专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2012027481A1 COMPOUNDS FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的化合物
公开(公告)号：WO2012027481A1
公开(公告)日：2012-03-01
申请号：PCT/US2011048980
申请日：2011-08-24
申请人： GTX INC , UNIV TENNESSEE REASEARCH FOUNDATION , DALTON JAMES T , MILLER DUANE D , LI CHIEN-MING , AHN SUNJOO , LU YAN , WANG ZHAO , CHEN JIANJUN , LI WEI , DUKE CHARLES
发明人： DALTON JAMES T , MILLER DUANE D , LI CHIEN-MING , AHN SUNJOO , LU YAN , WANG ZHAO , CHEN JIANJUN , LI WEI , DUKE CHARLES
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： A61K31/415 , C07D233/60 , C07D263/32 , C07D277/24 , C07D277/42 , C07D403/04 , C07D403/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
摘要翻译：本发明涉及具有抗癌活性的新化合物，制备这些化合物的方法及其用于治疗癌症和药物抗性肿瘤的用途，例如，黑素瘤，转移性黑素瘤，耐药性黑素瘤，前列腺癌和耐药前列腺癌。

12. 发明申请

WO2008024456A3 SUBSTITUTED ACYLANILIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译：取代的ACYLANILID及其使用方法
公开(公告)号：WO2008024456A3
公开(公告)日：2008-07-03
申请号：PCT/US2007018686
申请日：2007-08-24
申请人： UNIV TENNESSEE RES FOUNDATION , DALTON JAMES T , MILLER DUANE D
发明人： DALTON JAMES T , MILLER DUANE D
IPC分类号： A61K31/167 , A61P15/16 , C07C255/51
CPC分类号： C07C255/60 , C07B2200/07
摘要： This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.
摘要翻译：本发明提供了SARM化合物及其用于治疗受试者中各种疾病或病症的用途，其中包括肌肉消耗疾病和/或病症或骨相关疾病和/或病症。

13. 发明申请

WO2008011073A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS, ANALOGS AND DERIVATIVES THEREOF AND USES THEREOF 审中-公开
标题翻译：选择性雄激素受体调节剂，类似物及其衍生物及其用途
公开(公告)号：WO2008011073A2
公开(公告)日：2008-01-24
申请号：PCT/US2007016312
申请日：2007-07-19
申请人： OSURF , UNIV TENNESSEE RES FOUNDATION , DALTON JAMES T , MILLER DUANE D , RAKOV IGOR , BOHL CASEY , MOHLER MICHAEL L
发明人： DALTON JAMES T , MILLER DUANE D , RAKOV IGOR , BOHL CASEY , MOHLER MICHAEL L
IPC分类号： A61K31/473
CPC分类号： C07D241/04 , C07C255/54 , C07C255/58 , C07C255/60 , C07C317/46 , C07C323/60 , C07C335/18 , C07D233/86
摘要： This invention provides nuclear hormone receptor binding compounds, compositions comprising the same and methods of uses thereof in treating a variety of diseases or conditions in a subject, including, inter-alia, prostate cancer and/or diseases or disorders of bone and muscle.
摘要翻译：本发明提供了核激素受体结合化合物，包含其的组合物以及其在治疗受试者中的多种疾病或病症（包括尤其包括前列腺癌和/或骨骼和肌肉疾病或病症）中的用途的方法。

14. 发明申请

WO2007062230A2 NUCLEAR RECEPTOR BINDING AGENTS 审中-公开
标题翻译：核受体结合剂
公开(公告)号：WO2007062230A2
公开(公告)日：2007-05-31
申请号：PCT/US2006045451
申请日：2006-11-28
申请人： GTX INC , DALTON JAMES T , BARRETT CHRISTINA , HE YALI , HONG SEOUNG-SOO , MILLER DUANE D , MOHLER MICHAEL L , NARAYANAN RAMESH , WU ZHONGZHI
发明人： DALTON JAMES T , BARRETT CHRISTINA , HE YALI , HONG SEOUNG-SOO , MILLER DUANE D , MOHLER MICHAEL L , NARAYANAN RAMESH , WU ZHONGZHI
IPC分类号： A61K31/55 , A01N31/14 , A61K31/138 , A61K31/40 , A61K31/445
CPC分类号： A61K31/138 , A61K31/40 , A61K31/445 , A61K31/55 , C07D221/12
摘要： The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.
摘要翻译：本发明涉及一类新型选择性雌激素受体调节剂（SERM）。 SERM化合物适用于预防和/或治疗各种疾病和病症，包括预防和治疗癌症，例如前列腺癌和乳腺癌，骨质疏松症，激素相关性疾病，潮热或血管舒缩症状，神经病症，心血管疾病和肥胖症。

15. 发明申请

WO2005120483A3 SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：选择性雄激素受体调节剂及其使用方法
公开(公告)号：WO2005120483A3
公开(公告)日：2006-08-03
申请号：PCT/US2005019788
申请日：2005-06-07
申请人： UNIV TENNESSEE RES FOUNDATION , DALTON JAMES T , MILLER DUANE D , VEVERKA KAREN A
发明人： DALTON JAMES T , MILLER DUANE D , VEVERKA KAREN A
IPC分类号： A61K31/275 , A61K31/16 , A61K31/17 , A61K31/505 , A61K31/663 , A61K51/00 , C07C255/50
CPC分类号： C07C255/60 , A61K31/17 , A61K31/663 , C07B2200/07 , C07C235/24 , A61K2300/00
摘要： This invention provides SARM compounds and their use in treating a variety of diseases or conditions in a subject, including, inter-alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.
摘要翻译：本发明提供了SARM化合物及其在治疗受试者中的各种疾病或病症，特别是包括肌肉消瘦疾病和/或病症或骨相关疾病和/或病症中的用途。

16. 发明申请

WO03065992A2 TREATING BENIGN PROSTATE HYPERPLASIA WITH SARMS 审中-公开
标题翻译：用SARMS处理BENIGN PROSTATE HYPERPLASIA
公开(公告)号：WO03065992A2
公开(公告)日：2003-08-14
申请号：PCT/US0303447
申请日：2003-02-06
申请人： GTX INC , STEINER MITCHELL S , VEVERKA KAREN A , MILLER DUANE D , DALTON JAMES T , CHUNG KIWON , GAO WENQING
发明人： STEINER MITCHELL S , VEVERKA KAREN A , MILLER DUANE D , DALTON JAMES T , CHUNG KIWON , GAO WENQING
IPC分类号： A61K45/00 , A61K31/00 , A61K31/167 , A61K31/277 , A61K31/56 , A61P13/08 , A61P43/00 , A61K
CPC分类号： A61K31/277 , A61K31/00 , A61K31/167 , A61K31/56
摘要： This invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of benign prostate hyperplasia in a male subject, by administering to the subject a selective androgen receptor modulator(SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof as described herein. This invention also provides a method of treating a subject suffering from hair loss, comprising the step of administering to the subject a therapeutically effective amount of a 5-a reductase enzyme type 1 and /or type 2 inhibitor, wherein said inhibitor is a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite,pharmaceutically acceptable salt, pharmaceutical product, hydrate, Woxide, or any combination thereof as described herein. This invention also provides a method of inhibiting a 5-a reductase type 1 and/or type 2 enzyme, comprising contacting the enzyme with an effective 5-a reductase inhibitory amount of a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof, as described herein.
摘要翻译：本发明提供了通过向受试者施用选择性雄激素受体调节剂（SARM）和/或其类似物，衍生物，异构体，代谢物来治疗，预防，抑制或降低男性患者良性前列腺增生的发生率的方法，药学上可接受的盐，药物产品，水合物，N-氧化物或其任何组合。本发明还提供了一种治疗脱发患者的方法，包括向受试者施用治疗有效量的1型和/或2型抑制剂的5-a还原酶的步骤，其中所述抑制剂是选择性雄激素受体调节剂（SARM）和/或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物，氧化物或其任何组合。本发明还提供抑制1型和/或2型5α还原酶的方法，包括使酶与有效的5-a还原酶抑制量的选择性雄激素受体调节剂（SARM）和/或其类似物接触，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物，N-氧化物或其任何组合。

17. 发明申请

WO2007027582A3 TREATING RENAL DISEASE, BURNS, WOUNDS AND SPINAL CORD INJURY WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS 审中-公开
标题翻译：用选择性的受体调节剂治疗肾上腺疾病，疱疹，伤口和脊髓损伤
公开(公告)号：WO2007027582A3
公开(公告)日：2007-10-25
申请号：PCT/US2006033490
申请日：2006-08-28
申请人： GTX INC , DALTON JAMES T , MILLER DUANE D
发明人： DALTON JAMES T , MILLER DUANE D
IPC分类号： A01N37/18 , C07C233/00
CPC分类号： A61K31/165 , A61K31/277 , A61K31/32 , A61K31/405 , A61K31/4704 , A61K31/4709 , A61K31/555 , A61K31/675
摘要： This invention provides: 1) a method of treating a subject suffering from, or predisposed to a kidney disease or disorder; 2) a method of treating a subject suffering from a wound, or reducing the incidence of, or mitigating the severity of a wound in a subject; 3) a method of treating a subject suffering from a burn, or reducing the incidence of, or mitigating the severity of a burn in a subject, comprising the step of administering to said subject a selective androgen receptor modulator (SARM) compound; 4) a method of treating a subject suffering from a spinal cord injury, by administering to the subject a selective androgen receptor modulator (SARM) and/or an analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, impurity or crystal of said SARM compound, or any combination thereof.
摘要翻译：本发明提供：1）治疗患有或易患肾病或病症的受试者的方法; 2）治疗患有伤口的受试者或降低受试者的伤口的发生或减轻其严重程度的方法; 3）治疗患有烧伤的受试者或降低受试者的烧伤的发生或减轻其严重程度的方法，其包括向所述受试者施用选择性雄激素受体调节剂（SARM）化合物的步骤; 4）通过向受试者施用选择性雄激素受体调节剂（SARM）和/或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物N，治疗患有脊髓损伤的受试者的方法氧化物，前药，多晶型物，杂质或结晶，或其任何组合。

18. 发明申请

WO2007081696A2 TREATING ANDROGEN DECLINE IN AGING MALE (ADAM)-ASSOCIATED CONDITIONS WITH SARMS 审中-公开
标题翻译：治疗老年男性（ADAM）的SARS治疗条件恶化
公开(公告)号：WO2007081696A2
公开(公告)日：2007-07-19
申请号：PCT/US2007000052
申请日：2007-01-04
申请人： GTX INC , DALTON JAMES T , MILLER DUANE D , STEINER MITCHELL S , VEVERKA KAREN A
发明人： DALTON JAMES T , MILLER DUANE D , STEINER MITCHELL S , VEVERKA KAREN A
IPC分类号： A61K31/277 , C07K14/72
CPC分类号： A61K31/277 , C07K14/721
摘要： This invention provides methods for treatment and inhibition of a male subject having an Androgen Decline in Aging Male (ADAM)-associated condition, for example sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, an alteration in cognition and mood, depression, anemia, hair loss, obesity, muscle loss, dry eye, memory loss, benign prostate hyperplasia and/or prostate cancer, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, pro-drug, polymorph, crystal, or any combination thereof.
摘要翻译：本发明提供了用于治疗和抑制雄性雄性雄激素降低（ADAM）相关病症的男性受试者的方法，例如性功能障碍，性欲性降低，勃起功能障碍，性腺机能减退，肌肉减少症，骨质减少症，骨质疏松症，认知改变通过向受试者施用选择性雄激素受体调节剂（SARM）化合物和/或其类似物，通过向受试者施用选择性雄激素受体调节剂（SARM）化合物和/或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物，N-氧化物，前药，多晶型物，晶体或其任何组合。

19. 发明申请

WO2005037205A3 HALOACETAMIDE AND AZIDE SUBSTITUTED COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：羟基乙酰胺和酰胺取代的化合物及其使用方法
公开(公告)号：WO2005037205A3
公开(公告)日：2006-01-26
申请号：PCT/US2004033696
申请日：2004-10-14
申请人： UNIV TENNESSEE RES FOUNDATION , MILLER DUANE D , NAIR VIPIN , XU HUIPING , DALTON JAMES T
发明人： MILLER DUANE D , NAIR VIPIN , XU HUIPING , DALTON JAMES T
IPC分类号： A61K20060101 , A61K31/165 , A61K31/277 , A61K31/325 , A61K39/395 , C07C235/24 , C07C255/60 , C07C271/24 , C07C309/87 , C07C317/40 , C07C323/60 , C07D207/448 , C07F9/09 , A61K31/505 , A61K31/16 , A61K31/275 , A61K31/40 , C07C233/05 , C07C233/15 , C07C255/50 , C07D207/40
CPC分类号： C07D207/448 , C07C215/76 , C07C235/16 , C07C235/24 , C07C255/60 , C07C271/24 , C07C309/87 , C07C317/46 , C07C323/60 , C07D233/74
摘要： The present invention relates to a novel class of anti-cancer compounds, which contain a haloacetamide or azide moiety and are, in one embodiment, alkylating agents. These agents, either alone or in a composition, are useful for treating cancer, preventing cancer, delaying the progression of cancer, treating and/or preventing the recurrence of cancer, suppressing, inhibiting or reducing the incidence of cancer, or inducing apoptosis in a cancer cell. Accordingly, the present invention provides a) methods of treating cancer in a subject; b) methods of preventing cancer in a subject; c) methods of delaying the progression of cancer in a subject; d) methods of treating the recurrence of cancer in a subject; e) methods of preventing the recurrence of cancer in a subject; f) methods of suppressing, inhibiting or reducing the incidence of cancer in a subject; and g) methods of inducing apoptosis in a cancer cell; by administering to the subject an anti-cancer compound of the present invention or an analog or metabolite thereof, its N-oxide, ester, pharmaceutically acceptable salt, hydrate, or any combination thereof as described herein.
摘要翻译：本发明涉及一类新的抗癌化合物，其含有卤代乙酰胺或叠氮化物部分，在一个实施方案中是烷化剂。这些药物单独或组合物可用于治疗癌症，预防癌症，延缓癌症进展，治疗和/或预防癌症的复发，抑制，抑制或降低癌症的发生，或诱导癌细胞凋亡癌细胞。因此，本发明提供了a）在受试者中治疗癌症的方法; b）预防受试者癌症的方法; c）延缓受试者癌症进展的方法; d）治疗患者癌症复发的方法; e）预防受试者癌症复发的方法; f）抑制或抑制受试者癌症发病率的方法; 和g）诱导癌细胞凋亡的方法; 通过向受试者施用本文所述的抗癌化合物或其类似物或代谢物，其N-氧化物，酯，药学上可接受的盐，水合物或其任何组合。

20. 发明申请

WO2004066922A3 A METHOD OF TREATING BREAST CANCER WITH ANDROGEN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：一种用雄激素受体拮抗剂治疗乳腺癌的方法
公开(公告)号：WO2004066922A3
公开(公告)日：2005-09-15
申请号：PCT/US2004001313
申请日：2004-01-20
申请人： GTX INC , STEINER MITCHELL S , DALTON JAMES T , MILLER DUANE D , VEVERKA KAREN A
发明人： STEINER MITCHELL S , DALTON JAMES T , MILLER DUANE D , VEVERKA KAREN A
IPC分类号： A61K20060101 , A61K31/165 , A61K31/21 , A61K31/26 , A61K31/277 , A61K31/32 , A61K31/66 , A61P35/00
CPC分类号： A61K31/66 , A61K31/21 , A61K31/26
摘要： This invention relates to the prevention and treatment of breast cancer in a subject, for example a female subject. Accordingly, this invention provides methods of a) treating a subject suffering from breast cancer; b) preventing, suppressing, inhibiting or reducing the incidence of breast cancer in a subject; c) delaying the progression of breast cancer in a subject suffering from breast cancer; d) preventing the recurrence of breast cancer in a subject; e) treating the recurrence of breast cancer in a subject suffering from breast cancer; and/or f) treating, preventing, suppressing or inhibiting metastasis in a subject suffering from breast cancer, by administering to the subject a therapeutically effective amount of an Androgen Receptor Antagonist and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, phatmaceutical product, hydrate, N-Oxide, crystal polymorph, prodrug or any combination thereof, as described herein.
摘要翻译：本发明涉及预防和治疗受试者，例如女性受试者的乳腺癌。因此，本发明提供了a）治疗患有乳腺癌的受试者的方法; b）预防，抑制，抑制或降低患者乳腺癌的发生率; c）延缓乳腺癌患者乳腺癌的进展; d）预防受试者乳腺癌的复发; e）治疗乳腺癌患者乳腺癌的复发; 和/或f）通过向受试者施用治疗有效量的雄激素受体拮抗剂和/或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，治疗，预防，抑制或抑制患有乳腺癌的受试者的转移，药物产品，水合物，N-氧化物，晶体多晶型物，前药或其任何组合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式