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    • 16. 发明申请
    • POLYSILOXANE ANTIMICROBIALS
    • 多晶硅抗微生物
    • US20110110998A1
    • 2011-05-12
    • US12309091
    • 2007-07-04
    • Sophie Marquais-BienewaldOlof WallquistAndrea PreussStewart Todd Elder
    • Sophie Marquais-BienewaldOlof WallquistAndrea PreussStewart Todd Elder
    • A01N55/10A01N25/34C07F7/18A01P1/00C09D5/14
    • C08G77/388A01N55/00
    • Disclosed are oligo- or polysiloxanes, which are characterized by containing at least 3, for example 4-3000, Si atoms in the main chain, and wherein at least one thereof is contained in a moiety of the formula (I) whose open bond of the O atom is linked to another Si atom of the oligo- or polysiloxane main chain, and whose open bond of the Si atom is linked either to another O atom of the oligo- or polysiloxane main chain or to R′1, where R1 and R′1 independently are C1-C10alkyl, R2 and R3 independently are C1-C18alkylene, X is a divalent spacer group selected from O, NR4, N(COR′5), CONR′4, OCONR′4;. Y is selected from OCOR5, NHCOR5, NHR4, COOR5, CONHR4, NR′4R4; R4 is selected from C6-C18 organic residues containing at least one aryl moiety; R′4 is as defined for R4; or is selected from H, C1-C20alkyl, C7-C20phenylalkyl, C4-C12cycloalkyl; R5 is R7—Z; R′5 is as defined for R5; or is selected from H, C1-C20alkyl, C7-C20phenylalkyl, C4-C12cycloalkyl; R7 is C1-C20alkylene, which may be interrupted by phenylene, C4-C12cycloalkylene, O, NR′4; or is unsubstituted or substituted phenylene or C4-C12cycloalkylene; Z is halogen or N+R8R8R10; R8, R9 and R10 independently are selected from C1-C20alkyl, C7-C20phenylalkyl, C4-C12cycloalkyl, unsubstituted or substituted aryl; or 2 of R8, R9 and R10 are linked together to form a quaternized aliphatic, substituted or unsubstituted N-heterocyclic ring of 4-6 carbon atoms such as a piperidine ring; or all of R8, R9 and R10 are linked together to form, together with the nitrogen atom they are bonding to, a substituted or unsubstituted N-heterocyclic ring system of 4-7 carbon atoms. The novel compounds are effective as antimicrobials.
    • 公开了低聚或聚硅氧烷,其特征在于在主链中含有至少3个,例如4-3000个Si原子,并且其中至少一个包含在式(I)的部分中,其开环键 O原子与低聚或聚硅氧烷主链的另一个Si原子连接,并且其Si原子的开环键连接到寡聚或聚硅氧烷主链的另一个O原子或R'1,其中R 1和 R 1独立地是C 1 -C 10烷基,R 2和R 3独立地是C 1 -C 18亚烷基,X是选自O,NR 4,N(COR'5),CONR 4,OCONR 4的二价间隔基。 Y选自OCOR5,NHCOR5,NHR4,COOR5,CONHR4,NR'4R4; R4选自含有至少一个芳基部分的C6-C18有机残基; R'4如R4所定义; 或选自H,C 1 -C 20烷基,C 7 -C 20苯基烷基,C 4 -C 12环烷基; R5为R7-Z; R'5如R5所定义; 或选自H,C 1 -C 20烷基,C 7 -C 20苯基烷基,C 4 -C 12环烷基; R 7是C 1 -C 20亚烷基,其可被亚苯基,C 4 -C 12亚环烷基,O,NR'4中间; 或未取代或取代的亚苯基或C 4 -C 12亚环烷基; Z为卤素或N + R8R8R10; R 8,R 9和R 10独立地选自C 1 -C 20烷基,C 7 -C 20苯基烷基,C 4 -C 12环烷基,未取代或取代的芳基; 或2的R 8,R 9和R 10连接在一起形成4-6个碳原子的季铵化的脂族,取代或未取代的N-杂环,例如哌啶环; 或全部R 8,R 9和R 10连接在一起,与它们所键合的氮原子一起形成取代或未取代的4-7个碳原子的N-杂环体系。 新型化合物作为抗微生物剂是有效的。
    • 17. 发明申请
    • Oxazine Disulfide Dyes
    • US20090229059A1
    • 2009-09-17
    • US11992878
    • 2006-09-27
    • Christian CremerOlof Wallquist
    • Christian CremerOlof Wallquist
    • A61K8/49C09B19/00C09B17/02C09B21/00C09B49/06A61Q5/10
    • C09B19/00A61K8/49A61Q5/065A61Q5/10C09B17/02C09B21/00C09B49/06
    • Disclosed are oxazine disulfide dyes of formula (1) D1-(Z1)r-Y1—S-A, wherein A is hydrogen; or a radical of formula (1a)*—S—Y2-(Z2)r-D2; Y1 and Y2 independently from each other are unsubstituted or substituted, straight-chain or branched, interrupted or uninterrupted C—1—C—10alkylene; C5-C10cycloalkylene; C5-C10arylene; or —C5-C10arylene-(C1-C10alkylene); Z1 and Z2 independently from each other are *—(CH2)p—C(O)—**; *—(CH2CH2—O)S—**; *—(CH2)p—C(O)O—**; *—(CH2)p—OCO—**; *—(CH2)P—N(R1)—**; formula 1(g); —(CH2)p—CON(R1)—**; *—(CH2)p—(R1)NC(O)—**; , 0-; —S—; —S(O)—; —S(O)2—; or a cationic biradical of a substituted or unsubstituted aromatic or heteroaromatic compound of the formula (1a); (1b); (1c); (1d); or (1e); wherein the asterix * indicates the linkage to D1 and/or D2; the asterix ** indicates the linkage to Y1 and/or Y2; W1 is N or a radical of CR5; R1, R2, R3, R4 and R5 independently from each other are hydrogen; C1-C14alkyl; C2-C14alkenyl; C5-C10aryl; C5-C10aryl-(C1-C10alkyl); or —C1-C10alkyl(C5-C10aryl); D1 and D2 independently from each other ar the residue of an organic dye selected from the radical of formula (1f); R6 and R7 independently from each other are hydrogen; C1-C20alkyl; C1-C20alkoxy; C3-C6cycloalkyl; C5-C10aryl; anellated aromatic groups; carboxylate; or sulfonate groups; R8, R9 and R10, R11 and R12 each independently from each other are hydrogen; unsubstituted or substituted, straight-chain or branched, monocyclic or polycyclic, interrupted or uninterrupted C1-C14alkyl, C2-C14alkenyl, C6-C10aryl, C6-C10aryl-C1-C10alkyl or C5-C10alkyl(C5-C10aryl); or R8 and R9 or R10 and R11, together with the linking nitrogen atom form a 5 to 7 membered carbocyclic ring which may contain one or more than one hetero atom; or R8 is linked to C1 together with N+ forming a 5-7 membered carbocyclic ring; or R9 is linked to C2 together with N+ forming a 5-7 membered carbocyclic ring; X is —O—; or —N(R9)—; or —S—; p is a number from 0 to 5; r is 0 or 1; and s is a number from 1 to 5. The compounds are useful for the dyeing of organic materials, such as keratin fibers, preferably human hair.
    • 18. 发明申请
    • Nitrosulfide dyes
    • US20090130045A1
    • 2009-05-21
    • US11921810
    • 2006-06-14
    • Christian CremerOlof Wallquist
    • Christian CremerOlof Wallquist
    • A61K8/46C07C321/20
    • A61Q5/10A61K8/418A61K8/46C09B49/02C09B51/00
    • Disclosed are nitro-sulfide dyes of formula (1), their salts, isomers, hydrates and other solvates, wherein R1, R2, R3, independently from each other are hydrogen; C1-C20alkyl or C1-C20alkoxy, which may be substituted by one or more C1-C5alkoxy, halogen, —NH2, mono-C1-C5alkylamino, di-C1-C5alkylamino, —NO2 or hydroxy; C3-C6cycloalkyl; —C(O)H; —C(O)—C1-C5alkyl; —C(O)OH; —C(O)O—C1-C5alkyl; halogen; NO2; OH; SH; phenyl, which may be substituted by one or more C1-C5alkyl, C1-C5alkoxy, halogen, —NH2, mono-C1-C5alkylamino, di-C1-C5alkylamino, —NO2 or hydroxy; or a radical of formula (1a) —NR4R5, wherein R4 and R5 independently from each other are hydrogen; C1-C12alkyl, which may be substituted by one or more C1-C5alkyl, C1-C5-alkoxy, hydroxy or —(CO)—H; —(CO)—C1-C5alkyl; phenyl or phenyl-C1-C4alkyl, wherein the phenyl moiety may be substituted by one or more C1-C5alkyl, C1-C5alkoxy, halogen, —NH2, mono-C1-C5alkylamino, di-C1-C5alkylamino, —NO2, carboxy or hydroxy; or a radical of formula (2); wherein at least one of the radicals R1, R2 or R3 is NO2; Y1 is C1-C10alkylene; C5-C10cycloalkylene; C5-C10arylene; or C5-C10arylene-(C1-C10alkylene); Z1 is the direct bond; formula (3); or a cationic biradical of a saturated, aromatic or heteroaromatic group; Q1 is —C(O)—; —C(O)O—; —OCO—; —N(R6)—X2—; —CON(R6)—; —(R6)NC(O)—; —O—; —S—; —S(O)—; or —S(O)2—; X1 and X2 independently from each other are the direct bond; C1-C10alkylene; C5-C10cycloalkylene; C5-C10arylene; or C5-C10arylene-(C1-C10alkylene); and R6, R7 and R8 independently from each other are hydrogen; C1-C14alkyl; C2-C14alkenyl; C6-C10aryl; C6-C10aryl-C1-C10alkyl; or C1-C10alkyl(C5-C10aryl); m is 1; or 2; U is hydrogen, if m is 1; or the direct bond, if m is 2; with the proviso that the method does not comprise contacting hair with an enzyme of the type of a protein disulfidisomerase (EC 5.3.4.1). Further, the present invention relates to novel sulfide compounds, compositions thereof, especially comprising other dyes, and to processes for their preparation.
    • 20. 发明申请
    • Triarylmethane Dyes
    • US20090151091A1
    • 2009-06-18
    • US11992876
    • 2006-09-27
    • Christian CremerOlof Wallquist
    • Christian CremerOlof Wallquist
    • A61K8/46C07D403/06C07C233/88C07C229/54A61K8/49
    • A61K8/46A61K8/49A61K8/492A61Q5/10C09B11/04C09B49/126
    • Disclosed are triarylmethane dyes of formula (1) D1-(Z1J)r-Y1—S-A, wherein A is hydrogen; a radical of formula (1b) *—S—Y2-(Z2)-D2; or a radical of formula (1c) *—S—Y3; Y1 and Y2 independently from each other are unsubstituted or substituted, straight-chain or branched, interrupted or uninterrupted C1-C10alkylene; C5-C10cycloalkylene; C5-C10arylene; or —C5-C10arylene-(C1-C10alkylene); Y3 is an unsubstituted or substituted, straight-chain or branched, interrupted or uninterrupted C1C10alkyl; C5-C10cycloalkyl; C5-C10aryl; or —C5-C10aryl-(C1-C10alkyl); Z1 and Z2 independently from each other are *—(CH2)p—C(O)—**; *—(CH2CH2—O)—**; *—(CH2)p—C(O)O—**; *—(CH2)p—OCO—**; —(CH2)p—N(R1)—**; —(CH2)p—CON(R1)—**; —(CH2)p—(R1)NC(O)—**; -0-; —S—; —S(O)—; —S(O)2—; or a cationic biradical of a substituted or unsubstituted aromatic or heteroaromatic compound of the formula (1a); (1b); (1c); (1d); or (1e); wherein the asterix * indicates the linkage to D1 and/or D2; the asterix ** indicates the linkage to Y1 and/or Y2; W1 is N or a radical of CR5; R1, R2, R3, R4 and R5 independently from each other are hydrogen; C1-C14alkyl; C2-C14alkenyl; C5-C10aryl; C5-C10aryl-(C1-C10alkyl); or —C1-C10alkyl(C5-C10aryl); D1 and D2 independently from each other are hydrogen; or the residue of an organic dye selected from the radical of formula (1f), wherein B1 and B2, independently from each other are C6-C10aryl; or a 5-7-membered heterocyclic compound, which may be substituted by C1-C12alkyl, C1C12alkoxy, phenyl, hydroxy, halogen, sulfonic acid, carboxylate, or by the radical —NR6R7 or —OR6; B3 is C6-C10arylene, or a bivalent radical of a 5-7-membered heterocyclic compound, which may be substituted by C1-C12alkyl, C1-C12alkoxy, phenyl, hydroxy, halogen, sulfonic acid, carboxylate, or by the radical —NR6R7 or —OR6; R6 and R7 independently from each other are hydrogen; or C1-C12alkyl, which may be substituted by hydroxy or C6-C10aryl; or R6 and R7 together with the linking nitrogen atom form a 5 to 7 membered heterocyclic ring; or R6 and R7 together with the linking nitrogen atom form a piperidine ring of formula (1b)* 1H **. wherein the asterix(*) is directed to Z1 or Z2 respectively; and the asterix(**) is directed to the linking nitrogen atom; wherein one of D1 and D2 is not hydrogen; An is an anion; p is a number from O to 5; r is O or 1; and s is a number from 1 to 5. The compounds are useful for the dyeing of organic materials, such as keratin fibers, preferably human hair.