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11. 发明申请

WO2007104062A8 COMPOSITIONS AND METHODS RELATED TO PROFILING A PLURALITY OF CELL LINES BASED ON PEPTIDE BINDING 审中-公开
标题翻译：基于肽结合的多种细胞系的组成和方法
公开(公告)号：WO2007104062A8
公开(公告)日：2008-10-09
申请号：PCT/US2007063736
申请日：2007-03-09
申请人： UNIV TEXAS , ARAP WADIH , PASQUALINI RENATA , KOLONIN MIKHAIL
发明人： ARAP WADIH , PASQUALINI RENATA , KOLONIN MIKHAIL
IPC分类号： C40B40/02 , C40B30/06 , G01N33/574
CPC分类号： C07K7/64 , C07K7/06 , C12N15/1037 , G01N33/57492
摘要： Methods and compositions are described for classifying cells and/or peptides that associate or
摘要翻译：描述了用于分类细胞和/或肽的方法和组合物

12. 发明申请

WO0220722A9 METHODS AND COMPOSITIONS FOR IN VITRO TARGETING 审中-公开
标题翻译：用于体外定向的方法和组合物
公开(公告)号：WO0220722A9
公开(公告)日：2003-08-21
申请号：PCT/US0127702
申请日：2001-09-07
申请人： UNIV TEXAS , ARAP WADIH , PASQUALINI RENATA
发明人： ARAP WADIH , PASQUALINI RENATA
IPC分类号： C12N15/09 , A61K31/225 , A61K31/23 , A61K31/56 , A61K31/683 , A61K31/685 , A61K31/688 , A61K31/713 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61K39/395 , A61K45/00 , A61K47/42 , A61K47/48 , A61K48/00 , A61K49/00 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/10 , A61P13/02 , A61P19/02 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P43/00 , C07K1/04 , C07K5/08 , C07K5/10 , C07K7/04 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/005 , C07K14/47 , C07K14/52 , C07K16/08 , C07K16/18 , C07K19/00 , C12N7/02 , C12N15/10 , C12N15/861 , C12N15/864 , C12Q1/02 , C12Q1/70 , G01N33/50 , G01N33/53 , G01N33/566
CPC分类号： C07K14/52 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K1/047 , C07K7/06 , C12N15/1037 , C12N2810/40
摘要： The present invention concerns methods and comositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, including but not limited to gene therapy vectors. A novel class of gene therapy vectors is disclosed. Certain of the disclosed peptides have therapeutic use for inhibiting angiogenesis, inhibiting tumor growth, inducing apoptosis, inhibiting pregnancy or inducing weight loss. Methods of identifying novel targeting peptides in humans, as well as identifying endogenous receptor-ligand pairs are disclosed. Methods of identifying novel infectious agents that are causal for human disease states are also disclosed. A novel mechanism for inducing apoptosis is further disclosed.
摘要翻译：本发明涉及用于体内和体外靶向的方法和组合。公开了大量针对人器官，组织或细胞类型的靶向肽。肽可用于靶向递送治疗剂，包括但不限于基因治疗载体。公开了一类新型的基因治疗载体。某些所公开的肽具有抑制血管发生，抑制肿瘤生长，诱导凋亡，抑制妊娠或引起体重减轻的治疗用途。公开了鉴定人中新靶向肽的方法，以及鉴定内源性受体 - 配体对。还公开了鉴定对人类疾病状态有影响的新型感染因子的方法。进一步公开了诱导细胞凋亡的新机制。

13. 发明申请

WO0220722A2 METHODS AND COMPOSITIONS FOR IN VITRO TARGETING 审中-公开
标题翻译：用于“VITRO”瞄准的方法和组合
公开(公告)号：WO0220722A2
公开(公告)日：2002-03-14
申请号：PCT/US0127702
申请日：2001-09-07
申请人： UNIV TEXAS , ARAP WADIH , PASQUALINI RENATA
发明人： ARAP WADIH , PASQUALINI RENATA
IPC分类号： C12N15/09 , A61K31/225 , A61K31/23 , A61K31/56 , A61K31/683 , A61K31/685 , A61K31/688 , A61K31/713 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61K39/395 , A61K45/00 , A61K47/42 , A61K47/48 , A61K48/00 , A61K49/00 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/10 , A61P13/02 , A61P19/02 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P43/00 , C07K1/04 , C07K5/08 , C07K5/10 , C07K7/04 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/005 , C07K14/47 , C07K14/52 , C07K16/08 , C07K16/18 , C07K19/00 , C12N7/02 , C12N15/10 , C12N15/861 , C12N15/864 , C12Q1/02 , C12Q1/70 , G01N33/50 , G01N33/53 , G01N33/566 , C12N
CPC分类号： C07K14/52 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K1/047 , C07K7/06 , C12N15/1037 , C12N2810/40
摘要： The present invention concerns methods and comositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, including but not limited to gene therapy vectors. A novel class of gene therapy vectors is disclosed. Certain of the disclosed peptides have therapeutic use for inhibiting angiogenesis, inhibiting tumor growth, inducing apoptosis, inhibiting pregnancy or inducing weight loss. Methods of identifying novel targeting peptides in humans, as well as identifying endogenous receptor-ligand pairs are disclosed. Methods of identifying novel infectious agents that are causal for human disease states are also disclosed. A novel mechanism for inducing apoptosis is further disclosed.
摘要翻译：本发明涉及用于体内和体外靶向的方法和组合。公开了大量针对人器官，组织或细胞类型的靶向肽。肽可用于靶向递送治疗剂，包括但不限于基因治疗载体。公开了一类新型的基因治疗载体。某些所公开的肽具有抑制血管发生，抑制肿瘤生长，诱导凋亡，抑制妊娠或引起体重减轻的治疗用途。公开了鉴定人中新靶向肽的方法，以及鉴定内源性受体 - 配体对。还公开了鉴定对人类疾病状态有影响的新型感染因子的方法。进一步公开了诱导细胞凋亡的新机制。

14. 发明申请

WO2009032477A3 VEGFR-1/NRP-1 TARGETING PEPTIDES 审中-公开
标题翻译： VEGFR-1 / NRP-1靶向肽
公开(公告)号：WO2009032477A3
公开(公告)日：2011-01-13
申请号：PCT/US2008072675
申请日：2008-08-08
申请人： UNIV TEXAS , PASQUALINI RENATA , ARAP WADIH , GIORDANO RICARDO , CARDO-VILA MARINA , VALENTE ANA PAULA , CENEVIVA LACERDA DE ALMEIDA FABIO , UNIV RIO DE JANEIRO
发明人： PASQUALINI RENATA , ARAP WADIH , GIORDANO RICARDO , CARDO-VILA MARINA , VALENTE ANA PAULA , CENEVIVA LACERDA DE ALMEIDA FABIO
IPC分类号： C07K5/08 , C07K7/08
CPC分类号： C12N15/62 , A61K47/66 , B82Y5/00 , C07K5/0806 , C07K5/0808 , C07K5/0817 , C07K7/06 , C07K7/08 , C07K14/001
摘要： The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particularly D(LPR), that selectively target VEGFR-1 and NRP-1 expressing cells. Targeted molecules in accordance with the invention are useful in the treatment and detection of neovascular or angiogenic VEGF associated disorders, including but not limited to cancer, obesity, diabetes, asthma, arthritis, cirrhosis and ocular diseases.
摘要翻译：本发明涉及治疗剂的分子药物和靶向递送领域。更具体地，本发明涉及结合选择性靶向VEGFR-1和NRP-1表达细胞的氨基酸Leu-Pro-Arg（LPR），特别是D（LPR）的新肽序列的鉴定。根据本发明的靶向分子可用于治疗和检测新生血管或血管生成VEGF相关疾病，包括但不限于癌症，肥胖症，糖尿病，哮喘，关节炎，肝硬化和眼部疾病。

15. 发明申请

WO2009032477A2 VEGFR-1/NRP-1 TARGETING PEPTIDES 审中-公开
标题翻译： VEGFR-1 / NRP-1靶向肽
公开(公告)号：WO2009032477A2
公开(公告)日：2009-03-12
申请号：PCT/US2008072675
申请日：2008-08-08
申请人： UNIV TEXAS , PASQUALINI RENATA , ARAP WADIH , GIORDANO RICARDO , CARDO-VILA MARINA , VALENTE ANA PAULA , CENEVIVA LACERDA DE ALMEIDA FA
发明人： PASQUALINI RENATA , ARAP WADIH , GIORDANO RICARDO , CARDO-VILA MARINA , VALENTE ANA PAULA , CENEVIVA LACERDA DE ALMEIDA FABIO
CPC分类号： C12N15/62 , A61K47/66 , B82Y5/00 , C07K5/0806 , C07K5/0808 , C07K5/0817 , C07K7/06 , C07K7/08 , C07K14/001
摘要： The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particularly D(LPR), that selectively target VEGFR-I and NRP-I expressing cells. Targeted molecules in accordance with the invention are useful in the treatment and detection of neovascular or angiogenic VEGF associated disorders, including but not limited to cancer, obesity, diabetes, asthma, arthritis, cirrhosis and ocular diseases.
摘要翻译：本发明涉及治疗剂的分子药物和靶向递送领域。更具体地，本发明涉及结合选择性靶向VEGFR-1和NRP-1表达细胞的氨基酸Leu-Pro-Arg（LPR），特别是D（LPR）的新肽序列的鉴定。根据本发明的靶向分子可用于治疗和检测新生血管或血管生成VEGF相关疾病，包括但不限于癌症，肥胖症，糖尿病，哮喘，关节炎，肝硬化和眼部疾病。

16. 发明申请

WO2007104062A2 COMPOSITIONS AND METHODS RELATED TO PROFILING A PLURALITY OF CELL LINES BASED ON PEPTIDE BINDING 审中-公开
标题翻译：基于肽结合的多种细胞系的组成和方法
公开(公告)号：WO2007104062A2
公开(公告)日：2007-09-13
申请号：PCT/US2007063736
申请日：2007-03-09
申请人： UNIV TEXAS , ARAP WADIH , PASQUALINI RENATA
发明人： ARAP WADIH , PASQUALINI RENATA
IPC分类号： C40B40/02 , C40B30/06 , G01N33/574
CPC分类号： C07K7/64 , C07K7/06 , C12N15/1037 , G01N33/57492
摘要： Methods and compositions are described for classifying cells and/or peptides that associate or bind with a particular characteristic pattern to a plurality of cells or cell lines. Aspects of the invention also include the use of peptide(s) having an appropriate binding characteristic to deliver a drug to a cell or cell population.
摘要翻译：描述了用于将与特定特征图案缔合或结合至多个细胞或细胞系的细胞和/或肽分类的方法和组合物。本发明的方面还包括使用具有适当结合特征的肽将药物递送至细胞或细胞群体。

17. 发明申请

WO2005065418A3 COMPOSITIONS AND METHODS OF USE OF TARGETING PEPTIDES FOR DIAGNOSIS AND THERAPY 审中-公开
标题翻译：靶向肽用于诊断和治疗的组合物和方法
公开(公告)号：WO2005065418A3
公开(公告)日：2006-09-14
申请号：PCT/US2004044075
申请日：2004-12-30
申请人： UNIV TEXAS , PASQUALINI RENATA , ARAP WADIH , KOLONIN MIKHAIL , ZURITA AMADO J
发明人： PASQUALINI RENATA , ARAP WADIH , KOLONIN MIKHAIL , ZURITA AMADO J
IPC分类号： A61K38/00 , A01N37/18 , A61K39/395 , C07H21/02 , C07H21/04 , C12N5/06 , C12N9/10 , C12Q1/00 , G06Q40/00
CPC分类号： A61K35/768 , A61K38/00 , A61K38/45 , A61K47/64 , C07K7/06 , C07K2319/74 , C12N2795/00032 , G01N33/6869 , G01N2333/7155 , G01N2500/04
摘要： The compositions and methods include targeting peptides selective for tissue selective binding, particularly prostate and/or bone cancer, or adipose tissue. The methods may comprise targeting peptides that bind, for example, cell surface GRP78, IL-11Ra in blood vessels of bone, or prohibitin of adipose vascular tissue. These peptides may be used to induce targeted apoptosis in the presence or absence of at least one pro-apoptotic peptide. Antibodies against such targeting peptides, the targeting peptides, or their mimeotopes may be used for detection, diagnosis and/or staging of a condition, such as prostate cancer or metastatic prostate cancer.
摘要翻译：组合物和方法包括靶向选择性组织选择性结合的肽，特别是前列腺和/或骨癌或脂肪组织。所述方法可以包括靶向结合例如细胞表面GRP78，骨血管中的IL-11Ra或脂肪血管组织的抑制肽。在存在或不存在至少一种促凋亡肽的情况下，这些肽可用于诱导靶向凋亡。针对这种靶向肽，靶向肽或其肌炎组合物的抗体可用于病症如前列腺癌或转移性前列腺癌的检测，诊断和/或分期。

18. 发明申请

WO2006060171A2 METHODS AND COMPOSITIONS RELATED TO PHAGE-NANOPARTICLE ASSEMBLIES 审中-公开
标题翻译：相关的纳米材料组合物的方法和组合物
公开(公告)号：WO2006060171A2
公开(公告)日：2006-06-08
申请号：PCT/US2005041700
申请日：2005-11-16
申请人： UNIV TEXAS , SOUZA GLAUCO , ARAP WADIH , PASQUALINI RENATA
发明人： SOUZA GLAUCO , ARAP WADIH , PASQUALINI RENATA
CPC分类号： G01N33/587 , A61K35/76 , A61K47/6901 , A61K49/0065 , A61K49/0097 , C07K7/06 , C07K14/005 , C07K2319/01 , C07K2319/20 , C12N7/00 , C12N2795/14122 , C12N2795/14142 , C12N2810/50 , G01N33/569
摘要： Embodiments of the invention include additional compositions and related methods and devices for the use of phage-nanoparticle assemblies. Embodiments of the invention include compositions, methods and devices related to phage-nanoparticle assemblies and their use in a variety of methods including detection methods, in vitro and in vivo diagnostic methods, direct and/or indirect therapeutic methods, or combinations thereof. Phage-nanoparticle assemblies of the invention comprise a plurality of nanoparticles complexed with one or more phage particles to form a phage-nanoparticle assembly. In certain aspects, the phagenanoparticle assembly may also include other agents, including but not limited to organizing agents and/or therapeutic agents.
摘要翻译：本发明的实施方案包括另外的组合物和用于使用噬菌体 - 纳米颗粒组件的相关方法和装置。本发明的实施方案包括与噬菌体 - 纳米颗粒组件相关的组合物，方法和装置及其在各种方法中的应用，包括检测方法，体外和体内诊断方法，直接和/或间接治疗方法或其组合。本发明的噬菌体纳米颗粒组合物包含与一个或多个噬菌体颗粒复合以形成噬菌体 - 纳米颗粒组件的多个纳米颗粒。在某些方面，致癌物微粒组件还可以包括其它试剂，包括但不限于组织试剂和/或治疗剂。

19. 发明申请

WO2006010070A3 COMPOSITIONS AND METHODS RELATED TO PEPTIDES THAT SELECTIVELY BIND LEUKEMIA CELLS 审中-公开
标题翻译：与选择性结合白血病细胞的肽相关的组合物和方法
公开(公告)号：WO2006010070A3
公开(公告)日：2006-05-26
申请号：PCT/US2005024414
申请日：2005-07-11
申请人： UNIV TEXAS , JAALOUK DIANA , ARAP WADIH , PASQUALINI RENATA
发明人： JAALOUK DIANA , ARAP WADIH , PASQUALINI RENATA
IPC分类号： A61K38/00
CPC分类号： G01N33/57426 , C07K7/06 , C07K2319/20
摘要： The present invention provides additional methods and compositions for the preparation and use of targeting peptides that are selective and/or specific for leukemia. In some embodiments, the invention concerns particular targeting peptides selective or specific for leukemia cells, including but not limited to SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO: 7. Other embodiments concern such targeting peptides attached to therapeutic agents. In other embodiments, leukemia or other targeting peptides may be used to selectively or specifically deliver therapeutic agents to target cells, such as leukemia cells. In certain embodiments, the subject methods concern the identification, preparation, and use of targeting peptides selective or specific for a given target cell, tissue or organ, such as leukemia cells.
摘要翻译：本发明提供了用于制备和使用对白血病有选择性和/或特异性的靶向肽的其他方法和组合物。在一些实施方案中，本发明涉及对白血病细胞（包括但不限于SEQ ID NO：5，SEQ ID NO：6或SEQ ID NO：7）选择性或特异性的特定靶向肽。其他实施方案涉及这样的靶向肽，其与治疗剂代理商。在其他实施方案中，白血病或其他靶向肽可用于选择性或特异性地将治疗剂递送至靶细胞，如白血病细胞。在某些实施方案中，主题方法涉及对给定靶细胞，组织或器官（例如白血病细胞）选择性或特异性的靶向肽的鉴定，制备和使用。

20. 发明申请

WO0220769A9 HUMAN AND MOUSE TARGETING PEPTIDES IDENTIFIED BY PHAGE DISPLAY 审中-公开
标题翻译：由PHAGE显示识别的人和小鼠靶向肽
公开(公告)号：WO0220769A9
公开(公告)日：2003-09-04
申请号：PCT/US0127692
申请日：2001-09-07
申请人： UNIV TEXAS , ARAP WADIH , PASQUALINI RENATA
发明人： ARAP WADIH , PASQUALINI RENATA
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K45/00 , A61K47/42 , A61K47/48 , A61K48/00 , A61K49/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/08 , A61P15/18 , A61P19/02 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07K1/04 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/005 , C07K16/08 , C07K17/00 , C12N7/00 , C12N15/07 , C12N15/10 , C12N15/861 , C12N15/864 , C12Q1/02 , C12Q1/70 , C40B40/02 , C12N15/03 , A61K38/03 , A61K38/04 , A61K38/08 , A61K38/17 , C07K7/00 , C07K7/04 , C07K17/02 , C12N15/73 , C12N15/74 , C12N15/75
CPC分类号： C40B40/02 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/5256 , C07K1/047 , C07K7/06 , C07K7/08 , C07K14/001 , C12N15/1037 , C12N15/86 , C12N2710/10345 , C12N2750/14143 , C12N2810/40
摘要： The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, including but not limited to gene therapy vectors. A novel class of gene therapy vectors is disclosed. Certain of the disclosed peptides have therapeutic use for inhibiting angiogenesis, inhibiting tumor growth, inducing apoptosis, inhibiting pregnancy or inducing weight loss. Methods of identifying novel targeting peptides in humans, as well as identifying endogenous receptor-ligand pairs are disclosed. Methods of identifying novel infectious agents that are causal for human disease states are also disclosed. A novel mechanism for inducing apoptosis is further disclosed.
摘要翻译：本发明涉及用于体内和体外靶向的方法和组合物。公开了大量针对人器官，组织或细胞类型的靶向肽。肽可用于靶向递送治疗剂，包括但不限于基因治疗载体。公开了一类新型的基因治疗载体。某些所公开的肽具有抑制血管发生，抑制肿瘤生长，诱导凋亡，抑制妊娠或引起体重减轻的治疗用途。公开了鉴定人中新靶向肽的方法，以及鉴定内源性受体 - 配体对。还公开了鉴定对人类疾病状态有影响的新型感染因子的方法。进一步公开了诱导细胞凋亡的新机制。

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