01L2400/049 , B01L2400/0666 , G01N29/024 , G01N29/222 , G01N35/00 , G01N2800/224
摘要： Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.
摘要翻译：提供了用于评估止血的装置，系统和方法。还提供了声音聚焦组件。

14. 发明申请

WO2011127436A2 HEMOSTATIC PARAMETER DISPLAY 审中-公开
标题翻译： HEMOSTATIC参数显示
公开(公告)号：WO2011127436A2
公开(公告)日：2011-10-13
申请号：PCT/US2011/031832
申请日：2011-04-08
申请人： HEMOSONICS, LLC , VIOLA, Francesco , WALKER, William F. , BROWNE, Gregory V. , LOOKER, Adam , ROY, Bryan , HANSEN, Bjarne
发明人： VIOLA, Francesco , WALKER, William F. , BROWNE, Gregory V. , LOOKER, Adam , ROY, Bryan , HANSEN, Bjarne
IPC分类号： A61B19/00 , A61B1/04 , G08B21/02
CPC分类号： G06Q50/24 , G06F19/00 , G16H15/00
摘要： A system for displaying a plurality of hemostatic indexes is disclosed. The system includes a communication receiver configured to receive the hemostatic indexes and a graphical user interface (GUI) connected to the communication receiver and configured to simultaneously display the hemostatic indexes. The hemostatic indexes are derived from a plurality of independent measurements, such as the mechanical measurements determined using the sonorheometry systems and processes.
摘要翻译：公开了一种用于显示多个止血指标的系统。该系统包括被配置为接收止血指数的通信接收器和连接到通信接收器并被配置为同时显示止血指数的图形用户界面（GUI）。止血指数来源于多个独立的测量结果，例如使用sonorheometry系统和过程确定的机械测量。

15. 发明专利

CA2823729C DEVICES, SYSTEMS AND METHODS FOR EVALUATION OF HEMOSTASIS 未知
公开(公告)号：CA2823729C
公开(公告)日：2022-06-14
申请号：CA2823729
申请日：2012-02-15
申请人： HEMOSONICS LLC
发明人： VIOLA FRANCESCO , WALKER WILLIAM H , BROWNE GREGORY V , MAGYAR ROBERT S , HANSEN BJARNE , DENNY CHRISTOPHER G
IPC分类号： G01N33/50 , G01N33/48
摘要： Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.

16. 发明专利

ES2854873T3 Dispositivos, sistemas y procedimientos para la evaluación de la hemostasia 未知
公开(公告)号：ES2854873T3
公开(公告)日：2021-09-23
申请号：ES12865280
申请日：2012-02-15
申请人： HEMOSONICS LLC
发明人： VIOLA FRANCESCO , WALKER WILLIAM H , BROWNE GREGORY V , MAGYAR ROBERT S , HANSEN BJARNE , DENNY CHRISTOPHER G
IPC分类号： G01N35/00 , B01L3/00
摘要： Un dispositivo (100) de evaluación de la hemostasia, que comprende: una primera, segunda, tercera y cuarta cámaras de ensayo (110, 112, 114, 116) configuradas cada una para recibir una muestra de sangre de ensayo, comprendiendo cada cámara de ensayo un reactivo respectivo o una combinación de reactivos que interactúan con la muestra de sangre de ensayo recibida en su interior; y en el que cada cámara de ensayo comprende además un aparato de focalización del sonido respectivo posicionado para focalizar el sonido en la cámara de ensayo, en el que cada aparato de focalización del sonido es un montaje de lente (131) sellado sobre cada una de las cámaras de ensayo, de tal manera que cada una de la primera, segunda, tercera y cuarta cámaras de ensayo está configurada para ser interrogada para determinar un parámetro de hemostasia de las muestras de ensayo, y en el que la interrogación comprende la medición de al menos una propiedad viscoelástica de la respectiva muestra de ensayo.

17. 发明专利

PT2676136T DISPOSITIVOS, SISTEMAS E MÉTODOS PARA AVALIAÇÃO DE HEMOSTASIA 未知
公开(公告)号：PT2676136T
公开(公告)日：2021-03-25
申请号：PT12865280
申请日：2012-02-15
申请人： HEMOSONICS LLC
IPC分类号： G01N33/50 , G01N33/48

18. 发明专利

AU2017248548B2 DEVICES, SYSTEMS AND METHODS FOR EVALUATION OF HEMOSTASIS 未知
公开(公告)号：AU2017248548B2
公开(公告)日：2018-12-20
申请号：AU2017248548
申请日：2017-10-20
申请人： HEMOSONICS LLC
发明人： VIOLA FRANCESCO , WALKER WILLIAM H , BROWNE GREGORY V , MAGYAR ROBERT S , HANSEN BJARNE , DENNY CHRISTOPHER G
IPC分类号： G01N33/50 , G01N33/48
摘要： Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.

19. 发明专利

CA3065331A1 DISPOSABLE SYSTEM FOR ANALYSIS OF HEMOSTATIC FUNCTION 未知
公开(公告)号：CA3065331A1
公开(公告)日：2018-10-25
申请号：CA3065331
申请日：2018-04-20
申请人： HEMOSONICS LLC
发明人： VIOLA FRANCESCO , HIGGINS TIMOTHY , HOMYK ANDREW , COREY F SCOTT , REGAN FRANKLIN F , WALKER WILLIAM F , BRYANT DAVID , GIVENS THOMAS
IPC分类号： G01N33/49
摘要： A disposable system, in some embodiments, includes a multi-channel or multi-chamber test cartridge device configured to operate with a testing system for evaluation of hemostasis in a subject by in vitro evaluation of a test sample from the subject. The disposable system, in some embodiments, is configured to interrogate the test sample to evaluate clot stiffness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes occur during coagulation and/or dissolution of the resulting clot.

20. 发明专利

CA3020503A1 DETERMINING MECHANICAL PROPERTIES VIA ULTRASOUND-INDUCED RESONANCE 未知
公开(公告)号：CA3020503A1
公开(公告)日：2016-09-22
申请号：CA3020503
申请日：2016-03-17
申请人： HEMOSONICS LLC
发明人： WALKER WILLIAM F , COREY F SCOTT , HOMYK ANDREW , HIGGINS TIM , VIOLA FRANCESCO , REGAN FRANK , FERRANTE ELISA
IPC分类号： G01N29/036 , G01N15/05
摘要： A device for estimating a mechanical property of a sample is disclosed herein. The device may include a chamber configured to hold the sample; a transmitter configured to transmit a plurality of waveforms, including at least one forcing waveform; and a transducer assembly operatively connected to the transmitter and configured to transform the transmit waveforms into ultrasound waveforms. The transducer assembly can also transmit and receive ultrasound waveforms into and out of the chamber, as well as transform at least two received ultrasound waveforms into received electrical waveforms. The device also includes a data processor that can receive the received electrical waveforms; estimate a difference in the received electrical waveforms that results at least partially from movement of the sample; and estimate a mechanical property of the sample by comparing at least one feature of the estimated difference to at least one predicted feature, wherein the at least one predicted feature is based on a model of an effect of the chamber wall. Finally, the device can also include a controller configured to control the timing of the ultrasound transmitter and data processor.

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