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11. 发明授权

US5530155A Process for recovering L-phenylalanine 失效
标题翻译：回收L-苯丙氨酸的方法
公开(公告)号：US5530155A
公开(公告)日：1996-06-25
申请号：US409980
申请日：1995-03-24
申请人： Toyoto Hijiya , Chiaki Mochizuki , Tadashi Takemoto , Kazutaka Nagashima
发明人： Toyoto Hijiya , Chiaki Mochizuki , Tadashi Takemoto , Kazutaka Nagashima
IPC分类号： C07C227/42 , C07C227/40 , C07C229/36 , C07K5/075 , C07C229/34
CPC分类号： C07C227/40
摘要： Addition of a reaction mixture obtained by the mineral acid hydrolysis of at least one side flow generated from the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester to a crystallization slurry containing L-phenylalanine while maintaining the pH of the slurry at 3-8 by adding aqueous alkali affords crystallized L-phenylalanine having a low water content in a high yield.
摘要翻译：将由α-L-天冬氨酰基-L-苯丙氨酸甲酯的产生产生的至少一个侧流的无机酸水解获得的反应混合物加入含有L-苯丙氨酸的结晶浆料中，同时将浆料的pH保持在3 -8，通过加入碱水，以高收率提供低含水率的结晶L-苯丙氨酸。

12. 发明授权

US5856579A Adduct salts of novel substituted benzylamines and a process for optically resolving them 失效
标题翻译：新型取代苄胺的加成盐及其光学拆分方法
公开(公告)号：US5856579A
公开(公告)日：1999-01-05
申请号：US732860
申请日：1996-10-15
申请人： Tadashi Takemoto , Toyoto Hijiya , Teruo Yonekawa
发明人： Tadashi Takemoto , Toyoto Hijiya , Teruo Yonekawa
IPC分类号： C07B57/00 , C07B63/02 , C07C209/88 , C07C211/29 , C07C211/49 , C07C213/10 , C07C217/48 , C07C217/64 , C07C225/16 , C07C225/28 , C07C233/43 , C07C233/47 , C07C233/82 , C07C255/58 , C07C271/22 , C07C311/19 , C07C209/00
CPC分类号： C07C217/48 , C07C209/88 , C07C213/10
摘要： A process for optical resolution of a racemic substituted benzylamine is provided that involves reacting the racemic substituted benzylamine in a solvent with an optically active N-acyl-phenylalanine, -aspartic acid, or -glutamic acid, and separating the diastereomers formed by making use of the difference in the mutual solubilities of the two diastereomer salts which are generated therein.
摘要翻译：提供了外消旋取代的苄胺的光学拆分方法，其包括使外消旋取代的苄胺在溶剂中与旋光性N-酰基 - 苯丙氨酸，天冬氨酸或谷氨酸反应，并分离通过使用其中产生的两种非对映异构体盐的相互溶解度的差异。

13. 发明授权

US5616766A Method for recovering L-phenylalanine 失效
标题翻译： L-苯丙氨酸的回收方法
公开(公告)号：US5616766A
公开(公告)日：1997-04-01
申请号：US441737
申请日：1995-05-16
申请人： Tadashi Takemoto , Toyoto Hijiya , Teruo Yonekawa , Chiaki Mochizuki
发明人： Tadashi Takemoto , Toyoto Hijiya , Teruo Yonekawa , Chiaki Mochizuki
IPC分类号： C07C227/40 , C07C227/42 , C07C229/36 , C07C305/06
CPC分类号： C07C227/42 , C07C227/40 , C07C229/36 , Y02P20/582
摘要： The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalanine to crystallization.Further, the present invention also provides a process for recovering L-phenylalanine from a water layer by neutralizing the esterified reaction, extracting an ester of L-phenylalanine therefrom with an organic solvent, and recovering remaining L-phenylalanine in the water layer as L-phenylalanine monomethylsulfate. L-phenylalanine monomethyl sulfate is obtained by esterifying L-phenylalanine and methanol in the presence of sulfuric acid, neutralizing the esterified solution with a base in the presence of water, extracting the produced L-phenylalanine methyl ester from the neutralized solution with an organic solvent, and then crystallized the resultant water layer under acidic condition.
摘要翻译：本发明提供了与L-酪氨酸和D-苯丙氨酸相比具有低溶解度的L-苯丙氨酸单甲硫酸盐晶体。通过使含有单硫酸和苯丙氨酸的溶液结晶来获得L-苯丙氨酸单甲基硫酸盐晶体。此外，本发明还提供了通过中和酯化反应从水层中回收L-苯丙氨酸的方法，用有机溶剂从其中提取L-苯丙氨酸的酯，并将水层中剩余的L-苯丙氨酸回收为L- 苯丙氨酸单甲基硫酸盐。通过在硫酸存在下酯化L-苯丙氨酸和甲醇获得L-苯丙氨酸单甲硫酸盐，在水存在下用碱中和酯化溶液，用有机溶剂从中和溶液中萃取生成的L-苯丙氨酸甲酯，然后在酸性条件下使所得水层结晶。

14. 发明授权

US5581009A Process for crystallization of L-phenylalanine monomethyl sulfate using added salt 失效
标题翻译：使用加成盐结晶L-苯丙氨酸单甲硫酸盐的方法
公开(公告)号：US5581009A
公开(公告)日：1996-12-03
申请号：US420499
申请日：1995-04-12
申请人： Toyoto Hijiya , Naoko Sugiyama , Tadashi Takemoto
发明人： Toyoto Hijiya , Naoko Sugiyama , Tadashi Takemoto
IPC分类号： C07C227/42 , C07C229/36 , C07C303/44 , C07C305/06 , C07C303/24 , C07C303/42
CPC分类号： C07C227/42
摘要： A process for improving the yield of crystallization of L-phenylalanine monomethyl sulfate from an aqueous solution containing L-phenylalanine and monomethyl sulfate, by adding an effective crystallization improving amount of a salt of an inorganic or organic acid with an alkali metal, an alkaline earth metal or ammonium, to the aqueous solution.
摘要翻译：通过添加有效结晶提高量的无机或有机酸的盐与碱金属，碱土金属，提高L-苯丙氨酸单甲硫酸盐的结晶量，从含有L-苯丙氨酸和硫酸单甲酯的水溶液中提高结晶产率的方法金属或铵的水溶液。

15. 发明授权

US5466864A Method for recovering L-phenylalanine 失效
标题翻译： L-苯丙氨酸的回收方法
公开(公告)号：US5466864A
公开(公告)日：1995-11-14
申请号：US190450
申请日：1994-02-02
申请人： Tadashi Takemoto , Toyoto Hijiya , Teruo Yonekawa , Chiaki Mochizuki
发明人： Tadashi Takemoto , Toyoto Hijiya , Teruo Yonekawa , Chiaki Mochizuki
IPC分类号： C07C227/40 , C07C227/42 , C07C229/36 , C07C53/134
CPC分类号： C07C227/42 , C07C227/40 , C07C229/36 , Y02P20/582
摘要： The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalanine to crystallization.Further, the present invention also provides a process for recovering L-phenylalanine from a water layer by neutralizing the esterified reaction, extracting an ester of L-phenylalanine therefrom with an organic solvent, and recovering remaining L-phenylalanine in the water layer as L-phenylalanine monomethylsulfate. L-phenylalanine monomethyl sulfate is obtained by esterifying L-phenylalanine and methanol in the presence of sulfuric acid, neutralizing the esterified solution with a base in the presence of water, extracting the produced L-phenylalanine methyl ester from the neutralized solution with an organic solvent, and then crystallized the resultant water layer under acidic condition.
摘要翻译：本发明提供了与L-酪氨酸和D-苯丙氨酸相比具有低溶解度的L-苯丙氨酸单甲硫酸盐晶体。通过使含有单硫酸和苯丙氨酸的溶液结晶来获得L-苯丙氨酸单甲基硫酸盐晶体。此外，本发明还提供了通过中和酯化反应从水层中回收L-苯丙氨酸的方法，用有机溶剂从其中提取L-苯丙氨酸的酯，并将水层中剩余的L-苯丙氨酸回收为L- 苯丙氨酸单甲基硫酸盐。通过在硫酸存在下酯化L-苯丙氨酸和甲醇获得L-苯丙氨酸单甲硫酸盐，在水存在下用碱中和酯化溶液，用有机溶剂从中和溶液中萃取生成的L-苯丙氨酸甲酯，然后在酸性条件下使所得水层结晶。

16. 发明申请

US20050197396A1 Crystal of amino acid ester salt and process for producing the same 失效
标题翻译：氨基酸酯盐的晶体及其制备方法
公开(公告)号：US20050197396A1
公开(公告)日：2005-09-08
申请号：US11062879
申请日：2005-02-23
申请人： Toyoto Hijiya , Eriko Ono
发明人： Toyoto Hijiya , Eriko Ono
IPC分类号： A61K31/22 , C07C229/08 , C07C309/04 , C07C309/29 , C07C309/30 , C07C39/33
CPC分类号： C07C229/08 , C07C309/04 , C07C309/29 , C07C309/30
摘要： The present invention provides a novel crystal of alanine alkyl ester sulfonate having low hygroscopicity and low corrosiveness, which can be produced industrially economically. The present invention provides crystals of alanine alkyl ester sulfonates represented by formula (1): wherein R1 is a methyl group or an ethyl group, provided that when R1 is a methyl group, R2is an ethylphenyl group or a dimethylphenyl group; and when R1 is an ethyl group, R2 is a methyl group, a phenyl group, a chlorophenyl group, an ethylphenyl group, or a dimethylphenyl group.
摘要翻译：本发明提供了一种具有低吸湿性和低腐蚀性的丙氨酸烷基酯磺酸盐的新型结晶，其可以在工业上经济地得到。本发明提供由式（1）表示的丙氨酸烷基酯磺酸盐晶体：其中R 1是甲基或乙基，条件是当R 1为甲基，R 2是乙基苯基或二甲基苯基; 当R 1是乙基时，R 2是甲基，苯基，氯苯基，乙基苯基或二甲基苯基。

17. 发明授权

US4536842A System for measuring interfloor traffic for group control of elevator cars 失效
标题翻译：用于电梯轿厢集团控制的车内交通流量测量系统
公开(公告)号：US4536842A
公开(公告)日：1985-08-20
申请号：US479899
申请日：1983-03-29
申请人： Kiyoshi Yoneda , Hiroshi Takeuchi , Tetsuo Yamatani , Toyoto Hijiya , Hideo Takeda , Koji Shibuya , Kiichiro Tanaka
发明人： Kiyoshi Yoneda , Hiroshi Takeuchi , Tetsuo Yamatani , Toyoto Hijiya , Hideo Takeda , Koji Shibuya , Kiichiro Tanaka
IPC分类号： B66B1/20 , B66B1/24 , G06F15/46 , B66B1/18
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/214 , B66B2201/222 , B66B2201/235 , B66B2201/403
摘要： An elevator passenger traffic measuring system distributes passengers whose destination floors cannot be determined to each of origin-destination floor pairs in accordance with an elevator car position, an incoming passenger number and an outgoing passenger number at each floor, and registered car calls, using probability weights for the origin-destination floor pairs which are determined by previous traffic measurements. The system then estimates the number of passengers for each of the origin-destination floor pairs in accordance with the distributed passengers, and the passengers who moved the corresponding one of the origin-destination floor pairs.
摘要翻译：电梯客运测量系统根据电梯轿厢位置，每层楼的入场乘客人数和出行乘客人数以及使用概率的登记车辆呼叫来分配目的地楼层不能确定每个起点到目的地楼层对的乘客通过先前的流量测量确定的起始 - 目的地楼层对的权重。然后，该系统根据分配的乘客以及移动相应的一个起始 - 目的地楼层对的乘客来估计每个起始 - 目的地楼层对的乘客人数。

18. 发明授权

US07205433B2 Crystal of amino acid ester salt and process for producing the same 失效
标题翻译：氨基酸酯盐的晶体及其制备方法
公开(公告)号：US07205433B2
公开(公告)日：2007-04-17
申请号：US11062879
申请日：2005-02-23
申请人： Toyoto Hijiya , Eriko Ono
发明人： Toyoto Hijiya , Eriko Ono
IPC分类号： C07C229/00
CPC分类号： C07C229/08 , C07C309/04 , C07C309/29 , C07C309/30
摘要： The present invention provides a novel crystal of alanine alkyl ester sulfonate having low hygroscopicity and low corrosiveness, which can be produced industrially economically. The present invention provides crystals of alanine alkyl ester sulfonates represented by formula (1): wherein R1 is a methyl group or an ethyl group, provided that when R1 is a methyl group, R2is an ethylphenyl group or a dimethylphenyl group; and when R1 is an ethyl group, R2 is a methyl group, a phenyl group, a chlorophenyl group, an ethylphenyl group, or a dimethylphenyl group.
摘要翻译：本发明提供了一种具有低吸湿性和低腐蚀性的丙氨酸烷基酯磺酸盐的新型结晶，其可以在工业上经济地得到。本发明提供由式（1）表示的丙氨酸烷基酯磺酸盐晶体：

19. 发明授权

US4508912A Process for producing N-carbobenzoxy-L-aspartic anhydride 失效
标题翻译：制备N-苄氧羰基-L-天冬氨酸酐的方法
公开(公告)号：US4508912A
公开(公告)日：1985-04-02
申请号：US479898
申请日：1983-03-29
申请人： Tetsuo Yamatani , Toyoto Hijiya , Hideo Takeda , Koji Shibuya , Kiichiro Tanaka
发明人： Tetsuo Yamatani , Toyoto Hijiya , Hideo Takeda , Koji Shibuya , Kiichiro Tanaka
IPC分类号： C07D307/66
CPC分类号： C07D307/66
摘要： A process for producing a high yield of N-carbobenzoxy-L-aspartic anhydride from N-carbobenzoxy-L-aspartic acid in a very short period using commercially acceptable reaction conditions is disclosed. The process is characterized by reacting N-carbobenzoxy-L-aspartic acid with acetic anhydride in the presence of a metal oxide, a metal hydroxide, a metal salt of acid, an organobasic compound or an acid having a dissociation constant of 5.times.10.sup.-2 or more.
摘要翻译：公开了一种在非常短的时间内使用商业上可接受的反应条件从N-苄氧羰基-L-天冬氨酸生产N-苄氧羰基-L-天冬氨酸高产率的方法。该方法的特征在于N-烷氧羰基-L-天冬氨酸与乙酸酐在金属氧化物，金属氢氧化物，酸金属盐，有机碱化合物或解离常数为5×10 -2的酸的存在下反应，或更多。

20. 发明授权

US06761767B2 Production method of famciclovir and production and crystallization method of intermediate therefor 失效
标题翻译：泛昔洛韦的生产方法及其中间体的生产和结晶方法
公开(公告)号：US06761767B2
公开(公告)日：2004-07-13
申请号：US10231249
申请日：2002-08-30
申请人： Toyoto Hijiya , Takayoshi Torii , Kunisuke Izawa
发明人： Toyoto Hijiya , Takayoshi Torii , Kunisuke Izawa
IPC分类号： C30B2500
CPC分类号： C07D473/00 , C07D473/32 , C07D473/40
摘要： An N-9-position alkylated form is selectively precipitated by subjecting a mixture containing the N-9-position alkylated form and an N-7-position alkylated form of 2-amino-6-halopurine to a crystallization step using a mixed solvent of an organic solvent and water. Then, this N-9-position alkylated form is reduced to give famciclovir. By this method of the present invention, famciclovir known as an antiviral agent, and an intermediate compound therefor can be efficiently produced.
摘要翻译：通过使含有N-9位烷基化形式和N-7-位烷基化形式的2-氨基-6-卤代嘌呤的混合物进行结晶步骤，使用以下的混合溶剂将N-9位烷基化形式选择性沉淀：有机溶剂和水。然后，将该N-9-位烷基化形式还原，得到泛昔洛韦。通过本发明的方法，可以有效地制备称为抗病毒剂的泛昔洛韦及其中间体化合物。

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