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11. 发明专利

CZ9102611A3 PROCESS OF 1-O-ALKYL-2-ACYL-SN-GLYCERO-3-PHOSPHO-(N-ACYL)-ETHANOLAMINE AND 1-O-ALKYL-SN-GLYCERO-3-PHOSPHO-(N-ACYL)-ETHANOLAMINE SYNTHESIS 未知
公开(公告)号：CZ9102611A3
公开(公告)日：1993-03-17
申请号：CS261191
申请日：1991-08-23
申请人： VOJKOVSKY TOMAS
发明人： VOJKOVSKY TOMAS
IPC分类号： C07C231/12 , C07C233/16

12. 发明专利

CZ261191A3 PROCESS OF 1-O-ALKYL-2-ACYL-SN-GLYCERO-3-PHOSPHO-(N-ACYL)-ETHANOLAMINE AND 1-O-ALKYL-SN-GLYCERO-3-PHOSPHO-(N-ACYL)-ETHANOLAMINE SYNTHESIS 未知
公开(公告)号：CZ261191A3
公开(公告)日：1993-03-17
申请号：CS261191
申请日：1991-08-23
申请人： VOJKOVSKY TOMAS
发明人： VOJKOVSKY TOMAS
IPC分类号： C07C231/12 , C07C233/16

13. 发明专利

CZ280686B6 N-ACYLATED PHOSPHOLIPIDS OF THE TYPE 1-O-ALKYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINES, PROCESS OF THEIR SEMISYNTHETIC PREPARATION AND USE 未知
公开(公告)号：CZ280686B6
公开(公告)日：1996-04-17
申请号：CS105492
申请日：1992-04-07
申请人： VOJKOVSKY TOMAS , LIEBL VLASTIMIL CSC
发明人： VOJKOVSKY TOMAS , LIEBL VLASTIMIL RNDR CSC
IPC分类号： C07F9/10 , A61K31/66 , A61K38/00
摘要： N-acylated phospholipids of the type 1-0-alkyl-sn-glycero-3-phosphoethanolamines of general formula I where R is hydrogen or R CO, R1 and R2 are the same or mutually different radicals derived from a hydrocarbon with 2 to 30 carbon atoms and n = 14 to 22. The method of their preparation consists of the acylation of phosphatidylethanolamines of animal origin, preferably hydrogenated ones, or of a mixture of phospholipids of animal origin containing phosphatidylethanolamines, preferably hydrogenated ones, with an acylation agent, such as a mixture of carboxylic acid and a condensation agent or the chloride, anhydride, active ester, active amid of this acid and the subsequent deacylation with a base at a temperature of -40 to +10 degrees C. The product is then separated from the reaction mixture, e.g. chromatographically, and it may be possibly acylated to 2.0 glycerol units.

14. 发明专利

AU2018263965A1 Manufacture of trans-(tetrachlorobis(1H-indazole)ruthenate (III)) and compositions thereof 未知
公开(公告)号：AU2018263965A1
公开(公告)日：2019-11-21
申请号：AU2018263965
申请日：2018-05-07
申请人： CARIE ADAM , INTEZYNE TECHNOLOGIES INC , SILL KEVIN , VOJKOVSKY TOMAS
发明人： VOJKOVSKY TOMAS , SILL KEVIN , CARIE ADAM
IPC分类号： A61K31/416 , A61K31/555 , A61K33/24
摘要： The present invention relates to the preparation of compositions comprising sodium

15. 发明专利

SG11201910043PA MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] AND COMPOSITIONS THEREOF 未知
公开(公告)号：SG11201910043PA
公开(公告)日：2019-11-28
申请号：SG11201910043P
申请日：2018-05-07
申请人： INTEZYNE TECHNOLOGIES INC , VOJKOVSKY TOMAS , SILL KEVIN , CARIE ADAM
发明人： VOJKOVSKY TOMAS , SILL KEVIN , CARIE ADAM
IPC分类号： A61K31/555 , A61K31/416 , A61K33/24
摘要： INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT Iiiimmoimiolollmonolooloviimiflinomovom (10) International Publication Number WO 2018/204930 Al (51) International Patent Classification: A61K 31/416 (2006.01) A61K 33/24 (2006.01) A61K 31/555 (2006.01) (21) International Application Number: PCT/US2018/031436 (22) International Filing Date: 07 May 2018 (07.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/501,984 05 May 2017 (05.05.2017) US (71) Applicant: INTEZYNE TECHNOLOGIES, INC. [US/US]; 3720 Spectrum Blvd., Suite 104, Tampa, Florida 33612 (US). (72) Inventors; and (71) Applicants: VOJKOVSKY, Tomas [ /US]; 23 Shelby Lane, Palm Beach Gardens, Florida 33418 (US). SILL, Kevin [ /US]; 16308 Royal Park Ct., Tampa, Florida 33647 (US). CARIE, Adam [ /US]; 4206 Knob Lake Ct., Tampa, FL 33619 (US). (74) Agent: REID, Andrea L.C. et al.; One International Place, 100 Oliver Street, 40th Floor, Boston, Massachusetts 02110-2605 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] AND COMPOSITIONS = THEREOF 120 100 IT- 139 Drug Su b O cr O 1 \ \ 80 1 \ 1 \ \ 60 7 1 \\ \ \ \ 40d \ , 1 20 1 \\ \ 1 01 1 0 10 20 IT-139 2-8°C - -0- - IT-13918-22°C 30 40 50 60 Time (h) Figure 1 1-1 (57) : The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H- ei • mdazole)ruthenate (III)]. Synthesis and formulation preparation is detailed. Impurity profiles are also discussed. Compositions herein C are useful for anti-cancer applications. [Continued on next page] WO 2018/204930 Al MIDEDIMOMMIDIRE10100101011fifilIMIHMEMOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))

16. 发明专利

CZ9201054A3 N-ACYLATED PHOSPHOLIPIDS OF THE TYPE 1-0-ALKYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINES AND PROCESS OF THEIR SYNTHETIC PREPARATION 未知
公开(公告)号：CZ9201054A3
公开(公告)日：1994-01-19
申请号：CS105492
申请日：1992-04-07
申请人： VOJKOVSKY TOMAS , LIEBL VLASTIMIL
发明人： VOJKOVSKY TOMAS , LIEBL VLASTIMIL RNDR CSC
IPC分类号： C07F9/10 , A61K31/66 , A61K38/00

17. 发明公开

EP1644377A4 TRIAZOLOTRIAZINE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：三唑并三嗪化合物及其用途
公开(公告)号：EP1644377A4
公开(公告)日：2007-09-05
申请号：EP04776943
申请日：2004-06-25
申请人： SUGEN INC
发明人： ZHANG FANG-JIE , VOJKOVSKY TOMAS , HUANG PING , LIANG CONGXIN , DO STEVEN HUY , KOENIG MARCEL , CUI JINGRONG
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04

18. 发明专利

ME00415B PIROL SUPSTITUISANI 2-INDOL PROTEIN KINAZNI INHIBITORI 未知
公开(公告)号：ME00415B
公开(公告)日：2011-10-10
申请号：MEP53008
申请日：2001-02-15
申请人： PHARMACIA & UPJOHN CO LLC , SUGEN INC
发明人： TANG PENG CHO , MILLER TODD , LI XIAOYUAN , SUN LI , WEI CHUNG CHEN , SHIRAZIAN SHAHRZAD , LIANG CONGXIN , VOJKOVSKY TOMAS , NEMATALLA ASAAD S , HAWLEY MICHAEL
IPC分类号： C07D207/33 , C07D401/14 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D207/32 , C07D209/44 , C07D401/12 , C07D403/00 , C07D403/06 , C07D403/12 , C07D403/14 , C07D521/00
摘要： Ovaj pronalazak se odnosi na jedinjenja 2-indolininona supstituisana pirolom formule (I): Ovaj pronalazak se odnosi na jedinjenja 2-indolininona supstituisana pirolom formule (I): i njihove farmaceutski prihvatljive soli, koja modulišu aktivnost protein kinaza, pa se stoga očekuje da budu korisna za prevenciju i tretman ćelijskih poremećaja povezanih sa protein kinazom, kao što je kancer. i njihove farmaceutski prihvatljive soli, koja modulišu aktivnost protein kinaza, pa se stoga očekuje da budu korisna za prevenciju i tretman ćelijskih poremećaja povezanih sa protein kinazom, kao što je kancer.

19. 发明专利

AU2002247133B2 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors 未知
公开(公告)号：AU2002247133B2
公开(公告)日：2007-08-30
申请号：AU2002247133
申请日：2002-02-15
申请人： PHARMACIA & UPJOHN CO LLC , SUGEN INC
发明人： TANG PENG CHO , JIN QINGWU , SUN LI , VOJKOVSKY TOMAS , GUAN HUIPING , MAURAGIS MICHAEL A , WEI CHUNG CHEN , HERRINTON PAUL MATTHEW , LIANG CONGXIN
IPC分类号： C07D403/06 , A61K31/404 , A61K31/4178 , A61K31/437 , A61K31/5377 , A61K31/541 , A61P3/10 , A61P9/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , C07D20060101 , C07D403/14 , C07D413/14 , C07D471/04
摘要： The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula

20. 发明专利

AT369359T 未知
公开(公告)号：AT369359T
公开(公告)日：2007-08-15
申请号：AT01914376
申请日：2001-02-15
申请人： SUGEN INC , PHARMACIA & UPJOHN CO LLC
发明人： TANG PENG , MILLER TODD , LI XIAOYUAN , SUN LI , WEI CHUNG , SHIRAZIAN SHAHRZAD , LIANG CONGXIN , VOJKOVSKY TOMAS , NEMATALLA ASAAD , HAWLEY MICHAEL
IPC分类号： C07D401/14 , C07D403/06 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D207/32 , C07D207/33 , C07D209/44 , C07D401/12 , C07D403/00 , C07D403/12 , C07D403/14 , C07D521/00
摘要： The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

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