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11. 发明申请

US20060160992A1 Method of identifying cells expressing a protein having pre-B cell growth-supporting ability 审中-公开
公开(公告)号：US20060160992A1
公开(公告)日：2006-07-20
申请号：US11281344
申请日：2005-11-18
申请人： Toshio Hirano , Tsuneyasu Kaisho
发明人： Toshio Hirano , Tsuneyasu Kaisho
IPC分类号： C07K14/74 , C07H21/04 , C12P21/06 , A61K39/395 , C12N1/21 , C07K16/28
CPC分类号： C07K14/475 , C07K16/28 , G01N33/564
摘要： A gene encoding a novel membrane protein polypeptide having pre-B cell growth-supporting ability, and a novel membrane protein polypeptide consisting of 180 amino acid residues having pre-B cell growth-supporting ability or a part of it. A method for producing said novel membrane protein polypeptide by preparing transformants by transforming a host cell with a vector containing said gene and culturing said transformants. A monoclonal antibody recognizing said novel membrane protein polypeptide. The above gene encodes the membrane protein having pre-B cell growth-supporting ability. The homogeneous and purified novel membrane protein polypeptide can be produced in large quantities and in addition, monoclonal antibodies recognizing said polypeptide can be produced; thus it becomes possible to identify rheumatoid arthritis (RA) and also prepare reagents for the clinical diagnosis thereof.

12. 发明授权

US5362489A Use of recombinant B-cell differentiation factor for augmenting antibody production and stimulating bone marrow proliferation 失效
标题翻译：使用重组B细胞分化因子增强抗体产生和刺激骨髓增殖
公开(公告)号：US5362489A
公开(公告)日：1994-11-08
申请号：US877731
申请日：1992-05-04
申请人： Tadamitsu Kishimoto , Toshio Hirano , Hiroshi Matsui , Yoshiyuki Takahara , Yukio Akiyama , Akira Okano
发明人： Tadamitsu Kishimoto , Toshio Hirano , Hiroshi Matsui , Yoshiyuki Takahara , Yukio Akiyama , Akira Okano
IPC分类号： A61K38/00 , C07K14/54 , C07K14/55 , C12N1/21 , C12N15/24 , A61K37/02
CPC分类号： C07K14/54 , C07K14/5403 , C07K14/5412 , C07K14/55 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/75 , Y10S514/885
摘要： A purified human B-cell differentiation factor (BCDF) which does not have a natural signal peptide attached to the N-terminal thereof, DNA encoding the BCDF, transformed cells containing such DNA, a process for producing and obtaining the BCDF, compositions containing the BCDF and various therapeutic uses are disclosed.
摘要翻译：不具有与其N-末端连接的天然信号肽的纯化人B细胞分化因子（BCDF），编码BCDF的DNA，含有该DNA的转化细胞，制备和获得BCDF的方法，含有公开了BCDF和各种治疗用途。

13. 发明授权

US5360894A C/EBP2 gene and recombinant C/EBP2 失效
标题翻译： C / EBP2基因和重组C / EBP2
公开(公告)号：US5360894A
公开(公告)日：1994-11-01
申请号：US12735
申请日：1993-02-03
申请人： Tadamitsu Kishimoto , Toshio Hirano , Shizuo Akira , Hiroshi Isshiki , Osamu Tanabe , Shigemi Kinoshita , Takuya Shimamoto
发明人： Tadamitsu Kishimoto , Toshio Hirano , Shizuo Akira , Hiroshi Isshiki , Osamu Tanabe , Shigemi Kinoshita , Takuya Shimamoto
IPC分类号： C12N1/21 , C07K14/00 , C07K14/47 , C12N15/09 , C12P21/02 , C12R1/19 , C07K3/00 , C12N15/00 , C12P19/34
CPC分类号： C07K14/4705
摘要： This invention relates to a gene which codes for the IL-6 gene expression inducing nuclear factor C/EBP2 capable of binding sequence-specifically to the palindrome structure SEQ ID NO:2 located in the transcriptional regulatory region of the IL-6 gene; an expression plasmid with the C/EBP2 gene incorporated therein; an transformant harboring the expression plasmid; a recombinant C/EBP2 obtained by expressing the C/EBP2 gene; and a method of producing the recombinant C/EBP2.
摘要翻译：本发明涉及编码能够与位于IL-6基因的转录调节区中的回文结构SEQ ID NO：2的序列特异性结合的IL-6基因表达诱导核因子C / EBP2的基因; 含有C / EBP2基因的表达质粒; 携带表达质粒的转化体; 通过表达C / EBP2基因获得的重组C / EBP2; 以及生产重组C / EBP2的方法。

14. 发明授权

US5310550A Method of treating thrombocytopenia using human BCDF in combination with IL-3 失效
标题翻译：使用人BCDF联合IL-3治疗血小板减少症的方法
公开(公告)号：US5310550A
公开(公告)日：1994-05-10
申请号：US818527
申请日：1992-01-09
申请人： Tadamitsu Kishimoto , Toshio Hirano , Hideo Kimura , Toshiyuki Ishibashi , Yukio Akiyama , Akira Okano
发明人： Tadamitsu Kishimoto , Toshio Hirano , Hideo Kimura , Toshiyuki Ishibashi , Yukio Akiyama , Akira Okano
IPC分类号： A61K38/00 , A61K38/20 , A61P7/04 , C07K14/00 , C07K14/47 , C07K14/505 , C07K14/52 , C07K14/53 , C07K14/535 , C07K14/54 , C07K14/545 , A61K37/66 , A61K37/02
CPC分类号： A61K38/204
摘要： Thrombocytopenia is treated by administering a subject suffering from thrombocytopenia a composition containing human B cell differentiation activity in combination with IL-3.
摘要翻译：通过给予患有血小板减少症的受试者与IL-3组合含有人B细胞分化活性的组合物来治疗血小板减少症。

15. 发明授权

US4616271A Digital audio system with automatic fade in and fade out operations 失效
标题翻译：数字音频系统具有自动淡入和淡出操作
公开(公告)号：US4616271A
公开(公告)日：1986-10-07
申请号：US674667
申请日：1984-11-26
申请人： Kenichiro Yasukawa , Toshio Hirano , Masayuki Yoshida , Junichi Yoshio
发明人： Kenichiro Yasukawa , Toshio Hirano , Masayuki Yoshida , Junichi Yoshio
IPC分类号： H03F3/217 , G11B20/10 , H03F3/20 , H03G3/00 , H03G3/02 , H03M1/08 , H04B1/10 , H04B14/02 , G11B5/02 , G11B5/09
CPC分类号： G11B20/10527
摘要： A digital audio system constructed to reproduce an audio signal by separating low frequency components of a PAM (Pulse Amplitude Modulation) signal made up of pulses being produced at predetermined time intervals and representing a predetermined audio signal, the digital audio system including a pulse width control means for varying the pulse width of each of the pulses of the PAM signal in accordance with a predetermined command signal, whereby an automatic fade in and fade out operation is performed.
摘要翻译：一种数字音频系统，被构造为通过分离由预定时间间隔产生的脉冲组成的PAM（脉冲幅度调制）信号的低频分量并且表示预定音频信号来再现音频信号，该数字音频系统包括脉冲宽度控制用于根据预定的命令信号改变PAM信号的每个脉冲的脉冲宽度的装置，从而执行自动淡入和淡出操作。

16. 发明授权

US09057682B2 Blade vibration measuring apparatus 有权
标题翻译：刀片振动测量仪
公开(公告)号：US09057682B2
公开(公告)日：2015-06-16
申请号：US13613398
申请日：2012-09-13
申请人： Kohichi Nakayama , Kenji Osaki , Hisashi Matsuda , Hitoshi Sakakida , Toshio Hirano , Toshiaki Hirate , Sueyoshi Mizuno , Ikuo Saito
发明人： Kohichi Nakayama , Kenji Osaki , Hisashi Matsuda , Hitoshi Sakakida , Toshio Hirano , Toshiaki Hirate , Sueyoshi Mizuno , Ikuo Saito
IPC分类号： G01N29/12 , G01N29/04 , G01N29/00 , F01D5/16 , F01D21/00 , G01H3/04 , G01H3/10
CPC分类号： G01N29/12 , F01D5/16 , F01D21/003 , F05D2220/31 , G01H3/04 , G01H3/10
摘要： According to the embodiment, there is provided a blade vibration measuring apparatus, having, a contactless displacement sensor which outputs a displacement measurement signal as measuring a displacement of a turbine moving blade in a rotation axis direction, a blade top position identifying device which outputs a blade top position identification signal to identify a top position based on a distance between the contactless displacement sensor and the top position of the turbine moving blade as receiving the displacement measurement signal output from the contactless displacement sensor, and a blade vibration calculating device which calculates vibration amplitude and a vibration frequency of the turbine moving blade based on temporal variation of the distance between the contactless displacement sensor and the top position of the turbine moving blade as receiving the blade top position identification signal output from the blade top position identifying device.
摘要翻译：根据本实施方式，提供一种叶片振动测量装置，具有：无级位移传感器，其输出测定涡轮机动叶片沿旋转轴方向的位移的位移测量信号;叶片顶部位置识别装置，其输出叶片顶部位置识别信号，用于当接收从非接触位移传感器输出的位移测量信号时基于无接触位移传感器和涡轮机动叶片的顶部位置之间的距离来识别顶部位置;以及叶片振动计算装置，其计算振动基于从叶片顶部位置识别装置输出的叶片顶部位置识别信号，基于非接触位移传感器与涡轮机动叶片的顶部位置之间的距离的时间变化，涡轮机动叶片的振幅和振动频率。

17. 发明申请

US20080070836A1 Emt-Inducing Agents 审中-公开
标题翻译： Emt诱导剂
公开(公告)号：US20080070836A1
公开(公告)日：2008-03-20
申请号：US10584742
申请日：2004-12-22
申请人： Toshio Hirano , Susumu Yamashita
发明人： Toshio Hirano , Susumu Yamashita
IPC分类号： A61K38/16 , A61K31/7052 , A61P17/02 , A61P29/00 , A61P35/00 , C07H21/00 , C07K14/00 , C12N15/63 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00
摘要： The mechanism of STAT3, which is considered to play a crucial role in EMT, was elucidated using zebrafish embryos. Unexpectedly, a STAT3 target gene turned out to be zinc transporter LIV1. The present inventors studied the relationship between STAT3 and LIV1 in EMT, and further studied their relationship with zinc finger protein Snail, known for its association with EMT. The results showed that LIV1, whose expression is regulated by STAT3, activated Snail, thereby ultimately inducing EMT. LIV1 can be used as an EMT regulatory agent. Further, because EMT is involved in cancer progression, LIV1 antisense nucleotides and the like may be used as pharmaceuticals for treating cancer.
摘要翻译：被认为在EMT中发挥关键作用的STAT3的机制是使用斑马鱼胚胎来阐明的。意外的是，STAT3靶基因被证明是锌转运蛋白LIV1。本发明人研究了EMT中STAT3和LIV1之间的关系，并进一步研究了它们与与EMT相关的锌指蛋白Snail的关系。结果表明，其表达受STAT3调节的LIV1激活蜗牛，从而最终诱导EMT。 LIV1可用作EMT调节剂。此外，由于EMT涉及癌症进展，所以LIV1反义核苷酸等可以用作治疗癌症的药物。

18. 发明授权

US07049408B2 Antibody reactive with a protein having pre-B cell growth-supporting ability 有权
标题翻译：抗体与具有前B细胞生长支持能力的蛋白质反应
公开(公告)号：US07049408B2
公开(公告)日：2006-05-23
申请号：US09828217
申请日：2001-04-09
申请人： Toshio Hirano , Tsuneyasu Kaisho
发明人： Toshio Hirano , Tsuneyasu Kaisho
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395 , C12N5/20
CPC分类号： C07K14/475 , C07K16/28 , G01N33/564
摘要： A gene encoding a novel membrane protein polypeptide having pre-B cell growth-supporting ability and a membrane protein polypeptide consisting of 180 amino acid residues having pre-B cell growth-supporting ability. This gene encodes the membrane protein having pre-B cell growth-supporting ability. A method for producing a membrane protein having pre-B cell growth-supporting ability by transforming a host cell with a vector containing a gene encoding it and culturing the resulting transformants. A monoclonal antibody recognizing this membrane protein. The homogeneous and purified novel membrane protein pelypeptide can be produced in large quantities and used to produce monoclonal antibodies useful for identifying rheumatoid arthritis (RA) and for the preparation of reagents for the clinical diagnosis thereof.
摘要翻译：编码具有前B细胞生长支持能力的新型膜蛋白多肽的基因和由具有前B细胞生长支持能力的180个氨基酸残基组成的膜蛋白多肽。该基因编码具有前B细胞生长支持能力的膜蛋白。通过用含有编码它的基因的载体转化宿主细胞并培养所得的转化体来制备具有前B细胞生长支持能力的膜蛋白的方法。识别该膜蛋白的单克隆抗体。均匀和纯化的新型膜蛋白质pelypeptide可以大量生产，并用于产生用于鉴定类风湿性关节炎（RA）和用于临床诊断的试剂的制备的单克隆抗体。

19. 发明授权

US06307023B1 Gene encoding a polypeptide having pre-B cell growth-supporting ability 有权
标题翻译：编码具有前B细胞生长支持能力的多肽的基因
公开(公告)号：US06307023B1
公开(公告)日：2001-10-23
申请号：US09517739
申请日：2000-03-03
申请人： Toshio Hirano , Tsuneyasu Kaisho
发明人： Toshio Hirano , Tsuneyasu Kaisho
IPC分类号： C07K14475
CPC分类号： C07K14/52 , A61K38/00
摘要： The present invention provides (1) a polypeptide containing amino acids 1 to 269 of the amino acid sequence shown in SEQ ID No: 1, (2) polypeptide containing amino acids 1 to 290 of the amino acid sequence shown in SEQ ID No. 1, (3) a polypeptide containing amino acids −28 to 269 of the amino acid sequence shown in SEQ ID No. 1, and (4) a polypeptide containing amino acids −28 to 290 of the amino acid sequence shown in SEQ ID No. 1. The present invention also provides a fusion protein in which residues 1 to 269 of SEQ ID No. 1 are linked to a second polypeptide and a fusion protein in which residues 1 to 290 of SEQ ID No. 1 are linked to a second polypeptide.
摘要翻译：本发明提供（1）包含SEQ ID No：1所示氨基酸序列的氨基酸1至269的多肽，（2）包含SEQ ID No.1所示氨基酸序列的氨基酸1至290的多肽，（3）包含SEQ ID No.1所示的氨基酸序列的氨基酸-28〜269的多肽，（4）SEQ ID No.1所示的氨基酸序列的氨基酸-28〜290的多肽。本发明还提供了一种融合蛋白，其中SEQ ID No.1的残基1至269连接到第二多肽和融合蛋白，其中SEQ ID No.1的残基1至290与第二多肽连接。

20. 发明授权

US06232453B1 Gene encoding a polypeptide having pre-B cell growth-supporting ability 失效
标题翻译：编码具有前B细胞生长支持能力的多肽的基因
公开(公告)号：US06232453B1
公开(公告)日：2001-05-15
申请号：US08997252
申请日：1997-12-23
申请人： Toshio Hirano , Tsuneyasu Kaisho
发明人： Toshio Hirano , Tsuneyasu Kaisho
IPC分类号： C07H2104
CPC分类号： C07K14/52 , A61K38/00
摘要： Isolated DNAs which encode polypeptides having pre-B cell growth-supporting ability.
摘要翻译：编码具有前B细胞生长支持能力的多肽的分离的DNA

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