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11. 发明授权

US06949079B1 Programmable, fluid pressure actuated blood processing systems and methods 有权
标题翻译：可编程，流体压力驱动的血液处理系统和方法
公开(公告)号：US06949079B1
公开(公告)日：2005-09-27
申请号：US09390268
申请日：1999-09-03
申请人： Tom Westberg , Rohit Vishnoi
发明人： Tom Westberg , Rohit Vishnoi
IPC分类号： A61M1/10 , A61M1/30 , A61M1/36 , F04B13/02 , F04B43/02 , F04B49/06 , A61M37/00 , C02F1/44 , C02F9/00
CPC分类号： F04B43/026 , A61M1/1006 , A61M1/1037 , A61M1/1053 , A61M1/1062 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3696 , A61M2205/128 , A61M2205/331 , A61M2205/3393 , F04B13/02 , F04B49/065 , F04B2205/09
摘要： Programmable, fluid pressure actuated blood processing systems and methods are used in association a blood separation device. The systems and methods employ a cassette, which contains several preformed, pneumatically actuated pump stations, several preformed fluid flow paths, and several preformed, pneumatically actuated valves in the fluid flow paths. The systems and methods also employ a programmable pneumatic actuator to hold the cassette and selectively apply pneumatic force to the valves and pump stations.
摘要翻译：血液分离装置结合使用可编程的流体压力致动血液处理系统和方法。这些系统和方法采用一个盒，其包含几个预先形成的气动致动泵站，若干预制流体流动路径以及流体流动路径中的几个预先形成的，气动致动的阀。这些系统和方法还采用可编程气动致动器来保持盒并且选择性地向阀和泵站施加气动力。

12. 发明授权

US06706008B2 Automated system and method for withdrawing compounds from blood 有权
标题翻译：自动化系统和从血液中提取化合物的方法
公开(公告)号：US06706008B2
公开(公告)日：2004-03-16
申请号：US09800133
申请日：2001-03-06
申请人： Rohit Vishnoi , Richard I. Brown , Kyungyoon Min , Tom Westberg
发明人： Rohit Vishnoi , Richard I. Brown , Kyungyoon Min , Tom Westberg
IPC分类号： A61M3700
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/342 , A61M1/3441 , A61M1/3672 , A61M1/3675 , A61M1/3679 , A61M1/3687 , A61M1/3692 , A61M1/3696 , A61M2205/12
摘要： Automated systems and methods for withdrawing a selected compound from blood are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further combines the separated component with a solvent so as to remove a compound from the blood component.
摘要翻译：公开了用于从血液中取出选定化合物的自动化系统和方法。系统和方法利用安装在可重复使用的硬件部件或模块上的一次性流体回路。系统从供体或患者抽出血液，将血液分离成两个或更多个组分，并进一步将分离的组分与溶剂组合，以从血液组分中除去化合物。

13. 发明授权

US06348156B1 Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma 有权
标题翻译：具有传感器的血液处理系统和方法，用于检测由于存在细胞成分引起的污染或由于血浆的存在引起的稀释
公开(公告)号：US06348156B1
公开(公告)日：2002-02-19
申请号：US09390492
申请日：1999-09-03
申请人： Rohit Vishnoi , Tom Westberg , Matthew R. Muller , Kelly B Smith , Michel L. F. Joie , Mark R Vandlik
发明人： Rohit Vishnoi , Tom Westberg , Matthew R. Muller , Kelly B Smith , Michel L. F. Joie , Mark R Vandlik
IPC分类号： B01D2126
CPC分类号： B01D21/34 , A61M1/0236 , A61M1/3496 , A61M1/3646 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0429 , A61M2205/125 , A61M2205/128 , A61M2205/331 , A61M2205/3393 , B01D17/0217 , B01D21/2444 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/302 , B01D2221/08 , B01D2221/10
摘要： Blood processing systems and methods employ two sensors, one to detect a condition of plasma exiting a separation device and another sensor to detect a condition of a cellular component exiting the separation device. The first sensor detects, e.g., contamination of the plasma due to presence of unwanted cellular components. The second sensor detects, e.g., dilution of the cellular component due to presence of plasma. Blood processing parameters are carried out based, at least in part, by conditions detected by one or both of the sensors.
摘要翻译：血液处理系统和方法采用两个传感器，一个用于检测离开分离装置的等离子体的状态，另一个传感器用于检测离开分离装置的细胞组分的状况。第一传感器检测例如由于存在不想要的细胞组分而导致的等离子体的污染。第二传感器例如由于存在等离子体而检测细胞成分的稀释。至少部分地基于由一个或两个传感器检测到的条件进行血液处理参数。

14. 发明授权

US07517333B2 Blood processing systems and methods that employ an in-line, flexible leukofilter 有权
标题翻译：血液处理系统和方法采用在线柔性白细胞滤器
公开(公告)号：US07517333B2
公开(公告)日：2009-04-14
申请号：US10765498
申请日：2004-01-26
申请人： Mark R Vandlik , Michael J Kast , Kelly B Smith , Tom Westberg , Rohit Vishnoi
发明人： Mark R Vandlik , Michael J Kast , Kelly B Smith , Tom Westberg , Rohit Vishnoi
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/3696 , A61M1/0209 , A61M1/0218 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3633 , A61M1/3636 , A61M1/3693 , A61M2205/12 , A61M2205/128 , A61M2205/331 , A61M2205/3393
摘要： Systems and methods separate pump the blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter has a filtration medium enclosed within a flexile housing. The systems and methods can employ a fixture to restrain expansion of the flexible filter housing during operation of the pump.
摘要翻译：系统和方法将血液细胞通过直列式过滤器分离成血细胞储存容器。白细胞滤器具有封装在柔性壳体内的过滤介质。该系统和方法可以使用夹具来在泵的操作期间抑制柔性过滤器壳体的膨胀。

15. 发明申请

US20060178612A9 Blood processing systems with fluid flow cassette with a pressure actuated pump chamber and in-line air trap 审中-公开
公开(公告)号：US20060178612A9
公开(公告)日：2006-08-10
申请号：US10828440
申请日：2004-04-20
申请人： Mark Vandlik , Tom Westberg
发明人： Mark Vandlik , Tom Westberg
IPC分类号： A61M37/00
CPC分类号： A61M1/3696 , A61M1/0218 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1086 , A61M1/1087 , A61M1/1096 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3633 , A61M2205/128 , A61M2205/331 , A61M2205/3334 , A61M2205/3393 , F04B13/02 , F04B43/026 , F04B49/065 , F04B2205/09
摘要： A blood processing system comprises a processing chamber to process blood and a fluid flow cassette that communicates with the processing chamber. The cassette comprises a body, a pump chamber formed in the body, and a flexible diaphragm on the pump chamber responsive to an applied fluid pressures for flexure toward and away from the pump chamber to pump fluid through the pump chamber. The cassette also includes a flow path formed, at least in part, in the body to couple the pump chamber in fluid flow communication with the processing chamber, to convey fluid pumped by the pump chamber into the processing chamber. The cassette also includes an in line cavity formed in the body and located in the flow path to trap air to prevent entry of air into the processing chamber.

16. 发明申请

US20050234385A1 Blood processing systems with fluid flow cassette with a pressure actuated pump chamber and in-line air trap 审中-公开
标题翻译：血液处理系统具有流体流动盒，带有压力驱动泵室和直列空气阱
公开(公告)号：US20050234385A1
公开(公告)日：2005-10-20
申请号：US10828440
申请日：2004-04-17
申请人： Mark Vandlik , Tom Westberg
发明人： Mark Vandlik , Tom Westberg
IPC分类号： A61M1/10 , A61M1/30 , A61M1/36 , A61M37/00 , F04B13/02 , F04B43/02 , F04B49/06
CPC分类号： A61M1/3696 , A61M1/0218 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1086 , A61M1/1087 , A61M1/1096 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3633 , A61M2205/128 , A61M2205/331 , A61M2205/3334 , A61M2205/3393 , F04B13/02 , F04B43/026 , F04B49/065 , F04B2205/09
摘要： A blood processing system comprises a processing chamber to process blood and a fluid flow cassette that communicates with the processing chamber. The cassette comprises a body, a pump chamber formed in the body, and a flexible diaphragm on the pump chamber responsive to an applied fluid pressures for flexure toward and away from the pump chamber to pump fluid through the pump chamber. The cassette also includes a flow path formed, at least in part, in the body to couple the pump chamber in fluid flow communication with the processing chamber, to convey fluid pumped by the pump chamber into the processing chamber. The cassette also includes an in line cavity formed in the body and located in the flow path to trap air to prevent entry of air into the processing chamber.
摘要翻译：血液处理系统包括处理血液的处理室和与处理室连通的流体流动盒。盒体包括主体，形成在主体中的泵室，以及响应于所施加的流体压力的柔性膜片，其响应于朝向和远离泵室的挠曲，以将流体泵送通过泵室。该盒还包括至少部分地形成在主体中的流路，以将泵室与处理室流体流动连通，以将泵室泵送的流体输送到处理室中。该盒还包括形成在主体中并且位于流动路径中的吸入空气以防止空气进入处理室的入口腔。

17. 发明授权

US07613173B2 Interconnect network for operation within a communication node 有权
标题翻译：互连网络，用于在通信节点内运行
公开(公告)号：US07613173B2
公开(公告)日：2009-11-03
申请号：US11225009
申请日：2005-09-14
申请人： Frank Kastenholz , Tom Westberg , Steven R. Willis
发明人： Frank Kastenholz , Tom Westberg , Steven R. Willis
IPC分类号： H04L12/66
CPC分类号： H04L49/15 , H04L49/201 , H04L49/30 , H04L49/35
摘要： An interconnect network for operation within communication node, wherein the interconnect network may have features including the ability to transfer a variety of communication protocols, scalable bandwidth and reduced down-time. According to one embodiment of the invention, the communication node includes a plurality of I/O channels for coupling information into and out of the node, and the interconnect network includes at least one local interconnect module having local transfer elements for transferring information between the plurality of I/O channels; and scaling elements for expanding the interconnect network to include additional local interconnect modules, such that information can be transferred between the local interconnect modules included in the interconnect network.
摘要翻译：用于在通信节点内操作的互连网络，其中所述互连网络可以具有包括传送各种通信协议，可扩展带宽和减少停机时间的能力的特征。根据本发明的一个实施例，通信节点包括用于将信息耦合到和流出节点的多个I / O信道，并且互连网络包括至少一个本地互连模块，其具有用于在多个的I / O通道; 以及用于扩展互连网络以包括附加本地互连模块的缩放元件，使得可以在包括在互连网络中的本地互连模块之间传送信息。

18. 发明申请

US20060007946A1 Interconnect network for operation within a communication node 有权
公开(公告)号：US20060007946A1
公开(公告)日：2006-01-12
申请号：US11225009
申请日：2005-09-14
申请人： Frank Kastenholz , Tom Westberg , Steven Willis
发明人： Frank Kastenholz , Tom Westberg , Steven Willis
IPC分类号： H04L12/28
CPC分类号： H04L49/15 , H04L49/201 , H04L49/30 , H04L49/35
摘要： An interconnect network for operation within communication node, wherein the interconnect network may have features including the ability to transfer a variety of communication protocols, scalable bandwidth and reduced down-time. According to one embodiment of the invention, the communication node includes a plurality of I/O channels for coupling information into and out of the node, and the interconnect network includes at least one local interconnect module having local transfer elements for transferring information between the plurality of I/O channels; and scaling elements for expanding the interconnect network to include additional local interconnect modules, such that information can be transferred between the local interconnect modules included in the interconnect network.

19. 发明申请

US20050170493A1 Disposable sample processing module for detecting nucleic acids 有权
标题翻译：用于检测核酸的一次性样品处理模块
公开(公告)号：US20050170493A1
公开(公告)日：2005-08-04
申请号：US10982292
申请日：2004-11-05
申请人： Tim Patno , Tom Westberg
发明人： Tim Patno , Tom Westberg
IPC分类号： C12M1/34
CPC分类号： B01L3/502738 , B01F5/0256 , B01F5/0644 , B01F13/0059 , B01L3/0268 , B01L7/00 , B01L2200/0689 , B01L2300/0816 , B01L2300/0867 , B01L2400/0478 , B01L2400/0487 , B01L2400/065 , C12N15/1003
摘要： A disposable sample processing module is provided for processing DNA or RNA samples. The module includes a hybridization chamber adapted to receive an oligonucleotide covalently bonded to an internal surface of the hybridization chamber. The module also include a sample well adapted to hold a DNA or RNA sample, said sample well being coupled to the hybridization chamber, a moveable valve plate disposed between the sample well and hybridization chamber, said moveable valve plate having a first position that allows transfer of the DNA or RNA sample from the sample well to the hybridization chamber and a second position that blocks transfer to the hybridization chamber and a manifold adapted to exchange fluids with the hybridization chamber to hybridize the DNA or RNA sample with the oligonucleotide, to wash the hybridized sample and to amplify the hybridized sample.
摘要翻译：提供一次性样品处理模块来处理DNA或RNA样品。该模块包括适于接收共价键合到杂交室内表面的寡核苷酸的杂交室。该模块还包括适于保持DNA或RNA样品的样品，所述样品井与杂交室耦合，置于样品阱和杂交室之间的可移动阀板，所述可移动阀板具有允许转移的第一位置从样品孔到杂交室的DNA或RNA样品的第二个位置，阻止转移到杂交室的第二个位置和适于与杂交室交换流体的歧管以将DNA或RNA样品与寡核苷酸杂交以洗涤杂交样品并扩增杂交样品。

20. 发明授权

US06296450B1 Systems and methods for control of pumps employing gravimetric sensing 有权
标题翻译：使用重力感应控制泵的系统和方法
公开(公告)号：US06296450B1
公开(公告)日：2001-10-02
申请号：US09390269
申请日：1999-09-03
申请人： Tom Westberg , Richard E Mullen , Clement Lim Yu , Richard I Brown
发明人： Tom Westberg , Richard E Mullen , Clement Lim Yu , Richard I Brown
IPC分类号： F04B4900
CPC分类号： F04B49/06 , F04B49/12 , F04B2205/09
摘要： Systems and related methods pump fluid through a pump having a stroke volume. The systems and methods employ gravimetric control measures to monitor fluid flow through the pump. An actuator interacts with the pump during a stroke interval (TStroke) to pump fluid through the pump. The systems and methods couple a receptacle to the pump, to either dispense fluid into the pump or to receive fluid from the pump. The systems and methods detect changes in weight of the receptacle over a sample time period. The systems and methods achieve a desired flow rate (QDesired) by deriving an actual flow rate (QActual) by sensing changes in weight of the receptacle over the sample time period, taking into account the density of the fluid, and adjusting the stroke interval based upon QActual so that QDesired is achieved.
摘要翻译：系统和相关方法通过具有行程体积的泵来泵送流体。系统和方法采用重力控制措施来监测通过泵的流体流量。执行器在行程间隔（TStroke）期间与泵相互作用以泵送流体通过泵。系统和方法将容器连接到泵，以将流体分配到泵中或从泵接收流体。系统和方法在一个采样时间段内检测容器的重量变化。系统和方法通过在考虑到流体的密度的基础上感测容器在采样时间段内的重量变化并通过调节基于行程间隔的方式获得实际流量（QActual）来实现期望的流量（QDesire）在QActual上实现QDesired。

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