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11. 发明授权

US07645442B2 Rapid-heating drug delivery article and method of use 有权
标题翻译：快速加热药物输送物品及其使用方法
公开(公告)号：US07645442B2
公开(公告)日：2010-01-12
申请号：US10633876
申请日：2003-08-04
申请人： Ron L. Hale , Peter M. Lloyd , Amy Lu , Daniel J. Myers , Reynaldo J. Quintana , Joshua D. Rabinowitz , Dennis W. Solas , Soonho Song , Curtis Tom , Martin J. Wensley
发明人： Ron L. Hale , Peter M. Lloyd , Amy Lu , Daniel J. Myers , Reynaldo J. Quintana , Joshua D. Rabinowitz , Dennis W. Solas , Soonho Song , Curtis Tom , Martin J. Wensley
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61M11/041 , A61K9/007 , A61K9/0073 , A61M11/042 , A61M11/047 , A61M15/002 , A61M15/0028 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04 , Y10S514/958
摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300° C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
摘要翻译：公开了一种用于生产冷凝气雾剂的装置，方法和系统。该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。装置中的热源可操作以向衬底供应热量以产生大于300℃的衬底温度，并且在2秒或更短的时间内使药物组合物膜从衬底基本挥发。该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。

12. 发明申请

US20090229600A1 Method Of Forming An Aerosol For Inhalation Delivery 有权
标题翻译：形成用于吸入输送的气雾剂的方法
公开(公告)号：US20090229600A1
公开(公告)日：2009-09-17
申请号：US12471070
申请日：2009-05-22
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
IPC分类号： A61M11/00
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy
摘要翻译：本发明涉及含有小颗粒的气溶胶的吸入输送。具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中涂覆的组合物为小于10μm厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶

13. 发明申请

US20110240013A1 METHOD OF FORMING AN AEROSOL FOR INHALATION DELIVERY 审中-公开
标题翻译：形成用于吸入输送的气溶胶的方法
公开(公告)号：US20110240013A1
公开(公告)日：2011-10-06
申请号：US13078606
申请日：2011-04-01
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
IPC分类号： A61M11/00
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming a vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.
摘要翻译：本发明涉及含有小颗粒的气溶胶的吸入输送。具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中所述涂覆的组合物为小于10μ厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。

14. 发明授权

US07537009B2 Method of forming an aerosol for inhalation delivery 有权
标题翻译：形成用于吸入输送的气溶胶的方法
公开(公告)号：US07537009B2
公开(公告)日：2009-05-26
申请号：US10146088
申请日：2002-05-13
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
IPC分类号： A61L9/04
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.
摘要翻译：本发明涉及含有小颗粒的气溶胶的吸入输送。具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）加热涂覆有包含药物的组合物以形成蒸气的基底，其中涂覆的组合物为小于10微米的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。

15. 发明授权

US08074644B2 Method of forming an aerosol for inhalation delivery 有权
标题翻译：形成用于吸入输送的气溶胶的方法
公开(公告)号：US08074644B2
公开(公告)日：2011-12-13
申请号：US12471070
申请日：2009-05-22
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
IPC分类号： A61L9/04
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.
摘要翻译：本发明涉及含有小颗粒的气溶胶的吸入输送。具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中所述涂覆的组合物为小于10μ厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。

16. 发明申请

US20090062254A1 Acute Treatment of Headache with Phenothiazine Antipsychotics 审中-公开
标题翻译：苯并噻嗪类抗精神病药物头痛急性治疗
公开(公告)号：US20090062254A1
公开(公告)日：2009-03-05
申请号：US12245184
申请日：2008-10-03
申请人： Ron L. Hale , Peter M. Lloyd , Amy T. Lu , Patrik Munzar , Joshua D. Rabinowitz , Roman Skowronski
发明人： Ron L. Hale , Peter M. Lloyd , Amy T. Lu , Patrik Munzar , Joshua D. Rabinowitz , Roman Skowronski
IPC分类号： A61K31/5415 , A61K31/451 , A61K31/553 , A61K31/454 , A61P25/06 , A61K31/5377 , A61K31/4439
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/382 , A61K31/4439 , A61K31/4515 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61M15/00 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.
摘要翻译：提供了使用抗精神病药治疗头痛的方法。还提供了用于治疗头痛的试剂盒，其包含抗精神病药和用于快速递送抗精神病药的装置。

17. 发明授权

US07585493B2 Thin-film drug delivery article and method of use 有权
标题翻译：薄膜给药制品及使用方法
公开(公告)号：US07585493B2
公开(公告)日：2009-09-08
申请号：US10633877
申请日：2003-08-04
申请人： Ron L. Hale , Amy Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley
发明人： Ron L. Hale , Amy Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/7007 , A61K9/007 , Y10S514/958
摘要： An article for use in an aerosol device, for producing an aerosol of a drug composition is disclosed. The article includes a heat-conductive substrate having a surface with a selected surface area, and a drug composition film on the substrate surface having a selected film thickness of between 0.05 and 20 μm. The film thickness is such that an aerosol formed by vaporizing the drug composition by heating the substrate and condensing the vaporized compound contains 10% or less drug-degradation product and at least 50% of the total amount of drug composition contained in the film. The selected substrate surface area is such as to yield an effective human therapeutic dose of the drug aerosol. Also disclosed are methods of making and using the article.
摘要翻译：公开了一种用于产生药物组合物气溶胶的气溶胶装置的制品。所述制品包括具有选择的表面积的表面的导热基材和在所述基材表面上的具有0.05至20μm的选定膜厚度的药物组合物膜。膜厚度使得通过加热基底并冷凝汽化的化合物使药物组合物蒸发而形成的气溶胶含有10％以下的药物降解产物和膜中所含的药物组合物总量的至少50％。所选择的底物表面积是产生有效的人类治疗剂量的药物气溶胶。还公开了制造和使用制品的方法。

18. 发明授权

US07981401B2 Diuretic aerosols and methods of making and using them 有权
标题翻译：利尿剂及其使用方法
公开(公告)号：US07981401B2
公开(公告)日：2011-07-19
申请号：US11670892
申请日：2007-02-02
申请人： Nathan R. Every , Ron L. Hale , Amy T. Lu , Joshua D. Rabinowitz
发明人： Nathan R. Every , Ron L. Hale , Amy T. Lu , Joshua D. Rabinowitz
IPC分类号： A61K9/12 , A61K9/00 , A61K31/18 , A61K31/05 , A61K31/20 , A61K31/415 , A61K31/40 , A61K31/50 , A61K31/58 , A61K31/522
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/58
摘要： Described herein are diuretic condensation aerosols and methods of making and using them. Kits for delivering a condensation aerosol are also described. The diuretic aerosols typically comprise diuretic condensation aerosol particles that comprise a diuretic compound. In some variations the diuretic compound is selected from the group consisting of bumetanide, ethacrynic acid, furosemide, muzolimine, spironolactone, torsemide, triamterene, tripamide, BG 9928, and BG 9719. Methods of treating edema using the described aerosols are also provided. In general, the methods typically comprise the step of administering a therapeutically effective amount of diuretic condensation aerosol to a person with edema. The diuretic condensation aerosol may be administered in a single inhalation, or may be administered in more than one inhalation. Methods of forming a diuretic condensation aerosol are also described. The methods typically comprise the steps of providing a diuretic composition, vaporizing the composition to form a vapor, and then condensing the diuretic composition vapor.
摘要翻译：本文描述的是利尿凝结气溶胶及其制备和使用方法。还描述了用于递送冷凝气雾剂的组件。利尿剂气溶胶通常包含利尿剂缩合气溶胶颗粒，其包含利尿剂。在一些变体中，利尿剂化合物选自布美他尼，依西醋酸，呋塞米，多佐立胺，螺内酯，托塞米明，扑热息痛，三酰胺，BG 9928和BG 9719.还提供了使用所述气溶胶治疗水肿的方法。通常，所述方法通常包括向具有水肿的人施用治疗有效量的利尿冷凝气雾剂的步骤。利尿冷凝气雾剂可以在单次吸入中施用，或者可以在多于一次的吸入中施用。还描述了形成利尿冷凝气雾剂的方法。所述方法通常包括提供利尿组合物，蒸发组合物以形成蒸气，然后冷凝利尿组合物蒸气的步骤。

19. 发明申请

US20100055048A1 ACUTE TREATMENT OF HEADACHE WITH PHENOTHIAZINE ANTIPSYCHOTICS 审中-公开
标题翻译：用苯并噻唑类抗生素治疗头痛
公开(公告)号：US20100055048A1
公开(公告)日：2010-03-04
申请号：US12615185
申请日：2009-11-09
申请人： Ron L. Hale , Peter M. LIoyd , Amy T. Lu , Patrik Munzar , Joshua D. Rabinowitz , Roman Skowronski
发明人： Ron L. Hale , Peter M. LIoyd , Amy T. Lu , Patrik Munzar , Joshua D. Rabinowitz , Roman Skowronski
IPC分类号： A61K9/12 , A61K31/445 , A61K31/4439 , A61K31/382 , A61K31/496 , A61K31/553 , A61K31/5377 , A61K31/454 , A61K31/5415 , A61P29/00
CPC分类号： A61K31/553 , A61K9/007 , A61K9/0073 , A61K31/382 , A61K31/4439 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , A61M15/00 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.
摘要翻译：提供了使用抗精神病药治疗头痛的方法。还提供了用于治疗头痛的试剂盒，其包含抗精神病药和用于快速递送抗精神病药的装置。

20. 发明申请

US20080299048A1 MIXED DRUG AEROSOL COMPOSITIONS 审中-公开
标题翻译：混合药物气溶胶组合物
公开(公告)号：US20080299048A1
公开(公告)日：2008-12-04
申请号：US11964630
申请日：2007-12-26
申请人： Ron L. Hale , Kathleen Simis , Amy T. Lu , Joshua D. Rabinowitz , Krishnamohan Sharma , William Shen , Justin Virgili
发明人： Ron L. Hale , Kathleen Simis , Amy T. Lu , Joshua D. Rabinowitz , Krishnamohan Sharma , William Shen , Justin Virgili
IPC分类号： A61K9/12
CPC分类号： A61K31/137 , A61K9/0073 , A61K31/138 , A61K31/23 , A61K31/40 , A61K31/404 , A61K31/54 , A61K31/5415
摘要： The present invention pertains to aerosols which comprise a first compound which is physiologically active and a second compound which is different from the first compound. Such aerosols may be produced “on demand” and can be used to control drug release, to improve vaporizability, or to reduce, modify or eliminate undesirable taste associated with a drug aerosol. The present invention also pertains to methods for producing such aerosols.
摘要翻译：本发明涉及包含生理活性的第一化合物和不同于第一化合物的第二化合物的气溶胶。这种气溶胶可以“按要求”生产，并可用于控制药物释放，改善可燃性，或减少，改变或消除与药物气溶胶相关的不良味道。本发明还涉及生产这种气溶胶的方法。

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