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11. 发明申请

US20050130934A1 Antibacterial agents and process for producing the same 失效
标题翻译：抗菌剂及其制造方法
公开(公告)号：US20050130934A1
公开(公告)日：2005-06-16
申请号：US11049423
申请日：2005-02-02
申请人： Masato Nagaoka , Hideyuki Shibata , Itsuko Takagi , Shusuke Hashimoto
发明人： Masato Nagaoka , Hideyuki Shibata , Itsuko Takagi , Shusuke Hashimoto
IPC分类号： A61K31/731 , A61K31/737 , C08B37/00
CPC分类号： A61K31/702 , A61K31/731 , A61K31/737
摘要： An antibacterial agent showing a high affinity for Helicobactor pyroli and having an antibacterial effect specific to H. Pyroli. The agent has a chemical structure wherein an antibacterial substance is bonded to a sulfated polysaccharide or an oligosaccharide prepared by partial decomposition of the sulfated polysaccharide. Preferable embodiments are those having the chemical structure represented by Y—OCH(AH2NHR)n or Y—BH2NHR, wherein Y represents a sulfated polysaccharide or an oligosaccharide prepared by partial decomposition of the sulfated polysaccharide; A a carbon derived from aldehyde group occurring through the reduction of the reduced end sugar of Y and subsequent oxidation of the resulting product with an oxidant; B a carbon derived from the aldehyde group at the reduced end sugar of Y; R an antibacterial substance with a primary amino group or with an amino group introduced therein or represents an antibacterial substance derivative prepared by bonding an antibacterial substance through a spacer to the carbon A or the carbon B; and n=1 or 2.
摘要翻译：对Helicobactor pyroli具有高亲和力并具有对H. Pyroli特异性的抗菌作用的抗菌剂。该药剂具有抗菌物质与通过硫酸化多糖的部分分解制备的硫酸化多糖或寡糖结合的化学结构。优选的实施方案是具有由Y-OCH（AHN 2 NHR）n或Y-BH 2 NHR表示的化学结构的那些，其中Y表示通过硫酸化多糖的部分分解制备的硫酸化多糖或寡糖; 衍生自醛基的碳通过还原末端糖的Y而发生，随后用氧化剂氧化所得产物; B是衍生自Y的还原末端糖的醛基的碳; R是具有伯氨基或在其中引入氨基的抗菌物质，或代表通过间隔剂将抗菌物质与碳A或碳B结合而制备的抗菌物质衍生物; n = 1或2。

12. 发明授权

US07498317B2 Antibacterial agents and process for producing the same 失效
标题翻译：抗菌剂及其制造方法
公开(公告)号：US07498317B2
公开(公告)日：2009-03-03
申请号：US11049423
申请日：2005-02-02
申请人： Masato Nagaoka , Hideyuki Shibata , Itsuko Takagi , Shusuke Hashimoto
发明人： Masato Nagaoka , Hideyuki Shibata , Itsuko Takagi , Shusuke Hashimoto
IPC分类号： A61K31/731 , A61K31/737
CPC分类号： A61K31/702 , A61K31/731 , A61K31/737
摘要： An antibacterial agent showing a high affinity for Helicobactor pyroli and having an antibacterial effect specific to H. Pyroli. The agent has a chemical structure wherein an antibacterial substance is bonded to a sulfated polysaccharide or an oligosaccharide prepared by partial decomposition of the sulfated polysaccharide. Preferable embodiments are those having the chemical structure represented by Y—OCH(AH2NHR)n or Y—BH2NHR, wherein Y represents a sulfated polysaccharide or an oligosaccharide prepared by partial decomposition of the sulfated polysaccharide; A a carbon derived from aldehyde group occurring through the reduction of the reduced end sugar of Y and subsequent oxidation of the resulting product with an oxidant; B a carbon derived from the aldehyde group at the reduced end sugar of Y; R an antibacterial substance with a primary amino group or with an amino group introduced therein or represents an antibacterial substance derivative prepared by bonding an antibacterial substance through a spacer to the carbon A or the carbon B; and n=1 or 2.
摘要翻译：对Helicobactor pyroli具有高亲和力并具有对H. Pyroli特异性的抗菌作用的抗菌剂。该药剂具有抗菌物质与通过硫酸化多糖的部分分解制备的硫酸化多糖或寡糖结合的化学结构。优选的实施方案是具有由Y-OCH（AH2NHR）n或Y-BH2NHR表示的化学结构的那些，其中Y表示硫酸化多糖或通过硫酸化多糖的部分分解制备的寡糖; 衍生自醛基的碳通过还原末端糖的Y而发生，随后用氧化剂氧化所得产物; B是衍生自Y的还原末端糖的醛基的碳; R是具有伯氨基或在其中引入氨基的抗菌物质，或代表通过间隔剂将抗菌物质与碳A或碳B结合而制备的抗菌物质衍生物; n = 1或2。

13. 发明授权

US06645940B2 Oligosaccharide derivatives and process for producing the same 失效
公开(公告)号：US06645940B2
公开(公告)日：2003-11-11
申请号：US10313466
申请日：2002-12-06
申请人： Masato Nagaoka , Hideyuki Shibata , Itsuko Kimura , Shusuke Hashimoto
发明人： Masato Nagaoka , Hideyuki Shibata , Itsuko Kimura , Shusuke Hashimoto
IPC分类号： A61K3170
CPC分类号： C07H15/04
摘要： An oligosaccharide derivative, at higher homogeneity than fucose polysaccharide and rhamnose polysaccharide and with greater antiulcer effects, which is represented by the following general formula: Y—OCH(CH2NHR)2 wherein, Y represents an oligofucose or oligorhamnose at a polymerization number of 2 to 20, where the hydroxyl groups may or may not be partially modified in the form of sulfate ester, and R represents phenyl group, a higher alkylphenyl group, a higher alkyl group or —(CH2)n—NHX wherein n is an integer of 1 to 10 and X represents a higher alkanoyl group or an alkylamino group.

14. 发明授权

US06518249B1 Oligosaccharide derivatives and process for producing the same 失效
标题翻译：寡糖衍生物及其制备方法
公开(公告)号：US06518249B1
公开(公告)日：2003-02-11
申请号：US09485978
申请日：2000-02-18
申请人： Masato Nagaoka , Hideyuki Shibata , Itsuko Kimura , Shusuke Hashimoto
发明人： Masato Nagaoka , Hideyuki Shibata , Itsuko Kimura , Shusuke Hashimoto
IPC分类号： A61K3170
CPC分类号： C07H15/04
摘要： An oligosaccharide derivative, at higher homogeneity than fucose polysaccharide and rhamnose polysaccharide and with greater antiulcer effects, which is represented by the following general formula: Y—OCH(CH2NHR)2 wherein, Y represents an oligofucose or oligorhamnose at a polymerization number of 2 to 20, where the hydroxyl groups may or may not be partially modified in the form of sulfate ester, and R represents phenyl group, a higher alkylphenyl group, a higher alkyl group or —(CH2)n—NHX wherein n is an integer of 1 to 10 and X represents a higher alkanoyl group or an alkylamino group.
摘要翻译：一种低聚糖衍生物，其比岩藻糖多糖和鼠李糖多糖具有更高的均一性，并且具有较大的抗溃疡作用，其由以下通式表示：其中Y表示聚合数为2至20的寡聚核糖或寡鼠李糖，其中羟基可以或可以不以硫酸酯的形式部分修饰，R代表苯基，高级烷基苯基，高级烷基或 - （CH2）n-NHX，其中n为1至10的整数，X表示较高的烷酰基或烷基氨基。

15. 发明授权

US5698534A Antiulcer agent and process for preparing the same 失效
标题翻译：抗溃疡剂及其制备方法
公开(公告)号：US5698534A
公开(公告)日：1997-12-16
申请号：US202642
申请日：1994-02-28
申请人： Masato Nagaoka , Shusuke Hashimoto , Tsunekazu Watanabe , Teruo Yokokura
发明人： Masato Nagaoka , Shusuke Hashimoto , Tsunekazu Watanabe , Teruo Yokokura
IPC分类号： A61K31/70 , A61K31/715 , A61P1/04 , C07H3/08 , C08B37/00 , C12P19/06 , C12R1/01
CPC分类号： A61K31/7004 , A61K31/715
摘要： An antiulcer agent effective on prevention of ulceration and acceleration of healing of ulcers and processes for preparing the same are disclosed. The antiulcer agent comprises rhamnan (a homopolysaccharide), rhamnose or a rhamnose oligomer as an active ingredient. Rhamnan is prepared by separating rhamnan sulfate from rhamnan sulfate-containing algae and desulfurating the rhamnan sulfate. Rhamnan oligomers are prepared by hydrolyzing rhamnan obtained by desulfuration of rhamnan sulfate or by hydrolyzing microbial cells of a Bifidobacterium or polysaccharides separated therefrom.
摘要翻译：公开了一种有效预防溃疡溃疡和加速溃疡愈合的抗溃疡剂及其制备方法。抗溃疡剂含有作为活性成分的鼠李糖（均聚多糖），鼠李糖或鼠李糖寡聚物。鼠李糖通过从含有硫酸鼠李糖的藻类中分离出硫酸鼠李糖并且将硫酸鼠李糖硫酸盐脱硫来制备。通过水解通过硫酸鼠李糖硫酸脱硫获得的鼠李糖或通过水解分离的双歧杆菌或多糖的微生物细胞来制备鼠李糖低聚物。

16. 发明申请

US20070155013A1 Pluripotent stem cell growing method 有权
标题翻译：多能干细胞生长方法
公开(公告)号：US20070155013A1
公开(公告)日：2007-07-05
申请号：US10593831
申请日：2005-03-23
申请人： Toshihiro Akaike , Keiichi Fukuda , Masato Nagaoka , Uichi Koshimizu
发明人： Toshihiro Akaike , Keiichi Fukuda , Masato Nagaoka , Uichi Koshimizu
IPC分类号： C12N15/09 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0606 , C12N2533/50
摘要： A novel growing method is provided for pluripotent stem cells such as ES cells. The method of the invention is a pluripotent stem cell growing method and gene transfer method in which pluripotent stem cells are cultured under conditions that maintain their undifferentiated state and pluripotency, the method being characterized by using a liquid medium and a culturing vessel having immobilized or coated on a substrate solid phase surface a molecule which is adhesive to the pluripotent stem cells in a fixed concentration, to grow the pluripotent stem cells in a dispersed state while maintaining their undifferentiated state and pluripotency, without using feeder cells, or to transfer and express a gene therein.
摘要翻译：为多能干细胞（如ES细胞）提供了一种新的生长方法。本发明的方法是多能干细胞生长方法和基因转移方法，其中多能干细胞在保持其未分化状态和多能性的条件下培养，该方法的特征在于使用液体培养基和具有固定或涂覆的培养容器在基质固相表面上以固定浓度与多能干细胞粘合的分子，以分散状态生长多能干细胞，同时保持其未分化状态和多能性，而不使用饲养细胞，或转移和表达基因。

17. 发明授权

US07892835B2 Pluripotent stem cell growing method 有权
标题翻译：多能干细胞生长方法
公开(公告)号：US07892835B2
公开(公告)日：2011-02-22
申请号：US10593831
申请日：2005-03-23
申请人： Toshihiro Akaike , Keiichi Fukuda , Masato Nagaoka , Uichi Koshimizu
发明人： Toshihiro Akaike , Keiichi Fukuda , Masato Nagaoka , Uichi Koshimizu
IPC分类号： C12N15/09 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0606 , C12N2533/50
摘要： A novel growing method is provided for pluripotent stem cells such as ES cells. The method of the invention is a pluripotent stem cell growing method and gene transfer method in which pluripotent stem cells are cultured under conditions that maintain their undifferentiated state and pluripotency, the method being characterized by using a liquid medium and a culturing vessel having immobilized or coated on a substrate solid phase surface a molecule which is adhesive to the pluripotent stem cells in a fixed concentration, to grow the pluripotent stem cells in a dispersed state while maintaining their undifferentiated state and pluripotency, without using feeder cells, or to transfer and express a gene therein.
摘要翻译：为多能干细胞（如ES细胞）提供了一种新的生长方法。本发明的方法是多能干细胞生长方法和基因转移方法，其中多能干细胞在保持其未分化状态和多能性的条件下培养，该方法的特征在于使用液体培养基和具有固定或涂覆的培养容器在基质固相表面上以固定浓度与多能干细胞粘合的分子，以分散状态生长多能干细胞，同时保持其未分化状态和多能性，而不使用饲养细胞，或转移和表达基因。

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