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11. 发明授权

US08906424B2 Licorice polyphenol preparation 有权
标题翻译：甘草多酚制剂
公开(公告)号：US08906424B2
公开(公告)日：2014-12-09
申请号：US12297354
申请日：2007-04-12
申请人： Midori Sakai , Toshinori Ikehara
发明人： Midori Sakai , Toshinori Ikehara
IPC分类号： A61K36/00 , A61K38/43 , A61K36/899 , A61K31/225 , A23D7/01 , A61Q19/00 , A23L1/00 , A23K1/16 , A23L1/035 , A23D7/005 , A61K9/00 , A23L1/30 , A61K8/97 , A61K36/484 , A61K9/08 , A61K9/12
CPC分类号： A23L1/035 , A23D7/0053 , A23D7/011 , A23K20/111 , A23L29/10 , A23L33/105 , A23P10/30 , A23V2002/00 , A61K8/97 , A61K9/006 , A61K9/08 , A61K9/124 , A61K36/484 , A61Q19/00 , A23V2250/2132 , A23V2250/1842 , A23V2200/30
摘要： This invention provides a highly concentrated licorice polyphenol preparation with high bioavailability. Further, this invention is intended to maintain high transparency of a composition without deterioration of the indigenous properties of an aqueous substance, even when such composition is added thereto. Such licorice polyphenol preparation comprises a hydrophobic licorice extract comprising licorice polyphenol as a primary component, medium-chain fatty acid triglyceride, and polyoxyethylene sorbitan fatty acid ester, and the ratio of the total weight of the hydrophobic licorice extract and medium-chain fatty acid triglyceride to the weight of polyoxyethylene sorbitan fatty acid ester is between 1:1 and 1:10.
摘要翻译：本发明提供具有高生物利用度的高度浓缩的甘草多酚制剂。此外，本发明旨在保持组合物的高透明度，而不会降低水性物质的本土性质，即使添加这种组合物也是如此。这种甘草多酚制剂包含含甘草多酚作为主要成分的疏水甘草提取物，中链脂肪酸甘油三酯和聚氧乙烯失水山梨醇脂肪酸酯，疏水甘草提取物与中链脂肪酸甘油三酯的总重量之比至聚氧乙烯脱水山梨糖醇脂肪酸酯的重量为1:1至1:10。

12. 发明申请

US20090041876A1 OIL/FAT-CONTAINING COMPOSITION FOR SUPPRESSION OF CARCINOGENESIS 审中-公开
标题翻译：用于抑制致癌作用的油/含FAT组合物
公开(公告)号：US20090041876A1
公开(公告)日：2009-02-12
申请号：US11910381
申请日：2006-03-29
申请人： Mitsuaki Kitano , Naoki Arai , Toshinori Ikehara , Kaku Nakagawa
发明人： Mitsuaki Kitano , Naoki Arai , Toshinori Ikehara , Kaku Nakagawa
IPC分类号： A61K36/484 , A61P35/00
CPC分类号： A61K36/484 , A23C9/1315 , A23D7/0056 , A23D9/007 , A23L27/60 , A23L33/105 , A23V2002/00 , A61K47/14 , A61K47/44 , A61K47/46 , A23V2200/308 , A23V2250/21
摘要： The present invention relates to an oil/fat-containing composition for suppressing carcinogenesis, the composition including a solution produced by bringing a hydrophobic extract of licorice, which has been produced by bringing licorice into contact with an alcohol, into contact with an oil/fat. According to the present invention, there are provided an oil/fat-containing composition for prevention or treatment of the cancer, which can act through oral administration, and can be safely ingested on a day-to-day basis, pharmaceuticals and foods containing the oil/fat-containing composition.
摘要翻译：本发明涉及一种用于抑制致癌作用的含油脂的组合物，该组合物包括通过使甘草与醇接触而制备的甘草疏水性提取物与油/脂肪接触而制备的溶液。根据本发明，提供了一种用于预防或治疗癌症的含油/脂肪的组合物，其可以通过口服给药，并且可以每天安全摄取，药物和含有含油/脂肪的组合物。

13. 发明申请

US20050112266A1 Ubiquinol-enriched fat-containing foods 有权
标题翻译：富含蛋白质的富含脂肪的食物
公开(公告)号：US20050112266A1
公开(公告)日：2005-05-26
申请号：US10501669
申请日：2003-01-20
申请人： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
发明人： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
IPC分类号： A23D9/00 , A21D2/14 , A23C11/04 , A23C19/082 , A23D7/005 , A23D7/015 , A23D9/007 , A23D9/02 , A23F3/16 , A23F5/24 , A23G9/32 , A23L1/00 , A23L1/16 , A23L1/164 , A23L1/18 , A23L1/187 , A23L1/19 , A23L1/212 , A23L1/216 , A23L1/24 , A23L1/30 , A23L1/39 , A61K31/122 , C11B5/00 , A23D7/00
CPC分类号： A23G9/32 , A21D2/14 , A23C11/04 , A23C19/082 , A23D7/0056 , A23D7/015 , A23D9/007 , A23F3/163 , A23F5/243 , A23L7/111 , A23L7/122 , A23L7/13 , A23L7/165 , A23L9/12 , A23L9/22 , A23L19/03 , A23L19/14 , A23L23/00 , A23L27/60 , A23L33/10 , A23P20/11 , A23P30/40 , A23V2002/00 , C11B5/0092 , A23V2250/314
摘要： To provide a food which suitably supply ubiquinol, a substance indispensable to the living body but is liable to be decreased and fall short of the requirements, through ingestion in the same ways as the ordinary foods in daily living.
摘要翻译：提供适当地提供泛醌的食物，其通过以与日常生活中的普通食物相同的方式摄取，这是生物体不可缺少但易于降低并且不符合要求的物质。

14. 发明授权

US06495189B1 Process for producing fat composition 失效
标题翻译：生产脂肪成分的方法
公开(公告)号：US06495189B1
公开(公告)日：2002-12-17
申请号：US09744941
申请日：2001-01-31
申请人： Yasuharu Nosho , Kazuhiro Ueshima , Toshinori Ikehara , Shinichi Hashimoto , Masakazu Kato
发明人： Yasuharu Nosho , Kazuhiro Ueshima , Toshinori Ikehara , Shinichi Hashimoto , Masakazu Kato
IPC分类号： A23D900
CPC分类号： C11B15/00 , A23D7/04 , A23D7/05 , A23D9/04
摘要： Disclosed is a method of producing a fat and oil composition comprising the steps of melting a fat and oil, or emulsion comprising fat and oil, and crystallizing the above-mentioned fat and oil by cooling to produce a fat and oil composition in paste form or plastic form. The molten fat and oil, or emulsion comprising fat and oil, is pressurized under force at a pressure of 10 to 150 MPa during the above-mentioned crystallization in the production of fat and oil compositions such as fat and oil processed foods, etc. As a result the crystallization speed of the fat and oil is markedly increased and post-crystallization can be prevented. Thus, improvement in quality of the fat and oil processed food and improved efficiency of the production process in terms of time and energy is achieved.
摘要翻译：公开了一种生产油脂组合物的方法，其包括以下步骤：使脂肪和油或包含油脂的乳液熔化，并通过冷却使上述脂肪和油结晶，从而生成糊状的脂肪和油组合物塑料形式。在脂肪和油组合物如脂肪和油加工食品等的生产中，在上述结晶期间，将熔融的脂肪和油或包含脂肪和油的乳液在10至150MPa的压力下在压力下加压。结果，脂肪和油的结晶速度显着增加，并且可以防止后结晶。因此，实现了油脂加工食品的质量提高，并且在时间和能量方面提高了生产过程的效率。

15. 发明授权

US09919017B2 Biologically active substance-containing water-solubilizing preparation and method for producing the same 有权
公开(公告)号：US09919017B2
公开(公告)日：2018-03-20
申请号：US13982841
申请日：2012-01-31
申请人： Takao Yamaguchi , Toshinori Ikehara
发明人： Takao Yamaguchi , Toshinori Ikehara
IPC分类号： A61K36/484 , A61K47/14 , A61K36/287 , A61K9/00 , A61K9/08
CPC分类号： A61K36/484 , A61K9/0095 , A61K9/08 , A61K36/287 , A61K47/14 , A61K2236/00 , A61K2300/00
摘要： An object of the present invention is to provide a water-solubilizing preparation that is obtained by convenient steps without use of a special apparatus such as a high-pressure homogenizer, does not impair the original properties of a water-based material even after being added to the material, has high dispersibility and transparency and excellent heat resistance and acid resistance, and can maintain stability. The water-solubilizing preparation of the present invention is a biologically active substance-containing water-solubilizing preparation comprising 1 to 50% by weight of an oily ingredient (A) containing a biologically active substance and oil, 10 to 98% by weight of a polyglycerin fatty acid ester (B) having an HLB value of 12.5 or larger, and 1 to 40% by weight of a surfactant (C) having an HLB value of 7 to 11.8.

16. 发明申请

US20100284983A1 COENZYME Q10-CONTAINING WATER-SOLUBLE COMPOSITION AND PROCESS FOR PRODUCTION THEREOF 失效
标题翻译： COYZYME Q10-含水溶性组合物及其生产方法
公开(公告)号：US20100284983A1
公开(公告)日：2010-11-11
申请号：US11917454
申请日：2006-06-14
申请人： Toshinori Ikehara , Hideyuki Kishida
发明人： Toshinori Ikehara , Hideyuki Kishida
IPC分类号： A61K31/122 , A61K38/43 , A61K9/14 , A61K8/92 , A61Q1/02 , A61Q11/00 , A61Q19/00 , A61P43/00 , A23L1/30 , A23K1/00 , A23L2/52
CPC分类号： A23K20/174 , A23L29/10 , A23L33/10 , A61K8/355 , A61K8/39 , A61K9/107 , A61K31/122 , A61K47/14 , A61K47/26 , A61Q19/00
摘要： A coenzyme Q10-containing water soluble composition comprises coenzyme Q10, a hydrophilic polyglycerol fatty acid ester, a lipophilic sucrose fatty acid ester and an aqueous phase component and a process for producing the same are disclosed. A coenzyme Q10-containing water-soluble dry powder can be obtained by drying the above-mentioned coenzyme Q10-containing water soluble composition. A food, functional food, beverage, pharmaceutical product, quasi drug, cosmetic, or animal food can be obtained by using the above-mentioned coenzyme Q10-containing water soluble composition or the above-mentioned coenzyme Q10-containing water-soluble dry powder. The coenzyme Q10-containing water soluble composition has a high bioavailability, and maintains a stable emulsion form for a long period of time from refrigeration temperature to room temperature and allows efficient supply.
摘要翻译：含有辅酶Q10的水溶性组合物包括辅酶Q10，亲水性聚甘油脂肪酸酯，亲脂性蔗糖脂肪酸酯和水相成分及其制造方法。可以通过干燥上述含有辅酶Q10的水溶性组合物来获得含辅酶Q10的水溶性干粉。可以通过使用上述含有辅酶Q10的水溶性组合物或上述含有辅酶Q10的水溶性干粉来获得食品，功能性食品，饮料，药物，准药物，化妆品或动物性食品。含有辅酶Q10的水溶性组合物具有高的生物利用度，并且从制冷温度到室温长时间保持稳定的乳液形式并且可以有效地供应。

17. 发明申请

US20090208472A1 OIL-IN-WATER EMULSION COMPOSITION CONTAINING LICORICE-DERIVED POLYPHENOL 审中-公开
标题翻译：含有LICORICE衍生的聚苯乙烯的水包油乳液组合物
公开(公告)号：US20090208472A1
公开(公告)日：2009-08-20
申请号：US12280453
申请日：2007-02-23
申请人： Midori Sakai , Toshinori Ikehara
发明人： Midori Sakai , Toshinori Ikehara
IPC分类号： A61K31/22 , A61K31/122
CPC分类号： A61K9/107 , A23K20/111 , A23K20/121 , A23L2/38 , A23L2/39 , A23L33/105 , A23L33/115 , A61K8/062 , A61K8/85 , A61K8/97 , A61K31/352 , A61K31/37 , A61K36/484 , A61K47/14 , A61K47/44 , A61Q19/00
摘要： The present invention provides a licorice polyphenol-containing oil-in-water emulsion composition comprising medium-chain triglyceride, a licorice hydrophobic extract comprising, as a main component, licorice polyphenol in a weight ratio relative to the medium-chain triglyceride of 1-50%, and a polyglycerol fatty acid ester comprised of a fatty acid residue having a carbon number of not less than 14. Since the composition of the present invention is superior in transparency, stable to acid and heat, soluble in water, it can be used for food, drink, pharmaceutical product, quasi-drug, cosmetic and the like, which enables efficient supply of a licorice hydrophobic extract such as licorice polyphenol and the like.
摘要翻译：本发明提供了一种含甘油三酯的中草甘油三酯，其中甘草酸甘油酯以甘油三酯的重量比为1〜50的甘草多酚，作为主要成分的甘草酸疏水性提取物％，以及由碳数不少于14的脂肪酸残基组成的聚甘油脂肪酸酯。由于本发明的组合物的透明性优异，对酸和热稳定，易溶于水，因此可以使用用于食品，饮料，药物，准药物，化妆品等，其能够有效地供应甘草疏水性提取物如甘草多酚等。

18. 发明申请

US20090098097A1 COMPOSITION FOR NORMALIZING BLOOD PRESSURE 审中-公开
标题翻译：用于正常化血压的组合物
公开(公告)号：US20090098097A1
公开(公告)日：2009-04-16
申请号：US12162091
申请日：2007-01-25
申请人： Toshinori Ikehara , Kenji Fujii , Kiyoshi Temmaru , Mikio Kitahara , Naoki Fukutomi
发明人： Toshinori Ikehara , Kenji Fujii , Kiyoshi Temmaru , Mikio Kitahara , Naoki Fukutomi
IPC分类号： A61K38/43 , A61K31/09 , A61K31/122 , A61P9/00
CPC分类号： A61K31/09 , A61K31/122
摘要： The present invention aims to provide a composition suitable for normalizing the blood pressure, which is useful as food, health food, supplement, nutritional supplement, food for specified health uses, food with nutrient function claims, pharmaceutical product, quasi-drug, feed or pet food.The present inventors have found that coenzyme Q has a superior effect for normalizing the blood pressure and completed the present invention. That is, the present invention provides a composition for normalizing the blood pressure, which contains reduced coenzyme Q as an active ingredient, and a composition for normalizing the blood pressure, which contains oxidized coenzyme Q as an active ingredient and improves hypotension.
摘要翻译：本发明的目的是提供一种适用于使血压正常化的组合物，其可用作食品，保健食品，补充剂，营养补充剂，用于特定健康用途的食品，具有营养功能要求的食品，药物产品，准药物，饲料或宠物食品。本发明人发现辅酶Q具有优异的血压正常化效果，完成了本发明。也就是说，本发明提供了含有还原型辅酶Q作为活性成分的血压正常化用组合物和含有氧化型辅酶Q作为有效成分的血压正常化组合物，能够改善低血压。

19. 发明申请

US20090087419A1 LICORICE POLYPHENOL PREPARATION 有权
标题翻译： LICORICE POLYPHENOL制剂
公开(公告)号：US20090087419A1
公开(公告)日：2009-04-02
申请号：US12297354
申请日：2007-04-12
申请人： Midori Sakai , Toshinori Ikehara
发明人： Midori Sakai , Toshinori Ikehara
IPC分类号： A61K31/122 , A61K31/232
CPC分类号： A23L1/035 , A23D7/0053 , A23D7/011 , A23K20/111 , A23L29/10 , A23L33/105 , A23P10/30 , A23V2002/00 , A61K8/97 , A61K9/006 , A61K9/08 , A61K9/124 , A61K36/484 , A61Q19/00 , A23V2250/2132 , A23V2250/1842 , A23V2200/30
摘要： This invention provides a highly concentrated licorice polyphenol preparation with high bioavailability. Further, this invention is intended to maintain high transparency of a composition without deterioration of the indigenous properties of an aqueous substance, even when such composition is added thereto. Such licorice polyphenol preparation comprises a hydrophobic licorice extract comprising licorice polyphenol as a primary component, medium-chain fatty acid triglyceride, and polyoxyethylene sorbitan fatty acid ester, and the ratio of the total weight of the hydrophobic licorice extract and medium-chain fatty acid triglyceride to the weight of polyoxyethylene sorbitan fatty acid ester is between 1:1 and 1:10.
摘要翻译：本发明提供具有高生物利用度的高度浓缩的甘草多酚制剂。此外，本发明旨在保持组合物的高透明度，而不会降低水性物质的本土性质，即使添加这种组合物也是如此。这种甘草多酚制剂包含含甘草多酚作为主要成分的疏水甘草提取物，中链脂肪酸甘油三酯和聚氧乙烯失水山梨醇脂肪酸酯，疏水甘草提取物与中链脂肪酸甘油三酯的总重量之比至聚氧乙烯脱水山梨糖醇脂肪酸酯的重量为1:1至1:10。

20. 发明申请

US20090004304A1 COMPOSITION COMPRISING BIOACTIVE SUBSTANCE 审中-公开
标题翻译：包含生物物质的组合物
公开(公告)号：US20090004304A1
公开(公告)日：2009-01-01
申请号：US12144376
申请日：2008-06-23
申请人： Toshinori Ikehara , Takayuki Sakogawa
发明人： Toshinori Ikehara , Takayuki Sakogawa
IPC分类号： A61K36/752 , A61K47/36 , A61K31/122 , A61K36/00 , A61K31/07 , A61K31/59 , A61K31/355 , A61K36/236 , A61K36/906 , A61K36/54 , A61K36/53 , A61K36/8962 , A61K36/81
CPC分类号： A61K36/8962 , A23L33/10 , A23L33/105 , A23L33/15 , A23L33/19 , A23L33/21 , A23L33/22 , A23L33/24 , A23L33/25 , A23L33/26 , A23L33/28 , A61K9/1075 , A61K9/148 , A61K31/015 , A61K31/07 , A61K31/122 , A61K31/352 , A61K31/355 , A61K31/59 , A61K36/00 , A61K36/236 , A61K36/53 , A61K36/54 , A61K36/71 , A61K36/752 , A61K36/81 , A61K36/9068 , A61K45/06 , A61K2300/00
摘要： The present invention provides a powder superior in water-dispersibility/solubility, workability and tabletability, which contains an oil component containing a bioactive substance, a water-soluble polymer, a saccharide other than polysaccharides and a surfactant, at a particular ratio. The powder can be utilized for food, food with nutrient function claims, food for specified health uses, nutritional supplement, nutritional product, animal drug, drinks, feed, pharmaceutical product, quasi-drug, cosmetic and the like.
摘要翻译：本发明提供了水分散性/溶解性，可加工性和可压片性优异的粉末，其含有特定比例含有生物活性物质，水溶性聚合物，多糖类和表面活性剂以外的糖类的油成分。该粉末可用于食品，具有营养功能的食物，具有特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，药物，准药物，化妆品等。

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