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11. 发明授权

US5934278A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5934278A
公开(公告)日：1999-08-10
申请号：US442654
申请日：1995-05-16
申请人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
发明人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
IPC分类号： A61B5/145 , A61B5/00 , A61B5/026 , A61B5/1455 , G01N15/14 , G01N33/48 , A61B6/00
CPC分类号： G01N15/147 , A61B5/0261 , A61B5/1455
摘要： A non-invasive blood analyzer includes a light applying device for applying light to a detection region including a blood vessel in a living body and a capturing device for capturing an image of the detection region to which the light is applied. Finally, an analyzing device is included for further processing the captured image to analyze blood cells in the blood vessel included in the detection region. Preferably, the analyzing device includes a reference image forming device for forming a reference image by using at least one of a plurality of images which the capturing device repeatedly captures with respect to the same detection region. In addition, it includes a differential image forming device for calculating a difference in pixel information between the reference image and one of the plurality of images to form a differential image by using the calculated difference as pixel information. Finally, a blood cell image detecting device is included for detecting a blood cell image from the differential image.
摘要翻译：非侵入式血液分析仪包括：用于对包括生物体中的血管的检测区域进行光照射的光施加装置和用于拍摄被施加光的检测区域的图像的拍摄装置。最后，包括分析装置，用于进一步处理所捕获的图像，以分析检测区域中包括的血管中的血细胞。优选地，分析装置包括用于通过使用捕获装置相对于相同检测区域重复捕获的多个图像中的至少一个来形成参考图像的参考图像形成装置。此外，它包括差分图像形成装置，用于通过使用所计算的差分作为像素信息来计算参考图像和多个图像中的一个图像之间的像素信息的差异，以形成差分图像。最后，包括用于从差分图像检测血细胞图像的血细胞图像检测装置。

12. 发明申请

US20060129035A1 Devices, methods, and systems for measuring analytes extracted through skin 审中-公开
标题翻译：用于测量通过皮肤提取的分析物的装置，方法和系统
公开(公告)号：US20060129035A1
公开(公告)日：2006-06-15
申请号：US10745443
申请日：2003-12-23
申请人： Kaoru Asano , Takeshi Mizuno , Yasunori Maekawa , Kenichi Sawa
发明人： Kaoru Asano , Takeshi Mizuno , Yasunori Maekawa , Kenichi Sawa
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/1495 , A61B10/0045 , A61B2010/008
摘要： Measuring devices for measuring an analyte extracted through skin of a living body are described that include: a noninvasive sampling unit for extracting the analyte from the living body through analyte transmission paths formed in an extracting region of the skin; an analyte detection unit for detecting a quantity of extracted analyte; and a control unit for obtaining a corrected analyte quantity based on the quantity of the extracted analyte and number of analyte transmission paths in the extracting region. Methods and systems for measuring analytes extracted through skin are also described.
摘要翻译：描述了用于测量通过生物体的皮肤提取的分析物的测量装置，其包括：非侵入式取样单元，用于通过形成在皮肤提取区域中的分析物传播路径从活体提取分析物; 用于检测提取的分析物的量的分析物检测单元; 以及控制单元，用于基于所提取的分析物的量和提取区域中的分析物传播路径的数量来获得校正的分析物量。还描述了通过皮肤提取的测量分析物的方法和系统。

13. 发明授权

US5791345A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5791345A
公开(公告)日：1998-08-11
申请号：US565046
申请日：1995-11-30
申请人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa , Yasuhiro Kouchi
发明人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa , Yasuhiro Kouchi
IPC分类号： A61B5/00 , A61B5/026 , G01N15/00 , G01N15/02 , G01N21/53 , A61B1/04
CPC分类号： A61B5/1455 , A61B5/0261 , A61B5/14535 , G01N21/53 , A61B5/14532 , A61B5/14546 , G01N15/0227 , G01N2015/0065 , G01N2021/1791
摘要： A non-invasive blood analyzer is intended to capture images of a prescribed volume of blood in a blood vessel in a non-invasive manner and with a good contrast without collecting blood from a living body. The non-invasive blood analyzer includes a light application device for illuminating a detection region of vessels contained in a part of a living body, an image capturing device for capturing images of the detection region illuminated by the light application device, and an analyzer for analyzing blood components contained in the detection region by processing the images captured by the image capturing device. The image capturing device includes an object lens for converging the reflected light from the detection region. The light application device illuminates the detection region at an incident angle larger than an aperture angle of the object lens with respect to the detection region to provide dark-field illumination.
摘要翻译：非侵入性血液分析仪旨在以非侵入性的方式在血管中捕获规定体积的血液的图像，并且具有良好的对比度而不从活体收集血液。非侵入性血液分析装置包括：照射生物体的一部分容纳的血管的检测区域的照明装置，摄像装置，用于拍摄由光照射装置照射的检测区域的图像;以及分析装置，通过处理由图像捕获装置拍摄的图像，包含在检测区域中的血液成分。图像捕获装置包括用于会聚来自检测区域的反射光的物镜。光应用装置以相对于检测区域大于物镜的孔径角的入射角照射检测区域，以提供暗场照明。

14. 发明授权

US5769076A Non-invasive blood analyzer and method using the same 失效
标题翻译：非侵入性血液分析仪及其使用方法
公开(公告)号：US5769076A
公开(公告)日：1998-06-23
申请号：US641828
申请日：1996-05-02
申请人： Yasunori Maekawa , Kaoru Asano , Yasuhiro Kochi , Ken Ishihara
发明人： Yasunori Maekawa , Kaoru Asano , Yasuhiro Kochi , Ken Ishihara
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1495
CPC分类号： A61B5/1455
摘要： A non-invasive blood analyzer contains a light applicator for illuminating a detection region under the skin of a living body including a blood vessel; a camera for capturing an image of the illuminated detection region; an analyzer for processing the captured image and analyzing at least a component of blood in the blood vessel; a transparent plate; and a support for supporting the transparent plate and contacting the transparent plate closely with the skin over the detection region. The light applicator and the camera are constructed to illuminate the detection region and capture the image of the detection region through the transparent plate. Further, a drive controller is included for driving the support to move the transparent plate contacted closely with the skin in order to adjust the detection region to thereby compensate for any change in position of the blood vessel.
摘要翻译：非侵入性血液分析仪包括用于照射包括血管的生物体的皮肤下的检测区域的光施加器; 用于捕获所述被照亮检测区域的图像的照相机; 用于处理所捕获的图像并分析血管中的血液的至少一部分的分析器; 透明板以及用于支撑透明板并使透明板与检测区域上的皮肤紧密接触的支撑件。光照射器和相机被构造为照亮检测区域并通过透明板捕获检测区域的图像。此外，包括用于驱动支撑件的驱动控制器以移动与皮肤紧密接触的透明板，以便调整检测区域，从而补偿血管位置的任何改变。

15. 发明授权

US5722398A Apparatus for measuring concentration of hemoglobin and method for the same 失效
标题翻译：用于测量血红蛋白浓度的装置及其方法
公开(公告)号：US5722398A
公开(公告)日：1998-03-03
申请号：US557573
申请日：1995-11-14
申请人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
发明人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
IPC分类号： G01B11/08 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01N21/31 , G01N33/49
CPC分类号： A61B5/1455
摘要： An apparatus for measuring a concentration of hemoglobin includes a light application device for applying light to a detection region containing a blood vessel present in a living body; an image capturing device for capturing an image of the detection region to which the light is applied; and an analyzer for analyzing the concentration of hemoglobin in blood flowing through the blood vessel by processing the captured image. The analyzer includes a light intensity detector for detecting a light intensity of a body tissue and a light intensity of blood using the captured image. It further includes a calculator for calculating the concentration of hemoglobin from a ratio of the light intensity of the body tissue relative to the light intensity of blood thus detected.
摘要翻译：用于测量血红蛋白浓度的装置包括：用于将光照射到存在于生物体内的血管的检测区域的光施加装置; 用于捕获被施加光的检测区域的图像的图像捕获装置; 以及分析器，用于通过处理所捕获的图像分析血液中血红蛋白的浓度。该分析器包括用于使用捕获的图像检测身体组织的光强度和血液的光强度的光强度检测器。其还包括计算器，用于根据身体组织的光强度相对于这样检测的血液的光强度的比率计算血红蛋白的浓度。

16. 发明授权

US5598842A Non-invasive blood analyzer and method using the same 失效
标题翻译：非侵入性血液分析仪及其使用方法
公开(公告)号：US5598842A
公开(公告)日：1997-02-04
申请号：US296897
申请日：1994-08-29
申请人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa
发明人： Ken Ishihara , Hiroshi Yamamoto , Mitsuru Watanabe , Kaoru Asano , Akio Suzuki , Yasunori Maekawa
IPC分类号： A61B5/026 , G01N15/00 , G01N15/02 , G01N21/53 , A61B5/00 , A61B1/04
CPC分类号： G01N21/53 , A61B5/0261 , G01N15/0227 , G01N2015/0065 , G01N2021/1791
摘要： A non-invasive blood analyzer includes a light application device for applying light to a detection region of vessels contained in part of the living body, an imaging device for imaging the detection region to which light is applied, a fixing device for relatively fixing the imaging device and the part of the living body; a stabilizing device for stabilizing a focus of the imaging device with respect to the detection region; and an analyzer for analyzing the morphology and/or number of blood cells contained in the detection region by processing images captured with the imaging device, the light application device and the imaging device forming one image with a light application and capturing process during an interval of one ten thousandth to one billionth of a second.
摘要翻译：非侵入性血液分析仪包括：用于将光照射到生物体的一部分容纳的血管的检测区域的光施加装置，对被施加光的检测区域成像的成像装置，用于相对固定成像的定影装置装置和活体的一部分; 稳定装置，用于相对于所述检测区域稳定所述成像装置的焦点; 以及分析器，用于通过处理由成像装置拍摄的图像，所述光施加装置和所述成像装置在所述检测区域中包含的血细胞的形态和/或数量分析，万分之一到十分之一秒。

17. 发明授权

US07942831B2 Measuring method and measuring device 有权
标题翻译：测量方法和测量装置
公开(公告)号：US07942831B2
公开(公告)日：2011-05-17
申请号：US11789373
申请日：2007-04-24
申请人： Kenichi Sawa , Yasunori Maekawa , Yasuhito Ohnishi , Katsutoshi Mishima
发明人： Kenichi Sawa , Yasunori Maekawa , Yasuhito Ohnishi , Katsutoshi Mishima
IPC分类号： A61B5/00
CPC分类号： A61B10/0045 , A61B5/14514 , A61B5/14532 , A61B5/681 , A61B2010/008
摘要： The present invention is to present a measuring device which can conduct stable extraction and measurement of interstitial fluid. The measuring device comprises: a device body which comprises an extraction part for extracting body fluid from a living body and a measuring part for measuring a biological component contained in the extracted body fluid; a holding member which holds the device body and has an opening part for defining a measurement area on the living body; and a mounting member for mounting the holding member on the living body; wherein the measurement area on the living body is defined by the opening part when the holding member is mounted on the living body by the mounting member.
摘要翻译：本发明提供一种能够进行组织液的稳定提取和测定的测定装置。测量装置包括：装置主体，包括用于从活体提取体液的提取部分和用于测量提取的体液中所含的生物成分的测量部件; 保持构件，其保持所述装置主体并且具有用于限定所述生物体上的测量区域的开口部; 以及用于将保持构件安装在生物体上的安装构件; 其中当所述保持构件通过所述安装构件安装在所述生物体上时，所述生物体上的测量区域由所述开口部限定。

18. 发明申请

US20080128087A1 HIGH FREQUENCY POWER SUPPLY DEVICE AND HIGH FREQUENCY POWER SUPPLYING METHOD 审中-公开
标题翻译：高频电源装置和高频供电方法
公开(公告)号：US20080128087A1
公开(公告)日：2008-06-05
申请号：US11943759
申请日：2007-11-21
申请人： EIICH HAYANO , Takeshi Nakamura , Yasunori Maekawa , Hiroshi Iizuka , Jinyuan Chen
发明人： EIICH HAYANO , Takeshi Nakamura , Yasunori Maekawa , Hiroshi Iizuka , Jinyuan Chen
IPC分类号： C23F1/08 , B05C11/00 , H02M5/02
CPC分类号： H05H1/46 , H01J37/32091 , H01J37/32165 , H01J37/32174 , H05H2001/4645
摘要： A high frequency power supply device and power supplying method are disclosed, which can rapidly and accurately control power used for generation of plasmas. The device includes a first high frequency power supply, providing power at frequency f1, and a second high frequency power supply providing power at frequency f2 (f1>f2). The first power supply includes: a first high frequency oscillator, which excites the high frequency power at the first frequency and has a variable frequency; a first power amplification block, which amplifies the power of the high frequency oscillator; a heterodyne detection block, which performs heterodyne detection of a reflected wave; and a first control block, which receives a signal after detection of the heterodyne detection block and a traveling wave signal, and controls an oscillating frequency of the first high frequency oscillating block and an output of the first power amplification block.
摘要翻译：公开了一种高频电源装置和供电方法，其可以快速且准确地控制用于产生等离子体的功率。该装置包括以频率f 1提供功率的第一高频电源和以频率f 2（f 1> f 2）提供功率的第二高频电源。第一电源包括：第一高频振荡器，其以第一频率激发高频功率并具有可变频率; 第一功率放大块，其放大高频振荡器的功率; 外差检测块，其执行反射波的外差检测; 以及第一控制块，其在检测到外差检测块和行波信号之后接收信号，并且控制第一高频振荡块的振荡频率和第一功率放大块的输出。

19. 发明申请

US20080103374A1 Analyzer and Cartridge for Extracting Analyte 审中-公开
标题翻译：用于提取分析物的分析仪和墨盒
公开(公告)号：US20080103374A1
公开(公告)日：2008-05-01
申请号：US11795470
申请日：2006-01-10
申请人： Kenichi Sawa , Yasunori Maekawa , Yoshihiro Asakura
发明人： Kenichi Sawa , Yasunori Maekawa , Yoshihiro Asakura
IPC分类号： A61B5/00
CPC分类号： A61B5/14532
摘要： An analyzer (a blood glucose meter), which shows minor measurement errors even in the case of conducting the extraction and detection of an analyte in parallel, can be obtained. This blood glucose meter (100) comprises a sensor unit (26) having a measurement face (26a) to which glucose extracted from a subject is supplied, a light-receiving element (34) outputting a signal based on the glucose supplied to the measurement face, a sensor contact face (23a) to be in contact with the measurement face and a skin contact face (23b) to be in contact with the skin of the subject, as well as a mesh sheet (23) for supplying the glucose from the skin contact face to the measurement face. The mesh sheet is designed so that the distance between the measurement face and the skin is maintained substantially at a constant level during the contact with the skin.
摘要翻译：即使在平行进行分析物的提取和检测的情况下也能够得到微小的测定误差的分析仪（血糖计）。该血糖仪（100）具有传感器单元（26），该传感器单元（26）具有从被检体提取出的葡萄糖的测定面（26a），供给到被检体内的葡萄糖输出信号的光接收元件测量面，与测量面接触的传感器接触面（23a）和与被检体的皮肤接触的皮肤接触面（23b），以及用于供给的网片（23）来自皮肤的葡萄糖接触面到测量面。网眼片被设计成使得在与皮肤接触期间，测量面和皮肤之间的距离基本保持在恒定水平。

20. 发明授权

US07236236B2 Methods for detecting malaria parasites and reagent kits therefor 失效
标题翻译：检测疟原虫的方法及其试剂盒
公开(公告)号：US07236236B2
公开(公告)日：2007-06-26
申请号：US10678536
申请日：2003-10-03
申请人： Nobuaki Hanaoka , Yasunori Maekawa , Yasumasa Akai , Satoshi Nakayama
发明人： Nobuaki Hanaoka , Yasunori Maekawa , Yasumasa Akai , Satoshi Nakayama
IPC分类号： G01N37/00
CPC分类号： G01N33/56905 , G01N2333/445 , Y02A50/58
摘要： Methods for detecting a malaria parasite are described that include: releasing the malaria parasite by allowing an erythrocyte in a specimen to undergo hemolysis; staining the released malaria parasite with a fluorescent dye to prepare a measurement sample; detecting optical information from the measurement sample; and distinguishing the malaria parasite based on the optical information obtained. Apparatuses and reagent kits are also described.
摘要翻译：描述了用于检测疟原虫的方法，其包括：通过允许样品中的红细胞进行溶血来释放疟原虫; 用荧光染料染色释放的疟原虫以制备测量样品; 从测量样品检测光学信息; 并根据获得的光学信息区分疟疾寄生虫。还描述了装置和试剂盒。

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