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    • 16. 发明授权
    • System and method for identifying a prospective clinical therapy for a prospective patient having a medical device
    • 用于识别具有医疗装置的预期患者的预期临床治疗的系统和方法
    • US08688469B2
    • 2014-04-01
    • US12915945
    • 2010-10-29
    • Paul D. ZieglerShantanu SarkarJodi L. Redemske
    • Paul D. ZieglerShantanu SarkarJodi L. Redemske
    • G06Q10/00G06Q50/00
    • G06Q50/22G06F19/00
    • System and method for identifying a prospective clinical therapy for a prospective patient. The patient has a medical device, performed with a medical apparatus. The system has a historical database and an analyzer. The historical database incorporates information relating to a multiplicity of patients, each of the multiplicity of patients having a medical device and each of the multiplicity of patients having undergone a clinical therapy, the information including, for each of the multiplicity of patients, device characteristics of the medical device and an assessment of efficacy of clinical therapy. The analyzer correlates device characteristics of the prospective patient with the device characteristics and the assessment of efficacy of clinical therapy of the multiplicity of patients using the historical database to identify a prospective clinical therapy for the prospective patient associated with the device characteristics in the historical database having a relatively greater efficacy than the clinical therapy.
    • 用于鉴定潜在患者的预期临床治疗的系统和方法。 患者具有用医疗装置执行的医疗装置。 系统有一个历史数据库和一个分析器。 历史数据库包含与多个患者相关的信息,多个患者中的每一个具有医疗装置,并且每个患者已经经历了临床治疗,所述信息包括对于每个多个患者的装置特征 医疗器械和临床治疗效果评估。 分析仪将前瞻性患者的装置特征与装置特征以及使用历史数据库的多个患者的临床治疗效果的评估相结合,以鉴定与历史数据库中与装置特征有关的预期患者的预期临床疗法, 比临床治疗相对更大的功效。
    • 20. 发明授权
    • Detecting worsening heart failure based on impedance measurements
    • 基于阻抗测量检测恶化的心力衰竭
    • US08255046B2
    • 2012-08-28
    • US12184149
    • 2008-07-31
    • Shantanu SarkarDouglas A. HettrickRobert W. Stadler
    • Shantanu SarkarDouglas A. HettrickRobert W. Stadler
    • A61B5/05
    • A61B5/053A61B5/0031A61B5/6846A61N1/3627A61N1/36521A61N1/37235A61N1/37258A61N1/3962
    • Techniques for processing impedance data to provide an early warning for heart failure decompensation are described. An example device may be configured to measure intrathoracic impedance values, and increment an index when a determined impedance is less than a reference impedance. The incrementing may be based on the difference between the reference impedances and the determined impedance. In some examples, the amount of incrementing is reduced based on a variability of the impedances, or increased over time so long as the index remains above a threshold, e.g., zero. In some examples, the manner is which the reference impedances are determined changes over time to, for example, address rapid changes in impedance after device or system implantation. In some examples, the index is compared to a threshold to determine whether to provide an alert. In some examples, two thresholds are used to provide hysteresis.
    • 描述了用于处理阻抗数据以提供心力衰竭失代偿的早期警告的技术。 示例性装置可以被配置为测量胸内阻抗值,并且当确定的阻抗小于参考阻抗时增加指数。 增量可以基于参考阻抗和确定的阻抗之间的差异。 在一些示例中,只要索引保持高于阈值(例如零),基于阻抗的可变性减小增量的量,或随时间增加。 在一些示例中,确定参考阻抗的方式随着时间而变化,例如,在器件或系统植入之后阻抗的快速变化。 在一些示例中,将索引与阈值进行比较,以确定是否提供警报。 在一些示例中,使用两个阈值来提供滞后。