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11. 发明申请

US20060122264A1 Stem cell invasion inhibitor 审中-公开
标题翻译：干细胞侵袭抑制剂
公开(公告)号：US20060122264A1
公开(公告)日：2006-06-08
申请号：US10559708
申请日：2003-06-09
申请人： Yasumi Uchida , Haruko Uchida
发明人： Yasumi Uchida , Haruko Uchida
IPC分类号： A61K31/365
CPC分类号： A61L31/16 , A61K31/343 , A61K31/39 , A61L31/10 , A61L2300/442 , C07D327/04
摘要： The present invention provides an inhibitor of the invasion of bone-marrow-derived vascular stem cells or inflammatory cells into blood vessel walls, a blood vessel restenosis inhibitor, and a preventive or therapeutic drug for angiitis or myocardiitis, each containing a phthalein dye compound as an active ingredient; and an instrument for treating blood vessels which is coated with a resin containing a phthalein dye compound or made of such a resin. Use of the drug of the present invention enables effective prevention of restenosis of a blood vessel after, for example, angioplasy. Moreover, it is possible to prevent the progress and disruption of a lesion of angiitis, myocarditis, or arterioscrelosis, for which no efficacious preventive or therapeutic method has been established so far, as well as microvascular ischemic diseases. By performing a medical treatment such as angioplasy using the instrument of the present invention for treating blood vessels, events of vascular restenosis can be effectively prevented.
摘要翻译：本发明提供了将骨髓来源的血管干细胞或炎症细胞侵入血管壁的抑制剂，血管再狭窄抑制剂和用于血管炎或心肌炎的预防或治疗药物，每种含有酞菁染料化合物作为活性成分; 以及用于治疗血管的器械，其中涂有含有酞菁染料化合物或由这种树脂制成的树脂。使用本发明的药物能够有效地防止例如血管淤血后的血管再狭窄。此外，可以防止迄今为止没有建立有效的预防或治疗方法以及微血管缺血性疾病的血管炎，心肌炎或动脉硬化性病变的进展和破坏。通过使用本发明的用于治疗血管的器械进行诸如血管性皮炎的治疗，可以有效地防止血管再狭窄的事件。

12. 发明授权

US07025981B2 Therapeutic tool for vascular diseases 失效
公开(公告)号：US07025981B2
公开(公告)日：2006-04-11
申请号：US10237012
申请日：2002-09-09
申请人： Yasumi Uchida , Haruko Uchida
发明人： Yasumi Uchida , Haruko Uchida
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61L31/08 , A61L2300/416 , A61L2300/442 , A61L2300/606
摘要： The present invention relates to a therapeutic tool for vascular diseases, which is coated with a dye-containing resin that comprises one or more biocompatible dyes selected from the group consisting of sulfonic acid azo dye, phthalein dye, triphenylmethane dye, phenantridium dye, acrydine dye, xanthene dye, phenothiazine dye and cyanine dye; a medical treatment by the use of the therapeutic tool for vascular diseases; and a method of preventing vascular restenosis caused mainly through inhibition of migration of vascular progenitor cells by administering the medical treatment to a subject.Since the present therapeutic tool for vascular diseases is capable of staying in vivo for a long term, a medical treatment such as angioplasty (coronary angioplasty, peripheral angioplasty, cerebral angioplasty, etc.) and blood vessel bypass (coronary bypass, peripheral bypass) by the use of the present tool can effectively inhibit the generation of blood vessel restenosis by inhibiting migration of vascular progenitor cells. Thus, the present tool is extremely useful in clinical situations.

13. 发明授权

US4578465A Phenyliperazine derivatives 失效
标题翻译：苯基哌嗪衍生物
公开(公告)号：US4578465A
公开(公告)日：1986-03-25
申请号：US604415
申请日：1984-04-30
申请人： Hiroyuki Nagano , Mitiro Takagi , Noboru Kubodera , Isao Matsunaga , Hiroyuki Nabata , Yasuhiro Ohba , Kazushige Sakai , Shun-ichi Hata , Yasumi Uchida
发明人： Hiroyuki Nagano , Mitiro Takagi , Noboru Kubodera , Isao Matsunaga , Hiroyuki Nabata , Yasuhiro Ohba , Kazushige Sakai , Shun-ichi Hata , Yasumi Uchida
IPC分类号： C07D403/06 , A61K31/505 , A61K31/517 , A61P9/00 , A61P9/12 , C07D239/96
CPC分类号： C07D239/96
摘要： Phenylpiperazine derivatives of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a straight- or branched-chain saturated or unsaturated alkyl group having 1 to 8 carbon atoms which may be substituted at any position by a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group or an oxo group; and R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group, and a process for producing the same are disclosed. The derivatives of the formula have alpha blocking and serotonin antagonizing activities and are useful as a drug.
摘要翻译：具有下式的苯基哌嗪衍生物：其中R1是氢原子或可以在任何位置被羟基取代的具有1-8个碳原子的直链或支链饱和或不饱和烷基，羧基，低级烷氧基羰基或氧代基; R 2为氢原子，卤素原子，低级烷基或氨磺酰基及其制造方法。该衍生物具有α阻断和5-羟色胺拮抗活性，可用作药物。

14. 发明授权

US5510366A Indole derivatives, salts thereof, and congestive heart failure therapeutic agents comprising the same 失效
标题翻译：吲哚衍生物，其盐，以及包含其的充血性心力衰竭治疗剂
公开(公告)号：US5510366A
公开(公告)日：1996-04-23
申请号：US330670
申请日：1994-10-28
申请人： Yoshinori Kyotani , Katsumi Kawamine , Tsutomu Toma , Tadaaki Ohgiya , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Noboru Shimizu , Hiromichi Shigyo , Tomio Ohta , Toshiaki Oda , Yukihiro Okuno , Kimiyuki Shibuya , Yoshio Takahashi , Mikio Fujii , Yasumi Uchida
发明人： Yoshinori Kyotani , Katsumi Kawamine , Tsutomu Toma , Tadaaki Ohgiya , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Noboru Shimizu , Hiromichi Shigyo , Tomio Ohta , Toshiaki Oda , Yukihiro Okuno , Kimiyuki Shibuya , Yoshio Takahashi , Mikio Fujii , Yasumi Uchida
IPC分类号： C07D491/04 , C07D491/048 , A61K31/40 , C07D491/056
CPC分类号： C07D491/04
摘要： An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
摘要翻译：由式（1）表示的吲哚衍生物，本文R10为氢或低级烷基，虚线可以任选存在，R 1 -R 9表示各种取代基。化合物（1）对心肌呈现正性肌力作用，抗心律失常作用和血管舒张作用而不增加心率。包含该化合物作为有效成分的心脏治疗剂对于治疗心力衰竭和心律失常是非常有效的。

15. 发明授权

US4960883A Piperazines and homopiperazines 失效
标题翻译：哌嗪和高哌嗪
公开(公告)号：US4960883A
公开(公告)日：1990-10-02
申请号：US310683
申请日：1989-02-15
申请人： Sohei Tanabe , Seiichi Sato , Yoshinori Kyotani , Tomio Ohta , Yasumi Uchida
发明人： Sohei Tanabe , Seiichi Sato , Yoshinori Kyotani , Tomio Ohta , Yasumi Uchida
IPC分类号： C07D295/18 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/55 , A61P9/00 , C07D217/02 , C07D243/08 , C07D295/192 , C07D295/22 , C07D295/26
CPC分类号： C07D295/192 , C07D217/02 , C07D295/26
摘要： A propane derivative represented by the following formula ##STR1## wherein R represents a lower alkyl group; one of A and B represents a group of the formula ##STR2## and the other represents a group of the formula ##STR3## in which R.sup.1 and R.sup.2 are identical or different and each represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, R.sup.3 represents a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group, and X represents a sulfonyl group or a carbonyl group,and an acid addition salt thereof. The compounds provided by this invention have useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular diseases such as angina pectoris, cerebral circulation disorder and thrombosis.

16. 发明授权

US4948892A Sulfonamid compound useful for treating cardiovascular disorders 失效
标题翻译：用于治疗心血管疾病的磺酰胺类化合物
公开(公告)号：US4948892A
公开(公告)日：1990-08-14
申请号：US310684
申请日：1989-02-15
申请人： Sohei Tanabe , Seiichi Sato , Yoshinori Kyotani , Tomio Ohta , Yasumi Uchida
发明人： Sohei Tanabe , Seiichi Sato , Yoshinori Kyotani , Tomio Ohta , Yasumi Uchida
IPC分类号： C07D295/12 , A61K31/495 , A61P9/00 , C07D213/74 , C07D213/75 , C07D241/04 , C07D295/13
CPC分类号： C07D213/74 , C07D295/13
摘要： A sulfonamide compound represented by the following formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are identical or different, and each represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a hydrogen atom, a lower alkyl group, or a substituted or unsubstituted aralykyl group; R.sup.5 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group; R.sup.6 and R.sup.7 are identical or different and each represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; and n is an integer of 1 to 8,and an acid addition salt thereof. The compounds of formula (I) provided by this invention have some useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular disorders such as angina pectoris, cerebral circulation disorder and thrombosis.

17. 发明授权

US4886822A Substituted anilide compounds which are useful in the treatment of arrhythmia 失效
标题翻译：可用于治疗心律失常的替代的酰苯胺化合物
公开(公告)号：US4886822A
公开(公告)日：1989-12-12
申请号：US179218
申请日：1988-04-08
申请人： Kimiyuki Shibuya , Yoshio Takahashi , Seiichi Sato , Hiromichi Shigyo , Tomio Ohta , Yasumi Uchida
发明人： Kimiyuki Shibuya , Yoshio Takahashi , Seiichi Sato , Hiromichi Shigyo , Tomio Ohta , Yasumi Uchida
IPC分类号： C07D233/61 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P9/06 , C07D213/04 , C07D213/30 , C07D213/40 , C07D213/50 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/82 , C07D213/89 , C07D233/54 , C07D233/64 , C07D233/84 , C07D471/04 , C07D521/00
CPC分类号： C07D213/30 , C07D213/40 , C07D213/50 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/82 , C07D213/89 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D249/08 , C07D471/04
摘要： A substituted anilide derivative of the formula ##STR1## wherein R.sub.1 represents a mononuclear or binuclear heterocyclic group which contains 1 to 3 nitrogen atoms as ring members and may have a substituent.A represents a single bond, a carbonyl group, a sulfur atom, or a lower alkylene group which may be substituted by a hydroxyl group,R.sub.2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a trifluoromethyl group, a lower alkenyloxy group, or a C.sub.1 -C.sub.14 alkoxy group which may have a substituent,R.sub.3 and R.sub.4 are identical or different, and each represents a hydrogen atom, a lower alkyl group, a phenyl group, or a phenyl(lower alkyl) group which may have a substitutent, or taken together, may form a saturated nitrogen-containing heterocyclic group together with the nitrogen atom to which they are bonded, andB represents a single bond or a lower alkylene group which may have a substituent,or an acid addition salt thereof. The compound of formula (I) or a pharmaceutically acceptable acid addition salt thereof is useful for the manufacture of antiarrhythmically active medicaments.

18. 发明授权

US4560686A Method for treating circulatory diseases by using (2-lower alkoxyphenyl)piperazine derivatives 失效
标题翻译：通过使用（2-低级烷氧基苯基）哌嗪衍生物治疗循环系统疾病的方法
公开(公告)号：US4560686A
公开(公告)日：1985-12-24
申请号：US532271
申请日：1983-09-14
申请人： Hiroyuki Nagano , Mitiro Takagi , Noboru Kubodera , Isao Matsunaga , Hiroyuki Nabata , Yasuhiro Ohba , Kazushige Sakai , Shun-ichi Hata , Yasumi Uchida
发明人： Hiroyuki Nagano , Mitiro Takagi , Noboru Kubodera , Isao Matsunaga , Hiroyuki Nabata , Yasuhiro Ohba , Kazushige Sakai , Shun-ichi Hata , Yasumi Uchida
IPC分类号： C07D295/12 , A61K31/495 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , C07D295/13 , C07D317/68 , C07D241/04
CPC分类号： C07D295/13 , C07D317/68
摘要： Compounds of the formula ##STR1## (wherein R.sub.1 is a lower alkyl group, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a trifluoromethyl group or a lower alkoxycarbonyl group; two adjacent groups of R.sub.2, R.sub.3 and R.sub.4 may combine to form a methylenedioxy group; n is an integer of 2 to 6) or salts thereof, are disclosed.These compounds are useful as agents for treating circulatory diseases because they have hypotensive action and are capable of increasing the cerebral blood flow, decreasing the heart rate and suppressing ventricular arrhythmia due to myocardial ischemia.
摘要翻译：式（IMAGE）的化合物（其中R 1为低级烷基，R 2，R 3和R 4可相同或不同，表示氢原子，卤素原子，低级烷基，低级烷氧基，羟基，三氟甲基或低级烷氧基羰基; R 2，R 3和R 4的两个相邻基团可以结合形成亚甲二氧基; n是2至6的整数）或其盐。这些化合物可用作治疗循环系统疾病的药剂，因为它们具有降血压作用，并且能够增加脑血流量，降低心率并抑制心肌缺血引起的室性心律失常。

19. 发明授权

US4482562A Aromatic aminoethanol compounds, and utilization thereof as cardiovascular agents 失效
标题翻译：芳香族氨基乙醇化合物及其作为心血管药物的用途
公开(公告)号：US4482562A
公开(公告)日：1984-11-13
申请号：US414819
申请日：1982-09-03
申请人： Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
发明人： Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
IPC分类号： A61K31/21 , A61K31/135 , A61K31/165 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61P9/00 , A61P9/12 , A61P25/02 , A61P25/28 , C07C67/00 , C07C203/04 , C07C213/00 , C07C217/32 , C07C217/70 , C07C219/16 , C07C219/34 , C07C225/16 , C07C231/00 , C07C231/12 , C07C235/42 , C07C235/46 , C07C237/30 , C07C301/00 , C07C303/40 , C07C311/17 , C07C311/29 , C07C313/00 , C07C315/04 , C07C317/22 , C07C317/24 , C07C317/32 , C07C319/20 , C07C323/25 , C07D213/30 , C07D213/60 , C07D213/64 , C07D213/69 , C07D303/24 , C07D303/26 , C07D309/12 , C07D213/74
CPC分类号： C07D213/64 , C07C203/04 , C07D213/69 , C07D303/24 , C07D303/26 , C07D309/12
摘要： A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --O--CH.sub.2 --,B represents a C.sub.1 -C.sub.11 alkylene group bonded to a carbon atom of the aromatic ring D either directly or through --O--, --S--, --SO-- or --NH--,W represents a carbon or nitrogen atom,R.sub.1 represents a C.sub.3 -C.sub.7 alkyl group, a hydroxy-C.sub.1 -C.sub.6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms,R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, C.sub.1 -C.sub.4 alkyl, NO.sub.2, C.sub.1 -C.sub.4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R.sub.2 groups exist, they may be identical or different, andn represents 1, 2 or 3 and m represents 1 or 2, provided that n+m.gtoreq.4;and an acid addition salt thereof; a process for producing the same; and a pharmaceutical composition comprising aforesaid compound.

20. 发明授权

US4374840A Certain phenyl or pyridyl-propanol-amines containing alkyl-nitrate moieties 失效
标题翻译：含有烷基 - 硝酸盐部分的某些苯基或吡啶基 - 丙醇 - 胺
公开(公告)号：US4374840A
公开(公告)日：1983-02-22
申请号：US233643
申请日：1981-02-11
申请人： Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
发明人： Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
IPC分类号： A61K31/21 , A61K31/135 , A61K31/165 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61P9/00 , A61P9/12 , A61P25/02 , A61P25/28 , C07C67/00 , C07C203/04 , C07C213/00 , C07C217/32 , C07C217/70 , C07C219/16 , C07C219/34 , C07C225/16 , C07C231/00 , C07C231/12 , C07C235/42 , C07C235/46 , C07C237/30 , C07C301/00 , C07C303/40 , C07C311/17 , C07C311/29 , C07C313/00 , C07C315/04 , C07C317/22 , C07C317/24 , C07C317/32 , C07C319/20 , C07C323/25 , C07D213/30 , C07D213/60 , C07D213/64 , C07D213/69 , C07D303/24 , C07D303/26 , C07D309/12 , C07D213/74
CPC分类号： C07D213/64 , C07C203/04 , C07D213/69 , C07D303/24 , C07D303/26 , C07D309/12
摘要： A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --0--CH.sub.2--,B represents a C.sub.1 -C.sub.11 alkylene group bonded to a carbon atom of the aromatic ring D either directly or through --O--, --S--, --SO-- or --NH--,W represents a carbon or nitrogen atom,R.sub.1 represents a C.sub.3 -C.sub.7 alkyl group, a hydroxy-C.sub.1 -C.sub.6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms,R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, C.sub.1 -C.sub.4 alkyl, NO.sub.2, C.sub.1 -C.sub.4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R.sub.2 groups exist, they may be identical or different, andn represents 1, 2 or 3 and m represents 1 or 2, provided that n+m.gtoreq.4;and an acid addition salt thereof; a process for producing the same; and a pharmaceutical composition comprising aforesaid compound.
摘要翻译：由下式表示的化合物：其中A表示直接键或-O-CH 2 - 键，B表示与芳环D的碳原子键合的C1-C11亚烷基直接或-O- ，-S-，-SO-或-NH-，W表示碳原子或氮原子，R1表示C3-C7烷基，羟基-C1-C6烷基或苯基或二苯基 - 烷基，其中具有1至4个碳原子的烷基，R 2表示选自氢，卤素，OH，C 1 -C 4烷基，NO 2，C 1 -C 4烷氧基，乙酰基，烯丙氧基，氨基甲酰基和氨磺酰基的成员，当两个或更多个 R2基团存在，它们可以相同或不同，n表示1,2或3，m表示1或2，条件是n + m> = 4; 及其酸加成盐; 其制造方法; 和包含上述化合物的药物组合物。

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