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11. 发明申请

US20100278744A1 PREPARATION FOR RESTENOSIS PREVENTION 有权
标题翻译：预防预防的准备
公开(公告)号：US20100278744A1
公开(公告)日：2010-11-04
申请号：US12835414
申请日：2010-07-13
申请人： Ulrich Speck , Bruno Scheller
发明人： Ulrich Speck , Bruno Scheller
IPC分类号： A61K49/06 , A61K49/00 , A61K49/04
CPC分类号： A61L29/08 , A61K9/0019 , A61K9/5094 , A61K31/095 , A61K31/165 , A61K31/337 , A61K45/06 , A61K49/0433 , A61K49/0438 , A61K49/0447 , A61K49/0452 , A61K49/105 , A61K49/106 , A61K49/18 , A61L29/16 , A61L29/18 , A61L31/16 , A61L2300/416 , A61K2300/00
摘要： The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water .gtoreq.0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.
摘要翻译：本发明涉及预防再狭窄的制剂。已知的再狭窄预防制剂在血管壁的受影响部分中不能达到足够的活性剂浓度，因为较高剂量引起不期望的副作用。本发明是一种具有至少一种具有丁醇与水分配比例的抗高血压药物的制剂。亲脂性活性剂被血管壁快速且足够的量吸收。该制剂可以是可以通过毛细血管并且可以含有造影剂的液体，使得活性剂在没有任何额外的努力的同时转移到血管壁中，而通常需要的对比度放射照相。该制剂也可以应用于导管。

12. 发明申请

US20130023817A1 COATING FORMULATIONS FOR SCORING OR CUTTING BALLOON CATHETERS 有权
标题翻译：用于分选或切割气泡导管的涂层配方
公开(公告)号：US20130023817A1
公开(公告)日：2013-01-24
申请号：US13628627
申请日：2012-09-27
申请人： Ulrich Speck , Madeleine Caroline Berg
发明人： Ulrich Speck , Madeleine Caroline Berg
IPC分类号： A61M37/00
CPC分类号： A61L29/08 , A61B17/320725 , A61B2017/320733 , A61L29/143 , A61L29/16 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/606 , A61L2300/802 , A61M25/10 , A61M25/104 , A61M2025/105 , A61M2025/109
摘要： The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one drug or drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein a combination of the at least one drug being a limus drug and the at least one lipophilic antioxidant being butylated hydroxytoluene is excluded.
摘要翻译：本发明涉及评估或切割气球导管，其至少在其表面的一部分上携带至少一种药物或药物制剂和至少一种亲脂性抗氧化剂，其比例为至少一种亲脂性抗氧化剂的3-100重量％相对于100重量％的药物，其中排除了至少一种药物和至少一种亲脂性抗氧化剂作为药物的组合，其中所述至少一种亲脂性抗氧化剂是丁基化羟基甲苯。

13. 发明申请

US20110295200A1 DRUG-ELUTING MEDICAL DEVICE 审中-公开
标题翻译：药物治疗设备
公开(公告)号：US20110295200A1
公开(公告)日：2011-12-01
申请号：US13143703
申请日：2010-01-08
申请人： Ulrich Speck , Silvio Schaffner , Magdalena Renke-gluszko
发明人： Ulrich Speck , Silvio Schaffner , Magdalena Renke-gluszko
IPC分类号： A61M25/10 , B65B1/04 , B05C13/02 , A61M29/00 , B05C11/00
CPC分类号： A61L29/16 , A61L29/06 , A61L2300/216 , A61L2300/416 , A61L2300/602 , A61L2300/63 , A61M25/1002 , A61M25/1029 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , C08L77/00
摘要： The present invention relates to a drug-eluting medical device, in particular a balloon for angioplasty catheters with drug elution to prevent the restenosis of the vessel subjected to angioplasty. More particularly, the present invention relates to a catheter balloon completely or partially coated with paclitaxel in hydrated crystalline form or in hydrated solvated crystalline form, having an immediate release and bioavailability of a therapeutically effective amount of paclitaxel at the site of intervention. The balloon can be made of a polyether-polyamide block copolymer, or a polyester amide, or polyamide-12.
摘要翻译：本发明涉及一种药物洗脱医学装置，特别是用于血管成形术导管的气囊，其具有药物洗脱以防止经血管成形术的血管的再狭窄。更具体地说，本发明涉及完全或部分地涂覆有水合结晶形式的紫杉醇或水合溶剂化晶体形式的导管球囊，其在干预部位具有治疗有效量的紫杉醇的即时释放和生物利用度。气球可以由聚醚 - 聚酰胺嵌段共聚物或聚酯酰胺或聚酰胺-12制成。

14. 发明授权

US07655217B2 Near infrared imaging agent 失效
标题翻译：近红外成像剂
公开(公告)号：US07655217B2
公开(公告)日：2010-02-02
申请号：US11387367
申请日：2006-03-22
申请人： Kai Licha , Björn Riefke , Wolfhard Semmler , Ulrich Speck , Christoph-Stephan Hilger
发明人： Kai Licha , Björn Riefke , Wolfhard Semmler , Ulrich Speck , Christoph-Stephan Hilger
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译：本发明涉及一种基于近红外辐射（NIR辐射）的体内诊断方法，其使用水溶性染料及其生物分子加合物，其具有特定的光物理和药物化学性质，作为用于荧光和透照诊断的造影剂 NIR范围，新染料和含有这些染料的药物。

15. 发明申请

US20050008574A1 Use of intravenous contrast media for projection mammography 审中-公开
标题翻译：使用静脉造影剂进行投影乳房X线摄影
公开(公告)号：US20050008574A1
公开(公告)日：2005-01-13
申请号：US10851213
申请日：2004-05-24
申请人： Ulrich Speck , Irtel Von Brenndorff
发明人： Ulrich Speck , Irtel Von Brenndorff
IPC分类号： A61B6/00 , A61K49/00 , A61K49/04 , A61K49/06 , A61P35/04 , G06T5/00 , G06T5/50
CPC分类号： A61K49/0409 , A61K49/0457
摘要： The invention relates to the use of intravenous contrast media for projection mammography as well as new devices for projection mammography. The invention therefore relates to the use of intravenous contrast media for the production of a diagnostic agent for projection mammography. Through the additional intravenous administration of contrast media, projection mammography achieves a sensitivity that is comparable to that of the most modern processes such as magnetic resonance tomography (MRT) while being considerably more versatile and avoiding the costs of MRT. The new process can be implemented simply and without special stress on the patients and provides a significant improvement in a) sensitivity to the detection of focal lesions in the breast, and b) additional information on the nature of lesions detected previously.
摘要翻译：本发明涉及用于投影乳房X线照相术的静脉造影剂的使用以及用于投影乳房X线照相术的新装置。因此，本发明涉及静脉造影剂用于生产用于投影乳房X线照相术的诊断剂的用途。通过额外静脉注射造影剂，投影乳房X线照相术的灵敏度可以达到最现代的方法，如磁共振断层扫描（MRT）的灵敏度，同时具有更大的灵活性，避免了MRT的成本。新过程可以简单实现，对患者没有特别的压力，并且对a）对乳房局灶性病变检测的敏感度以及b）关于先前检测到的病变性质的额外信息提供了显着的改善。

16. 发明授权

US06709693B1 Stents with a radioactive surface coating, processes for their production and their use for restenosis prophylaxis 失效
标题翻译：具有放射性表面涂层的支架，其生产过程及其用于再狭窄预防
公开(公告)号：US06709693B1
公开(公告)日：2004-03-23
申请号：US09627321
申请日：2000-07-27
申请人： Ludger Dinkelborg , Friedhelm Blume , Christoph-Stephan Hilger , Dieter Heldmann , Johannes Platzek , Ulrich Niedballa , Heribert Miklautz , Ulrich Speck , Stephan Duda , Gunnar Tepe , Bernhard Noll , Heidemarie Goerner
发明人： Ludger Dinkelborg , Friedhelm Blume , Christoph-Stephan Hilger , Dieter Heldmann , Johannes Platzek , Ulrich Niedballa , Heribert Miklautz , Ulrich Speck , Stephan Duda , Gunnar Tepe , Bernhard Noll , Heidemarie Goerner
IPC分类号： A61L2700
CPC分类号： A61K51/1282 , A61F2/82 , A61F2210/0095 , A61L31/082 , A61L31/14 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/44 , A61L2300/606 , A61N5/1002
摘要： The invention relates to radioactive stents, characterized in that the stent is coated on the surface with the radioactive isotope, as well as processes for their production.
摘要翻译：本发明涉及放射性支架，其特征在于，用放射性同位素将支架涂覆在表面上，以及其生产方法。

17. 发明授权

US06495118B1 Lipophilic metal complexes for necrosis and infarction imaging 失效
标题翻译：用于坏死和梗死成像的亲脂性金属络合物
公开(公告)号：US06495118B1
公开(公告)日：2002-12-17
申请号：US09159657
申请日：1998-09-24
申请人： Johannes Platzek , Ulrich Speck , Ulrich Niedballa , Bernd Radüchel , Hanns Joachim Weinmann , Wolfgang Ebert
发明人： Johannes Platzek , Ulrich Speck , Ulrich Niedballa , Bernd Radüchel , Hanns Joachim Weinmann , Wolfgang Ebert
IPC分类号： A61K5100
CPC分类号： A61K49/06
摘要： This invention describes the use of metal complexes that have a plasma protein bond of at least 10% as imaging diagnostic agents for locating an infarction or a necrosis using lasting positive visualization.
摘要翻译：本发明描述了使用具有至少10％的血浆蛋白质键的金属络合物作为用于定位梗死或坏死的成像诊断剂，其使用持久的阳性可视化。

18. 发明授权

US6083485A Near infrared radiation in-vivo diagnostic methods and dyes 失效
标题翻译：近红外辐射体内诊断方法和染料
公开(公告)号：US6083485A
公开(公告)日：2000-07-04
申请号：US849369
申请日：1997-11-07
申请人： Kai Licha , Bjorn Riefke , Wolfhard Semmler , Ulrich Speck , Christoph-Stephan Hilger
发明人： Kai Licha , Bjorn Riefke , Wolfhard Semmler , Ulrich Speck , Christoph-Stephan Hilger
IPC分类号： C07D403/06 , A61K20060101 , A61K49/00 , C07D209/14 , C07D209/18 , C07D209/60 , C09B23/00 , C09B23/08 , C09B69/10 , G01N31/00 , G01N33/48
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
摘要翻译： PCT No.PCT / DE95 / 01465 Sec。 371日期：1997年11月7日 102（e）日期1997年11月7日PCT提交1995年10月10日PCT公布。公开号WO96 / 17628 日期1996年6月13日本发明涉及一种使用水溶性染料及其生物分子加合物的近红外辐射（NIR辐射）的体内诊断方法，其具有特定的光物理和药物化学性质，作为造影剂 NIR系列中的荧光和透照诊断，新染料和含有这些染料的药物。

19. 发明授权

US6071496A Polyalkylcyanoacrylate agents and methods for enhancing contrast in ultrasound imaging 失效
标题翻译：聚氰基氰基丙烯酸酯试剂和用于增强超声成像中的对比度的方法
公开(公告)号：US6071496A
公开(公告)日：2000-06-06
申请号：US477642
申请日：1995-06-07
申请人： Michael Stein , Dieter Heldmann , Thomas Fritzsch , Joachim Siegert , Georg Roessling , Ulrich Speck
发明人： Michael Stein , Dieter Heldmann , Thomas Fritzsch , Joachim Siegert , Georg Roessling , Ulrich Speck
IPC分类号： A61K49/00 , A61K49/22 , A61B8/13
CPC分类号： B82Y5/00 , A61K49/228
摘要： The invention relates to ultrasonic contrast agents comprising microparticles which comprise synthetic biodegradable polymer which is a polyalkylcyanoarylate and a gas and/or a fluid with a boiling point below 60.degree. C., processes for the preparation thereof and their use as diagnostic and therapeutic agents.
摘要翻译：本发明涉及包含微粒的超声造影剂，其包含合成的可生物降解的聚合物，其是聚氰基氰化芳基化合物和气体和/或沸点低于60℃的流体，其制备方法及其作为诊断和治疗剂的用途。

20. 发明授权

US5746995A DTPA derivatives substituted in a novel way, their metal complexes, and their use in diagnosis and therapy 失效
标题翻译： DTPA衍生物以新颖的方式取代，其金属络合物及其在诊断和治疗中的应用
公开(公告)号：US5746995A
公开(公告)日：1998-05-05
申请号：US565025
申请日：1995-11-30
申请人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampieri , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
发明人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampieri , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
IPC分类号： A61K31/16 , A61K31/20 , A61K31/28 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61P1/16 , A61P39/02 , C07C229/16 , C07C229/22 , C07C229/24 , C07C229/36 , C07C229/76 , C07C323/63 , A61B5/055
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0004 , A61K49/04 , Y10S514/836 , Y10T436/24
摘要： The invention relates to new diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents that contain these compounds and their use as contrast media and antidotes.
摘要翻译：本发明涉及含有原子序数20-32,39-51或57-83的元素的新的二亚乙基三胺五乙酸衍生物，其络合物和络合盐，含有这些化合物的药物及其作为造影介质和解毒剂的用途。

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