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11. 发明专利

NO20084993L 未知
公开(公告)号：NO20084993L
公开(公告)日：2008-11-28
申请号：NO20084993
申请日：2008-11-28
申请人： SENOMYX INC
发明人： MOYER BRYAN , LU MIN , ECHEVERRI FERNANDO , KALABAT DALIA , GAO NA , HEVEZI PETER
IPC分类号： C12N15/10 , C12N5/08 , C12Q1/68

12. 发明专利

NO20035808L 未知
公开(公告)号：NO20035808L
公开(公告)日：2004-02-09
申请号：NO20035808
申请日：2003-12-23
申请人： SENOMYX INC
发明人： ADLER JON ELLIOT , STASZEWSKI LENA , ZOLLER MARK , XU HONG , MOYER BRYAN , PRONIN ALEXY , SERVANT GUY , CALLAMARAS NICHOLAS
IPC分类号： G01N33/483 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , G01N21/78 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/53 , G01N33/567

13. 发明专利

NO20035808A 未知
公开(公告)号：NO20035808A
公开(公告)日：2004-02-09
申请号：NO20035808
申请日：2003-12-23
申请人： SENOMYX INC
发明人： ADLER JON ELLIOT , STASZEWSKI LENA , ZOLLER MARK , XU HONG , MOYER BRYAN , PRONIN ALEXY , SERVANT GUY , CALLAMARAS NICHOLAS
IPC分类号： G01N33/483 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , G01N21/78 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/53 , G01N33/567
CPC分类号： C07K14/705

14. 发明专利

CA2452315A1 EXPRESSION OF FUNCTIONAL HUMAN OLFACTORY CYCLIC NUCLEOTIDE GATED (CNG) CHANNEL IN RECOMBINANT HOST CELLS AND USE THEREOF IN CELL BASED ASSAYS TO IDENTIFY SMELL MODULATORS 未知
公开(公告)号：CA2452315A1
公开(公告)日：2003-01-16
申请号：CA2452315
申请日：2002-07-08
申请人： SENOMYX INC
发明人： PRONIN ALEXY , MOYER BRYAN , ADLER JON ELLIOTT , CALLAMARAS NICHOLAS , STASZEWSKI LENA , SERVANT GUY , XU HONG , ZOLLER MARK T
IPC分类号： G01N33/483 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , G01N21/78 , G01N33/15 , G01N33/50 , G01N33/566 , C07K14/435 , C07K14/47 , C12N15/63 , C12Q1/04 , G01N33/543
摘要： The present invention relates to isolated nucleic acid sequences that encode human olfactory cyclic nucleotide gated (CNG) channel subunits, and the corresponding polypeptides. The invention further relates to the use of huma n CNG channels to profile, screen for, and identify compounds that modulate th e human olfactory CNG channel. More specifically, the invention relates to the expression of the human olfactory CNG channel in cells, preferably mammalian cells, and the use of these cells in high throughput cell-based assays to identify compounds that enhance or block human olfactory CNG function. Compounds that activate the olfactory CNG channel will enhance smell and can be used to make foods more palatable for individuals with attenuated olfacto ry function. Conversely, compounds that inhibit the olfactory CNG channel will inhibit smell and can be use to block malodors. Additionally, the invention relates to the use of cell-based olfactory CNG channel assays to identify modulates of G-protein coupled receptor (GPCRs) and other proteins that regulate cyclic nucleotide levels.

15. 发明专利

AU2002329196B2 Human olfactory nucleotide-gated ion channels 未知
公开(公告)号：AU2002329196B2
公开(公告)日：2008-08-07
申请号：AU2002329196
申请日：2002-07-08
申请人： SENOMYX INC
发明人： ZOLLER MARK T , CALLAMARAS NICHOLAS , XU HONG , PRONIN ALEXY , STASZEWSKI LENA , MOYER BRYAN , SERVANT GUY , ADLER JON ELLIOTT
IPC分类号： G01N33/483 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , G01N21/78 , G01N33/15 , G01N33/50 , G01N33/566

16. 发明专利

CA2654552A1 RATIONALE, METHODS, AND ASSAYS FOR IDENTIFYING NOVEL TASTE CELL GENES AND SALTY TASTE RECEPTOR TARGETS AND ASSAYS USING THESE IDENTIFIEDGENES OR GENE PRODUCTS 未知
公开(公告)号：CA2654552A1
公开(公告)日：2007-12-21
申请号：CA2654552
申请日：2007-06-08
申请人： SENOMYX INC
发明人： LU MIN , MOYER BRYAN , HEVEZI PETER , GAO NA , KALABAT DALIA , ECHEVERRI FERNANDO
IPC分类号： C12N5/06 , C07K14/705 , C12N5/08 , C12N5/10 , C12Q1/02 , C12Q1/04 , C12Q1/68 , C40B30/00
摘要： This invention relates to novel rationale and methods for identifying tas te-specific genes, including genes involved in salty taste perception, espec ially human salty taste perception, but also genes involved in sweet, bitter , umami, and sour taste perception, and genes involved in other taste cell o r taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and dig estive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modul ators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or block ing) taste perception, especially salty taste perception and as potential th erapeutics. In addition, this invention relates to novel methods for identif ying taste- specific genes that can be used as markers for different taste c ell types, including sweet, bitter, umami, sour, salt, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter , umami, or sour receptor in the presence of these genes to identify modulat ors of sweet, bitter, umami, and sour taste and to identify therapeutics esp ecially for treating digestive or metabolic disorders, taste loss, and oral infections. Further, the invention provides specific methods of purifying, e nriching, isolating or marking desired taste cell subtypes or lineages such as sweet, umami, bitter, salty, sour, fat or stem cells et al. e.g., by use of FACS, magnetic beads or other selection methods that purify, enrich, mark , or eliminate such as by use of labeled cytotoxins, cells that express or d o not express one or more taste specific genes.

17. 发明专利

AU2007258511A1 Rationale, methods, and assays for identifying novel taste cell genes and salty taste receptor targets and assays using these identified genes or gene products 未知
公开(公告)号：AU2007258511A1
公开(公告)日：2007-12-21
申请号：AU2007258511
申请日：2007-06-08
申请人： SENOMYX INC
发明人： KALABAT DALIA , LU MIN , HEVEZI PETER , GAO NA , MOYER BRYAN , ECHEVERRI FERNANDO
IPC分类号： C12Q1/68

18. 发明公开

EP2024518A4 RATIONALE, METHODS, AND ASSAYS FOR IDENTIFYING NOVEL TASTE CELL GENES AND SALTY TASTE RECEPTOR TARGETS AND ASSAYS USING THESE IDENTIFIED GENES OR GENE PRODUCTS 审中-公开
标题翻译：基本原理，鉴定新味觉细胞的基因和咸味受体靶点和安排与这些确定的基因程序和安排或基因产物
公开(公告)号：EP2024518A4
公开(公告)日：2010-05-26
申请号：EP07809397
申请日：2007-06-08
申请人： SENOMYX INC
发明人： MOYER BRYAN , LU MIN , ECHEVERRI FERNANDO , KALABAT DALIA , GAO NA , HEVEZI PETER
IPC分类号： C12Q1/68
CPC分类号： C12N15/1072 , C12N15/1086 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158

19. 发明公开

EP2167643A4 IDENTIFICATION OF TRPML3 (MCOLN3) AS A SALTY TASTE RECEPTOR AND USE IN ASSAYS FOR IDENTIFYING TASTE (SALTY) MODULATORS AND/OR THERAPEUTICS THAT MODULATE SODIUM TRANSPORT, ABSORPTION OR EXCRETION AND/OR ALDOSTERONE AND/OR VASOPRESSIN PRODUCTION OR RELEASE 审中-公开
标题翻译： TRPML3（MCOLN3）咸味觉受体的结构和用法ASSAYS用于识别（咸）调制器和/或治疗调制钠转运功能的，吸收或消除和/或醛固酮和/或加压素或制识别 - RELEASE
公开(公告)号：EP2167643A4
公开(公告)日：2010-06-16
申请号：EP08826211
申请日：2008-06-06
申请人： SENOMYX INC
发明人： MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK , KALABAT DALIA , WHITE EVAN CARL , LAITA BIANCA , DAHAN DAVID , SAGANICH MICHAEL
IPC分类号： G01N33/68 , C12N5/00
CPC分类号： G01N33/566 , C12Q1/6806 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C40B30/04 , C40B40/10 , G01N33/5005 , G01N33/5044 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.

20. 发明公开

EP2164976A4 RATIONALE, METHODS, AND ASSAYS FOR IDENTIFYING HUMAN AND NON-HUMAN PRIMATE TASTE SPECIFIC GENES AND USE THEREOF IN TASTE MODULATOR AND THERAPEUTIC SCREENING ASSAYS 审中-公开
标题翻译：理论基础，方法和试验确定具体的基因和人不是人灵长类动物和它们的用途和治疗GESCHMACKSMODULATOR-甄别试验中TASTE
公开(公告)号：EP2164976A4
公开(公告)日：2010-06-30
申请号：EP08768178
申请日：2008-06-06
申请人： SENOMYX INC
发明人： MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , KALABAT DALIA , LU MIN , GAO NA , WHITE EVAN
IPC分类号： G01N33/68 , C12N5/00
CPC分类号： G01N33/566 , C12Q1/6806 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C40B30/04 , C40B40/10 , G01N33/5005 , G01N33/5044 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.

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