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11. 发明授权

US06224909B1 Fast decomposing pellets 有权
标题翻译：快速分解颗粒
公开(公告)号：US06224909B1
公开(公告)日：2001-05-01
申请号：US09147817
申请日：1999-05-11
申请人： Michaela Opitz , Hendrik Von Büren , Rolf-Dieter Gabel , Geoffrey Lee
发明人： Michaela Opitz , Hendrik Von Büren , Rolf-Dieter Gabel , Geoffrey Lee
IPC分类号： A61K914
CPC分类号： A61K9/1652 , A61K9/1617 , A61K9/1641 , A61K9/1694 , B01J2/20
摘要： The invention concerns pharmaceutical forms of administration that are in the form of pellets which contain a retarding agent in which the release rate of the active substance is not delayed or is substantially identical compared to corresponding pellets that contain no retarding agent. The release rate of these rapidly disintegrating pellets is at least about 90% within a time period of 30 minutes. In addition the present invention also concerns processes for the production these pellets.
摘要翻译：本发明涉及丸剂形式的药物形式，其含有阻滞剂，其中活性物质的释放速率不延迟或与不含阻滞剂的相应颗粒相比基本相同。这些快速崩解颗粒的释放速率在30分钟的时间段内为至少约90％。此外，本发明还涉及生产这些颗粒的方法。

12. 发明授权

US6143326A Oral pharmaceutical preparation containing ibandronat 有权
标题翻译：含有伊班膦酸钠的口服药物制剂
公开(公告)号：US6143326A
公开(公告)日：2000-11-07
申请号：US147149
申请日：1998-11-25
申请人： Jorn Mockel , Rolf-Dieter Gabel , Heinrich Woog
发明人： Jorn Mockel , Rolf-Dieter Gabel , Heinrich Woog
IPC分类号： A61K9/36 , A61K20060101 , A61K9/14 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/30 , A61K9/50 , A61K9/52 , A61K9/54 , A61K31/00 , A61K31/66 , A61K31/662 , A61K31/663 , A61K47/30 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/44 , A61P3/00 , A61P3/14 , A61P19/00 , A61P19/08 , A61P19/10 , A61P35/04 , C07F9/38
CPC分类号： A61K31/663 , A61K31/66 , A61K9/2846 , A61K9/2866
摘要： The invention is directed to well-tolerated pharmaceutical compositions for oral application, containing ibandronate or a physiologically tolerable salt thereof as active substance, the administration form consisting of an active substance-containing inner portion enclosed in such fashion by a coat free of active substance that rapid release of the active substance takes place.
摘要翻译： PCT No.PCT / EP97 / 01940 Sec。 371日期：1998年11月25日 102（e）日期1998年11月25日PCT 1997年4月21日PCT PCT。出版物WO97 / 39755 日期1997年10月30日本发明涉及用于口服应用的耐受良好的药物组合物，其含有伊班膦酸盐或其生理上可耐受的盐作为活性物质，所述给药形式由含有活性物质的内部部分组成，不含活性物质的快速释放的活性物质。

13. 发明授权

US5955106A Pharmaceutical preparation containing metformin and a process for producing it 无效
标题翻译：含二甲双胍的药物制剂及其制备方法
公开(公告)号：US5955106A
公开(公告)日：1999-09-21
申请号：US793753
申请日：1997-03-14
申请人： Jorn Moeckel , Rolf-Dieter Gabel , Heinrich Woog
发明人： Jorn Moeckel , Rolf-Dieter Gabel , Heinrich Woog
IPC分类号： A61K9/20 , A61K9/28 , A61K9/48 , A61K31/155 , A61K47/30 , A61K47/36 , A61P3/08 , A61P3/10
CPC分类号： A61K9/2027 , A61K31/155 , A61K9/2054 , A61K9/2866
摘要： The present invention concerns pharmaceutical compositions containing metformin as an active substance and a hydrocolloid-forming agent as a retardant and optionally standard pharmaceutical auxiliary substances, the residual moisture content in the pharmaceutical composition being 0.5-3% by weight. The invention also concerns a process for producing pharmaceutical compositions containing metformin as an active substance and a hydrocolloid-forming agent as a retardant and optionally standard pharmaceutical auxiliary substances characterized in that the active substance and retarding agent or a portion thereof are granulated with an aqueous solvent which can optionally contain a binder and where appropriate the other portion of the retardant or other standard pharmaceutical auxiliaries are admixed with the granulate which is then dried until the residual moisture content is reduced to 0.5-3% by weight.
摘要翻译： PCT No.PCT / EP95 / 03610 Sec。 371日期1997年3月14日 102（e）1997年3月14日PCT PCT 1995年9月14日PCT公布。出版物WO96 / 08243 日期1996年3月21日本发明涉及含有作为活性物质的二甲双胍和作为阻滞剂和任选的标准药物辅助物质的水解胶体形成剂的药物组合物，药物组合物中的残留水分含量为0.5-3重量％。本发明还涉及一种生产含有作为活性物质的二甲双胍和作为阻滞剂的水胶体形成剂和任选的标准药物辅助物质的药物组合物的方法，其特征在于将活性物质和延缓剂或其一部分用水性溶剂其可任选地含有粘合剂，并且适当时将阻燃剂或其它标准药用助剂的其它部分与颗粒混合，然后将其干燥直到残余水分含量降低至0.5-3重量％。

14. 发明申请

US20110024419A1 TRANSFER CONTAINER FOR PHARMACEUTICAL RECIPIENTS 有权
标题翻译：转运用于药物接收的容器
公开(公告)号：US20110024419A1
公开(公告)日：2011-02-03
申请号：US12855491
申请日：2010-08-12
申请人： Rolf-Dieter Gabel , Martin Knierim
发明人： Rolf-Dieter Gabel , Martin Knierim
IPC分类号： B65D51/00
CPC分类号： A61M5/008 , A61L2/26 , A61L2202/182 , A61L2202/21 , A61M5/001 , A61M2207/00 , B65B3/003 , B65B55/027 , Y10S220/20 , Y10S604/905 , Y10T137/6851 , Y10T137/86292
摘要： A reusable container for the sterile transfer of pharmaceutical recipients, in particular of syringe bodies. The container comprises an outer case and a sterilizable interior, wherein the interior is microbially isolated from the environment of the container. The interior has at least one holder for accommodating at least one nest for storing a plurality of pharmaceutical recipients. The nest can be removably accommodated in the holder. The container further has at least one container door for removing or introducing the nest into the interior and at least one lock for coupling the container to a sterile space. The lock is configured in such a way that, after coupling to the sterile space, it is possible to open the container door without substantially suspending sterility.
摘要翻译：用于药物接收者，特别是注射器体的无菌转移的可重复使用的容器。容器包括外壳和可灭菌的内部，其中内部与容器的环境微生物隔离。内部具有至少一个保持器，用于容纳至少一个用于存储多个药物接收者的巢。巢可以可拆卸地容纳在支架中。容器还具有至少一个用于将嵌套移入或引入内部的容器门和用于将容器连接到无菌空间的至少一个锁。锁被配置成使得在联接到无菌空间之后，可以打开容器门而不会基本上悬挂无菌。

15. 发明申请

US20050089573A1 Oral pharmaceutical formulation containing ibandronate 审中-公开
标题翻译：含有伊班膦酸盐的口服药物制剂
公开(公告)号：US20050089573A1
公开(公告)日：2005-04-28
申请号：US10660785
申请日：2003-09-12
申请人： Joern Moeckel , Rolf-Dieter Gabel , Heinrich Woog
发明人： Joern Moeckel , Rolf-Dieter Gabel , Heinrich Woog
IPC分类号： A61K9/36 , A61K20060101 , A61K9/14 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/30 , A61K9/50 , A61K9/52 , A61K9/54 , A61K31/00 , A61K31/66 , A61K31/662 , A61K31/663 , A61K47/30 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/44 , A61P3/00 , A61P3/14 , A61P19/00 , A61P19/08 , A61P19/10 , A61P35/04 , C07F9/38 , A61K9/24
CPC分类号： A61K31/663 , A61K9/2846 , A61K9/2866 , A61K31/66
摘要： The invention is directed to well-tolerated pharmaceutical compositions for oral application, containing ibandronate or a physiologically tolerable salt thereof as active substance, the administration form consisting of an active substance-containing inner portion enclosed in such fashion by a coat free of active substance that rapid release of the active substance takes place.
摘要翻译：本发明涉及用于口服应用的耐受良好的药物组合物，其含有伊班膦酸盐或其生理上可耐受的盐作为活性物质，所述给药形式由含有活性物质的内部部分组成，所述内部部分以不含活性物质的衣服包裹，发生活性物质的快速释放。

16. 发明授权

US06431399B1 Pharmaceutical dosing dispenser 有权
公开(公告)号：US06431399B1
公开(公告)日：2002-08-13
申请号：US09739040
申请日：2000-12-18
申请人： Rolf-Dieter Gabel , Jörn Möckel
发明人： Rolf-Dieter Gabel , Jörn Möckel
IPC分类号： B65G5900
摘要： A pill dispenser allows for alternating removal of two or more solid forms of pharmaceutical medications, such as tablets, film tablets, coated tablets, or capsules. The pill dispenser has a housing, a baseplate, at least two storage containers for receiving and storing a solid form of medication, and a dosing slide. The baseplate is attached to the bottom end of the housing and has at least one ejecting opening. The storage containers are adapted for receiving and storing solid forms of medications. Each storage container has a bottom opening. A dosing slide is movably mounted between the storage containers and the baseplate and has receiving openings arranged in the dosing slide so that each of the receiving openings can be positioned under a bottom opening of a storage container and above an ejecting opening.

17. 发明授权

US06689755B1 Method of stabilizing biologically active substances 有权
标题翻译：稳定生物活性物质的方法
公开(公告)号：US06689755B1
公开(公告)日：2004-02-10
申请号：US09184866
申请日：1998-11-03
申请人： Rolf-Dieter Gabel , Markus Mattern , Gerhard Winter , Alexander Wirl , Heinrich Woog
发明人： Rolf-Dieter Gabel , Markus Mattern , Gerhard Winter , Alexander Wirl , Heinrich Woog
IPC分类号： C08B3000
CPC分类号： A61K9/1617 , A61K9/1623 , A61K47/183 , B01D1/18 , F26B3/02 , Y10S435/81 , Y10S514/911 , Y10S514/97
摘要： The present invention relates to a rapid and readily reproducible process for stabilizing biologically active substances by combining the biologically active substance witha a stabilizingmixture and drying the resulting mixture into a dry, amorphous product by means of convection drying. The invention also relates to the amorphous, microscopically homogeneous products which are obtained by this process, are in the form of powders and have a uniform geometric, in particular spherical, shape. The invention furthermore relates to the use of substance mixtures for stabilizing biologically active material, in particular proteins by means of spray drying.
摘要翻译：本发明涉及通过将生物活性物质与稳定混合物组合并通过对流干燥将所得混合物干燥成干燥的无定形产物来稳定生物活性物质的快速和容易重现的方法。本发明还涉及通过该方法获得的无定形，微观均匀的产品，其为粉末形式并且具有均匀的几何形状，特别是球形的形状。本发明还涉及物质混合物用于通过喷雾干燥来稳定生物活性物质，特别是蛋白质的用途。

18. 发明授权

US06521262B2 Solid instant-release forms of administration and process for producing the same 失效
标题翻译：固体即时释放形式的施用和其制备方法
公开(公告)号：US06521262B2
公开(公告)日：2003-02-18
申请号：US09117170
申请日：1998-07-27
申请人： Rolf-Dieter Gabel , Alexander Wirl , Heinrich Woog
发明人： Rolf-Dieter Gabel , Alexander Wirl , Heinrich Woog
IPC分类号： A61K914
CPC分类号： A61K9/2081 , A61K9/0056
摘要： The present invention concerns solid instant-release forms of administration (IR form of administration) comprising therapeutic active substances or active substance concentrates in particular lipid conjugates of nucleosides which have gel-forming properties in aqueous media as well as processes for their production.
摘要翻译：本发明涉及包含在含水介质中具有凝胶形成性质的核苷的特定脂质缀合物的治疗活性物质或活性物质浓缩物的固体即时释放形式的施用（IR给药形式）及其制备方法。

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