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11. 发明申请

WO2015085132A1 2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF 审中-公开
标题翻译：作为ATR激酶抑制剂，其制备，不同固体形式和无定形衍生物的2-氨基-6-氟-N- [5-氟 - 吡啶-3-YL]吡唑并[1,5-A]嘧啶-3-羰氧基化合物 THEREOF
公开(公告)号：WO2015085132A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/068713
申请日：2014-12-05
申请人： VERTEX PHARMACEUTICALS INCORPORATED
发明人： CHARRIER, Jean-Damien , DAVIS, Christopher, John , FRAYSSE, Damien , ETXEBARRIA I JARDI, Gorka , PEGG, Simon , PIERARD, Francoise , PINDER, Joanne , STUDLEY, John , ZWICKER, Carl , SANGHVI, Tapan , WALDO, Michael , MEDEK, Ales , SHAW, David, Matthew , PANESAR, Maninder , ZHANG, Yuegang , ALEM, Naziha
IPC分类号： C07D487/04 , C07B59/00 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , C07B59/002 , C07B2200/13 , C07C45/00 , C07C45/63
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.
摘要翻译：本发明涉及可用作ATR蛋白激酶抑制剂的化合物。本发明涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 和本发明化合物的固体形式。本发明的化合物具有式I-A或I-B：其中变量如本文所定义。

12. 发明申请

WO2016183120A1 INHIBITORS OF INFLUENZA VIRUSES REPLICATION 审中-公开
标题翻译：流感病毒复制的抑制剂
公开(公告)号：WO2016183120A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/031713
申请日：2016-05-11
申请人： VERTEX PHARMACEUTICALS INCORPORATED
发明人： FARMER, Luc, J. , BOYD, Michael, John , SHANNON, Dean , WALDO, Michael , NTI-ADDAE, Kwarne, W. , ZHANG, Yuegang
IPC分类号： C07D471/04 , A61K31/506 , A61P31/16
CPC分类号： C07D471/04 , A61K31/4965 , A61K31/506 , A61K45/06 , C07B2200/13
摘要： Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula, include Hydrate 2 of Compound (1), Hydrate 3 of Compound (1), Form A of Compound (1), Form B of Compound (1), Form C of Compound (1), Form D of Compound (1), and amorphous Compound (1). Such polymorphic forms are useful for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.
摘要翻译：化合物（1）的多晶型或其药学上可接受的盐，其中化合物（1）由下列结构式表示：包括化合物（1）的水合物2，化合物（1）的水合物3，化合物（1）），化合物（1）的形式B，化合物（1）的形式C，化合物（1）的形式D和无定形化合物（1）。这样的多晶型可用于治疗流感，抑制流感病毒的复制，或减少生物样品或受试者中流感病毒的数量。

13. 发明申请

WO2015058067A1 CO-CRYSTALS OF (S)-N-METHYL-8-(1-((2'-METHYL-[4,5'-BIPYRIMIDIN]-6-YL)AMINO)PROPAN-2-YL)QUINOLINE-4-CARBOXAMIDE AND DEUTERATED DERIVATIVES THEREOF AS DNA-PK INHIBITORS 审中-公开
标题翻译：（S）-N-甲基-8-（1 - （（2'-甲基 - [4,5'-联吡啶] -6-YL）氨基）丙-2-炔基）喹啉-4-羧酰胺和作为DNA-PK抑制剂的DEUTERATED衍生物
公开(公告)号：WO2015058067A1
公开(公告)日：2015-04-23
申请号：PCT/US2014/061102
申请日：2014-10-17
申请人： VERTEX PHARMACEUTICALS INCORPORATED
发明人： NTI-ADDAE, Kwame, Wiredu , O'NEIL, Simon, Adam , ZHANG, Yuegang
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： A61K31/506 , A61K31/337 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/39558 , A61K45/06 , A61N2005/1098 , C07B59/002 , C07B2200/05 , C07B2200/13 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , C07D401/14 , C07K16/2863 , C07K2317/24
摘要： The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R 1 and R 2 is H or 2 H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
摘要翻译：本发明涉及各自包含具有以下结构的式I化合物的组合物和共晶体：其中R 1和R 2各自为H或2H，并且选自己二酸，柠檬酸，富马酸，马来酸，琥珀酸或苯甲酸。在本发明的范围内也是制造和使用本发明的方法。

14. 发明申请

WO2005066367A2 METHODS OF PRODUCING CARBON NANOTUBES USING PEPTIDE OR NUCLEIC ACID MICROPATTERNING 审中-公开
标题翻译：使用肽或核酸微生物生产碳纳米管的方法
公开(公告)号：WO2005066367A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043364
申请日：2004-12-24
申请人： INTEL CORPORATION , SU, Xing , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo , BERLIN, Andrew , SUN, Lei , ZHANG, Yuegang
发明人： SU, Xing , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo , BERLIN, Andrew , SUN, Lei , ZHANG, Yuegang
IPC分类号： C12Q1/68
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
摘要： The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles (140, 230) to polymer (120, 210) molecules, attaching the polymer (120, 210) molecules to a substrate, removing the polymer (120, 210) molecules and producing carbon nanotubes on the catalyst nanoparticles (140, 230). The polymer (120, 210) molecules alignment techniques. The nanotube arrays can be attached to selected areas (110, 310) of the substrate. Within the selected areas (110, 310), the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
摘要翻译：本文公开的方法，装置和系统涉及碳纳米管的有序阵列。在本发明的具体实施方案中，通过包括将催化剂纳米颗粒（140,230）附着到聚合物（120,210）分子上的方法形成纳米管阵列，将聚合物（120,210）分子连接到基底上，去除聚合物 120,210）分子并在催化剂纳米颗粒（140,230）上产生碳纳米管。聚合物（120,210）分子对齐技术。纳米管阵列可以附着到基板的选定区域（110,310）。在所选择的区域（110,310）内，纳米管是非随机分布的。本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列的装置以及包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统。在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

15. 发明申请

WO2012125853A1 METHOD FOR THE PREPARATION OF GRAPHENE/SILICON MULTILAYER STRUCTURED ANODES FOR LITHIUM ION BATTERIES 审中-公开
标题翻译：用于制造锂离子电池的石墨/硅多层结构阳极的方法
公开(公告)号：WO2012125853A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029274
申请日：2012-03-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ZHANG, Yuegang , JI, Liwen , ISMACH, Ariel
发明人： ZHANG, Yuegang , JI, Liwen , ISMACH, Ariel
IPC分类号： H01L21/20
CPC分类号： H01M4/366 , H01M4/0428 , H01M4/043 , H01M4/133 , H01M4/134 , H01M4/1393 , H01M4/1395 , H01M4/386 , H01M4/587 , H01M4/661
摘要： Multilayer structures with alternating graphene and Si thin films were constructed by a repeated process of filtering liquid-phase exfoliated grapheme film and subsequent coating of amorphous Si film using plasma-enhanced chemical vapor deposition ( PECVD ) method. The multilayer-structure composite films, fabricated on copper current collectors, can be directly used as anodes for rechargeable lithium-ion batteries ( LI Bs) without the addition of polymer bmders or conductive additives. Fabricated coin-type half cells based on the new anode materials easily achieved a capacity almost four times higher than the theoretical value of graphite even after 30 cycles. These cells also demonstrated improved capacity retention and enhanced rate capabi lity during charge/discharge processes compared to those of pure Si film-based anodes.
摘要翻译：采用等离子体增强化学气相沉积（PECVD）法，通过重复的液相剥离形象薄膜过滤和非晶Si膜的涂覆，构建了具有交替石墨烯和Si薄膜的多层结构。在铜集电器上制造的多层结构复合膜可以直接用作可再充电锂离子电池（LI B）的阳极，而不添加聚合物颗粒或导电添加剂。基于新阳极材料制造的硬币型半电池即使在30个循环后也容易达到石墨理论值几乎高出四倍的能力。与纯Si膜基阳极相比，这些电池还显示出在充电/放电过程中改进的容量保持率和提高的速率能力。

16. 发明申请

WO2006135426A2 APPLICATION OF STATIC LIGHT TO A FLUID FLOW OF CNTs FOR PURPOSES OF SORTING THE CNTs 审中-公开
标题翻译：将静态光应用于碳纳米管的流体流中，用于分配CNT的用途
公开(公告)号：WO2006135426A2
公开(公告)日：2006-12-21
申请号：PCT/US2005/035403
申请日：2005-09-30
申请人： INTEL CORPORATION , ZHANG, Yuegang , LOPEZ, Herman , TAN, Shida
发明人： ZHANG, Yuegang , LOPEZ, Herman , TAN, Shida
IPC分类号： C01B31/02
CPC分类号： B07C5/344 , B82Y30/00 , B82Y40/00 , C01B32/172 , G01N2030/0035 , Y10S977/845
摘要： A method is described that comprises sorting carbon nanotubes (CNTs) within a fluidic flow for a targeted subset of CNTs. The sorting comprises attracting at least a portion of the CNTs within the fluidic flow in a direction of increasing intensity of an electric field component of a substantially stationary beam of light. The electric field component has a frequency that is less than one or more resonant frequencies of the CNTs within the portion.
摘要翻译：描述了一种方法，其包括在CNT的靶向子集的流体流中分选碳纳米管（CNT）。排序包括在基本上静止的光束的电场分量的强度增加的方向上吸引流体流中的至少一部分CNT _{。电场分量具有小于该部分内的CNT _{的一个或多个谐振频率的频率。}}

17. 发明申请

WO2005030640A1 SORTING OF SINGLE-WALLED CARBON NANOTUBES USING OPTICAL DIPOLE TRAPS 审中-公开
标题翻译：使用光学DIPOLE TRAPS分离单壁碳纳米管
公开(公告)号：WO2005030640A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031404
申请日：2004-09-23
申请人： INTEL CORPORATION , ZHANG, Yuegang , HANNAH, Eric , KOO, Tae-Woong
发明人： ZHANG, Yuegang , HANNAH, Eric , KOO, Tae-Woong
IPC分类号： C01B31/02
CPC分类号： B82Y30/00 , B07C5/12 , B82Y10/00 , B82Y40/00 , C01B32/172 , C01B2202/02 , Y10S977/845
摘要： In embodiments of the present invention, the electric field of a focused laser beam induces a dipole in a single-walled carbon nanotube. The single-walled carbon nanotube has one or more resonant frequencies. When the frequency of the laser beam is less than a resonance frequency of the single-walled carbon nanotube, the single-walled carbon nanotube may be trapped and the laser beam may move the single-walled carbon nanotube from a first microfluidic laminar flow to a second microfluidic laminar flow. When the frequency of the laser beam is higher than a resonant frequency of the single-walled carbon nanotube , the single-walled carbon nanotube may be repelled and the laser beam may not move the single-walled carbon nanotube.
摘要翻译：在本发明的实施例中，聚焦激光束的电场在单壁碳纳米管中诱导偶极子。单壁碳纳米管具有一个或多个谐振频率。当激光束的频率小于单壁碳纳米管的共振频率时，单层碳纳米管可能被捕获，并且激光束可以将单壁碳纳米管从第一微流体层流移动到第二微流体层流。当激光束的频率高于单壁碳纳米管的谐振频率时，单壁碳纳米管可能被排斥，激光束可能不会移动单壁碳纳米管。

18. 发明申请

WO2006127018A3 REAL-TIME MONITORING OPTICALLY TRAPPED CARBON NANOTUBES 审中-公开
公开(公告)号：WO2006127018A3
公开(公告)日：2006-11-30
申请号：PCT/US2005/021626
申请日：2005-06-17
申请人： INTEL CORPORATION , TAN, Shida , ZHANG, Yuegang
发明人： TAN, Shida , ZHANG, Yuegang
IPC分类号： B23K26/14 , C01B31/02 , D01F9/12
摘要： An embodiment of the present invention is a technique to monitor carbon nanotubes (CNTs). A carbon nanotube (CNT) is manipulated in a fluid by a laser beam. An illuminating light from a light source is aligned along axis of the CNT to produce an optical response from the CNT. The CNT is monitored using an optical sensor according to the optical response.

19. 发明申请

WO2005066635A1 BIOSENSOR UTILIZING A RESONATOR HAVING A FUNCTIONALIZED SURFACE 审中-公开
标题翻译：生物传感器利用具有功能化表面的共振器
公开(公告)号：WO2005066635A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/043363
申请日：2004-12-24
申请人： INTEL CORPORATION , RAO, Valluri , MA, Qing , YAMAKAWA, Mineo , BERLIN, Andrew , WANG, Li-Peng , ZHANG, Yuegang
发明人： RAO, Valluri , MA, Qing , YAMAKAWA, Mineo , BERLIN, Andrew , WANG, Li-Peng , ZHANG, Yuegang
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y30/00 , G01N27/126 , G01N29/022 , G01N29/036 , G01N29/2437 , G01N29/348 , G01N33/0031 , G01N2291/02466 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , Y10T436/11 , Y10T436/143333 , Y10T436/144444 , Y10T436/25375
摘要： Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator’s frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator’s frequency response.
摘要翻译：使用包含具有功能化表面以与靶生物分子反应的共振器的生物传感器来检测样品中存在生物分子的系统和方法。在一个实施例中，器件包括压电谐振器，其具有被配置为与靶分子反应的官能化表面，从而改变谐振器的质量和/或电荷，从而改变谐振器的频率响应。将曝光后的谐振器频率响应与参考值进行比较，例如在暴露于采样之前的频率响应，存储的基准频率响应或控制谐振器的频率响应。

20. 发明公开

EP2560651A1 PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF 审中-公开
标题翻译：药物组合物及其施用
公开(公告)号：EP2560651A1
公开(公告)日：2013-02-27
申请号：EP11718598.3
申请日：2011-04-22
申请人： Vertex Pharmaceuticals Incorporated
发明人： VAN GOOR, Fredrick, F. , ALARGOVA, Rossitza, Gueorguieva , ALCACIO, Tim, Edward , BINCH, Hayley, Marie , BOTFIELD, Martyn, Curtis , FANNING, Lev Tyler, Dewey , GROOTENHUIS, Peter Diederik, Jan , HURLEY, Dennis, James , KADIYALA, Irina, Nikolaevna , KAUSHIK, Ritu, Rohit , KESHAVARZ-SHOKRI, Ali , KRAWIEC, Mariusz , LEE, Elaine, Chungmin , LUISI, Brian , MEDEK, Ales , NUMA, Mehdi , SHETH, Urvi, Jagdishbhai , SILINA, Alina , VERWIJS, Marinus, Jacobus , YANG, Xiaoqing , YOUNG, Christopher Ryan , ZAMAN, Noreen, Tasneem , ZHANG, Beili , ZHANG, Yuegang , ZLOKARNIK, Gregor
IPC分类号： A61K31/4704 , A61K31/404 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4704 , A61K45/06 , C07D405/12 , C12Q1/34 , G01N2500/04 , G01N2500/20 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.(Formula I), (Formula II), (Formula III).
摘要翻译：本发明涉及药物组合物，其包含式I化合物与式II化合物和/或式III化合物中的一种或两种的组合。本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化（式I），（式II），（式III）的方法。

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