专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US5821247A Hydroquinone derivative and pharmaceutical use thereof 失效
标题翻译：对苯二酚衍生物及其药物用途
公开(公告)号：US5821247A
公开(公告)日：1998-10-13
申请号：US933208
申请日：1997-09-16
申请人： Yoshiaki Isobe , Yuso Goto , Masanori Tobe , Osamu Takahashi
发明人： Yoshiaki Isobe , Yuso Goto , Masanori Tobe , Osamu Takahashi
IPC分类号： C07D239/54 , C07D239/545 , C07D405/12 , A61K31/51
CPC分类号： C07D239/545 , C07D405/12
摘要： Disclosed is a hydroquinone derivative or a pharmaceutically acceptable salt thereof, the hydroquinone derivative being represented by formula (I): ##STR1## wherein R.sup.1 is a phenyl group which is unsubstituted or substituted with a substituent or substituents each independently selected from the group consisting of a halogen atom, a C1-4 alkyl group and a C1-4 alkoxy group; R.sup.2 is a hydrogen atom or a C1-4 alkyl group; each of R.sup.3 and R.sup.4 is independently a hydrogen atom or a C1-4 alkyl group; R.sup.5 is a hydrogen atom or a C1-4 alkyl group; each of R.sup.6, R.sup.7 and R.sup.8 is independently a hydrogen atom or a C1-4 alkyl group; P is a hydroxyl group; Q is a hydroxyl group, a C1-4 alkoxy group, a C1-18 acyloxy group or an oxo group; P may form together with Q an ether bond; R is a hydroxyl group, a C1-4 alkoxy group, a C1-18 acyloxy group or an oxo group, provided that when one of said Q and said R is an oxo group, the other is also an oxo group; X is a single bond, an --NR.sup.10 --group or a --CH.sub.2 --NR.sup.10 --group in which R.sup.10 is a hydrogen atom or a C1-4 alkyl group; Y is a methylene group or a carbonyl group; and dotted bonds in a six membered ring represent that said six membered ring has the maximum number of double bonds.
摘要翻译：公开了氢醌衍生物或其药学上可接受的盐，所述对苯二酚衍生物由式（I）表示：未取代的或被各自独立地选自卤素原子，C 1-4烷基的取代基或取代基取代和C 1-4烷氧基; R2是氢原子或C1-4烷基; R 3和R 4各自独立地为氢原子或C 1-4烷基; R5是氢原子或C1-4烷基; R6，R7和R8各自独立地为氢原子或C1-4烷基; P是羟基; Q是羟基，C 1-4烷氧基，C 1-18酰氧基或氧代基; P可与Q形成醚键; R是羟基，C 1-4烷氧基，C 1-18酰氧基或氧代基，条件是当所述Q和所述R中的一个是氧代基时，另一个也是氧代基; X是单键，-NR 10 - 基或-CH 2 -NR 10 - 基，其中R 10是氢原子或C 1-4烷基; Y是亚甲基或羰基; 六元环中的点状键表示所述六元环具有最大数量的双键。

12. 发明申请

US20060094737A1 Novel uracil derivatives and medicinal use thereof 审中-公开
标题翻译：新型尿嘧啶衍生物及其药用
公开(公告)号：US20060094737A1
公开(公告)日：2006-05-04
申请号：US10528373
申请日：2003-09-17
申请人： Yoshiaki Isobe , Masanori Tobe , Yoshifumi Inoue , Masakazu Isobe
发明人： Yoshiaki Isobe , Masanori Tobe , Yoshifumi Inoue , Masakazu Isobe
IPC分类号： A61K31/513 , C07D405/02 , C07D239/54
CPC分类号： C07D239/545 , A61K31/513 , C07D405/06 , C07D405/12 , C07D405/14
摘要： It is intended to provide an uracil derivative represented by the following general formula (I): (I) wherein X represents a group selected from among NHCO, NHCH2, CO, CONH and CH2NH; R1 represents hydrogen or optionally substituted C1-6 alkyl; R2 represents a group of the following general formula (II) or (III): (II) (III) (wherein m is 0 or 1; n is an integer of from 1 to 3; Y represents OH or NH2; and a dotted line shows a binding position), provided that when R2 is a group of the general formula (III), X represents NHCO or NHCH2; R3 and R4 independently represent each hydrogen or C1-6 alkyl; and Ar represents phenyl substituted by C1-6 alkyl at the o- and m-positions, optionally substituted heteroaryl or a bicyclic aromatic group; its pharmaceutically acceptable salt, and a remedy containing the above uracil derivative or its pharmaceutically acceptable salt as the active ingredient for, in particular, allergic diseases relating to a type IV allergic reaction, i.e., a novel compound useful in treating diseases in which a type IV allergic reaction participates and a remedy for allergic diseases containing the same as the active ingredient.
摘要翻译：旨在提供由以下通式（I）表示的尿嘧啶衍生物：（I）其中X表示选自NHCO，NHCH 2，CO，CONH和CH 2的基团 NH; R 1表示氢或任选取代的C 1-6烷基; R 2表示下述通式（II）或（III）的基团：（II）（III）（其中m为0或1; n为1至3的整数; Y 表示OH或NH 2，虚线表示结合位置），条件是当R 2为通式（III）的基团时，X表示NHCO或 NHCH 2

13. 发明申请

US20140179670A1 URACIL DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES 有权
标题翻译：尿嘧啶衍生物及其用于医疗用途
公开(公告)号：US20140179670A1
公开(公告)日：2014-06-26
申请号：US14236571
申请日：2012-07-31
申请人： Tomoya Shiro , Masanori Tobe , Katsumi Kubota , Yosuke Takanashi , Tomoaki Nakamura , Toshihiko Sone
发明人： Tomoya Shiro , Masanori Tobe , Katsumi Kubota , Yosuke Takanashi , Tomoaki Nakamura , Toshihiko Sone
IPC分类号： C07D403/04 , C07D401/04 , C07D417/14 , C07D403/14 , C07D413/14 , C07D401/14 , C07D405/14
CPC分类号： C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07F7/1804
摘要： The present invention provides: an uracil derivative represented by general formula (I) or a physiologically acceptable salt thereof (in the formula, R1 represents a hydrogen atom, a C1-10 alkyl group, a C2-6 alkene group or a 3- to 6-membered saturated or 4- to 6-membered unsaturated aliphatic ring group which may contain 1 to 2 hetero atoms independently selected from the group consisting of N, O and S; R2 represents a hydrogen atom, a halogen atom, a cyano group, —NRcRd, —N═CHN(CH3)2, or an C1-3 alkyl group; Ar1 and Ar2 independently represent a 5- to 6-membered aromatic ring group which may contain 1 to 3 hetero atoms independently selected from the group consisting of N, O and S; and L represents a 6-membered aromatic ring group which may contain 1 to 4 nitrogen atoms, a pyrazole group, a triazole group, or an imidazole group); and a therapeutic agent or prophylactic agent for various inflammatory diseases associated with elastase, comprises the compound or the like as an active ingredient.
摘要翻译：本发明提供：由通式（I）表示的尿嘧啶衍生物或其生理学上可接受的盐（式中，R1表示氢原子，C1-10烷基，C2-6烯基或3-至可以含有1〜2个独立地选自N，O和S的杂原子的6元饱和或4〜6元不饱和脂肪族环基; R2表示氢原子，卤素原子，氰基， -NR c R d，-N = CHN（CH 3）2或C 1-3烷基; Ar 1和Ar 2独立地表示可以含有1-3个独立地选自以下的杂原子的5至6元芳族环基团： N，O和S; L表示可含有1至4个氮原子的6元芳族环基，吡唑基，三唑基或咪唑基）。和用于与弹性蛋白酶相关的各种炎性疾病的治疗剂或预防剂包含作为活性成分的化合物等。

14. 发明授权

US09040516B2 Uracil derivative and use thereof for medical purposes 有权
标题翻译：尿嘧啶衍生物及其用途用于医疗用途
公开(公告)号：US09040516B2
公开(公告)日：2015-05-26
申请号：US14236571
申请日：2012-07-31
申请人： Tomoya Shiro , Masanori Tobe , Katsumi Kubota , Yosuke Takanashi , Tomoaki Nakamura , Toshihiko Sone
发明人： Tomoya Shiro , Masanori Tobe , Katsumi Kubota , Yosuke Takanashi , Tomoaki Nakamura , Toshihiko Sone
IPC分类号： A61K31/505 , A61K31/4015 , A61K31/497 , A61K31/535 , A61K31/54 , C07D401/04 , C07D403/14 , C07D413/14 , C07D417/14 , C07D403/04 , C07D401/14 , C07D405/14 , C07D409/14
CPC分类号： C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07F7/1804
摘要： The present invention provides: an uracil derivative represented by general formula (I) or a physiologically acceptable salt thereof (in the formula, R1 represents a hydrogen atom, a C1-10 alkyl group, a C2-6 alkene group or a 3- to 6-membered saturated or 4- to 6-membered unsaturated aliphatic ring group which may contain 1 to 2 hetero atoms independently selected from the group consisting of N, O and S; R2 represents a hydrogen atom, a halogen atom, a cyano group, —NRcRd, —N═CHN(CH3)2, or an C1-3 alkyl group; Ar1 and Ar2 independently represent a 5- to 6-membered aromatic ring group which may contain 1 to 3 hetero atoms independently selected from the group consisting of N, O and S; and L represents a 6-membered aromatic ring group which may contain 1 to 4 nitrogen atoms, a pyrazole group, a triazole group, or an imidazole group); and a therapeutic agent or prophylactic agent for various inflammatory diseases associated with elastase, comprises the compound or the like as an active ingredient.
摘要翻译：本发明提供：由通式（I）表示的尿嘧啶衍生物或其生理学上可接受的盐（式中，R1表示氢原子，C1-10烷基，C2-6烯基或3-至可以含有1〜2个独立地选自N，O和S的杂原子的6元饱和或4〜6元不饱和脂肪族环基; R2表示氢原子，卤素原子，氰基， -NR c R d，-N = CHN（CH 3）2或C 1-3烷基; Ar 1和Ar 2独立地表示可以含有1-3个独立地选自以下的杂原子的5至6元芳族环基团： N，O和S; L表示可含有1至4个氮原子的6元芳族环基，吡唑基，三唑基或咪唑基）。和用于与弹性蛋白酶相关的各种炎性疾病的治疗剂或预防剂包含作为活性成分的化合物等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式