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11. 发明申请

US20090108194A1 METHOD AND APPARATUS FOR SELECTIVE FILTERING OF IONS 有权
标题翻译：选择性过滤离子的方法和装置
公开(公告)号：US20090108194A1
公开(公告)日：2009-04-30
申请号：US11251529
申请日：2005-09-30
申请人： Jason S. Page , Keqi Tang , Richard D. Smith
发明人： Jason S. Page , Keqi Tang , Richard D. Smith
IPC分类号： B01D59/44
CPC分类号： H01J49/066 , G01N27/622
摘要： An adjustable, low mass-to-charge (m/z) filter is disclosed employing electrospray ionization to block ions associated with unwanted low m/z species from entering the mass spectrometer and contributing their space charge to down-stream ion accumulation steps. The low-mass filter is made by using an adjustable potential energy barrier from the conductance limiting terminal electrode of an electrodynamic ion funnel, which prohibits species with higher ion mobilities from being transmitted. The filter provides a linear voltage adjustment of low-mass filtering from m/z values from about 50 to about 500. Mass filtering above m/z 500 can also be performed; however, higher m/z species are attenuated. The mass filter was evaluated with a liquid chromatography-mass spectrometry analysis of an albumin tryptic digest and resulted in the ability to block low-mass, “background” ions which account for 40-70% of the total ion current from the ESI source during peak elution.
摘要翻译：公开了一种可调节的低质量 - 电荷（m / z）滤波器，其使用电喷雾电离来阻挡与不想要的低m / z物质相关的离子进入质谱仪并且为下游离子累积步骤贡献其空间电荷。低质量过滤器通过使用来自电动离子漏斗的电导限制端子电极的可调势势垒来制造，其阻止具有较高离子迁移率的物质被传输。滤波器提供从大约50到大约500的m / z值的低质量滤波的线性电压调节。也可以执行m / z 500以上的质量过滤; 然而，更高的m / z物种减弱。通过对白蛋白胰蛋白酶消化物的液相色谱 - 质谱分析来评估质量过滤器，并且导致阻断低质量“背景”离子的能力，其占离子源的总离子电流的40-70％峰洗脱。

12. 发明授权

US07499807B1 Methods for recalibration of mass spectrometry data 失效
标题翻译：重新校准质谱数据的方法
公开(公告)号：US07499807B1
公开(公告)日：2009-03-03
申请号：US11524028
申请日：2006-09-19
申请人： Aleksey V. Tolmachev , Richard D. Smith
发明人： Aleksey V. Tolmachev , Richard D. Smith
IPC分类号： G06F3/00
CPC分类号： H01J49/0009
摘要： Disclosed are methods for recalibrating mass spectrometry data that provide improvement in both mass accuracy and precision by adjusting for experimental variance in parameters that have a substantial impact on mass measurement accuracy. Optimal coefficients are determined using correlated pairs of mass values compiled by matching sets of measured and putative mass values that minimize overall effective mass error and mass error spread. Coefficients are subsequently used to correct mass values for peaks detected in the measured dataset, providing recalibration thereof. Sub-ppm mass measurement accuracy has been demonstrated on a complex fungal proteome after recalibration, providing improved confidence for peptide identifications.
摘要翻译：公开了重新校准质谱数据的方法，其通过调整对质量测量精度具有实质性影响的参数的实验方差来提高质量精度和精度。使用通过匹配集合的测量和推定质量值编译的相关质量值对来确定最优系数，从而使总体有效质量误差和质量误差扩展最小化。随后使用系数来校正在测量数据集中检测到的峰的质量值，从而提供其重新校准。在重新校准后，在复杂的真菌蛋白质组上已经证明了亚ppm质量测量精度，为肽鉴定提供了改进的置信度。

13. 发明授权

US07148474B2 Device for two-dimensional gas-phase separation and characterization of ion mixtures 有权
标题翻译：用于二维气相分离和表征离子混合物的装置
公开(公告)号：US07148474B2
公开(公告)日：2006-12-12
申请号：US11103984
申请日：2005-04-11
申请人： Keqi Tang , Alexandre A. Shvartsburg , Richard D. Smith
发明人： Keqi Tang , Alexandre A. Shvartsburg , Richard D. Smith
IPC分类号： H01J49/40 , H01J49/26 , B01D59/44
CPC分类号： G01N27/624 , H01J49/004
摘要： The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer, an ion mobility spectrometry (IMS) drift tube, and an ion detector. In one aspect of the invention, FAIMS operating voltages are electrically floated on top of the IMS drift voltage. In the other aspect, the FAIMS/IMS interface is implemented employing an electrodynamic ion funnel, including in particular an hourglass ion funnel. The present invention improves the efficiency (peak capacity) and sensitivity of gas-phase separations; the online FAIMS/IMS coupling creates a fundamentally novel two-dimensional gas-phase separation technology with high peak capacity, specificity, and exceptional throughput.
摘要翻译：本发明涉及气相离子的分离和表征装置。该装置包括离子源，场非对称波形离子迁移谱（FAIMS）分析仪，离子迁移谱（IMS）漂移管和离子检测器。在本发明的一个方面，FAIMS工作电压在IMS漂移电压的顶部被浮动。另一方面，使用电动离子漏斗实现FAIMS / IMS接口，特别包括沙漏离子漏斗。本发明提高气相分离的效率（峰值容量）和灵敏度; 在线FAIMS / IMS耦合产生了具有高峰值容量，特异性和卓越吞吐量的基本上新颖的二维气相分离技术。

14. 发明授权

US06787760B2 Method for increasing the dynamic range of mass spectrometers 有权
标题翻译：增加质谱仪动态范围的方法
公开(公告)号：US06787760B2
公开(公告)日：2004-09-07
申请号：US09976505
申请日：2001-10-12
申请人： Mikhail Belov , Richard D. Smith , Harold R. Udseth
发明人： Mikhail Belov , Richard D. Smith , Harold R. Udseth
IPC分类号： H01J4900
CPC分类号： H01J49/4215 , H01J49/004
摘要： A method for enhancing the dynamic range of a mass spectrometer by first passing a sample of ions through the mass spectrometer having a quadrupole ion filter, whereupon the intensities of the mass spectrum of the sample are measured. From the mass spectrum, ions within this sample are then identified for subsequent ejection. As further sampling introduces more ions into the mass spectrometer, the appropriate rf voltages are applied to a quadrupole ion filter, thereby selectively ejecting the undesired ions previously identified. In this manner, the desired ions may be collected for longer periods of time in an ion trap, thus allowing better collection and subsequent analysis of the desired ions. The ion trap used for accumulation may be the same ion trap used for mass analysis, in which case the mass analysis is performed directly, or it may be an intermediate trap. In the case where collection is an intermediate trap, the desired ions are accumulated in the intermediate trap, and then transferred to a separate mass analyzer. The present invention finds particular utility where the mass analysis is performed in an ion trap mass spectrometer or a Fourier transform ion cyclotron resonance mass spectrometer.
摘要翻译：首先使离子样品通过具有四极离子过滤器的质谱仪来提高质谱仪的动态范围的方法，由此测定样品的质谱强度。从质谱中，然后鉴定该样品内的离子用于随后的喷射。随着进一步的采样将更多的离子引入质谱仪中，将适当的rf电压施加到四极离子过滤器，从而选择性地排出先前识别的不需要的离子。以这种方式，期望的离子可以在离子阱中收集较长时间，从而允许更好地收集和随后分析所需的离子。用于积聚的离子阱可以是用于质量分析的相同的离子阱，在这种情况下，质量分析是直接进行的，或者它可以是中间阱。在收集是中间阱的情况下，期望的离子积聚在中间阱中，然后转移到单独的质量分析器。在离子阱质谱仪或傅里叶变换离子回旋共振质谱仪中进行质量分析的本发明具有特殊的用途。

15. 发明授权

US06612654B2 Chair with upholstered inserts 失效
标题翻译：椅子带有软垫插入物
公开(公告)号：US06612654B2
公开(公告)日：2003-09-02
申请号：US10039206
申请日：2002-01-04
申请人： David J. Laws , Livingston E. Atkins, III , Richard D. Smith , Gregory W. Wilson
发明人： David J. Laws , Livingston E. Atkins, III , Richard D. Smith , Gregory W. Wilson
IPC分类号： A47C724
CPC分类号： A47C5/06 , A47C4/24 , A47C31/02
摘要： An upholstered folding chair includes a chair frame, a base member permanently attached to the frame, and an upholstered insert configured to slide into and removably interlock with either the base member or the chair frame. The base member includes a retaining rim, which covers and protects at least some of the edges of the upholstered insert, and the base member and upholstered insert may have interlocking members which become hidden between the base and insert when the two are interlocked together. The base can be either a back base for receiving and supporting an upholstered chair back insert, or a seat base for receiving and supporting an upholstered chair seat insert.
摘要翻译：一种装有折叠椅的椅子包括一个椅子框架，一个固定在该框架上的基座构件，以及一个被配置成滑动到可拆卸地与该底座构件或椅子框架互锁的软垫插入件。基座构件包括保持边缘，该保持边缘覆盖并保护软垫插入件的至少一些边缘，并且当两者互锁在一起时，基部构件和软垫插入件可具有互锁构件，该构件在底座和插入件之间被隐藏。基座可以是用于接收和支撑软垫椅背插入件的后底座，或用于接收和支撑软垫椅座插入件的座椅底座。

16. 发明授权

US06523641B2 Trailer mounted, retractable elevated hunting stand 有权
公开(公告)号：US06523641B2
公开(公告)日：2003-02-25
申请号：US09843371
申请日：2001-04-26
申请人： Richard D. Smith
发明人： Richard D. Smith
IPC分类号： E06C500
CPC分类号： A01M31/02
摘要： A trailer-mounted, retractable elevated hunting stand, especially but not exclusively suitable for deer hunting. The stand comprises a wheeled trailer, suitable for pulling behind a tow vehicle. The elevated stand is hingedly mounted on the trailer in a “jack-knife” configuration, with a main shaft mounted via a hinge to the trailer, and a platform atop the shaft. The platform is hinged to permit rotation for compact storage. A spring biases the shaft toward a vertical position. To use the stand, the shaft is rotated to the vertical position and the seating platform is rotated on its shaft mounting so as to be substantially horizontal when the shaft is vertical. The shaft is then locked in place. A ladder permits access to the elevated platform. The shaft telescopes for additional height if desired. The trailer permits hauling of an ATV when the stand is retracted.

17. 外观设计

USD463116S1 Carrying case 失效
公开(公告)号：USD463116S1
公开(公告)日：2002-09-24
申请号：US29153462
申请日：2002-01-04
申请人： Richard D. Smith
设计人： Richard D. Smith

18. 发明授权

US5545304A Ion current detector for high pressure ion sources for monitoring separations 失效
标题翻译：用于高压离子源的离子电流检测器用于监测分离
公开(公告)号：US5545304A
公开(公告)日：1996-08-13
申请号：US441319
申请日：1995-05-15
申请人： Richard D. Smith , Jon H. Wahl , Steven A. Hofstadler
发明人： Richard D. Smith , Jon H. Wahl , Steven A. Hofstadler
IPC分类号： G01N27/447 , H01J49/04 , B01D59/44 , G01N27/26
CPC分类号： H01J49/025 , G01N27/44717 , G01N27/4473
摘要： The present invention relates generally to any application involving the monitoring of signal arising from ions produced by electrospray or other high pressure (>100 torr) ion sources. The present invention relates specifically to an apparatus and method for the detection of ions emitted from a capillary electrophoresis (CE) system, liquid chromatography, or other small-scale separation methods. And further, the invention provides a very simple diagnostic as to the quality of the separation and the operation of an electrospray source.
摘要翻译：本发明一般涉及涉及监测由电喷雾或其它高压（> 100托）离子源产生的离子产生的信号的任何应用。本发明具体涉及用于检测从毛细管电泳（CE）系统，液相色谱法或其他小规模分离方法发射的离子的装置和方法。此外，本发明提供了关于电喷雾源的分离和操作的质量的非常简单的诊断。

19. 发明授权

US5478603A Methods for imparting stain-resistance to polyamide and wool textile products which are lightfast and durable to alkaline washing 失效
标题翻译：赋予耐碱性洗涤耐光性的聚酰胺和羊毛纺织品的耐污染性的方法
公开(公告)号：US5478603A
公开(公告)日：1995-12-26
申请号：US215986
申请日：1994-03-22
申请人： Richard D. Smith
发明人： Richard D. Smith
IPC分类号： D06M11/17 , D06M11/57 , D06M11/64 , D06M13/224 , D06M15/263 , D06M15/41 , B05D7/24 , B05D1/34 , B05D1/36
CPC分类号： D06M11/64 , D06M11/17 , D06M11/57 , D06M13/224 , D06M15/263 , D06M15/412 , Y10S8/17 , Y10T428/23986 , Y10T428/2938 , Y10T428/2958 , Y10T428/2969 , Y10T442/2574
摘要： This invention relates to an improved process for providing fibrous polyamide materials and wool materials with stain resistance and superior lightfastness that are more durable against alkaline washing. This is accomplished by treating the materials with an aqueous solution comprising a combination of a partially sulfonated novolak resin, methacrylic polymer and a soluble aluminum compound or a combination of a partially sulfonated novolak resin and a soluble aluminum compound.
摘要翻译：本发明涉及一种提供纤维聚酰胺材料和羊毛材料的改进方法，其具有耐污染性和优异的耐光性，对碱洗涤更耐用。这是通过用包含部分磺化的酚醛清漆树脂，甲基丙烯酸聚合物和可溶性铝化合物的组合的水溶液或部分磺化的酚醛清漆树脂和可溶性铝化合物的组合来处理材料来实现的。

20. 发明授权

US5396715A Microwave clothes dryer and method with fire protection 失效
标题翻译：微波干衣机和防火方法
公开(公告)号：US5396715A
公开(公告)日：1995-03-14
申请号：US257180
申请日：1994-06-09
申请人： Richard D. Smith
发明人： Richard D. Smith
IPC分类号： D06F58/20 , D06F58/26 , F26B3/34
CPC分类号： D06F58/266 , D06F58/203
摘要： Microwave clothes dryer and method in which water is introduced into the chamber in response to detection of an impending fire to immediately increase the moisture content of the clothes throughout the chamber to a level which will not sustain combustion.
摘要翻译：微波干衣机和方法，其中响应于即将发生的火灾的检测将水引入室中，以便立即将整个室中的衣服的水分含量提高至不会持续燃烧的水平。

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