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11. 发明申请

US20090028926A1 Method and mixture for in vivo photochemical cross-linking of collagen 审中-公开
标题翻译：胶原蛋白体内光化学交联的方法和混合物
公开(公告)号：US20090028926A1
公开(公告)日：2009-01-29
申请号：US11880973
申请日：2007-07-25
申请人： Susanna Grafe , Wolfgang Neuberger , Danilo Castro
发明人： Susanna Grafe , Wolfgang Neuberger , Danilo Castro
IPC分类号： A61K38/00 , A61K31/33 , A61K9/70 , A61L15/00 , A61P17/00
CPC分类号： A61K31/33 , A61K9/0019 , A61K9/127 , A61K47/24
摘要： A method and a composition for photochemical cross linking of collagen by photoactive agent in-vivo are presented. The method includes a non-toxic photoactive formulation of the composition with collagen, which is administered to treatment area locally; followed by irradiation with suitable wavelength. In one of the embodiment liposomal formulated mTHPC is added to the collagen and is irradiated with a 652 nm laser, resulting in producing efficient collagen scaffolds with strengthen and stabilized microstructure, thus improving the physiochemical properties of the collagen scaffold. It improves the thermostability, mechanical property and swelling ratio of newly formed scaffold. Photochemical cross-linked collagens shows antimicrobial effect, when irradiated with suitable wavelength it disinfects the treatment site and curbs microbial growth.
摘要翻译：提出了通过光活性剂在体内对胶原蛋白的光化学交联的方法和组合物。该方法包括具有胶原蛋白的组合物的无毒光活性制剂，其局部施用于治疗区域; 然后用合适的波长照射。在其中一个实施方案中，将脂质体配制的mTHPC加入到胶原中并用652nm激光照射，从而产生具有强化和稳定的微结构的有效的胶原支架，从而改善胶原支架的物理化学性质。提高新型脚手架的热稳定性，机械性能和溶胀比。光化学交联胶原显示抗菌效果，当用合适的波长照射时，其消毒处理部位并抑制微生物生长。

12. 发明申请

US20090162423A1 Formulations for cosmetic and wound care treatments with photosensitizes as fluorescent markers 审中-公开
标题翻译：用于化妆品和伤口护理治疗的制剂，作为荧光标记物进行光敏化
公开(公告)号：US20090162423A1
公开(公告)日：2009-06-25
申请号：US12004325
申请日：2007-12-20
申请人： Wolfgang Neuberger , Susanna Grafe , Nikolay E. Nifantiev
发明人： Wolfgang Neuberger , Susanna Grafe , Nikolay E. Nifantiev
IPC分类号： A61K9/127 , A61K38/00 , A61P17/00 , A61K31/715
CPC分类号： A61K31/715 , A61K9/0019 , A61K9/06 , A61L27/50
摘要： Photoactive materials, such as photosensitizers, are used as fluorescent markers for in vivo detection of the distribution of the injected filler material during cosmetic treatments. In one preferred embodiment, liposomal formulated temoporfin is used, as the photoactive component, in very small concentrations along with fillers for cosmetic and wound healing applications. Fillers, which can be used in the invention, include collagen, hyaluronic acids and other synthetic or natural products which are generally used in wound healing, scar reduction and other such medical applications. In a preferred embodiment, the formulated photosensitizer is coupled to the filler so that tracking is possible over longer periods of time A liposomal formulated photosensitizer is injected with the fillers into the treatment area, and is irradiated with laser light shortly after injection. The emitted fluorescence is measured by a special non-invasive device. Thereby it is possible to monitor the injection site and the distribution of the injected solution around the injection site. When irradiated with laser or other light source, the fluorescence of the photosensitizer is detected using a fluorescence detector, which permits tracking the filler at injection site and in the injection volume.
摘要翻译：光敏剂如光敏剂被用作荧光标记物，用于在化妆品处理期间体内检测注射的填充材料的分布。在一个优选的实施方案中，作为光活性成分的脂质体配制的temoporfin以非常小的浓度与用于化妆品和伤口愈合应用的填充剂一起使用。可用于本发明的填充剂包括胶原蛋白，透明质酸和通常用于伤口愈合，瘢痕减少等医学应用中的其它合成或天然产物。在优选的实施方案中，将配制的光敏剂偶联到填料，使得可以在更长时间内进行跟踪。将脂质体配制的光敏剂注射到处理区域中，并在注射后不久用激光照射。发射的荧光通过特殊的非侵入性装置测量。因此，可以监测注射部位和注射部位周围注射溶液的分布情况。当用激光或其他光源照射时，使用荧光检测器检测光敏剂的荧光，其允许在注射部位和注射体积中追踪填料。

13. 发明申请

US20110034854A1 PDT ASSISTED VISION CORRECTION AND SCAR PREVENTION 审中-公开
标题翻译： PDT辅助视力矫正和防护
公开(公告)号：US20110034854A1
公开(公告)日：2011-02-10
申请号：US12743515
申请日：2008-11-20
申请人： Wolfgang Neuberger , Volker Albrecht
发明人： Wolfgang Neuberger , Volker Albrecht
IPC分类号： A61M37/00 , A61K31/409 , A61K9/127 , A61P17/02
CPC分类号： A61N5/062 , A61F9/00802 , A61F2009/00872
摘要： A method and formulation are disclosed for improving the results of corneal refractive surgery, and generally reducing post-operative scarring and scarring arising from other traumas. In the vision examples, after completion of a procedure, including Photorefractive Keratotomy (PRK) or Laser-In-Situ Keratomileusis (LASIK), a photosensitizer or photosensitizer precursor is applied to the treatment site. After allowing sufficient time for the photosensitizers to accumulate among proliferating cells that occur as a result of ablation, radiation appropriate to activate the photosensitizers is administered to the treatment site. The photosensitizer is thus activated to destroy only those proliferating cells. In this way, proliferating tissue is eliminated and the cornea maintains the shape created during the surgery. As a result, instances of regression and the need for follow-up treatments, is minimized. This method is also useful for preventing post-surgical scarring that can lead to vision problems such as corneal haze. Likewise the method and formulations, presented here, are suitable for reducing post-operative scarring, and trauma cased scarring in general. For such scars, a photosensitizer or photosensitizer precursor is topically applied to the treatment site. After allowing sufficient time for the photosensitizers to attach to proliferating cells, radiation appropriate to activate the photosensitizers is administered to the treatment site. The photosensitizer is activated to destroy only those proliferating cells.
摘要翻译：公开了用于改善角膜屈光手术结果的方法和制剂，并且通常减少由其他创伤引起的术后瘢痕形成和瘢痕形成。在视觉实例中，在完成包括光折射角膜切开术（PRK）或激光原位角膜磨镶术（LASIK））的手术完成后，将光敏剂或光敏剂前体施用于治疗部位。在允许足够的时间使光敏剂在由于消融引起的增殖细胞之间累积，适当激活光敏剂的辐射被施用于治疗部位。因此，光敏剂被激活以仅破坏那些增殖细胞。以这种方式，消除增殖组织，并且角膜保持手术期间产生的形状。因此，尽可能减少了回归和后续治疗的需要。这种方法也可用于预防术后瘢痕形成，导致视力问题，如角膜混浊。同样地，这里给出的方法和制剂适用于减少手术后瘢痕形成和一般的外伤瘢痕形成。对于这种疤痕，将光敏剂或光敏剂前体局部施用于治疗部位。在允许足够的时间使光敏剂附着于增殖细胞之后，向治疗部位施用适于激活光敏剂的辐射。光敏剂被激活以仅破坏那些增殖细胞。

14. 发明授权

US09409037B2 Enhanced anti-microbial PDT 有权
标题翻译：增强抗微生物PDT
公开(公告)号：US09409037B2
公开(公告)日：2016-08-09
申请号：US13006274
申请日：2011-01-13
申请人： Volker Albrecht , Gerhard Wieland , Burkhard Gitter , Wolfgang Neuberger
发明人： Volker Albrecht , Gerhard Wieland , Burkhard Gitter , Wolfgang Neuberger
IPC分类号： A61N5/06 , A61M1/36 , A61L2/00
CPC分类号： A61N5/062 , A61L2/0029 , A61L2/0052 , A61L2202/21 , A61M1/3681 , A61M1/3686 , A61N5/0624 , A61N2005/063 , A61N2005/0652
摘要： Methods and devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids are provided. In preferred embodiments, an antimicrobial photodynamic therapy (PDT) treatment is given that effectively inactivates, reduces and/or destroys both Gram (−) and Gram (+) bacteria in complex body fluids. Methods to enhance antimicrobial PDT activity include administering a photosensitizer to bacteria-contaminated fluid, after a dwell time guiding bacteria-contaminated fluid with photosensitizer through a channel, emitting radiation preferably in an intermittent manner, and restoring treated body fluids to corresponding body regions. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. Additionally, the method/device diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.
摘要翻译：提供了用于消除，减少，破坏和/或抑制诸如病原体微生物和诸如血液，血清和其他体液的复杂环境中的恶化或恶性细胞的不期望的体液物质的方法和装置。在优选的实施方案中，给出了在复合体液中有效灭活，减少和/或破坏革兰氏（ - ）和革兰氏阴性（+）细菌的抗微生物光动力疗法（PDT）治疗。增强抗微生物PDT活性的方法包括在通过通道引导细菌污染的流体与光敏剂停留时间之后，向细菌污染的流体施用光敏剂，优选以间歇方式发射辐射，并将经处理的体液恢复到相应的身体区域。基于治疗参数，电磁辐射优选间歇地以脉冲宽度递送。此外，该方法/装置通过中和致病微生物片段的生物活性并减少和/或除去负责其的病原微生物片段来减少不良宿主的炎症反应。

15. 发明申请

US20110160642A1 PEGYLATED LIPOSOMAL FORMULATIONS FOR PHOTODYNAMIC TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译：用于荧光动力治疗炎性疾病的聚乙二醇脂质体制剂
公开(公告)号：US20110160642A1
公开(公告)日：2011-06-30
申请号：US12742336
申请日：2008-11-14
申请人： Wolfgang Neuberger , Volker Albrecht
发明人： Wolfgang Neuberger , Volker Albrecht
IPC分类号： A61M37/00 , A61K9/127 , A61K31/409 , A61P29/00 , A61P19/02
CPC分类号： A61K9/1271 , A61K41/0071 , A61K47/6911
摘要： A PDT treatment system designed to treat all types of human inflammatory disorders. A suitable drug delivery system is developed to target proliferating cells, at inflamed sites, populated with macrophages and other inflammatory mediators. The hydrophobic photosensitizer is loaded into the liposomal bilayer formed of synthetic phospholipids; at least one of the synthetic phospholipids is conjugated to polyethylene glycol (PEG) molecules, to prevent accumulation in the liver and spleen. Further, (PEG) formulated photosensitizer increases the circulatory half-life of the drug, enhances solubility, and modifies pharmacokinetic and pharmacodynamic properties. The formulation, thus, leads to a higher amount of delivered drug to the diseased target synovial tissue, increasing clinical effectiveness. In one embodiment, pegylated liposomes loaded with mTHPC are administered to diseased synovial joints, followed by light irradiation. Activated photosensitizer induces cytotoxic effect in the diseased synovial cells, thus preventing further inflammation and joint erosion and minimizing joint damage.
摘要翻译：设计用于治疗所有类型的人类炎症性疾病的PDT治疗系统。开发合适的药物递送系统以靶向增殖细胞，在发炎部位，富含巨噬细胞和其他炎症介质。将疏水性光敏剂加载到由合成磷脂形成的脂质体双层中; 至少一种合成磷脂与聚乙二醇（PEG）分子缀合，以防止在肝脏和脾脏中积累。此外，（PEG）配制的光敏剂可增加药物的循环半衰期，增强溶解性，并改变药代动力学和药效学性质。因此，该制剂导致更高量的递送药物到患病的目标滑液组织，增加临床有效性。在一个实施方案中，将装载有mTHPC的聚乙二醇化脂质体施用于患病的滑膜关节，随后进行光照射。活化的光敏剂在患病的滑膜细胞中诱导细胞毒性作用，从而防止进一步的炎症和关节侵蚀并最小化关节损伤。

16. 发明申请

US20070154538A1 Removal of fat cells by PDT 审中-公开
标题翻译：通过PDT去除脂肪细胞
公开(公告)号：US20070154538A1
公开(公告)日：2007-07-05
申请号：US11321105
申请日：2005-12-29
申请人： Wolfgang Neuberger , Volker Albrecht
发明人： Wolfgang Neuberger , Volker Albrecht
IPC分类号： A61K31/409 , A61K31/555 , A61K9/127
CPC分类号： A61K9/0019 , A61K9/127 , A61K31/409 , A61K31/555
摘要： A non-surgical, minimally invasive PhotoDynamic Therapy (PDT) method for destruction of undesirable fat cells in the body, which cause obesity, obesity related health problems, and undesirable body contours. In this method photosensitizing agents are formulated into a liposomal formulation or into other delivery means for administering the drug systemically, directly by injection and/or topical application. The photosensitizing formulation is selectively targeted at adipose tissue in the subcutaneous layer. Photosensitized adipose cells are illuminated with a predetermined wavelength of light energy known to initiate a photo cytotoxic effect. The light energy for photoactivation of the photosensitizing agent may be applied interstitially through optical fibers with or without a diffuser tip. Alternatively, a photosensitizing agent is selected to have an activating wavelength which permits external irradiation through the skin. The method ensures safe and permanent fat reduction, minimizes trauma to the area of treatment and also hastens the healing process. A lasting and permanent effect is provided in regions of fat accumulation as the adipose cells are permanently destroyed. This approach is also effective for fat deposits which do not respond to other treatments.
摘要翻译：用于破坏身体中不需要的脂肪细胞的非手术，微创光动力治疗（PDT）方法，其导致肥胖，肥胖相关的健康问题和不期望的身体轮廓。在该方法中，将光敏剂配制成脂质体制剂或其它递送装置，以直接通过注射和/或局部施用全身施用药物。光敏制剂选择性地靶向皮下层中的脂肪组织。用已知的预定波长的光能照射光敏脂肪细胞以引发光细胞毒作用。用于光敏剂的光活化的光能可以通过具有或不具有扩散器尖端的光纤在空隙中施加。或者，选择光敏剂以具有允许通过皮肤的外部照射的激活波长。该方法可确保安全和永久的脂肪减少，减少对治疗领域的创伤，并加快愈合过程。由于脂肪细胞被永久破坏，脂肪堆积区域的持久和永久效应。这种方法对于不响应其他处理的脂肪沉积物也是有效的。

17. 发明授权

US08999933B2 Photodynamic cosmetic procedure and healing method 有权
标题翻译：光动力美容手术和治疗方法
公开(公告)号：US08999933B2
公开(公告)日：2015-04-07
申请号：US11650207
申请日：2007-01-05
申请人： Wolfgang Neuberger , Volker Albrecht , Danilo Castro
发明人： Wolfgang Neuberger , Volker Albrecht , Danilo Castro
IPC分类号： A61K9/127 , A61K8/65 , A61K8/49 , A61K31/407 , A61K31/555 , A61L27/24 , A61L27/54 , A61Q19/06 , A61Q19/08 , A61K41/00 , A61K38/00
CPC分类号： A61K8/65 , A61K8/4946 , A61K9/1271 , A61K31/407 , A61K31/555 , A61K41/0071 , A61K2800/434 , A61K2800/81 , A61L27/24 , A61L27/54 , A61L2300/414 , A61L2300/604 , A61Q19/06 , A61Q19/08
摘要： Innovative non-surgical methods and compositions are provided for administering PDT to promote tissue regeneration or augmentation while minimizing scarring and risk of infection. Among several areas of application, is the treatment of acute and chronic wounds which have afflicted epidermal and connective tissue layers of the body. Another application area is as cosmetic surgery/treatments, including: reducing wrinkles, sulcus, scars (acne or traumatic caused), sequelae cellulite, as well as for other skin irregularities, to give a smoother skin surface. This invention consists of a collagen based or other suitable biodegradable supporting matrix which is embedded with a liposomal loaded photosensitizer. In one embodiment of this invention a liposomal formulated photosensitizer is first injected at the site followed by collagen implantation and PDT treatment. In another embodiment a liposomal formulated photosensitizer is incorporated in the collagen. Generally 30 minutes after collagen is mixed with photosensitizer the light activation is done. The matrix may also carry important growth factors and cytokines, which promote fibroblast cell migration and proliferation, to the wound site. Microbial infection at the wound site can also be controlled by antibacterial PDT.
摘要翻译：提供创新的非手术方法和组合物用于施用PDT以促进组织再生或增强，同时最小化瘢痕形成和感染风险。在几个应用领域中，治疗急性和慢性伤害已经影响了身体的表皮和结缔组织层。另一个应用领域是整容手术/治疗，包括：减少皱纹，沟，疤痕（引起痤疮或创伤），后遗症，以及其他皮肤不规则，使皮肤表面光滑。本发明由胶原基或其它合适的可生物降解的支撑基质组成，其中嵌有脂质体加载的光敏剂。在本发明的一个实施方案中，首先在该部位注射脂质体配制的光敏剂，随后进行胶原植入和PDT处理。在另一个实施方案中，脂质体配制的光敏剂掺入胶原蛋白。一般30分钟后，胶原与光敏剂混合，光激活完成。基质还可以携带重要的生长因子和促进成纤维细胞迁移和增殖的细胞因子到伤口部位。伤口部位的微生物感染也可以通过抗菌PDT来控制。

18. 发明申请

US20070166369A1 Photodynamic cosmetic procedure and healing method 有权
标题翻译：光动力美容手术和治疗方法
公开(公告)号：US20070166369A1
公开(公告)日：2007-07-19
申请号：US11650207
申请日：2007-01-05
申请人： Wolfgang Neuberger , Volker Albrecht , Danilo Castro
发明人： Wolfgang Neuberger , Volker Albrecht , Danilo Castro
IPC分类号： A61K31/555 , A61K31/407 , A61K9/127 , A61K9/14
CPC分类号： A61K8/65 , A61K8/4946 , A61K9/1271 , A61K31/407 , A61K31/555 , A61K41/0071 , A61K2800/434 , A61K2800/81 , A61L27/24 , A61L27/54 , A61L2300/414 , A61L2300/604 , A61Q19/06 , A61Q19/08
摘要： Innovative non-surgical methods and compositions are provided for administering PDT to promote tissue regeneration or augmentation while minimizing scarring and risk of infection. Among several areas of application, is the treatment of acute and chronic wounds which have afflicted epidermal and connective tissue layers of the body. Another application area is as cosmetic surgery/treatments, including: reducing wrinkles, sulcus, scars (acne or traumatic caused), sequelae cellulite, as well as for other skin irregularities, to give a smoother skin surface. This invention consists of a collagen based or other suitable biodegradable supporting matrix which is embedded with a liposomal loaded photosensitizer. In one embodiment of this invention a liposomal formulated photosensitizer is first injected at the site followed by collagen implantation and PDT treatment. In another embodiment a liposomal formulated photosensitizer is incorporated in the collagen. Generally 30 minutes after collagen is mixed with photosensitizer the light activation is done. The matrix may also carry important growth factors and cytokines, which promote fibroblast cell migration and proliferation, to the wound site. Microbial infection at the wound site can also be controlled by antibacterial PDT.
摘要翻译：提供创新的非手术方法和组合物用于施用PDT以促进组织再生或增强，同时最小化瘢痕形成和感染风险。在几个应用领域中，治疗急性和慢性伤害已经影响了身体的表皮和结缔组织层。另一个应用领域是整容手术/治疗，包括：减少皱纹，沟，疤痕（引起痤疮或创伤），后遗症，以及其他皮肤不规则，使皮肤表面光滑。本发明由胶原基或其它合适的可生物降解的支撑基质组成，其中嵌有脂质体加载的光敏剂。在本发明的一个实施方案中，首先在该部位注射脂质体配制的光敏剂，随后进行胶原植入和PDT处理。在另一个实施方案中，脂质体配制的光敏剂掺入胶原蛋白。一般30分钟后，胶原与光敏剂混合，光激活完成。基质还可以携带重要的生长因子和促进成纤维细胞迁移和增殖的细胞因子到伤口部位。伤口部位的微生物感染也可以通过抗菌PDT来控制。

19. 发明授权

US08153111B2 Photo-triggered release of active substances from dendrimer-photosensitizer complexes 失效
标题翻译：从树枝状大分子光敏剂复合物照片触发释放活性物质
公开(公告)号：US08153111B2
公开(公告)日：2012-04-10
申请号：US10871676
申请日：2004-06-18
申请人： Volker Albrecht , Arno Wiehe , Beate Roeder , Wolfgang Neuberger
发明人： Volker Albrecht , Arno Wiehe , Beate Roeder , Wolfgang Neuberger
IPC分类号： A61K31/00 , A61K9/00
CPC分类号： A61K31/785 , A61K41/00 , A61K47/59 , A61K47/595 , Y10S424/16 , A61K2300/00
摘要： Compositions of dendrimer-photosensitizer complexes including therapeutic molecules, and methods for their synthesis and use are disclosed. The therapeutic molecules and the photosensitizers are each covalently attached to the dendrimer at its end-groups, essentially randomly. Upon exposure to radiation of a suitable wavelength, the photosensitizers are activated to break up the dendrimer structure and thus release the therapeutic molecules. In a preferred embodiment, the end-groups of the dendrimer are replaced with or covalently connected to therapeutic molecules and photosensitizers. In a further preferred embodiment, targeting molecules may also be attached to the dendrimer to create a more accurate treatment. The present invention is especially useful for medical applications, where therapeutic molecules can be delivered to body areas for treatment of a variety of diseases without risk of premature release in the body, due to the strength and stability of the bonds between the end-groups and the photosensitizers and therapeutic molecules.
摘要翻译：公开了包括治疗分子的树枝状大分子光敏剂复合物的组合物及其合成和使用的方法。治疗分子和光敏剂在其端基基本上随机共价连接到树枝状大分子。在暴露于合适波长的辐射下，激活光敏剂以分解树枝状聚合物结构，从而释放治疗分子。在优选的实施方案中，树枝状大分子的端基被治疗分子和光敏剂替代或共价连接。在另一个优选的实施方案中，靶向分子也可以连接到树枝状大分子以产生更准确的处理。本发明特别适用于医疗应用，其中治疗分子可以递送到身体区域以治疗各种疾病，而不会在体内过早释放的风险，这是由于端基之间的键的强度和稳定性光敏剂和治疗分子。

20. 发明申请

US20110178580A1 ENHANCED ANTI-MICROBIAL PDT 有权
标题翻译：增强抗微生物PDT
公开(公告)号：US20110178580A1
公开(公告)日：2011-07-21
申请号：US13006274
申请日：2011-01-13
申请人： Volker Albrecht , Gerhard Wieland , Burkhard Gitter , Wolfgang Neuberger
发明人： Volker Albrecht , Gerhard Wieland , Burkhard Gitter , Wolfgang Neuberger
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61L2/0029 , A61L2/0052 , A61L2202/21 , A61M1/3681 , A61M1/3686 , A61N5/0624 , A61N2005/063 , A61N2005/0652
摘要： Present invention provides enhanced methods and improved devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids. In preferred embodiments, present invention provides an antimicrobial PDT treatment that effectively inactivates, reduces and/or destroys both Gram (−) and Gram (+) bacteria in complex body fluids. Methods to enhance antimicrobial PDT activity includes the steps of administering a photosensitizer to bacteria-contaminated fluid, after a dwell time guiding bacteria-contaminated fluid with photosensitizer through a channel, emitting radiation preferably in an intermittent manner, and restoring treated body fluids to corresponding body regions. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. Preferred device embodiments comprise guiding channels and at least one electromagnetic radiation source, arranged separately or in sequence. Preferably, laser device or LED-panels are used to deliver electromagnetic radiation to activate the photosensitizer. When used with preferred photosensitizer composition based on Safranin O, preferred laser radiation wavelength is in the range of 500-580 nm. Additionally, present invention diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.
摘要翻译：本发明提供增强的方法和改进的装置，以消除，减少，破坏和/或抑制不期望的体液物质，例如病原体微生物和复杂环境如血液，血清和其它体液中的恶化或恶性细胞。在优选的实施方案中，本发明提供了在复合体液中有效灭活，减少和/或破坏革兰氏（ - ）和革兰氏阴性（+）细菌的抗微生物PDT治疗。增强抗菌PDT活性的方法包括以下步骤：在细菌污染的流体与光敏剂通过通道引导细菌污染的流体停留时间之后，向细菌污染的流体施用光敏剂，优选以间歇的方式发射辐射，并将经处理的体液恢复到对应的身体地区。基于治疗参数，电磁辐射优选间歇地以脉冲宽度递送。优选的装置实施例包括分开或依次布置的引导通道和至少一个电磁辐射源。优选地，激光装置或LED面板用于递送电磁辐射以激活光敏剂。当与基于Safranin O的优选光敏剂组合物一起使用时，优选的激光辐射波长在500-580nm的范围内。此外，本发明通过中和病原微生物片段的生物活性来减少不良宿主的炎症反应，还原和/或除去负责其的病原微生物片段。

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