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11. 发明申请

WO1992004865A1 ARTERIAL CO2 MONITOR AND CLOSED LOOP CONTROLLER 审中-公开
标题翻译：动物二氧化碳监测器和闭环控制器
公开(公告)号：WO1992004865A1
公开(公告)日：1992-04-02
申请号：PCT/AU1991000435
申请日：1991-09-19
申请人： THE UNIVERSITY OF MELBOURNE , PACKER, John, Stuart , CADE, John, Francis , LAW, Eng-Boon
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： A61B05/08
CPC分类号： A61B5/091 , A61B5/0836 , A61M16/0051 , A61M16/026 , A61M2230/202
摘要： The arterial CO2 monitor and closed loop controller for use with a ventilator monitors a patient's breath and determines PaCO2 based upon a determination of a deadspace ratio, which is the ratio of the alveolar deadspace to alveolar tidal volume. The method generally comprises the steps of continuously monitoring measurable parameters of a patient's breath; obtaining an input value of PaCO2 from a blood sample of the patient and using the patient's breath parameters and the input value to calculate the deadspace ratio; and continuously determining PaCO2 based on the assumption that the deadspace ratio subsequently remains constant. Decision rules obtained from other measurable data are preferably also used to identify the onset of changes in the deadspace ratio, and a new deadspace ratio is then determined from the patient's breath parameters and further input value of PaCO2 from the patient's blood sample.
摘要翻译：与呼吸机一起使用的动脉CO2监测器和闭环控制器监测患者的呼吸，并且基于空洞比（其是肺泡死区与肺泡潮气量的比率）的确定来确定PaCO2。该方法通常包括以下步骤：连续监测患者呼吸的可测量参数; 从患者的血液样本获得PaCO2的输入值，并使用患者的呼吸参数和输入值来计算死空比; 并且基于以下假设，连续地确定PaCO2：空位比随后保持恒定。从其他可测量数据获得的判定规则优选也用于识别死空间比率变化的开始，然后根据患者的呼吸参数和来自患者血液样本的PaCO2的进一步输入值确定新的空穴比。

12. 发明申请

WO1991006570A1 HYBRID Fc RECEPTOR MOLECULES 审中-公开
标题翻译：混合Fc受体分子
公开(公告)号：WO1991006570A1
公开(公告)日：1991-05-16
申请号：PCT/AU1990000513
申请日：1990-10-25
申请人： THE UNIVERSITY OF MELBOURNE , HOGARTH, Phillip, Mark , HULETT, Mark, Darren , IERINO, Francesco, Libero , McKENZIE, Ian, Farquhar, Campbell , OSMAN, Narin
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： C07K15/06
CPC分类号： C07K14/70535 , A61K38/00 , C07K16/283 , C07K2317/24 , C07K2319/00 , C07K2319/033 , C07K2319/32
摘要： A novel immunoglobulin binding molecule is provided being a hybrid of two or more binding molecules such as to provide a hybrid immunoglobulin binding molecule having chimeric properties characteristic of two or more individual immunoglobulin binding molecules in one molecule. Methods of production and applications of such hybrid molecules is also provided.
摘要翻译：提供了一种新的免疫球蛋白结合分子，其是两个或多个结合分子的杂交体，以提供具有在一个分子中两个或多个单独的免疫球蛋白结合分子的特征的嵌合特性的杂交免疫球蛋白结合分子。还提供了这种杂交分子的生产方法和应用。

13. 发明申请

WO1989002145A1 SPEECH ANALYSIS 审中-公开
标题翻译：语音分析
公开(公告)号：WO1989002145A1
公开(公告)日：1989-03-09
申请号：PCT/AU1988000325
申请日：1988-08-25
申请人： THE UNIVERSITY OF MELBOURNE , JOHNSON, Donald, Archibald, Harvey , NANDAGOPAL, Daraisamy
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： G10L05/00
CPC分类号： G10L19/08
摘要： A pole-zero speech analysis method in which cepstral coefficients are first obtained from the Linear Predictive Coding method of analysing a short speech segment. The negative derivative of the phase spectrum is then obtained and used to resolve the poles and the zeros.
摘要翻译：一种极零语音分析方法，其中首先从分析短语音段的线性预测编码方法获得倒谱系数。然后获得相位谱的负导数并用于解析极点和零点。

14. 发明申请

WO1988010383A1 INFUSION PUMP AND DRIVE SYSTEMS THEREFORE 审中-公开
标题翻译：输液泵和驱动系统
公开(公告)号：WO1988010383A1
公开(公告)日：1988-12-29
申请号：PCT/AU1988000198
申请日：1988-06-20
申请人： THE UNIVERSITY OF MELBOURNE , CRANKSHAW, David, Pilkington
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： F16H37/04
CPC分类号： A61M5/1456 , A61M5/1452 , A61M5/1458 , A61M5/16854 , Y10S128/01 , Y10S128/12
摘要： A drug infusion pump having a drive system including a drive motor (49), a worm gear (53) on the output shaft of said motor, a worm wheel (55) meshing with said worm gear (53) and constructed to drive an output reduction gear (60) and clutch means (62) associated with said output gear (60) for disengaging drive to a drive head (61) engaged by a drive belt (83) which is permanently connected to a syringe actuator (7) to cause controlled infusion of the contents of a syringe under the control of a central control system including a microprocessor (20) and programmable memory means (21 and 23) which determine the manner in which the infusion is performed. A syringe clamping arm (5) is associated with a potentiometer (24) which provides to the controller diameter information regarding the syringe. The programmable memory means (23) includes data relating to one or more standard syringe sizes to enable automatic operation on insertion of a standard syringe. In the event that a non-standard syringe is to be used, the infusion pump may be simply programmed to allow such non-standard syringes to be used.
摘要翻译：一种具有驱动系统的药液输注泵，包括驱动马达（49），在所述马达的输出轴上的蜗轮（53），与所述蜗轮（53）啮合的蜗轮（55），构成为驱动输出与所述输出齿轮（60）相关联的减速齿轮（60）和离合器装置（62），用于使驱动头与由永久连接到注射器致动器（7）的传动带（83）接合的驱动头（61）在包括微处理器（20）和可编程存储器装置（21和23）的中央控制系统的控制下控制注射器的内容物，该可编程存储器装置确定进行输液的方式。注射器夹持臂（5）与电位计（24）相关联，电位计（24）向控制器提供关于注射器的直径信息。可编程存储装置（23）包括与一个或多个标准注射器尺寸相关的数据，以便能够在插入标准注射器时进行自动操作。在使用非标准注射器的情况下，输注泵可以被简单地编程以允许使用这种非标准注射器。

15. 发明申请

WO1988006043A1 PRECIPITATION OF COLLAGEN IN TACTOID FORM 审中-公开
标题翻译：胶原蛋白形式的降解
公开(公告)号：WO1988006043A1
公开(公告)日：1988-08-25
申请号：PCT/AU1987000038
申请日：1987-02-12
申请人： THE UNIVERSITY OF MELBOURNE
发明人： THE UNIVERSITY OF MELBOURNE , BATEMAN, John, Francis , RAMSHAW, John, Alan, Maurice , PETERS, David, Edward , TULLOCH, Peter, Archibald
IPC分类号： A61L27/00
CPC分类号： C08J3/14 , A61F2310/00365 , A61K38/00 , A61K47/42 , A61L27/24 , C07K14/78 , C08J2389/06 , C08L89/06
摘要： Collagen in tactoid form obtained by forming an aqueous solution containing dissolved collagen and a water soluble or miscible polymer adapted to precipitate collagen out of solution in the form of tactoids.
摘要翻译：通过形成含有溶解的胶原的水溶液和适于以胶质形式将胶原蛋白从溶液中沉淀出来的水溶性或可混溶的聚合物获得的眼镜状胶原蛋白。

16. 发明申请

WO1998016882A1 A METHOD AND SYSTEM FOR CONTINUOUS SOFTWARE MONITORING 审中-公开
标题翻译：连续软件监控的方法和系统
公开(公告)号：WO1998016882A1
公开(公告)日：1998-04-23
申请号：PCT/AU1997000678
申请日：1997-10-09
申请人： ERICSSON AUSTRALIA PTY. LTD. , ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY , THE UNIVERSITY OF MELBOURNE , WONG, Geoffrey, Peter , O'BRIEN, Fergus
发明人： ERICSSON AUSTRALIA PTY. LTD. , ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY , THE UNIVERSITY OF MELBOURNE
IPC分类号： G06F11/30
CPC分类号： G06F11/3466 , G06F11/0715
摘要： A method and system for continuous software monitoring is provided in which the attributes or parameters (21) of the functional computer program to be monitored are specified at the time the functional computer program is compiled and a monitoring computer program is simultaneously compiled by a compiler (20) for parallel execution in a target computer environment (30, 40). The functional and monitoring programs are compiled to include links (14, 24) to enable data to be extracted from the functional computer program, the main application (32), by the monitoring program. The main application (32) is arranged to include a spawn monitor (34) so that each process of the main application which is spawned during execution in the main application processor (30) has its own monitoring process which is spawned in the monitoring processor (40).
摘要翻译：提供了一种用于连续软件监视的方法和系统，其中在编辑功能计算机程序时指定要监视的功能计算机程序的属性或参数（21），并且由编译器同时编译监视计算机程序 20），用于在目标计算机环境（30,40）中并行执行。功能和监视程序被编译成包括链接（14,24），以便通过监视程序使得能够从功能计算机程序（主应用程序）（32）中提取数据。主应用程序（32）被布置为包括产生监视器（34），使得在主应用处理器（30）中执行期间产生的主应用程序的每个进程都具有在监视处理器中产生的自己的监视进程（ 40）。

17. 发明申请

WO1998003686A1 SEMI-SOLID FORMING 审中-公开
标题翻译：半固体成型
公开(公告)号：WO1998003686A1
公开(公告)日：1998-01-29
申请号：PCT/AU1997000458
申请日：1997-07-18
申请人： THE UNIVERSITY OF MELBOURNE , TAUSIG, Gabriela , XIA, Kenong
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： C21D08/00
CPC分类号： B21J5/004 , C21D7/13 , C22C1/005 , Y10S164/90
摘要： A process for producing a shaped metallic article includes the steps of melting a metal alloy, reducing the temperature of the molten metal to the liquidus temperature, casting the molten metal at the liquidus temperature into a mould and solidifying the molten metal to obtain a feedstock material. The feedstock material is subsequently heated to a temperature between the liquidus and solidus temperatures to produce a self-supporting thixotropic material which is then formed to the desired shape. Casting the feedstock material from a melt at substantially the liquidus temperature produces a microstructure that is especially suitable for subsequent forming of the thixotropic material and this allows use of slower forming speeds and lower forming pressure during the forming step.
摘要翻译：一种成形金属制品的制造方法包括熔融金属合金，将熔融金属的温度降低至液相线温度的步骤，将液相线温度下的熔融金属浇注到模具中并固化熔融金属以获得原料。随后将原料材料加热至液相线和固相线温度之间的温度，以产生自支撑触变材料，然后将其形成为所需形状。基本上在液相线温度下从熔体铸造原材料产生特别适用于随后形成触变材料的微结构，并且这允许在成形步骤期间使用较慢的成形速度和较低的成形压力。

18. 发明申请

WO1997043871A1 CALCULATING ELECTRODE FREQUENCY ALLOCATION IN A COCHLEAR IMPLANT 审中-公开
标题翻译：计算电极在COCHLEAR IMPLANE中的频率分配
公开(公告)号：WO1997043871A1
公开(公告)日：1997-11-20
申请号：PCT/AU1997000295
申请日：1997-05-14
申请人： THE UNIVERSITY OF MELBOURNE , COCHLEAR LIMITED , COHEN, Lawrence, Thomas , XU, Jin , XU, Shiang , McKAY, Colette , MARSH, Michael , MORTLOCK, Andrew, Tennant , BLAMEY, Peter, John , WHITFORD, Lesley, Anne
发明人： THE UNIVERSITY OF MELBOURNE , COCHLEAR LIMITED
IPC分类号： H04R25/00
CPC分类号： A61N1/36036
摘要： A system for predicting the characteristic frequency of each electrode of an implanted cochlear electrode array from electrode position data contained in an image of the implanted cochlear. Also provided is a system for setting the frequency range to electrode map of a cochlear prosthesis.
摘要翻译：一种用于从植入的人工耳蜗的图像中包含的电极位置数据中预测植入的耳蜗电极阵列的每个电极的特征频率的系统。还提供了一种用于将频率范围设置为耳蜗假体的电极图的系统。

19. 发明申请

WO1995024926A1 FORMULATION FOR USE IN INDUCING CYTOTOXIC T-CELLS 审中-公开
标题翻译：用于诱导细胞毒T细胞的配方
公开(公告)号：WO1995024926A1
公开(公告)日：1995-09-21
申请号：PCT/AU1995000141
申请日：1995-03-16
申请人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED , COX, John, Cooper , SUHRBIER, Andreas , ELLIOTT, Suzanne, Louise
发明人： THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BIOTECH AUSTRALIA PTY. LIMITED , CSL LIMITED
IPC分类号： A61K39/245
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16122 , C12N2710/16222 , C12N2710/16722 , Y02A50/466
摘要： The present invention provides a composition where a CTL peptide is presented in such a way as to maximise the attachment of peptide to class 1 MHC molecules on the external surface of cells and the subsequent processing of these cells in the optimal way to induce high-affinity CD8 CTL responses. Preferably, the composition comprises a water-in-oil formulation including at least one antigen to which the individual will mount an anamnestic response and at least one cytotoxic T-cell epitope.
摘要翻译：本发明提供了一种组合物，其中CTL肽以使得肽在细胞外表面上与1类MHC分子的连接最大化的方式存在，并且以最佳方式随后处理这些细胞以诱导高亲和力 CD8 + CTL反应。优选地，组合物包含油包水制剂，其包含至少一种抗原，所述抗原将个体将载持至少一种毒性反应和至少一种细胞毒性T细胞表位。

20. 发明申请

WO1994004564A1 T CELL EPITOPES OF RYEGRASS POLLEN ALLERGEN 审中-公开
标题翻译： RYEGRASS POLLEN ALLERGEN的T细胞抗原
公开(公告)号：WO1994004564A1
公开(公告)日：1994-03-03
申请号：PCT/AU1993000415
申请日：1993-08-13
申请人： THE UNIVERSITY OF MELBOURNE , KNOX, Robert, Bruce , SINGH, Mohan, Bir , ROLLAND, Jennifer , BLAHER, Bella , SUPHIOGLU, Cenk
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： C07K07/08
CPC分类号： C07K16/16 , A61K39/00 , C07K14/415 , C07K2317/34 , G01N33/56961 , G01N33/56972 , G01N33/689 , G01N2800/24
摘要： The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne. Therapeutic peptides within the scope of the invention comprise at least on T cell epitope, or preferably at least two T cell epitopes of a protein allergen of Lol p V. Diagnostic peptides within the scope of the invention bind IgE. The invention also provides modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or diagnosis of sensitivity to Lol p V or an allergen immunologically related to Lol p V in an individual. Therapeutic compositions comprising one or more peptides of the invention are also provided.
摘要翻译：本发明提供了Lol p V的孤立肽，Lol p V是白僵菌物种的主要蛋白质过敏原。本发明范围内的治疗肽至少包含T细胞表位，或优选Lol p V蛋白变应原的至少两个T细胞表位。本发明范围内的诊断肽结合IgE。本发明还提供了与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的修饰肽。本发明还提供了编码本发明的肽的核酸序列。治疗或诊断对Lol p V的敏感性或与个体中Lol p V免疫相关的变应原的方法。还提供了包含本发明的一种或多种肽的治疗组合物。

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