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11. 发明授权

US08715740B2 Silk nanospheres and microspheres and methods of making same 有权
标题翻译：丝纳米球和微球及其制备方法
公开(公告)号：US08715740B2
公开(公告)日：2014-05-06
申请号：US13496227
申请日：2010-09-29
申请人： Xiaoqin Wang , David L. Kaplan
发明人： Xiaoqin Wang , David L. Kaplan
IPC分类号： A61K9/50 , A61K9/127 , B01J13/02
CPC分类号： A61K9/5169 , A61K9/14 , A61K9/1605 , A61K9/1647 , A61K9/5052 , A61K9/5089 , A61K9/5192 , A61K31/352 , Y10T428/2982
摘要： The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles.
摘要翻译：本发明提供了制备丝纳米颗粒和微粒的方法，将活性剂包封在丝纳米和微粒中的方法和包含这些丝颗粒的组合物。

12. 发明授权

US08614293B2 Concentrated aqueous silk fibroin solution and use thereof 有权
公开(公告)号：US08614293B2
公开(公告)日：2013-12-24
申请号：US12611256
申请日：2009-11-03
申请人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
发明人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： A61L27/227 , A61L27/3604 , A61L27/38 , A61L27/52 , A61L27/56 , A61L2430/02 , B29C39/003 , B29C39/203 , B29C55/005 , B29D7/01 , B29K2089/00 , B29L2007/00 , B29L2009/00 , C07K14/43536 , C07K14/43586 , C08J3/07 , C08J3/075 , C08J5/18 , C08J9/0061 , C08J9/26 , C08J9/28 , C08J2201/0444 , C08J2201/0504 , C08J2205/022 , C08J2389/00 , C08L89/00 , D01D5/0007 , D01F4/02 , Y10T428/249921 , Y10T442/10 , Y10T442/60
摘要： The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

13. 发明授权

US08529835B2 Biopolymer sensor and method of manufacturing the same 有权
标题翻译：生物聚合物传感器及其制造方法
公开(公告)号：US08529835B2
公开(公告)日：2013-09-10
申请号：US12513441
申请日：2007-11-05
申请人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi
发明人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi
IPC分类号： C12Q1/68
CPC分类号： B29D11/0074 , B29C41/02
摘要： A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
摘要翻译：一种制备生物聚合物传感器的方法，包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，在生物聚合物基质中添加生物材料，提供基材，将基质溶液浇铸在基材上，并将生物聚合物基质溶液干燥在基材上形成凝固的生物聚合物传感器。还提供了一种生物聚合物传感器，其包括具有嵌入的生物材料的固化的生物聚合物膜。

14. 发明授权

US08501172B2 pH-induced silk gels and uses thereof 有权
标题翻译： pH诱导的丝凝胶及其用途
公开(公告)号：US08501172B2
公开(公告)日：2013-08-06
申请号：US12974796
申请日：2010-12-21
申请人： David L. Kaplan , Tuna Yucel , Tim Jia-Ching Lo , Gary G. Leisk
发明人： David L. Kaplan , Tuna Yucel , Tim Jia-Ching Lo , Gary G. Leisk
IPC分类号： A61K39/395
CPC分类号： A61K47/42 , A61K9/10 , A61K41/00 , A61L26/0047 , A61L27/227 , A61L27/34 , A61L27/3604 , A61L27/38 , A61L27/52 , H01L41/193 , C08L89/00
摘要： This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to β-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels.
摘要翻译：本发明提供了在称为电凝胶的方法中，使用直接施加电压将丝素蛋白溶液快速转化成丝素蛋白凝胶的组合物，方法和装置。丝素蛋白凝胶可以通过施加反向电压而可逆地转化为液体形式，或者可以通过施加剪切力或其它处理而进一步转化成β-折叠结构。电致凝胶丝可以用作提取的体积凝胶，喷雾或凝胶流加工成材料或装置，或者可以用作设备的丝凝胶涂层。活性剂可以嵌入丝绸凝胶中用于各种医疗应用。本发明还提供了制备粘性丝pH凝胶的方法和组合物。例如，该方法包括降低丝素蛋白溶液的pH值以增加丝素蛋白溶液的体积或局部质子浓度，由此形成粘性丝凝胶。

15. 发明申请

US20130039986A1 Silk-Based Ionomeric Compositions 有权
标题翻译：丝绸类离聚物组合物
公开(公告)号：US20130039986A1
公开(公告)日：2013-02-14
申请号：US13582903
申请日：2011-03-04
申请人： David L. Kaplan , Monica A. Serban
发明人： David L. Kaplan , Monica A. Serban
IPC分类号： A61K47/42 , C07K1/00 , A61K9/14 , A61K38/02 , A61K35/00 , A61K31/7088 , A61K39/395 , A61K38/19 , A61K38/43 , A61P31/00 , A61K35/76 , A61P31/12 , C07K1/107 , A61P35/00 , A61P5/00 , C07K14/435 , B82Y5/00
CPC分类号： A61L27/52 , A61K9/5063 , A61L15/26 , A61L15/32 , A61L15/42 , A61L27/18 , A61L27/227 , A61L27/26 , A61L27/50 , A61L27/54 , A61L2300/00 , Y10T428/2982 , C08L77/04
摘要： Disclosed herein are pH-dependent silk fibroin-based ionomeric compositions and colloids, and methods of making the same. The state of the silk fibroin ionomeric compositions is reversible and can transform from a gel-like colloid to a more fluid-like solution, or vice versa, upon an environmental stimulus, e.g., pH. Thus, the silk-based ionomeric compositions and colloids can be applied in various industries, ranging from electronic applications to biomedical applications, such as sensors, gel diodes, absorbent materials, drug delivery systems, tissue implants and contrast agents.
摘要翻译：本文公开了基于pH的丝心蛋白基离聚物组合物和胶体及其制备方法。丝素蛋白离聚物组合物的状态是可逆的，并且可以在诸如pH的环境刺激下从凝胶状胶体转化为更流体状的溶液，或反之亦然。因此，基于丝的离聚物组合物和胶体可以应用于各种行业，从电子应用到生物医学应用，例如传感器，凝胶二极管，吸收材料，药物递送系统，组织植入物和造影剂。

16. 发明申请

US20120070427A1 VORTEX-INDUCED SILK FIBROIN GELATION FOR ENCAPSULATION AND DELIVERY 审中-公开
标题翻译： VORTEX诱导的丝状纤维素凝胶用于包扎和递送
公开(公告)号：US20120070427A1
公开(公告)日：2012-03-22
申请号：US13320036
申请日：2010-06-01
申请人： David L. Kaplan , Tuna Yucel
发明人： David L. Kaplan , Tuna Yucel
IPC分类号： A61K38/17 , A61K39/395 , A61K38/18 , A61K39/00 , A61K38/43 , A61K35/76 , A61K35/12 , A61K35/34 , A61K35/23 , A61K35/407 , A61K35/28 , A61K35/54 , A61K35/48 , A61P31/00 , A61K35/00
CPC分类号： A61K9/5052 , A61K9/0024 , A61K9/06 , A61K9/5089 , A61K38/00 , A61K47/42
摘要： The present invention provided for a novel process of forming silk fibroin gels, and controlling the rate of β-sheet formation and resulting hydrogelation kinetics, by vortex treatment of silk fibroin solution. In addition, the vortex treatment of the present invention provides a silk fibroin gel that may be reversibly shear-thinned, enabling the use of these approach for precise control of silk self-assembly, both spatially and temporally. Active agents, including biological materials, viable cells or therapeutic agents, can be encapsulated in the hydrogels formed from the processes, and be used as delivery vehicles. Hence, the present invention provide for methods for silk fibroin gelation that are useful for biotechnological applications such as encapsulation and delivery of active agents, cells, and bioactive molecules.
摘要翻译：本发明提供了一种形成丝素蛋白凝胶的新方法，并且通过涡旋处理丝素蛋白溶液来控制成型速率和形成的水凝胶化动力学。此外，本发明的涡流处理提供了可逆地剪切变薄的丝素蛋白凝胶，使得能够在空间和时间上精确地控制丝自组装的这些方法。包括生物材料，活细胞或治疗剂在内的活性剂可以包封在由该方法形成的水凝胶中，并用作递送载体。因此，本发明提供丝素蛋白凝胶化方法，其可用于生物技术应用如活性剂，细胞和生物活性分子的包封和递送。

17. 发明授权

US08129141B2 Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials 有权
标题翻译：纤维蛋白融合及其在先进的有机/无机复合材料的形成中的应用
公开(公告)号：US08129141B2
公开(公告)日：2012-03-06
申请号：US13097538
申请日：2011-04-29
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： C12P1/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.
摘要翻译：要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。该融合用于形成有机 - 无机复合材料。这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。这可以在组装材料期间或在矿化步骤期间在材料形成中实现。

18. 发明申请

US20120034291A1 NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS 有权
标题翻译：用于生物医学和生物医学应用的丝素纤维结构的纳米生物
公开(公告)号：US20120034291A1
公开(公告)日：2012-02-09
申请号：US13201380
申请日：2010-02-12
申请人： Jason J. Amsden , David L. Kaplan , Fiorenzo Omenetto
发明人： Jason J. Amsden , David L. Kaplan , Fiorenzo Omenetto
IPC分类号： A61K9/70 , A61K35/00 , A61K38/43 , A61K31/7088 , B29D11/00 , B32B3/10 , A61K39/395 , A61K38/00 , B82Y5/00 , B82Y40/00
CPC分类号： A61K9/7007 , A61K9/70 , A61K41/00 , A61K47/42 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , G01N21/4788 , G01N21/774 , G01N2021/7776 , G02B5/1809 , G02B5/1847 , G02B6/02061 , G02B6/1225 , G02B6/262 , G03F7/0002 , Y10T428/24479
摘要： The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass sition temperature of the silk film Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.
摘要翻译：本发明提供了基于光子纳米压印的丝素蛋白的材料及其制备方法，其包括用丝光纳米尺度图案压花丝素蛋白基膜。此外，本发明提供了通过局部降低丝膜的玻璃化温度，可以在室温下将丝素蛋白基膜纳米压印的方法。这种纳米压印方法增加了高通量并提高了掺入丝基光子学的潜力进入生物医学和其他光学器件。

19. 发明申请

US20110275788A1 FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS 有权
标题翻译：纤维蛋白融合及其在先进有机/无机复合材料的形成中的应用
公开(公告)号：US20110275788A1
公开(公告)日：2011-11-10
申请号：US13097538
申请日：2011-04-29
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： C07K7/08 , C07K17/00 , A61K38/17 , C07K14/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.
摘要翻译：要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。该融合用于形成有机 - 无机复合材料。这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。这可以在组装材料期间或在矿化步骤期间在材料形成中实现。

20. 发明申请

US20110171239A1 pH INDUCED SILK GELS AND USES THEREOF 有权
标题翻译： pH诱导丝光凝胶及其用途
公开(公告)号：US20110171239A1
公开(公告)日：2011-07-14
申请号：US12974796
申请日：2010-12-21
申请人： David L. Kaplan , Tuna Yucel , Tim Jia-Ching Lo , Gary G. Leisk
发明人： David L. Kaplan , Tuna Yucel , Tim Jia-Ching Lo , Gary G. Leisk
IPC分类号： A61K39/395 , C07K14/00 , A61K47/42 , A61K35/12 , A61K38/00 , A61K31/7088 , A61K39/00 , A61K38/22 , A61K38/18 , A61K38/43 , A61K35/76 , A61P17/02 , C25B3/00
CPC分类号： A61K47/42 , A61K9/10 , A61K41/00 , A61L26/0047 , A61L27/227 , A61L27/34 , A61L27/3604 , A61L27/38 , A61L27/52 , H01L41/193 , C08L89/00
摘要： This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to β-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels.
摘要翻译：本发明提供了在称为电凝胶的方法中，使用直接施加电压将丝素蛋白溶液快速转化成丝素蛋白凝胶的组合物，方法和装置。丝素蛋白凝胶可以通过施加反向电压而可逆地转化回液体形式，或者可以通过施加剪切力或其它处理而进一步转化为“薄片”结构。电致凝胶丝可以用作提取的体积凝胶，喷雾或凝胶流加工成材料或装置，或者可以用作设备的丝凝胶涂层。活性剂可以嵌入丝绸凝胶中用于各种医疗应用。本发明还提供了制备粘性丝pH凝胶的方法和组合物。例如，该方法包括降低丝素蛋白溶液的pH值以增加丝素蛋白溶液的体积或局部质子浓度，由此形成粘性丝凝胶。

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