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11. 发明专利

ES2659209T3 Procedimiento para generar organismos hipermutables 未知
公开(公告)号：ES2659209T3
公开(公告)日：2018-03-14
申请号：ES01935403
申请日：2001-05-14
申请人： UNIV JOHNS HOPKINS , MORPHOTEK INC , NICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH
发明人： NICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH W
IPC分类号： A01K67/027 , C12N15/10 , C07K14/47 , C12N15/01 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
摘要： Procedimiento para generar una célula genéticamente estable in vitro que comprende una mutación en un gen de interés, comprendiendo dicho procedimiento las etapas de: cultivar una célula de mamífero hipermutable que comprende el gen de interés y un polinucleótido que codifica una proteína hPMS2 de reparación de errores de apareamiento del péptido truncado que consiste en los 133 aminoácidos N-terminales de HPMS2 (hPMS2-134); probar la célula para determinar si el gen de interés alberga una mutación y detectar la mutación; y restaurar la actividad de reparación de errores de apareamiento a la célula disminuyendo o suprimiendo la expresión del polinucleótido que codifica hPMS2-134, generando de ese modo una célula genéticamente estable que comprende una mutación en un gen de interés.

12. 发明专利

CA2399191C METHODS FOR GENERATING HYPERMUTABLE YEAST 未知
公开(公告)号：CA2399191C
公开(公告)日：2010-12-14
申请号：CA2399191
申请日：2001-02-21
申请人： UNIV JOHNS HOPKINS , MORPHOTEK INC
发明人： NICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH W
IPC分类号： C12N15/81 , C12N1/18 , C12N1/19 , C12N5/10 , C12N15/01 , C12N15/74
摘要： Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but after selection of desired mutant yeast strains, they can be rendered genetically stable by restoring the mismatch repair system to proper functionality.

13. 发明专利

AT399871T 未知
公开(公告)号：AT399871T
公开(公告)日：2008-07-15
申请号：AT00989525
申请日：2000-12-28
申请人： MORPHOTEK INC , UNIV JOHNS HOPKINS
发明人： NICOLAIDES NICHOLAS C , GRASSO LUIGI , SASS PHILIP M , KINZLER KENNETH , VOGELSTEIN BERT
IPC分类号： C12N15/82 , A01H5/00 , C07K14/415 , C12N5/10 , C12N15/10 , C12N15/29
摘要： Blockade of mismatch repair in a plant can lead to hypermutation and a new genotype and/or phenotype. One approach used to generate hypermutable plants is through the expression of dominant negative alleles of mismatch repair genes in transgenic plants or derived cells. By introducing these genes into cells and transgenic plants, new cell lines and plant varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. Moreover, methods to inhibit the expression and activity of endogenous plant MMR genes and their encoded products are also useful to generate hypermutable plants.

14. 发明申请

WO0159092A2 METHODS FOR GENERATING HYPERMUTABLE MICROBES 审中-公开
标题翻译：用于生成可转移微生物的方法
公开(公告)号：WO0159092A2
公开(公告)日：2001-08-16
申请号：PCT/US0104339
申请日：2001-02-12
申请人： UNIV JOHNS HOPKINS , NICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH W
发明人： NICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH W
IPC分类号： C12N15/01 , C12N15/10 , C12N15/00
CPC分类号： C12N15/1024 , C12N15/01 , C12N15/102
摘要： Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficinecy and exogenously applied mutagens. Stable bacteria containing desirable output traits are obtained by restoring mismatch reparir activity to the bacteria.
摘要翻译：操纵细菌以使用错配修复蛋白的显性负等位基因产生理想的输出性状。通过错配修复缺陷和外源应用诱变剂的组合实现增强的超突变。通过恢复对细菌的错配修复活性获得含有所需输出性状的稳定细菌。

15. 发明专利

JP2013031445A Method for generating hypermutable organism 审中-公开
标题翻译：用于生成可转换有机物的方法
公开(公告)号：JP2013031445A
公开(公告)日：2013-02-14
申请号：JP2012193802
申请日：2012-09-04
申请人： Johns Hopkins Univ , ザジョンズホプキンスユニバーシティ , Morphotek Inc , モルフォテック・インコーポレーテッド , Nicholas C Nicolaides , ニコラスシー. ニコライデス , Philip M Sass , フィリップエム. サス , Luigi Grasso , ルイージグラッソ , Bert Vogelstein , ベールボーゲルステイン , Kenneth W Kinzler , ケネスダブリュ. キンズラー
发明人： NICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH W
IPC分类号： A01K67/027 , C12N15/09 , C07K14/47 , C12N5/071 , C12N15/01 , C12N15/10 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide a method for rendering cells hypermutable, and hypermutable cell lines altered genetically and phenotypically.SOLUTION: The invention relates to use of dominant negative alleles of human mismatch repair genes to generate hypermutable cells and organisms; the use of introducing genes into cells and transgenic animals by which new cell lines and animal varieties with new and useful properties can be prepared more efficiently than by relying on the natural rate of mutation; and use of mutagens for enhancing a rate of further augmented mutation.
摘要翻译：要解决的问题：提供用于使细胞变性的方法，以及基因上和表型上改变的超可变细胞系。解决方案：本发明涉及使用人类错配修复基因的显性负等位基因来产生超可变细胞和生物体; 将基因引入细胞和转基因动物中，通过其可以比通过依赖于自然的突变率更有效地制备具有新的和有用的新的细胞系和动物品种的基因; 并使用诱变剂提高进一步增强突变率。版权所有（C）2013，JPO＆INPIT

16. 发明专利

JP2012100676A Antibody with immune effector activity and that internalizes in endosialin-positive cell 审中-公开
标题翻译：具有免疫效应的抗体以及内皮素阳性细胞内部化
公开(公告)号：JP2012100676A
公开(公告)日：2012-05-31
申请号：JP2011290448
申请日：2011-12-29
申请人： Morphotek Inc , モルフォテック、インク.
发明人： GRASSO LUIGI , NICOLAIDES NICHOLAS C , SASS PHILIP M
IPC分类号： C12N15/09 , A61K39/395 , A61K45/00 , A61K49/00 , A61K51/00 , A61P35/00 , A61P43/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/00 , C12P21/08
CPC分类号： A61K39/39583 , A61K47/6825 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/28 , C07K16/2851 , C07K2317/732 , C07K2317/77
摘要： PROBLEM TO BE SOLVED: To provide monoclonal and polyclonal antibodies that specifically bind to cells expressing endosialin and have the ability in the alternative to become internalized by the cells and to induce immune effector activity such as antibody-dependent cellular cytotoxicity; and to provide uses thereof.SOLUTION: The anti-endosialin antibodies are useful in specific delivery of agents to endosialin-expressing cells as well as in eliciting immune-effector activity particularly on tumor cells and neovascular cells and precursors. The invention is also related to nucleotides encoding the antibodies, cells expressing the antibodies, methods for detecting cancer and neovascular cells, and methods for treating cancer and neovascular disease using the antibodies, derivatives and fragments thereof.
摘要翻译：要解决的问题：提供特异性结合表达内皮素的细胞的单克隆和多克隆抗体，并且具有替代性的能力被细胞内化并诱导免疫效应子活性如抗体依赖性细胞毒性; 并提供其用途。解决方案：抗内皮唾液酸蛋白抗体可用于特异性递送代谢物到表达唾液酸的细胞，以及引发免疫效应物特异性对肿瘤细胞和新生血管细胞和前体的活性。本发明还涉及编码抗体的核苷酸，表达抗体的细胞，用于检测癌症和新生血管细胞的方法，以及使用抗体，其衍生物和片段治疗癌症和新生血管疾病的方法。版权所有（C）2012，JPO＆INPIT

17. 发明专利

JP2013150618A Method for inhibiting binding of endosialin to ligand 审中-公开
标题翻译：抑制内啡肽与配体结合的方法
公开(公告)号：JP2013150618A
公开(公告)日：2013-08-08
申请号：JP2013041304
申请日：2013-03-01
申请人： Morphotek Inc , モルフォテック、インク.
发明人： ZHOU YUHONG , TOMKOWICZ BRIAN E , GRASSO LUIGI , SASS PHILIP M , NICOLAIDES NICHOLAS C
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61K49/00 , A61K51/00 , A61P27/02 , A61P29/00 , A61P35/00 , C07K16/30 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
CPC分类号： C07K16/2851 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/30
摘要： PROBLEM TO BE SOLVED: To provide methods for inhibiting the interaction of endosialin with endosialin ligands.SOLUTION: The inhibition is effectuated by blocking the interaction of endosialin expressed on the cell surface with ligands such as fibronectin and collagen using an anti-endosialin antibody M4, also known as FB5, thereby inhibiting angiogenesis and neovascularization.
摘要翻译：要解决的问题：提供抑制内皮唾液酸与内皮唾液酸配体相互作用的方法。解决方案：通过使用抗内皮唾液酸蛋白抗体M4阻断在细胞表面上表达的内皮唾液酸与配体如纤连蛋白和胶原的相互作用来实现抑制，也称为FB5，从而抑制血管生成和新生血管形成。

18. 发明申请

WO0159092A9 METHODS FOR GENERATING HYPERMUTABLE BACTERIA 审中-公开
标题翻译：产生超嗜热菌的方法
公开(公告)号：WO0159092A9
公开(公告)日：2002-10-24
申请号：PCT/US0104339
申请日：2001-02-12
申请人： UNIV JOHNS HOPKINS , NICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH W
发明人： NICOLAIDES NICHOLAS C , SASS PHILIP M , GRASSO LUIGI , VOGELSTEIN BERT , KINZLER KENNETH W
IPC分类号： C12N15/01 , C12N15/10 , C12N1/20
CPC分类号： C12N15/1024 , C12N15/01 , C12N15/102
摘要： Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficinecy and exogenously applied mutagens. Stable bacteria containing desirable output traits are obtained by restoring mismatch reparir activity to the bacteria.
摘要翻译：使用错配修复蛋白的显性负性等位基因操纵细菌以产生理想的产量性状。通过错配修复缺陷和外源应用的诱变剂的组合实现超强突变。通过恢复对细菌的错配reparir活性获得含有理想产量性状的稳定细菌。

19. 发明专利

JP2012100677A Anti-mesothelin antibody 有权
标题翻译：抗丝氨酸抗体
公开(公告)号：JP2012100677A
公开(公告)日：2012-05-31
申请号：JP2011290449
申请日：2011-12-29
申请人： Morphotek Inc , モルフォテック、インク.
发明人： EBEL WOLFGANG , GRASSO LUIGI , NICOLAIDES NICHOLAS C , SASS PHILIP M , ROUTHIER ERIC
IPC分类号： C12N15/09 , C07K16/28
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/56 , C07K2317/732 , C07K2317/77
摘要： PROBLEM TO BE SOLVED: To provide antibodies that specifically bind to mesothelin and uses thereof.SOLUTION: This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce immune effector activity such as antibody-dependent cellular cytotoxicity. The antibodies are used in specific delivery of pharmacologic agents to mesothelin-expressing cells as well as eliciting immune effector activity particularly on tumor cells and precursors. The invention is also related to monoclonal antibodies, polyclonal antibodies, antibody derivatives, such as human, humanized, and chimeric monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods for treating cancer using the antibodies, derivatives and fragments.
摘要翻译：待解决的问题：提供特异性结合间皮素的抗体及其用途。解决方案：本发明涉及单克隆和多克隆抗体的使用，其特异性结合并被间皮素阳性细胞内化，并且还诱导免疫效应子活性如抗体依赖性细胞毒性。所述抗体用于特异性递送表达间皮素的细胞的药理学试剂，以及引发免疫效应子活性，特别是对肿瘤细胞和前体。本发明还涉及单克隆抗体，多克隆抗体，抗体衍生物，例如人，人源化和嵌合单克隆抗体，抗体片段，表达单克隆抗体的哺乳动物细胞，衍生物和片段，以及使用抗体衍生物治疗癌症的方法和碎片。版权所有（C）2012，JPO＆INPIT

20. 发明专利

JP2012100675A Antibody with immune effector activity and that internalizes in folate receptor alpha-positive cell 审中-公开
标题翻译：具有免疫效应的抗体，并且内含在受体亲和细胞中的内含子
公开(公告)号：JP2012100675A
公开(公告)日：2012-05-31
申请号：JP2011290406
申请日：2011-12-29
申请人： Morphotek Inc , モルフォテック、インク.
发明人： GRASSO LUIGI , NICOLAIDES NICHOLAS C , SASS PHILIP M
IPC分类号： C12N15/09 , A61K39/395 , A61K51/00 , A61P35/00 , C07K14/705 , C07K16/28 , C07K16/46 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/53
CPC分类号： C07K16/30 , A61K31/704 , A61K31/7068 , A61K39/39558 , A61K47/6825 , A61K47/6851 , A61K47/6869 , A61K47/6897 , B82Y5/00 , C07K16/22 , C07K16/28 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/732 , C07K2317/76 , C07K2317/77
摘要： PROBLEM TO BE SOLVED: To provide antibodies targeting folate receptor alpha (FRA) that overexpresses in a variety of carcinoma, and diagnostic and therapeutic agents for cancers.SOLUTION: This invention relates to: the use of monoclonal and polyclonal antibodies that specifically bind to cells expressing FRA and have the ability in the alternative to become internalized by the cells and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity; nucleotides encoding the antibodies; cells expressing the antibodies; and methods for detecting and treating cancer cells using the antibodies.

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