专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US5837531A Recombinant adenoviruses for gene therapy in cancers 失效
标题翻译：用于癌症基因治疗的重组腺病毒
公开(公告)号：US5837531A
公开(公告)日：1998-11-17
申请号：US646246
申请日：1996-05-13
申请人： Jean-Fran.cedilla.ois Dedieu , Aude Le Roux , Michel Perricaudet
发明人： Jean-Fran.cedilla.ois Dedieu , Aude Le Roux , Michel Perricaudet
IPC分类号： C12N15/09 , A61K31/52 , A61K31/70 , A61K35/76 , A61K38/45 , A61K48/00 , A61P35/00 , C07H21/04 , C12N7/00 , C12N15/85 , C12N15/861 , C12N15/63
CPC分类号： A61K38/45 , C12N15/85 , C12N15/86 , A61K48/00 , C12N2710/10343 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/15 , C12N2830/60
摘要： The invention concerns recombinant viruses comprising a heterologous DNA sequence under the control of expression signals specifically active in tumour cells, and their preparation and use in the treatment and prevention of cancers
摘要翻译： PCT No.PCT / FR94 / 01284 Sec。 371日期：1996年5月13日 102（e）日期1996年5月13日PCT 1994年11月7日PCT PCT。第WO95 / 14101号公报日期1995年5月26日本发明涉及包含在肿瘤细胞中特异性活化的表达信号控制下的异源DNA序列的重组病毒及其在治疗和预防癌症中的制备和用途

12. 发明申请

US20130164262A1 Recombinant Viruses and their Use for Treatment of Atherosclerosis and Othe Forms of Coronary Artery Disease and Method, Reagent, and Kit for Evaluating Susceptibiity to Same 审中-公开
标题翻译：重组病毒及其用于治疗动脉粥样硬化和冠状动脉疾病形式的方法，试剂和评估易感性的试剂盒
公开(公告)号：US20130164262A1
公开(公告)日：2013-06-27
申请号：US13584203
申请日：2012-08-13
申请人： Patrick Benoit , Patrice Denefle , Michel Perricaudet , M.E. Suzanne Lewis , Michael R. Hayden
发明人： Patrick Benoit , Patrice Denefle , Michel Perricaudet , M.E. Suzanne Lewis , Michael R. Hayden
IPC分类号： C12N7/00
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C12N9/20 , C12N15/86 , C12N2710/10343 , C12N2740/13043 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/44 , C12Q1/6858 , C12Q2600/156 , C12Y301/01034 , C12Q2535/131 , C12Q2525/131
摘要： Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant viruses, especially for the treatment or prevention of dyslipoproteinemia-related pathologies.
摘要翻译：包含编码参与脂蛋白代谢的脂肪酶的异源DNA序列的重组病毒。本发明还涉及在所述重组病毒的治疗中的制备和用途，特别是用于治疗或预防与脂蛋白血症相关的病症。

13. 发明授权

US07306793B2 Defective recombinant adenoviruses expressing cytokines for antitumor treatment 失效
标题翻译：表达用于抗肿瘤治疗的细胞因子的重组腺病毒的缺陷
公开(公告)号：US07306793B2
公开(公告)日：2007-12-11
申请号：US10940358
申请日：2004-09-13
申请人： Hédi Mohamed Haddada , Thierry Ragot , Michel Perricaudet
发明人： Hédi Mohamed Haddada , Thierry Ragot , Michel Perricaudet
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： C12N7/00 , A61K35/761 , A61K38/00 , A61K48/00 , C07K14/52 , C12N15/86 , C12N2710/10243 , C12N2710/10332 , C12N2710/10343 , A61K2300/00
摘要： A recombinant nucleic acid used for the production of a defective adenovirus containing an inserted sequence coding for a cytokine under the control of a promoter in the genomic sequence of the recombinant adenovirus. This recombinant adenovirus is useful in the preparation of anti-tumoral drugs which can be directly injected into the tumor of the host.
摘要翻译：用于产生缺陷型腺病毒的重组核酸，其含有编码在重组腺病毒的基因组序列中的启动子控制下的细胞因子的插入序列。该重组腺病毒可用于制备可直接注射到宿主肿瘤中的抗肿瘤药物。

14. 发明授权

US06410011B1 Gene therapy for restenosis using an adenoviral vector 失效
标题翻译：使用腺病毒载体进行再狭窄的基因治疗
公开(公告)号：US06410011B1
公开(公告)日：2002-06-25
申请号：US08633769
申请日：1996-06-20
申请人： Didier Branellec , Jean-François Dedieu , Patrice Denefle , Laurent Feldman , Michel Perricaudet , Philippe Gabriel Steg
发明人： Didier Branellec , Jean-François Dedieu , Patrice Denefle , Laurent Feldman , Michel Perricaudet , Philippe Gabriel Steg
IPC分类号： A61K4800
CPC分类号： A61K48/00 , A61K38/45 , A61K38/50 , C12N15/86 , C12N2710/10343 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12Y207/01021 , C12Y305/04001
摘要： A method for treating restenosis by gene therapy is disclosed, said method comprising delivering a recombinant suicide-gene-containing adenovirus.
摘要翻译：公开了通过基因治疗治疗再狭窄的方法，所述方法包括递送含重组自杀基因的腺病毒。

15. 发明授权

US06245330B1 Recombinant adenoviruses coding for glial-derived neurotrophic factor (GDNF) 失效
标题翻译：编码胶质神经营养因子（GDNF）的重组腺病毒
公开(公告)号：US06245330B1
公开(公告)日：2001-06-12
申请号：US08716326
申请日：1996-10-04
申请人： Philippe Horellou , Jacques Mallet , Michel Perricaudet , Frédéric Revah , Emmanuelle Vigne
发明人： Philippe Horellou , Jacques Mallet , Michel Perricaudet , Frédéric Revah , Emmanuelle Vigne
IPC分类号： A61K4800
CPC分类号： A61K48/00 , A61K38/00 , C07K14/475 , C12N15/86 , C12N2710/10343
摘要： Recombinant adenoviruses comprising a heterologous DNA sequence coding for glial-derived neurotrophic growth factor (GDNF) are provided. The recombinant adenoviruses are useful in a method of expressing GDNF in a cell, wherein the cell is present in a mammal suffering from Parkinson's disease, comprising infecting said cell with a replication-defective recombinant adenovirus comprising a DNA sequence encoding GDNF operably linked to a promoter by administering the adenovirus into cells of the central nervous system. The recombinant adenoviruses of the invention are also useful in a method of treating Parkinson's disease comprising administering into cells of the central nervous system of a mammal suffering therefrom a replication defective recombinant adenovirus comprising ITRs, an encapsidation sequence and a DNA sequence encoding GDNF operably linked to a promoter, wherein the adenovirus E1 gene is non-functional and GDNF is expressed at a level that provides a therapeutic effect.
摘要翻译：提供了包含编码神经胶质来源的神经营养生长因子（GDNF）的异源DNA序列的重组腺病毒。所述重组腺病毒可用于在细胞中表达GDNF的方法，其中所述细胞存在于患有帕金森病的哺乳动物中，所述方法包括用复制缺陷型重组腺病毒感染所述细胞，所述复制缺陷型重组腺病毒包含与启动子可操作地连接的编码GDNF的DNA序列通过将腺病毒施用于中枢神经系统的细胞。本发明的重组腺病毒也可用于治疗帕金森病的方法，包括向患有其的哺乳动物的中枢神经系统的细胞施用包含ITR的复制缺陷型重组腺病毒，包封序列和编码GDNF的DNA序列，其可操作地连接到启动子，其中腺病毒E1基因是非功能性的，并且GDNF以提供治疗效果的水平表达。

16. 发明申请

US20130164327A1 Adenovirus vaccine vectors 有权
标题翻译：腺病毒疫苗载体
公开(公告)号：US20130164327A1
公开(公告)日：2013-06-27
申请号：US13643788
申请日：2011-04-28
申请人： Karim Benihoud , Anastasia Lanzi , Michel Perricaudet
发明人： Karim Benihoud , Anastasia Lanzi , Michel Perricaudet
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5256 , A61K2039/545 , A61K2039/55 , C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362
摘要： The invention relates to recombinant adenovirus displaying one or more heterologous epitope(s) on their fiber protein. These recombinant adenovirus are useful as vaccines for generating an immune response against said epitope(s) in individuals having a pre-existing anti-Ad immunity.
摘要翻译：本发明涉及在其纤维蛋白上显示一个或多个异源表位的重组腺病毒。这些重组腺病毒可用作在具有预先存在的抗Ad免疫的个体中产生针对所述表位的免疫应答的疫苗。

17. 发明申请

US20060002893A1 Targeted adenovirus vectors for delivery of heterologous genes 审中-公开
标题翻译：用于递送异源基因的靶向腺病毒载体
公开(公告)号：US20060002893A1
公开(公告)日：2006-01-05
申请号：US11038980
申请日：2005-01-20
申请人： Emmanuelle Vigne , Jean-Francois Dedieu , Martine Latta , Patrice Yeh , Michel Perricaudet
发明人： Emmanuelle Vigne , Jean-Francois Dedieu , Martine Latta , Patrice Yeh , Michel Perricaudet
IPC分类号： A61K48/00 , C12N7/00 , C12N15/861
CPC分类号： C07K14/005 , A61K48/00 , C07K14/501 , C07K14/78 , C07K2319/00 , C12N9/6462 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2770/32622 , C12N2770/32634 , C12N2810/40 , C12N2810/55 , C12N2810/60 , C12N2810/6018 , C12N2810/80 , C12N2810/851 , C12N2810/855 , C12N2810/857 , C12Y304/21073
摘要： Modification of internal sites of the adenovirus fiber protein and hexon protein permit effective targeting of adenovirus vectors. Accessible sites to redirect adenovirus targeting were identified. The HVR5 loop of the hexon protein and the HI loop of the fiber protein (knob) were highly permissive for the insertion of foreign protein sequences, which apparently did not impact on the viability and productivity of corresponding viruses. Accessibility and functionality of the epitope strongly depend on the size of the neighboring spacers. Other results suggest that short targeting peptides can be effectively fused to the C-terminus of the fiber protein. In a specific embodiment, a series of adenovirus vectors modified at the HVR5 site, the fiber protein HI loop, or the fiber protein C-terminus to target urokinase-type plasminogen activator receptor bearing cells were prepared. Such vectors are particularly useful for targeting the vasculature, e.g., for gene therapy of cancers or cardiovascular conditions.
摘要翻译：腺病毒纤维蛋白和六邻体蛋白的内部位点的修饰允许有效靶向腺病毒载体。确定了用于重定向腺病毒靶向的可访问网站。六邻体蛋白的HVR5环和纤维蛋白（旋钮）的HI环对于插入外源蛋白序列是高度允许的，其显然不影响相应病毒的活力和生产力。表位的可访问性和功能性强烈地取决于相邻间隔物的尺寸。其他结果表明，短目标肽可以有效融合到纤维蛋白的C末端。在一个具体实施方案中，制备了在HVR5位点修饰的一系列腺病毒载体，纤维蛋白质HI环或纤维蛋白C末端以靶向尿激酶型纤溶酶原激活物受体的细胞。这样的载体特别可用于靶向脉管系统，例如用于癌症或心血管病症的基因治疗。

18. 发明授权

US06811774B2 Defective recombinant adenoviruses expressing cytokines for antitumor treatment 失效
标题翻译：表达用于抗肿瘤治疗的细胞因子的重组腺病毒的缺陷
公开(公告)号：US06811774B2
公开(公告)日：2004-11-02
申请号：US09204427
申请日：1998-12-03
申请人： Hedi Mohamed Haddada , Thierry Ragot , Michel Perricaudet
发明人： Hedi Mohamed Haddada , Thierry Ragot , Michel Perricaudet
IPC分类号： A61K3500
CPC分类号： C12N7/00 , A61K35/761 , A61K38/00 , A61K48/00 , C07K14/52 , C12N15/86 , C12N2710/10243 , C12N2710/10332 , C12N2710/10343 , A61K2300/00
摘要： A recombinant nucleic acid used for the production of a defective adenovirus containing an inserted sequence coding for a cytokine under the control of a promoter in the genomic sequence of the recombinant adenovirus. This recombinant adenovirus is useful in the preparation of anti-tumoral drugs which can be directly injected into the tumor of the host.
摘要翻译：用于产生缺陷型腺病毒的重组核酸，其含有编码在重组腺病毒的基因组序列中的启动子控制下的细胞因子的插入序列。该重组腺病毒可用于制备可直接注射到宿主肿瘤中的抗肿瘤药物。

19. 再颁专利

USRE38556E1 Recombinant adeno viruses comprising an inserted gene encoding apolipoprotein and their use in gene therapy for dyslipoproteinemias 有权
标题翻译：包含编码载脂蛋白的插入基因及其在脂蛋白血症基因治疗中的应用的重组腺病毒
公开(公告)号：USRE38556E1
公开(公告)日：2004-07-13
申请号：US09636771
申请日：2000-08-04
申请人： Patrick Benoit , Patrice Denefle , Michel Perricaudet , Sandrine Seguret , Emmanuelle Vigne
发明人： Patrick Benoit , Patrice Denefle , Michel Perricaudet , Sandrine Seguret , Emmanuelle Vigne
IPC分类号： A01N6300
CPC分类号： C12N15/86 , A61K38/00 , C07K14/775 , C12N2710/10343
摘要： The present invention concerns defective recombinant adenoviruses containing an inserted gene encoding apolipoproteins, pharmaceutical compositions comprising the adenovirus, and their use for the treatment or prevention of pathologies linked to dyslipoproteinemias.

20. 发明授权

US06669942B2 Defective adenoviruses including a therapeutic gene and an immunoprotectove gene 失效
标题翻译：含有免疫保护基因的腺病毒载体
公开(公告)号：US06669942B2
公开(公告)日：2003-12-30
申请号：US08817494
申请日：1997-04-15
申请人： Michel Perricaudet , Martin Lee
发明人： Michel Perricaudet , Martin Lee
IPC分类号： A61K3912
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N2710/10322 , C12N2710/10343
摘要： Novel adenovirus-derived viral vectors, the preparation thereof, and the use of such vectors in gene therapy, are disclosed. In particular, defective adenoviruses having a genome that includes a first recombinant DNA containing a therapeutic gene and a second recombinant DNA containing an immunoprotective gene, are disclosed.
摘要翻译：公开了新型腺病毒衍生的病毒载体，其制备方法和这种载体在基因治疗中的用途。特别地，公开了具有包含含有治疗基因的第一重组DNA和含有免疫保护基因的第二重组DNA的基因组的缺陷型腺病毒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式