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11. 发明授权

US06841356B1 Processes for cell traced based testing of biological cells 失效
标题翻译：用于细胞追踪的生物细胞检测方法
公开(公告)号：US06841356B1
公开(公告)日：2005-01-11
申请号：US09868200
申请日：1999-12-10
申请人： Gunter Fuhr , Rolf Hagedorn , Stephen Graham Shirley , Ekkehard Richter
发明人： Gunter Fuhr , Rolf Hagedorn , Stephen Graham Shirley , Ekkehard Richter
IPC分类号： C12M1/26 , C12N5/00 , G01N33/487 , C12Q1/02
CPC分类号： C12N5/0068 , C12N2535/10
摘要： For the cell trace based testing of biological cells, wherein the cells (16) are applied to an at least partially structured and/or surface modified substrate (11) and move adhesively over surface track regions (13, 15) of the substrate while producing cell traces (14a, 14b) consisting of material residues separated from the cells, cell tests are performed on the cell traces. A process for cell cultivation on biocompatible modified substrates whose surfaces are covered by cell traces is also described.
摘要翻译：对于生物细胞的基于细胞痕量的测试，其中细胞（16）被施加到至少部分结构化和/或表面改性的基底（11）并且粘附地移动到基底的表面轨迹区域（13,15）上，同时产生由从细胞分离的材料残留物组成的细胞痕迹（14a，14b），对细胞痕迹进行细胞测试。还描述了其表面被细胞痕迹覆盖的生物相容性修饰基质上的细胞培养方法。

12. 发明授权

US07276207B2 Microsystem for the dielectric and optical manipulation of particles 失效
标题翻译：微系统用于电介质和光学操纵的粒子
公开(公告)号：US07276207B2
公开(公告)日：2007-10-02
申请号：US10432793
申请日：2001-11-28
申请人： Torsten Muller , Thomas Schnelle , Gunter Fuhr
发明人： Torsten Muller , Thomas Schnelle , Gunter Fuhr
IPC分类号： B01L3/00 , G01N27/447 , G01N27/453
CPC分类号： G01N15/1056 , B03C5/026 , B03C5/028 , H05H3/04
摘要： Described is a fluidic microsystem with at least one compartment for the receiving and/or the through-flow of a liquid and having an electrode arrangement with a multiplicity of electrodes, between which a coaction zone is established, whereby the compartment possesses at least one wall, through which electromagnetic radiation can be linked into the said coaction zone in accord with a predetermined incident direction, and on at least one electrode a cooling apparatus is provided, and on which at least one respective electrode at least one reflector layer is provided, and wherein the respective electrode is at least partially shielded in reference to the incident beam direction, and having at least one heat conducting layer by means of which the respective electrode stands in thermal communication with a wall of the compartment, and/or includes an active cooling element, which is placed in thermal contact with the respective electrode.
摘要翻译：描述了一种流体微系统，其具有至少一个用于液体的接收和/或通过流动的隔室，并且具有多个电极的电极装置，在其间建立了一个共同作用区域，从而隔室具有至少一个壁，电磁辐射可以根据预定的入射方向连接到所述配位区中，并且在至少一个电极上设置有冷却装置，并且在其上设置至少一个相应的电极至少一个反射器层，以及其中相应的电极相对于入射光束方向被至少部分地屏蔽，并且具有至少一个导热层，通过该导热层，相应的电极与隔室的壁热连通，和/或包括主动冷却元件，其被放置成与相应的电极热接触。

13. 发明授权

US6056861A Process and device for generating resonance phenomena in particle suspensions 失效
标题翻译：用于在颗粒悬浮液中产生共振现象的方法和装置
公开(公告)号：US6056861A
公开(公告)日：2000-05-02
申请号：US77334
申请日：1998-07-27
申请人： Gunter Fuhr , Jan Gimsa , Torsten Muller , Thomas Schnelle
发明人： Gunter Fuhr , Jan Gimsa , Torsten Muller , Thomas Schnelle
IPC分类号： G01N33/483 , B03C5/00 , B03C5/02 , C12M1/00 , C12M1/42 , C12N13/00 , G01N15/00 , H02N13/00 , G01N27/26
CPC分类号： C12N13/00 , B03C5/028 , C12M33/00 , H02N13/00
摘要： A method and a device for position and/or type-selective control of the position and/or change of position of suspended particles in a multielectrode system by the effect of polarization forces that are induced in the particles by alternating electric fields in the multielectrode system, which particles comprise biological or synthetic objects with dimensions essentially corresponding to those of biological cells or cell organelles, viruses or macromolecules, base on the fact that the multielectrode system forms with the particle suspension an electrical network, in which means of resonance are provided for creating a resonant increase or damping of the field strength of the alternating electric fields at certain frequencies in at least one locally demarcated region of the multielectrode system.
摘要翻译： PCT No.PCT / EP96 / 05244 Sec。 371日期：1998年7月27日 102（e）1998年7月27日PCT PCT 1996年11月27日PCT公布。出版物WO97 / 20210 日期：1997年6月5日在多电极系统中通过交替电致使粒子诱导的极化力的作用，位置和/或型式选择性地控制悬浮颗粒的位置和/或位置变化的方法和装置所述多电极系统中的所述颗粒包含基本上对应于生物细胞或细胞器，病毒或大分子的尺寸的生物或合成物体，其基于所述多电极系统与所述粒子悬浮液形成电网，提供谐振以在多电极系统的至少一个局部分界区域中产生在某些频率处的交变电场的场强的共振增加或阻尼。

14. 发明申请

US20080038806A1 Magnetic Manipulation of Biological Samples 有权
标题翻译：生物样品的磁操作
公开(公告)号：US20080038806A1
公开(公告)日：2008-02-14
申请号：US10591068
申请日：2005-02-25
申请人： Gunter Fuhr
发明人： Gunter Fuhr
IPC分类号： C12N13/00 , C12M1/00
CPC分类号： C12M25/16
摘要： The invention relates to a cell carrier (10) for receiving a biological sample. Said carrier comprises a magnetic element (20) and a floor element (30) that forms a stable support (31) that can be displaced on a solid base surface in at least one direction. The invention also relates to a manipulation device for biological samples and to a method for manipulating biological samples.
摘要翻译：本发明涉及用于接收生物样品的细胞载体（10）。所述载体包括形成可在至少一个方向上在固体基底表面上移位的稳定支撑体（31）的磁性元件（20）和地板元件（30）。本发明还涉及用于生物样品的操作装置和用于操纵生物样品的方法。

15. 发明申请

US20060051735A1 Method and devices for transferring biological cells between a carrier and a probe 有权
标题翻译：用于在载体和探针之间转移生物细胞的方法和装置
公开(公告)号：US20060051735A1
公开(公告)日：2006-03-09
申请号：US10545829
申请日：2003-12-02
申请人： Gunter Fuhr , Heiko Zimmermann , Hagen Thielecke
发明人： Gunter Fuhr , Heiko Zimmermann , Hagen Thielecke
IPC分类号： C12M1/34 , C12Q1/00
CPC分类号： B01L3/021 , A61B10/0233 , A61B10/0283 , A61B2010/0208 , B01L2200/0647 , B01L2300/0838 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , C12M33/02 , C12M35/00 , G01N1/286 , G01N15/12 , G01N15/14 , G01N2015/1486 , G01N2015/1493
摘要： A cell transfer method is described, in which transfer of at least one biological cell (21) describing a natural cell locomotion between a carrier (80) and a probe (10) is provided, and whereby positioning the probe (10) and the carrier (80) relative to one another in a transfer arrangement is provided, in which transfer of the cell (21) takes place due to the natural cell locomotion. Probes and cell manipulators for transferring biological cells are also described
摘要翻译：描述了一种细胞转移方法，其中提供描述载体（80）和探针（10）之间的天然细胞运动的至少一个生物细胞（21）的转移，由此将探针（10）和载体（80）在传送装置中相对于彼此设置，其中由于天然细胞运动而发生细胞（21）的转移。还描述了用于转移生物细胞的探针和细胞操纵器

16. 发明申请

US20060014134A1 Low-temperature storage of suspension samples in suspended sample chambers 失效
标题翻译：悬浮样品在悬浮样品室中的低温储存
公开(公告)号：US20060014134A1
公开(公告)日：2006-01-19
申请号：US10532017
申请日：2003-11-05
申请人： Gunter Fuhr , Heiko Zimmermann
发明人： Gunter Fuhr , Heiko Zimmermann
IPC分类号： A01N1/02 , F25C1/00
CPC分类号： A01N1/02 , A01N1/0257 , A01N1/0263 , A01N1/0268 , B01L3/505 , B01L3/545 , B01L2300/021 , B01L2300/024 , B01L2300/0838 , B01L2400/0406 , G01N1/42
摘要： A cryostorage device (100) is described that includes at least one data storage device (200) and at least one sample receptacle device (300) with at least one sample chamber (301, 302, etc.) for the uptake of a suspension sample, the at least one sample chamber (301, 302, etc.) being connected to the data storage device (200) and having a elongated, hollow shape that extends from an inlet end (320) over a predetermined length to an outlet end (330) and being attached to the at least one data storage device (200) in a flexible and movably hanging manner.
摘要翻译：描述了一种包括至少一个数据存储装置（200）和至少一个具有用于吸收悬浮液样品的至少一个样品室（301,302等）的样品容器装置（300）的冷冻装置（100），所述至少一个样品室（301,302等）连接到所述数据存储装置（200）并且具有从入口端（320）延伸超过预定长度的细长的中空形状到出口端（ 330）并且以柔性和可移动的悬挂方式附接到所述至少一个数据存储设备（200）。

17. 发明授权

US08241906B2 Magnetic manipulation of biological samples 有权
标题翻译：生物样品的磁操作
公开(公告)号：US08241906B2
公开(公告)日：2012-08-14
申请号：US10591068
申请日：2005-02-25
申请人： Gunter Fuhr
发明人： Gunter Fuhr
IPC分类号： C12N11/00 , C12N13/00 , C12M1/00
CPC分类号： C12M25/16
摘要： The invention relates to a cell carrier (10) for receiving a biological sample. The carrier comprises a magnetic element (20) and a floor element (30) that forms a stable support (31) that can be displaced on a solid base surface in at least one direction. The invention also relates to a manipulation device for biological samples and to a method for manipulating biological samples.
摘要翻译：本发明涉及用于接收生物样品的细胞载体（10）。载体包括形成可在至少一个方向上在固体基底表面上移位的稳定支撑体（31）的磁性元件（20）和地板元件（30）。本发明还涉及用于生物样品的操作装置和用于操纵生物样品的方法。

18. 发明申请

US20070248716A1 Method For the Production of a Biological Material Composition Having an Animal Origin 审中-公开
标题翻译：用于生产具有动物来源的生物材料组合物的方法
公开(公告)号：US20070248716A1
公开(公告)日：2007-10-25
申请号：US10599713
申请日：2005-03-04
申请人： Charli Kruse , Gunter Fuhr , Jurgen Rohwedel
发明人： Charli Kruse , Gunter Fuhr , Jurgen Rohwedel
IPC分类号： A23K1/00 , A23L1/00 , C12N5/02 , C12N5/06
CPC分类号： C12N5/0677
摘要： A method for producing a biological material composition of animal, non-human origin, especially as feed or food, is described. The method includes an aggregation of stem cells from differentiated exocrine glandular tissue of an animal organism to organoid bodies, and a preparation of the material composition from the organoid bodies.
摘要翻译：描述了用于生产动物，非人来源的生物材料组合物的方法，特别是作为饲料或食物。该方法包括将来自动物生物体的分化的外分泌腺体组织的干细胞与组织体的聚集，以及来自有机体的物质组合物的制备。

19. 发明申请

US20050064590A1 Cryoconservation on woven textiles 审中-公开
标题翻译：纺织品上的低温保存
公开(公告)号：US20050064590A1
公开(公告)日：2005-03-24
申请号：US10502869
申请日：2003-01-29
申请人： Heiko Zimmermann , Jorg-Uwe Meyer , Gunter Fuhr
发明人： Heiko Zimmermann , Jorg-Uwe Meyer , Gunter Fuhr
IPC分类号： A01N1/02 , G01N1/42 , C12N5/00
CPC分类号： G01N1/42 , A01N1/02 , A01N1/0231
摘要： A cryosubstrate, in particular for cryopreservation of biological specimens, having at least one solid-phase element is described. This solid-phase element is equipped for adherent fixation of specimens, with the solid-phase element comprising at least one carrier filament. Furthermore, a method of cryopreservation of biological specimens using such a cryosubstrate is described.
摘要翻译：描述了具有至少一个固相元件的低温底物，特别是用于生物标本的低温保存。该固相元件装备用于样品的贴附固定，固相元件包括至少一个载体长丝。此外，描述了使用这种低温底物冷冻保存生物样品的方法。

20. 发明申请

US20080193421A1 Multicellular Tissue and Organ Culture Systems 有权
标题翻译：多细胞组织和器官培养系统
公开(公告)号：US20080193421A1
公开(公告)日：2008-08-14
申请号：US11597317
申请日：2005-05-09
申请人： Charli Kruse , Gunter Fuhr
发明人： Charli Kruse , Gunter Fuhr
IPC分类号： A61K35/12 , C12N5/02 , A61P43/00 , A01N1/02
CPC分类号： A61L27/3886 , A61K35/12 , A61L27/3839 , C12N5/0062
摘要： The invention relates to methods for producing three-dimensional multicellular tissue and organ culture systems using multicellular mammalian cell aggregates, these systems themselves and their use for various medical purposes, in particular implantations.
摘要翻译：本发明涉及使用多细胞哺乳动物细胞聚集体制备三维多细胞组织和器官培养系统的方法，这些系统本身及其用于各种医疗目的，特别是植入物的用途。

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