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    • 11. 发明申请
    • Use of antibody-ligand binding to characterise diseases
    • 使用抗体 - 配体结合来表征疾病
    • US20090136965A1
    • 2009-05-28
    • US11914152
    • 2006-05-08
    • Peter LloydPhil LoweSteve Pascoe
    • Peter LloydPhil LoweSteve Pascoe
    • G01N33/53
    • G01N33/6854G01N33/536
    • We have found that when an antibody binds to (captures) its specific ligand, the antibody-ligand complex is redirected to a route of elimination which is different from that which occurs naturally for the specific ligand that is not bound to an antibody. As a consequence, the amount of antibody-bound ligand in the blood increases over time. The increase in total ligand concentration is a property that is specific to the patient to whom the antibody is administered. Accordingly, the invention provides a method for diagnosing disease in a subject and a method for identifying the most appropriate treatment for a particular patient. Patients who produce more ligand, and thus more antibody-ligand complex, may be more likely to have a disease which is predominantly driven by that ligand. These patients should respond better to a therapy targeted against that ligand. The better understanding of the underlying malfunctions in disease biology provided by the methods of the invention, in respect of the rates of production of natural ligands in health and disease, provides a logical and targeted selection of the appropriate treatments to address specific biological abnormalities.
    • 我们已经发现,当抗体结合(捕获)其特异性配体时,抗体 - 配体复合物被重定向到消除途径,其不同于不与抗体结合的特异性配体天然存在的途径。 因此,血液中抗体结合配体的量随时间增加。 总配体浓度的增加是对施用抗体的患者特异性的特性。 因此,本发明提供了用于诊断受试者疾病的方法以及用于鉴定特定患者最合适治疗的方法。 产生更多配体,因此更多的抗体 - 配体复合物的患者可能更可能具有主要由该配体驱动的疾病。 这些患者应该对针对该配体的治疗效果更好。 通过本发明方法提供的关于疾病生物学中潜在的功能障碍的更好的理解,就天然配体在健康和疾病中的生产率而言,提供了适当的治疗方案的合乎逻辑和有针对性的选择,以解决具体的生物学异常。
    • 12. 发明申请
    • Emergency Device
    • 紧急装置
    • US20070295857A1
    • 2007-12-27
    • US11557115
    • 2006-11-07
    • Peter Lloyd
    • Peter Lloyd
    • B64C27/82
    • B64C27/82B64C2027/8245
    • The basic concept of the invention is to provide an auxiliary thrust mechanism that may be brought into action by the pilot or by an automatic on-board system that will allow the controlled flight to be maintained even after the loss of thrust from the tail rotor or fan for enough time under most circumstances for the pilot to bring the helicopter in to a safe landing. The preferred method of this invention is to use a solid rocket motor 7 and a thrust vectoring device 8 that the pilot may control the thrust to counter the spinning tendency and guide the helicopter safely for a certain time.
    • 本发明的基本概念是提供一种辅助推力机构,该辅助推力机构可以由驾驶员或自动车载系统起作用,即使在从尾部转子失去推力之后也能够保持受控飞行, 在大多数情况下,飞行员有足够的时间让飞行员直升机进入安全着陆。 本发明的优选方法是使用固体火箭发动机7和推力矢量装置8,导向装置可以控制推力以抵抗旋转趋势,并将安全地引导直升机一段时间。
    • 13. 发明申请
    • Articulating device
    • 铰接装置
    • US20060196066A1
    • 2006-09-07
    • US11340609
    • 2006-01-27
    • Peter LloydDavid WallaceDavid McMurtryJames ChaseDavid Jones
    • Peter LloydDavid WallaceDavid McMurtryJames ChaseDavid Jones
    • G01B5/00
    • G05B19/404G05B2219/39179G05B2219/41048G05B2219/41081
    • Disclosed is a method of moving an articulating mechanism (22,410) for a measuring device, comprising the steps of: releasing two bodies (14,16, 410a,410b) which form the articulating mechanism allowing relative movement thereof; moving one of the bodies with respect to the other until a desired position is reached; and re-constraining the two bodies so they are relatively fixed, perhaps as part of a locking process, characterised in that relative movement prior to re-constraining at the desired position occurs under particular conditions. The particular conditions including moving from the same direction; and stopping, slowing down or maintaining the condition at a position adjacent to the desired position. Also disclosed is a method of positioning an articulating mechanism (22,410) for a measuring device which is controlled by a potentiometer and a controller (11) for a measuring device.
    • 公开了一种移动用于测量装置的铰接机构(22,410)的方法,包括以下步骤:释放形成铰接机构的两个主体(14,16,410a,410b),允许其相对移动; 将一个物体相对于另一个移动到达到期望的位置; 并且重新限制两个体,使得它们相对固定,可能作为锁定过程的一部分,其特征在于,在特定条件下发生在期望位置处重新约束之前的相对运动。 特定条件包括从同一方向移动; 并且在与期望位置相邻的位置处停止,减缓或维持状态。 还公开了一种定位用于由电位器和用于测量装置的控制器(11)控制的测量装置的关节运动机构(22,410)的方法。
    • 14. 发明申请
    • Autonomous reconnaissance sonde, and method for deployment thereof
    • 自主侦察侦察机及其部署方法
    • US20060010998A1
    • 2006-01-19
    • US11178440
    • 2005-07-12
    • Peter LloydPaul Stein
    • Peter LloydPaul Stein
    • G01D21/02F41F1/00
    • F42B12/365
    • A method for deploying a reconnaissance sonde, including the steps of: incorporating at least one environmental sensor and an associated communication device into a robust, aerodynamically efficient casing; deploying the sonde by imparting a spin and a directional velocity to the casing, sufficient to carry the sonde into a region of interest; and establishing communication with the communication device, thereby enabling data from the sensor(s) to be transmitted to a remote location. A sonde for remote data collection is also provided, including at least one environmental sensor, an energy source and communication means. The sonde is generally shaped as a discus or saucer, a clay pigeon or skeet, for deployment by applying a spin and directional velocity to the sonde.
    • 一种用于部署侦察探空仪的方法,包括以下步骤:将至少一个环境传感器和相关联的通信装置并入鲁棒的,具有空气动力学效能的壳体中; 通过向套管施加旋转和定向速度来部署探测器,足以将探空仪携带到感兴趣的区域中; 以及建立与通信设备的通信,从而使来自传感器的数据能够被传送到远程位置。 还提供了用于远程数据收集的探头,包括至少一个环境传感器,能量源和通信装置。 探头通常被形成为铁饼或碟子,粘土鸽子或梭子,用于通过向探头施加自旋和定向速度进行部署。
    • 16. 发明申请
    • APPARATUS, METHOD AND SYSTEM FOR REMOVING ORBITAL DEBRIS
    • 装置,方法和系统,用于移除ORBITAL DEBRIS
    • US20120085869A1
    • 2012-04-12
    • US13196869
    • 2011-08-02
    • Peter Lloyd
    • Peter Lloyd
    • B64G1/66B64G1/10
    • B64G1/52B64G1/66B64G1/68
    • Apparatus for a space platform comprises a magnetic field generator and/or an electric field generator respectively configured to generate fields for influencing the trajectory of one or more items of space debris passing within a region of the apparatus. A system comprising a plurality of such space platforms may be placed in an orbit proximal to an orbit containing space debris. An individual space platform or system thereof may be used in a method for displacing earth orbital space debris out of the orbit and either towards the Earth's atmosphere where it is likely to be destroyed by the burning on re-entry into the atmosphere, or into a safer orbit from which it may be collected or in which it may be left.
    • 用于空间平台的装置包括磁场发生器和/或电场发生器,其分别被配置为产生用于影响在装置的区域内通过的一个或多个空间碎片物品的轨迹的场。 包括多个这样的空间平台的系统可以放置在靠近包含空间碎片的轨道的轨道中。 一种单独的空间平台或其系统可以用于将地球轨道空间碎片从轨道中移出并且朝向地球大气层的方法中,其中它可能被重新进入大气中的燃烧而被破坏,或者变成 更安全的轨道,可以从中收集或在其中留下。
    • 17. 发明授权
    • Hot in-place asphalt recycling machine
    • 热就地沥青回收机
    • US07077601B2
    • 2006-07-18
    • US11073389
    • 2005-03-07
    • Peter Lloyd
    • Peter Lloyd
    • B62D61/12
    • E01C23/065E01C2301/50
    • A machine for providing hot-in-place recycling and repaving of an existing asphalt-based pavement, in which the pavement is first heated. Using this machine the heated pavement surface is then scarified, and new aggregate is dispensed onto it, to form a recycled, preheated asphalt and aggregate mixture. This mixture is again heated and scarified to premix it, and a new pavement surface is now milled to grade and width by applying this mixture using a plurality of extension mills having a main frame. The pavement surface is then remilled to grade using a main mill. Rejuvenator fluid is introduced in the main mill of the machine, and mixed with the recycled asphalt and aggregate mxiture. Rejuvenator fluid is also introduced into a pug mill of the machine and again mixed with the recycled asphalt and aggregate mixture. The rejuvenator-enriched, recycled asphalt and aggregate windrow thus formed is then laid to grade using one or more screeds.
    • 一种用于提供现场沥青路面的热回收再利用的机器,其中路面首先被加热。 使用该机器,加热的路面表面然后被划伤,并且将新的骨料分配到其上,以形成再循环的,预热的沥青和骨料混合物。 将该混合物再次加热并划伤以预混合,并且通过使用具有主框架的多个延伸磨机施加该混合物,现在将新的路面磨平成等级和宽度。 然后使用主磨机将路面重新浇注成型。 振动液被引入机器的主磨机,并与回收的沥青和骨料混合。 还可以将复原液引入机器的搅拌机中,再次与再生沥青和骨料混合物混合。 然后将如此形成的富含再生芦笋的再生沥青和骨料堆放置成使用一种或多种砂浆进行分级。
    • 19. 发明授权
    • Hot-in-place asphalt recycling machine and process
    • 现场沥青回收机和工艺流程
    • US06769836B2
    • 2004-08-03
    • US10171798
    • 2002-06-14
    • Peter Lloyd
    • Peter Lloyd
    • E01C700
    • E01C23/065E01C2301/50
    • A method for providing hot-in-place recycling and repaving of an existing asphalt-based pavement, in which the pavement is first heated. The heated pavement surface is then sacrified, and new aggregate is dispensed onto it, to form a recycled, preheated asphalt and aggregate mixture. This mixture is again heated and scarified to premix it, and a new pavement surface is now milled to grade and width by applying this mixture using a plurality of extension mills having a main frame. The pavement surface is then remilled to grade using a main mill. Rejuvenator fluid is introduced in the main mill, and mixed with the recycled asphalt and aggregate mixture. Rejuvenator fluid is also introduced into a pug mill and again mixed with the recycled asphalt and aggregate mixture. The rejuvenator-enriched, recycled asphalt and aggregate windrow thus formed is then laid to grade using one or more screeds.
    • 一种用于提供现有沥青路面的现场再循环和重新铺筑的方法,其中路面首先被加热。 然后处理加热的路面,并将新的骨料分配到其上,以形成再循环的,预热的沥青和骨料混合物。 将该混合物再次加热并划伤以预混合,并且通过使用具有主框架的多个延伸磨机施加该混合物,现在将新的路面磨平成等级和宽度。 然后使用主磨机将路面重新浇注成型。 在主磨机中引入复原液,并与回收的沥青和骨料混合物混合。 还原剂流体也被引入搅拌机中,再次与再循环的沥青和骨料混合物混合。 然后将如此形成的富含再生芦笋的再生沥青和骨料堆放置成使用一种或多种砂浆进行分级。
    • 20. 发明授权
    • Electroluminescent device
    • 电致发光器件
    • US4552782A
    • 1985-11-12
    • US634497
    • 1984-07-26
    • Alan F. CattellJohn KirtonPeter Lloyd
    • Alan F. CattellJohn KirtonPeter Lloyd
    • H05B33/10H05B33/12H05B33/14H05B33/22H05B33/28B05D3/02B05D5/12
    • H05B33/145H05B33/22H05B33/28
    • A method of electroluminescent panel manufacture in which a doped zinc chalcogenide phospher film--for example manganese doped zinc sulphide, is deposited upon an electrode bearing substrate in the presence of a hydrogen enriched atmosphere--for example a 90%:10% argon:hydrogen atmosphere. This is followed by rapid anneal treatment, the substrate being raised quickly to a temperature of 450.degree. C., or greater, and cooled rapidly. It is preferable that, prior to film deposition, the substrate is pretreated by baking in the hydrogen enriched atmosphere. An additional current density limiting film may be applied--a film of low resistance cermet material--for example silica/nickel 20% Ni in SiO.sub.2, or a film of amorphous silicon.
    • 一种电致发光面板制造方法,其中掺杂的硫化锌元素磷光体膜(例如掺杂锰的硫化锌)在富含氢气的气氛(例如90%:10%氩:氢气氛)的情况下沉积在带电极的衬底上 。 然后进行快速退火处理,将衬底快速升高至450℃或更高的温度,并迅速冷却。 优选的是,在膜沉积之前,通过在富氢气氛中的烘烤来预处理基板。 可以施加另外的电流密度限制膜 - 低电阻金属陶瓷材料的膜 - 例如SiO 2中的二氧化硅/镍20%Ni或非晶硅膜。