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11. 发明专利

NO20015857L 未知
公开(公告)号：NO20015857L
公开(公告)日：2002-01-29
申请号：NO20015857
申请日：2001-11-30
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： JORDIS ULRICH , FROEHLICH JOHANNES , TREU MATTHIAS , HIRNSCHALL MANFRED , CZOLLNER LASZLO , KAELZ BEATE , WELZIG STEFAN
IPC分类号： C07D487/04 , A61K20060101 , A61K31/343 , A61K31/35 , A61K31/443 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D20060101 , C07D307/94 , C07D413/02 , C07D417/02 , C07D491/10 , C07D491/107 , C40B40/04
摘要： New compounds of general formula I

12. 发明专利

NO20015857A 未知
公开(公告)号：NO20015857A
公开(公告)日：2002-01-29
申请号：NO20015857
申请日：2001-11-30
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： JORDIS ULRICH , FROEHLICH JOHANNES , TREU MATTHIAS , HIRNSCHALL MANFRED , CZOLLNER LASZLO , KAELZ BEATE , WELZIG STEFAN
IPC分类号： C07D487/04 , A61K20060101 , A61K31/343 , A61K31/35 , A61K31/443 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D20060101 , C07D307/94 , C07D413/02 , C07D417/02 , C07D491/10 , C07D491/107 , C40B40/04
CPC分类号： C07D307/94 , C07D491/10

13. 发明专利

IS4839A Nýjar bensazepín afleiður, læknislyf sem innihalda þær og notkun þeirra við að útbúa læknislyf 未知
公开(公告)号：IS4839A
公开(公告)日：1998-08-28
申请号：IS4839
申请日：1998-08-28
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： CZOLLNER LASZLO , FROEHLICH JOHANNES , JORDIS ULRICH , KUEENBURG BERNHARD
IPC分类号： C07D471/08 , C07D487/08 , C07D491/056 , C07D491/10 , C07D491/107 , C07D491/20 , C07D519/00 , A61K31/55 , C07D491/14

14. 发明专利

CZ300211B6 Galanthaminové deriváty, lécivo tyto deriváty obsahující a použití techto derivátu pro výrobu léciva 未知
公开(公告)号：CZ300211B6
公开(公告)日：2009-03-18
申请号：CZ332498
申请日：1997-04-21
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： CZOLLNER LASZLO , FROEHLICH JOHANNES , JORDIS ULRICH , KUEENBURG BERNHARD
IPC分类号： C07D491/048 , A61K31/343 , A61K31/55 , A61P25/28 , C07D223/16 , C07D307/78 , C07D471/08 , C07D487/08 , C07D491/056 , C07D491/10 , C07D491/107 , C07D491/20 , C07D519/00
摘要： Vynález se týká souboru specifických galanthaminových derivátu, léciv obsahujících tyto deriváty a použití techto derivátu pro výrobu léciv urcených pro lécení Alzheimerovy choroby a trizómie a stavusouvisejících s temito chorobami.

15. 发明专利

AT424892T 未知
公开(公告)号：AT424892T
公开(公告)日：2009-03-15
申请号：AT04761031
申请日：2004-09-09
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： CZOLLNER LASZLO , KAELZ BEATE , WELZIG STEFAN , FRANTSITS WERNER , JORDIS ULRICH , FROEHLICH JOHANNES
IPC分类号： A61P25/28 , A61K31/55 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , C07D491/10
摘要： The invention relates to novel derivatives of 4a,5,9,10,11,12-hexahydro-benzofuro[3a,3,2] [2]benzazepine of general formulae 1a, 1b and 1c. Compounds 1a, 1b and 1c can be produced in an efficient manner on an industrial scale with the desired optical purity and are suitable for the production of medicaments for the treatment of a diverse range of symptoms, particularly diseases of the central nervous system (CNS), on account of the pharmacological effect thereof.

16. 发明专利

BG65134B1 DERIVATIVES AND ANALOGUES OF GALANTHAMIN 未知
公开(公告)号：BG65134B1
公开(公告)日：2007-03-30
申请号：BG10615501
申请日：2001-11-28
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： JORDIS ULRICH , FROEHLICH JOHANNES , TREU MATTHIAS , HIRNSCHALL MANFRED , CZOLLNER LASZLO , KAELZ BEATE , WELZIG STEFAN
IPC分类号： C07D487/04 , A61K20060101 , A61K31/343 , A61K31/35 , A61K31/443 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D20060101 , C07D307/94 , C07D413/02 , C07D417/02 , C07D491/10 , C07D491/107 , C40B40/04
摘要： The invention relates to novel compounds of general formula where the meanings of the substituents are given in the description. The compounds are active substances for the preparation of formulations for treatment in human medicine.

17. 发明专利

PL189834B1 NOVEL DERIVATIVES OF BENZAZEPIN, THERAPEUTIC AGENTS CONTAINING SUCH DERIVATIVES AND THEIR APPLICATION IN PRODUCTION OF THERAPEUTIC AGENTS 未知
公开(公告)号：PL189834B1
公开(公告)日：2005-09-30
申请号：PL32941197
申请日：1997-04-21
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： CZOLLNER LASZLO , FROEHLICH JOHANNES , JORDIS ULRICH , KUEENBURG BERNHARD
IPC分类号： C07D471/08 , C07D487/08 , C07D491/056 , C07D491/10 , C07D491/107 , C07D491/20 , C07D519/00 , C07D491/14 , A61K31/55 , A61P25/28
摘要： Benzofuro[3a,3,2,ef][2]benzazepines (I), their ring-opened form (II) and diazabicycloalkanes (III) as well as their enantiomers and addition salts are new: Z = N; or N+ if both R6 and R7 are present and if R7 = O-; R1, R2 = H; F; Cl; Br; I; CN; NC; OH; SH; NO2; SO3H; NH2; NH2; CF3; 1-6C (sic) optionally substituted (ar)alkyl or (ar)alkoxy; NH2 optionally mono- or disubstituted by 1-6C (Ar)alkyl, (Ar)alkylcarbonyl or (Ar)alkoxycarbonyl; COOH; COO(Ar)alkyl; CONH; CON(Ar)alkyl; -(CH2)n-Q; n = 1-3; Q = Cl; Br; OH; COOH; CN; or NC; or R1+R2 = -CH=CH-CH=CH- or -O-(CH2)n-O-; R3 = R1, especially OH or OMe; or R2+R3 = -O-(CH2)n-O-; R4, R5 = either both H; or, alternatively, each combination of H, (ar)alkyl, (ar)alkenyl or (ar)alkynyl with the following: SR8; SOR8; SO2R8; OH (optionally with a protecting group, e.g. TMS, TBDMS); OCSNR8; OCONR9; OCOR8, especially of formula (a): or, when R4 or R5 is other than H, the other may be OH; or R4+R5 = a group of formula =N-NH-R10; =N-NR10R11; or =N-O-R11; or a N-NH-C(=Y1)-Q1; L = -CH2-COOBn; -CH2-SMe; or Ph; R8 = H or 1-10C optionally substituted (ar)alkyl; R9 = -CO-NH-C*(H)(Me)-Ph (where * indicates an optically active centre, the Me being depicted in alpha or beta configurations); R10 = H; 1-6C optionally substituted (ar)alkyl, (ar)alkylcarbonyl or (ar)alkylcarbonyloxy; or a sulphonic acid group, e.g. tosyl or mesyl; R11 = R10 except (Ar)alkylcarbonyloxy; Q1 = Y2 or COOR8; Y1, Y2 = O; S; NH; or NR10 (any spare valencies = H); G1, G2 = -C(R13R14)- or G1+G2 = 3-9C cycloalkan-(1,2)-diyl; R13, R14 = H; OH; lower optionally substituted (ar)alkyl, aryl, (ar)alkoxy or aryloxy or R13+R14 = a 3-7C spiro ring; m = 1-7; G3 = CH2 or CO; R6 = -(G4)p-(G5)q-G6; p, q = 0 or 1; G4 = (CH2)r, C(R15R16)-(CH2)r, O, NR15, or a group of formula (f), (g) or (h): r = 1-6; R15, R16 = H; or lower optionally substituted (ar)alkyl, cycloalkyl or aryl; s = 1-4; t = 0-4; G7 = NR15, O or S; G5 = G4; or S when p = 1; G6 = CHO; COOR17; CONHR17; lower optionally substituted (Ar)alkyl, (Ar)alkenyl, (Ar)alkynyl, cycloalkyl or aryl; OR17; NR17R18; phthalimido; CN; NC; or a group of formula (i)-(k): R17-R20 = H; lower optionally substituted (Ar)alkyl, cycloalkyl or aryl; or R17+R18 or R19+R20 = a 3-8 ring C cycloalkyl; G8 = O; S; NH; NR21; or -(CH2)n-; R21 = CHO; COOR17; aryl or heteroaryl (preferably 2- or 4-pyridyl or 2-pyrimidinyl) optionally substituted by 1 or more F, Cl, Br, I, NO2, NH2, OH, alkyl, alkoxy, CN, NC, CF3, CHO, COOH, COOalkyl, SO3H, SH or S-alkyl; or methyl mono-, di- or trisubstituted by Ph (optionally substituted by 1 or more F, Cl, Br, I, NO2, NH2, alkyl, alkoxy, CN, NC or CF3); R7 = R6 or O- or free electron pair; or R6+R7 = a 3-8 membered ring; R22 = (hetero)aryl optionally with the same substituents as the heteroaryl group R21; or methyl disubstituted by phenyl (optionally with the same substituents as the heteroaryl group R21); R23 = -(G5)q-(G4)p-G9; G9 = H; F; Cl; Br; I; OH; OTs; OMs; O-triflate; COOH; COCl; CHO; OR17; NR17R18; phthalimido; CN; NC; or a group suitable for nucleophilic substitutions or addition or condensation reactions, etc.; X = (if present) inorganic or organic acid ion.

18. 发明专利

TR200400857T4 未知
公开(公告)号：TR200400857T4
公开(公告)日：2004-06-21
申请号：TR200400857
申请日：2001-03-22
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： JORDIS ULRICH , FROEHLICH JOHANNES , TREU MATTHIAS , HIRNSCHALL MANFRED , CZOLLNER LASZLO , KALZ BEATE , WELZIG STEFAN
IPC分类号： C07D487/04 , A61K20060101 , A61K31/343 , A61K31/35 , A61K31/443 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D20060101 , C07D307/94 , C07D413/02 , C07D417/02 , C07D491/10 , C07D491/107 , C40B40/04
摘要： New compounds of general formula I

19. 发明专利

BR0105563A 未知
公开(公告)号：BR0105563A
公开(公告)日：2002-04-02
申请号：BR0105563
申请日：2001-03-22
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： JORDIS ULRICH , FROEHLICH JOHANNES , TREU MATTHIAS , HIRNSCHALL MANFRED , CZOLLNER LASZLO , KAELZ BEATE , WELZIG STEFAN
IPC分类号： C07D487/04 , A61K20060101 , A61K31/343 , A61K31/35 , A61K31/443 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D20060101 , C07D307/94 , C07D413/02 , C07D417/02 , C07D491/10 , C07D491/107 , C40B40/04
摘要： New compounds of general formula I

20. 发明专利

BR9809661A 未知
公开(公告)号：BR9809661A
公开(公告)日：2000-07-11
申请号：BR9809661
申请日：1998-04-30
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： CZOLLNER LASZELO , FROEHLICH JOHANNES , JORDIS ULRICH , KUENBURG BERNHARD
IPC分类号： C07D491/06 , C07B31/00 , C07C1/26 , C07C15/24 , C07D333/10 , C07D491/20 , C07D223/00 , C07D307/00 , C07D491/10

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