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11. 发明授权

US08263102B2 Drug delivery coating for use with a stent 有权
标题翻译：用于支架的药物输送涂层
公开(公告)号：US08263102B2
公开(公告)日：2012-09-11
申请号：US11236908
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F2/00 , A61K9/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device an a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译：涂覆的医疗装置是在可植入医疗装置上提供涂层的方法，导致具有生物吸收性涂层的医疗装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。

12. 发明授权

US08722132B2 Application of a coating on a medical device 有权
标题翻译：涂在医疗器械上的应用
公开(公告)号：US08722132B2
公开(公告)日：2014-05-13
申请号：US13185135
申请日：2011-07-18
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： B05D3/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译：用于在可植入医疗装置上提供涂层的方法和装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。所述方法和装置提供了具有改进的均匀性和覆盖度的涂层，其又允许更大程度地控制涂层的量和剂量。

13. 发明申请

US20110274823A1 APPLICATION OF A COATING ON A MEDICAL DEVICE 有权
标题翻译：涂料在医疗器械上的应用
公开(公告)号：US20110274823A1
公开(公告)日：2011-11-10
申请号：US13185135
申请日：2011-07-18
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： B05D7/00 , B05D1/00 , B05D1/18 , B05D1/28 , B05D3/00 , B05D1/02
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译：用于在可植入医疗装置上提供涂层的方法和装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。所述方法和装置提供了具有改进的均匀性和覆盖度的涂层，其又允许更大程度地控制涂层的量和剂量。

14. 发明授权

US06890463B2 Method for treating expandable polymer materials 有权
标题翻译：处理可膨胀聚合物材料的方法
公开(公告)号：US06890463B2
公开(公告)日：2005-05-10
申请号：US10131446
申请日：2002-04-22
申请人： Paul Martakos , Roger Labrecque , Geoffrey Moodie , Steve A. Herweck , Theodore Karwoski
发明人： Paul Martakos , Roger Labrecque , Geoffrey Moodie , Steve A. Herweck , Theodore Karwoski
IPC分类号： A61F2/06 , B29B11/10 , B29B11/14 , B29B13/00 , B29B13/02 , B29B15/00
CPC分类号： A61F2/06
摘要： The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The wettable liquid can be formed of a drug and/or an agent, such that the resulting polymer contains and emits the drug upon positioning at a target location of a patient body. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.
摘要翻译：本发明涉及包括用可湿性液体再湿润可膨胀聚合物以允许在室温或低于室温下增强膨胀而不破裂的方法，并且在某些情况下允许使用已知方法获得比在升高的温度下更大的膨胀比。可湿性液体可以由药物和/或药剂形成，使得所得聚合物在定位在患者身体的目标位置时含有和释放药物。本发明还可以实现具有独特性质和处理特性的材料。这些性质包括材料厚度减小，密度增加，节点/原纤维形态改变，以及在平坦材料情况下更一致的网。该方法不限于室温条件，只要可膨胀聚合物材料用可湿性液体润湿，并且膨胀在优选低于该液体的蒸发或沸点的温度下进行。

15. 发明申请

US20140308333A1 COATING MATERIAL AND MEDICAL DEVICE SYSTEM INCLUDING SAME 有权
标题翻译：包装材料和医疗器械系统
公开(公告)号：US20140308333A1
公开(公告)日：2014-10-16
申请号：US14252671
申请日：2014-04-14
申请人： Roger Labrecque , Geoffrey Moodie , Joseph F. Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph F. Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coating material including a bio-absorbable cross-linked material and a cellular uptake inhibitor. The bio-absorbable cross-linked material includes two or more fatty acids cross-linked into a substantially random configuration by ester bonds. The coating material may be adhered to a medical device. A medical device system including a medical device and a coating is also included.
摘要翻译：包括生物可吸收交联材料和细胞吸收抑制剂的涂层材料。生物可吸收交联材料包括通过酯键交联成基本上无规构型的两种或更多种脂肪酸。涂层材料可以粘附到医疗装置。还包括包括医疗装置和涂层的医疗装置系统。

16. 发明授权

US06923927B2 Method for forming expandable polymers having drugs or agents included therewith 失效
标题翻译：形成含有药物或试剂的可发性聚合物的方法
公开(公告)号：US06923927B2
公开(公告)日：2005-08-02
申请号：US10807709
申请日：2004-03-23
申请人： Paul Martakos , Roger Labrecque , Geoffrey Moodie , Steve A. Herweck , Theodore Karwoski
发明人： Paul Martakos , Roger Labrecque , Geoffrey Moodie , Steve A. Herweck , Theodore Karwoski
IPC分类号： A61F2/06 , B29B11/10 , B29B11/14 , B29B13/00 , B29B13/02 , B29B15/00
CPC分类号： A61F2/06
摘要： The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The wettable liquid can be formed of a drug and/or an agent, such that the resulting polymer contains and emits the drug upon positioning at a target location of a patient body. The expandable polymer can also have the drug or agent added to its structure at a polymer resin preparation stage, through use of an aqueous solution mixed with one or more fluoropolymers, or in a mixing stage. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.
摘要翻译：本发明涉及包括用可湿性液体再湿润可膨胀聚合物以允许在室温或低于室温下增强膨胀而不破裂的方法，并且在某些情况下允许使用已知方法获得比在升高的温度下更大的膨胀比。可湿性液体可以由药物和/或药剂形成，使得所得聚合物在定位在患者身体的目标位置时含有和释放药物。可膨胀聚合物还可以通过使用与一种或多种含氟聚合物混合的水溶液，或在混合阶段中，在聚合物树脂制备阶段将药物或试剂加入到其结构中。本发明还可以实现具有独特性质和处理特性的材料。这些性质包括材料厚度减小，密度增加，节点/原纤维形态改变，以及在平坦材料情况下更一致的网。该方法不限于室温条件，只要可膨胀聚合物材料用可湿性液体润湿，并且膨胀在优选低于该液体的蒸发或沸点的温度下进行。

17. 发明授权

US08367099B2 Perforated fatty acid films 有权
标题翻译：穿孔脂肪酸膜
公开(公告)号：US08367099B2
公开(公告)日：2013-02-05
申请号：US11525390
申请日：2006-09-22
申请人： Steve A. Herweck , Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith M. Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
发明人： Steve A. Herweck , Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith M. Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
IPC分类号： A61L15/16
CPC分类号： B65B55/18 , A61B2017/00004 , A61B2017/320044 , A61B2090/0816 , A61F2/0059 , A61F2/0095 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/14 , A61L2/186 , A61L2/206 , A61L2/208 , A61L31/00 , A61L31/145 , A61L31/148 , A61L2202/24 , B26F1/18 , B29C39/02 , B65B31/04 , Y10T83/0481
摘要： A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：生物可吸收的独立膜至少部分地由脂肪酸衍生。生物吸收性独立膜可以具有抗粘连性，抗炎性，非炎性和伤口愈合性，并且还可以包括一种或多种掺入其中的治疗剂。独立膜具有形成在其中的一个或多个穿孔或凹陷。使具有一个或多个穿孔或凹陷的生物吸收性独立薄膜的相应方法包括成型，切割，雕刻，穿刺或以其它方式适当地在生物吸收性独立薄膜中产生穿孔或凹陷的方法。所得到的独立膜是生物可吸收的。

18. 发明申请

US20050113687A1 Application of a therapeutic substance to a tissue location using a porous medical device 审中-公开
标题翻译：使用多孔医疗装置将治疗物质施用于组织位置
公开(公告)号：US20050113687A1
公开(公告)日：2005-05-26
申请号：US10943075
申请日：2004-09-15
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
IPC分类号： A61B5/05 , A61F2/82 , A61M20060101
CPC分类号： A61M25/10 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61M25/1027 , A61M25/104 , A61M2025/105 , A61M2025/1088
摘要： A non-polymeric or biological coating applied to porous radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.
摘要翻译：应用于多孔径向可扩张介入医疗装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀药物分布和渗透到体内的目标治疗区域。涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。

19. 发明申请

US20080015500A1 Application of a therapeutic substance to a tissue location using an expandable medical device 有权
标题翻译：使用可扩张医疗装置将治疗物质施用于组织位置
公开(公告)号：US20080015500A1
公开(公告)日：2008-01-17
申请号：US11804478
申请日：2007-05-18
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
IPC分类号： A61M29/02
CPC分类号： A61M25/1027 , A61L29/085 , A61L29/146 , A61L29/16 , A61L2300/22 , A61L2300/606 , A61M2025/1075 , A61M2025/1088 , C08L27/18
摘要： A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and/or inert.
摘要翻译：应用于可径向扩张的医疗输送装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。输送装置使用充气流体的压力膨胀。在将输送装置膨胀至预定尺寸和形状之后，充气流体通过输送装置的多孔表面而流失。涂层释放输送装置并漂浮在充气流体上，直到由于其对组织的亲和力而结合到组织。一旦涂层通过涂层材料的组织细胞通过吸收机制结合或固定到组织，涂层和其中包含的任何治疗剂被递送到组织。流体可以含有治疗剂，或者可以以其他方式生物相容和/或惰性。

20. 发明申请

US20060112536A1 Method of coating a folded medical device 有权
标题翻译：折叠式医疗装置的涂敷方法
公开(公告)号：US20060112536A1
公开(公告)日：2006-06-01
申请号：US11250768
申请日：2005-10-14
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
IPC分类号： B23P17/04
CPC分类号： B05D1/00 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61L29/08 , A61L29/16 , A61L2300/606 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , B05D2259/00 , Y10T29/49
摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.
摘要翻译：以折叠的，包裹的或折叠的构造施加到可径向展开的介入医疗装置的非聚合或生物涂层。调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。

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