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11. 发明申请

US20060258688A1 Method of treating brain ischemia 审中-公开
标题翻译：治疗脑缺血的方法
公开(公告)号：US20060258688A1
公开(公告)日：2006-11-16
申请号：US11488623
申请日：2006-07-19
申请人： Junichi Shimada , Masako Kurokawa , Ken Ikeda , Fumio Suzuki , Yoshihisa Kuwana
发明人： Junichi Shimada , Masako Kurokawa , Ken Ikeda , Fumio Suzuki , Yoshihisa Kuwana
IPC分类号： A61K31/522
CPC分类号： A61K31/52 , A61K31/522 , C07D473/06
摘要： The present invention relates to a method of treating various neurodegenerative disorders, in which a xanthine derivative represented by formula (I): or a pharmaceutically acceptable salt thereof, as an active ingredient, is administered.
摘要翻译：本发明涉及一种治疗各种神经变性疾病的方法，其中施用式（I）表示的黄嘌呤衍生物或其药学上可接受的盐作为活性成分。

12. 发明授权

US6017927A Quinuclidine derivatives and medicinal composition thereof 失效
标题翻译：奎宁环衍生物及其药用组合物
公开(公告)号：US6017927A
公开(公告)日：2000-01-25
申请号：US860377
申请日：1997-08-28
申请人： Makoto Takeuchi , Ryo Naito , Masahiko Hayakawa , Yoshinori Okamoto , Yasuhiro Yonetoku , Ken Ikeda , Yasuo Isomura
发明人： Makoto Takeuchi , Ryo Naito , Masahiko Hayakawa , Yoshinori Okamoto , Yasuhiro Yonetoku , Ken Ikeda , Yasuo Isomura
IPC分类号： A61K31/439 , A61P1/00 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/10 , A61P29/00 , A61P31/00 , A61P43/00 , C07D221/12 , C07D453/02 , C07D471/04 , C09K19/34 , C09K19/40 , A61K31/435
CPC分类号： C07D221/12 , C07D453/02 , C09K19/3444
摘要： Quinuclidine derivatives represented by general following general formula (I), salts, N-oxides or quaternary ammonium salts thereof, and medicinal compositions containing the same. ##STR1## The compound has an antagonistic effect on muscarinic M.sub.3 receptors and is useful as a preventive or remedy for urologic diseases, respiratory diseases or digestive diseases.
摘要翻译： PCT No.PCT / JP95 / 02713 Sec。 371日期1997年8月28日 102（e）日期1997年8月28日PCT 1995年12月27日PCT PCT。公开号WO96 / 20194 日本时间1997年7月4日由以下通式（I）表示的奎宁环衍生物，其盐，N-氧化物或季铵盐，以及含有它们的药物组合物。该化合物对毒蕈碱M3受体具有拮抗作用，可用作泌尿系统疾病，呼吸系统疾病或消化系统疾病的预防或治疗。

13. 发明授权

US5762929A Anti-motoneuron-disease agent 失效
标题翻译：抗运动神经元疾病剂
公开(公告)号：US5762929A
公开(公告)日：1998-06-09
申请号：US508952
申请日：1995-07-31
申请人： Masao Kinoshita , Yasuo Iwasaki , Ken Ikeda , Toshiya Shiojima , Nozomu Tagaya , Tomoko Kobayashi
发明人： Masao Kinoshita , Yasuo Iwasaki , Ken Ikeda , Toshiya Shiojima , Nozomu Tagaya , Tomoko Kobayashi
IPC分类号： A61K38/00 , A61K38/44 , A61P21/00 , C12N9/02 , C12N9/96 , A61K38/54
CPC分类号： C12N9/0089 , C12N9/96 , A61K38/00
摘要： The present invention relates to an novel anti-motoneuron-disease agent, comprising superoxide dismutase conjugated with lecithin through chemical crosslinking represented in the following generic formula (PC-SOD) as an effective ingredient: SOD--�C(O)--(CH.sub.2).sub.n --C(O)--X!.sub.m wherein SOD represents superoxide dismutase and X represents a residue of lysolecithin having a hydroxy group at position 2 of glycerol whose hydrogen atom of the hydroxyl group at position 2 is removed. A pharmaceutical agent of the present invention may improve symptoms of motoneuron diseases such as amyotrophic lateral sclerosis etc. by oral or parenteral administration. The present invention also relates to a novel treatment method for motoneuron disease by administrating PC-SOD and novel use of PC-SOD as a medical composition for preparing an agent for treating motoneuron disease.
摘要翻译：本发明涉及一种新型抗运动神经元疾病药物，其包含通过以下通式（PC-SOD）表示的化学交联作为有效成分与卵磷脂缀合的超氧化物歧化酶：SOD- [C（O） - （CH 2） nC（O）-X] m，其中SOD表示超氧化物歧化酶，X表示除去位置2的羟基的甘油的位置2具有羟基的溶血卵磷脂的残基。本发明的药剂可以通过口服或肠胃外给药改善运动神经元疾病如肌萎缩性侧索硬化等的症状。本发明还涉及通过施用PC-SOD的运动神经元疾病的新颖治疗方法和PC-SOD的新型用作制备治疗运动神经元疾病的药物的医药组合物。

14. 发明授权

US07867881B2 Method of manufacturing nitride semiconductor substrate 有权
标题翻译：氮化物半导体衬底的制造方法
公开(公告)号：US07867881B2
公开(公告)日：2011-01-11
申请号：US12397544
申请日：2009-03-04
申请人： Takeshi Meguro , Takayuki Suzuki , Ken Ikeda
发明人： Takeshi Meguro , Takayuki Suzuki , Ken Ikeda
IPC分类号： H01L21/20 , H01L21/36
CPC分类号： C30B29/403 , C30B25/02 , C30B29/406 , H01L21/0242 , H01L21/02433 , H01L21/0254 , H01L21/02609
摘要： A method for manufacturing a nitride semiconductor substrate including the steps of: forming a nitride semiconductor layer on a sapphire substrate, and manufacturing a freestanding nitride semiconductor substrate by using the nitride semiconductor layer separated from the sapphire substrate, wherein variability of inclinations of the C-axes, being a difference between a maximum value and a minimum value of inclination of the C-axes in a radially-outward direction at each point on a front surface of the sapphire substrate is 0.3° or more and 1° or less.
摘要翻译：一种氮化物半导体衬底的制造方法，包括以下步骤：在蓝宝石衬底上形成氮化物半导体层，并通过使用与蓝宝石衬底分离的氮化物半导体层来制造独立氮化物半导体衬底，其中，作为在蓝宝石基板的前表面上的每个点处的径向向外方向上的C轴的最大值和最小值的最小值之间的差异为0.3°以上且1°以下。

15. 发明申请

US20090233423A1 METHOD OF MANUFACTURING NITRIDE SEMICONDUCTOR SUBSTRATE 有权
标题翻译：制备氮化物半导体衬底的方法
公开(公告)号：US20090233423A1
公开(公告)日：2009-09-17
申请号：US12397544
申请日：2009-03-04
申请人： Takeshi MEGURO , Takayuki Suzuki , Ken Ikeda
发明人： Takeshi MEGURO , Takayuki Suzuki , Ken Ikeda
IPC分类号： H01L21/20
CPC分类号： C30B29/403 , C30B25/02 , C30B29/406 , H01L21/0242 , H01L21/02433 , H01L21/0254 , H01L21/02609
摘要： A method for manufacturing a nitride semiconductor substrate including the steps of: forming a nitride semiconductor layer on a sapphire substrate, and manufacturing a freestanding nitride semiconductor substrate by using the nitride semiconductor layer separated from the sapphire substrate, wherein variability of inclinations of the C-axes, being a difference between a maximum value and a minimum value of inclination of the C-axes in a radially-outward direction at each point on a front surface of the sapphire substrate is 0.3° or more and 1° or less.
摘要翻译：一种氮化物半导体衬底的制造方法，包括以下步骤：在蓝宝石衬底上形成氮化物半导体层，通过使用与蓝宝石衬底分离的氮化物半导体层来制造独立氮化物半导体衬底，其中，作为在蓝宝石基板的前表面上的每个点处的径向向外方向上的C轴的最大值和最小值的最小值之间的差异为0.3°以上且1°以下。

16. 发明授权

US07335668B2 Pharmaceutical composition for therapy of interstitial cystitis 有权
标题翻译：用于间质性膀胱炎治疗的药物组合物
公开(公告)号：US07335668B2
公开(公告)日：2008-02-26
申请号：US10479798
申请日：2002-07-08
申请人： Ken Ikeda , Makoto Takeuchi
发明人： Ken Ikeda , Makoto Takeuchi
IPC分类号： A01N43/90 , A61K31/44 , C07D453/02
CPC分类号： A61K31/439
摘要： A depressant of capsaicin-sensitive sensory nerve, containing quinuclidin-3′-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate or a salt thereof as an active ingredient, specifically a therapeutic drug of interstitial cystitis, hypersensitive disorder of the lower urinary tract, and/or abacterial prostatitis.
摘要翻译：含有奎宁环-3'-基1-苯基-1,2,3,4-四氢异喹啉-2-羧酸钠或其盐作为活性成分的具有辣椒素敏感性感觉神经抑制剂，特别是间质性膀胱炎的治疗药物，下尿路过敏性疾病和/或非细菌性前列腺炎。

17. 发明申请

US20070105934A1 Pharmaceutical composition for treatment of tear and salivary fluid drying 审中-公开
标题翻译：用于治疗泪液和唾液流体干燥的药物组合物
公开(公告)号：US20070105934A1
公开(公告)日：2007-05-10
申请号：US10578682
申请日：2005-10-04
申请人： Yohei Okada , Ken Ikeda , Fumikazu Wanibuchi , Keiichi Yoshihara , Hiromu Kondo , Hiroyuki Kojima
发明人： Yohei Okada , Ken Ikeda , Fumikazu Wanibuchi , Keiichi Yoshihara , Hiromu Kondo , Hiroyuki Kojima
IPC分类号： A61K31/407
CPC分类号： C07D491/107 , A61K31/438
摘要： [Problem]An agent for treating eye and mouth dryness, which does not accompanies undesirable actions is provided. [Means for Resolution]Administration of the compound A made it possible to accelerate tear and salivary fluid secretion without accompanying sweating and its sustained release administration enabled acceleration of lacrimal gland and salivary gland cell growth as well.
摘要翻译： [问题]提供了不伴随不良作用的治疗眼睛和口腔干燥的药剂。 [解决方法]化合物A的给药使得可以加速泪液和唾液分泌而不伴随出汗，并且其持续释放给药使得能够加速泪腺和唾液腺细胞生长。

18. 发明授权

US5583852A Wireless data communication system 失效
标题翻译：无线数据通信系统
公开(公告)号：US5583852A
公开(公告)日：1996-12-10
申请号：US360620
申请日：1994-12-21
申请人： Ken Ikeda , Kenichi Takahashi , Minako Takeishi
发明人： Ken Ikeda , Kenichi Takahashi , Minako Takeishi
IPC分类号： H04B7/26 , H04L12/28 , H04W16/28 , H04W16/30 , H04W16/32 , H04W24/00 , H04W24/10 , H04W36/06 , H04W48/08 , H04W56/00 , H04W64/00 , H04W72/00 , H04W72/04 , H04W76/02 , H04W84/08 , H04Q11/04
CPC分类号： H04B1/7075 , H04W48/08 , H04W24/00 , H04W24/10 , H04W64/006 , H04W72/00
摘要： A wireless data communication system comprises: base stations located to have cells arranged equidistantly therebetween; mobile units, each being located within either of the cells, each of the base stations communicating with mobile units within its cell through plural channels provided by FDM. In the system, each of the base station may comprise a detector for monitoring the channels and detecting a free channel, and a transmission portion for continuously transmitting a signal including data indicative of the detected free channel. In the system, the plurality of channels used in one of cells have given frequency bands respectively which are the same as given frequency bands in other cells. In the system, each of the mobile stations may comprise a chip synchronizing circuit for effecting chip synchronizing between the each of the mobile stations and its base station. In that system, a mobile unit having an antenna whose directivity is controllable, measures distances to determine a direction to its base station with measured distances and received distance from other mobile unit. In that system, a channel with an interference is detected and inhibited to be used and data indicative of the channel with the interference may be stored in a memory and the absence of the interference may be detected and the memory is renewed.
摘要翻译：一种无线数据通信系统包括：基站位于具有等距离地间隔的小区; 每个移动单元位于任一小区内，每个基站通过由FDM提供的多个信道与小区内的移动单元通信。在该系统中，基站中的每一个可以包括用于监视信道和检测空闲信道的检测器，以及用于连续发送包括表示检测到的空闲信道的数据的信号的发送部分。在系统中，在一个小区中使用的多个信道分别具有与其他小区中的给定频带相同的频带。在该系统中，每个移动站可以包括用于在每个移动台及其基站之间进行码片同步的码片同步电路。在该系统中，具有方向性可控的天线的移动单元测量距离，以确定具有测量距离的距离和与其他移动单元的接收距离到其基站的方向。在该系统中，检测并禁止具有干扰的信道，并且指示具有干扰的信道的数据可以存储在存储器中，并且可以检测不存在干扰并更新存储器。

19. 发明授权

US08796301B2 Therapeutic or prophylactic agent for dyskinesia 有权
标题翻译：运动障碍的治疗或预防剂
公开(公告)号：US08796301B2
公开(公告)日：2014-08-05
申请号：US12597442
申请日：2008-04-24
申请人： Ken Ikeda , Hidenori Mochizuki
发明人： Ken Ikeda , Hidenori Mochizuki
IPC分类号： A01N43/42 , A61K31/44 , C07D489/00
CPC分类号： C07D489/08 , A61K31/485
摘要： An object of the present invention is to provide a drug with a high therapeutic or prophylactic effect on dyskinesia, without accompanying aggravation of symptoms of the primary disease, and with fewer side effects.Accordingly, the present invention provides a therapeutic or prophylactic agent for dyskinesia, comprising as an effective component a compound having a 4,5-epoxy morphinan skeleton, which compound is represented by the Formula (I) below, or a pharmaceutically acceptable acid addition salt thereof: [wherein the double line composed of a dashed line and a solid line represents a double bond or single bond, R1 is C4-C7 cycloalkylalkyl, R2 is C1-C5 straight or branched alkyl, and B is —CH═CH—.]
摘要翻译：本发明的目的是提供对运动障碍具有高治疗或预防效果的药物，而不伴随着原发性疾病症状加重，副作用较少。因此，本发明提供了一种用于运动障碍的治疗或预防剂，其包含作为有效成分的具有4,5-环氧吗啡喃骨架的化合物，该化合物由下式（I）表示，或其药学上可接受的酸加成盐 [其中由虚线和实线构成的双线表示双键或单键，R 1为C 4 -C 7环烷基烷基，R 2为C 1 -C 5直链或支链烷基，B为-CH = CH-。 ]

20. 发明申请

US20110281919A1 AGENT FOR TREATING OR PREVENTING DIGESTIVE ULCER 失效
标题翻译：用于治疗或预防消化性溃疡的药剂
公开(公告)号：US20110281919A1
公开(公告)日：2011-11-17
申请号：US13188628
申请日：2011-07-22
申请人： Masakatsu Kawakami , Yoshihiro Keto , Ken Ikeda , Mari Fukuda , Junji Sato
发明人： Masakatsu Kawakami , Yoshihiro Keto , Ken Ikeda , Mari Fukuda , Junji Sato
IPC分类号： A61K31/426 , A61P1/04
CPC分类号： C07D401/12 , A61K31/00 , A61K31/381 , A61K31/4025 , A61K31/4155 , A61K31/42 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/4535 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D213/79 , C07D231/14 , C07D261/18 , C07D275/03 , C07D277/56 , C07D333/40 , C07D401/10 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D417/10 , C07D417/12
摘要： An object of the present invention is to provide an agent for treating or preventing digestive ulcer that is effective even to ulcer of small intestine and others, for which gastric acid secretion inhibitors such as proton pump inhibitors are ineffective, and is superior to allopurinol in the efficaciousness and the safety.The pharmaceutical composition of the present invention comprising a non-purine xanthine oxidase inhibitor as the active ingredient is useful as an agent for treating or preventing ulcer that forms in digestive tracts by the attack of gastric acid, pepsin, stress, Helicobacter pylori bacteria, NSAID, etc. In particular, it is useful as an ulcer remedy heretofore unknown in the art as it is effective even for ulcer in small intestine for which gastric/duodenal ulcer remedies that inhibit gastric acid secretion such as proton pump inhibitors are ineffective.
摘要翻译：本发明的目的是提供一种用于治疗或预防消化性溃疡的药剂，即使对于小肠等溃疡也是有效的，其中胃酸分泌抑制剂如质子泵抑制剂无效，并且优于别嘌呤醇有效性和安全性。包含非嘌呤黄嘌呤氧化酶抑制剂作为活性成分的本发明的药物组合物可用作治疗或预防胃酸，胃蛋白酶，应激，幽门螺杆菌，NSAID的侵袭在消化道中形成的溃疡的药剂特别地，作为本领域未知的溃疡治疗是有用的，因为即使对于抑制胃酸分泌的胃/十二指肠溃疡治疗如质子泵抑制剂的小肠中的溃疡也是无效的，其是有效的。

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