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11. 发明申请

US20170265464A1 CYCLOHEXYLAMINE-BASED COMPOUNDS AND USES THEREOF 审中-公开
公开(公告)号：US20170265464A1
公开(公告)日：2017-09-21
申请号：US15459656
申请日：2017-03-15
申请人： Roger A. Laine , Lucas Veillon , Gregg Henderson
发明人： Roger A. Laine , Lucas Veillon , Gregg Henderson
IPC分类号： A01N33/04 , A01N25/08
CPC分类号： A01N33/04 , A01N25/08 , A01N33/12 , A01N57/12
摘要： Compositions are described comprising an amount of a toxicant comprising a compound of the formula HNR1R2, or a salt thereof, wherein R1 and R2 are independently hydrogen, a substituted or unsubstituted C4-C6-cycloalkyl group or a substituted or unsubstituted C6-C12-aryl group; wherein the amount of the toxicant is sufficient to control termites. Methods for controlling termites using such compositions are also described.

12. 发明授权

US07351744B2 Naphthalene derivatives as termite repellents and toxicants 有权
标题翻译：萘衍生物作为白蚁驱避剂和有毒物质
公开(公告)号：US07351744B2
公开(公告)日：2008-04-01
申请号：US10641315
申请日：2003-08-14
申请人： Gregg Henderson , Sanaa A. Ibrahim , Rosemary Patton , Roger A. Laine , Betty C. R. Zhu , Feng Chen
发明人： Gregg Henderson , Sanaa A. Ibrahim , Rosemary Patton , Roger A. Laine , Betty C. R. Zhu , Feng Chen
IPC分类号： A01N35/00
CPC分类号： A01N31/04 , A01N27/00 , A01N31/14 , A01N35/04 , Y10S424/11
摘要： Several derivatives of naphthalene, including 1′-acetonaphthone, 2′-acetpnaphthone, 1-methoxynaphthalene, and 2-methoxynaphthalene, were discovered to be effective toxicants and repellents of termites, and resulted in significant reduction in termite feeding activity. For example, 2′-acetonaphthone was found to be an effective repellent and feeding deterrent of termites. Termites exposed to concentrations as low as 8 mg/kg sand exhibited a significant reduction in tunneling and feeding activity. Moreover, some of the dead termites had symptoms indicative of a failure to molt. At concentrations ≧20 μg/cm2, 2′-acetonaphthone was a strong repellent. Interestingly, at 160-fold lower concentration (0.125 μg/cm2), 2′-acetonaphthone stimulated termite feeding activity. As a sand barrier, 2′-acetonaphthone significantly inhibited tunneling and feeding activity in concentrations from 8.33 to 35.0 mg/kg. Molting problems were also identified in termites exposed to 2′-acetonaphthone.
摘要翻译：发现了萘的几种衍生物，包括1'-乙酰萘酮，2'-乙酸萘，1-甲氧基萘和2-甲氧基萘，是白蚁的有效毒素和驱避剂，导致白蚁进食活动显着降低。例如，发现2'-乙酰萘酮是有效的驱避剂和抑制白蚁的威慑。暴露于浓度低至8 mg / kg沙粒的白蚁显示隧道和进食活动的显着减少。此外，一些死亡的白蚁有表现为蜕皮失败的症状。在浓度≥20mug/ cm 2的情况下，2'-乙酰萘酮是强驱虫剂。有趣的是，在浓度为160倍（0.125mug / cm 2））的情况下，2'-乙酰萘酮刺激白蚁进食活性。作为沙屏障，2'-乙酰萘酮显着抑制了浓度为8.33〜35.0mg / kg的隧道和摄食活性。在暴露于2'-乙酰四氢萘酮的白蚁中也发现了溶解问题。

13. 发明授权

US5914239A Diagnosis of fungal infections, and a chitin-binding lectin useful in such diagnoses 失效
标题翻译：真菌感染的诊断和可用于这种诊断的几丁质结合凝集素
公开(公告)号：US5914239A
公开(公告)日：1999-06-22
申请号：US745881
申请日：1996-11-08
申请人： Roger A. Laine
发明人： Roger A. Laine
IPC分类号： C07K14/28 , G01N33/569 , G01N33/53
CPC分类号： C07K14/28 , G01N33/56961 , G01N2333/4724
摘要： A 134 kDa, calcium-independent, chitin-binding lectin called chitovibrin is secreted by marine bacteria of the genus Vibrio. The secretion of chitovibrin is inducible by chitin or chitin-oligomers. Chitovibrin shows no apparent enzymatic activity, but has a strong affinity for chitin and for chito-oligomers dp9 and larger. The protein has an isoelectric pH of 3.6, shows thermal tolerance, binds chitin with an optimum at pH 6 and is active in 0-4 M NaCl. Chitovibrin is useful as a stain for fungi and other chitin-containing organisms. Chitovibrin may be used to detect the presence of chitin, particularly in diagnosing fungal infections in humans, animals, and plant materials. Fungal infections are a particular problem in immunocompromised hosts such as AIDS patients and bone marrow transplant patients, because they can cause opportunistic infections. The chitovibrin diagnostic method allows the convenient, broad spectrum diagnosis of fungal infections in tissue samples or in body fluids. Other, smaller polypeptide fragments of chitovibrin will exhibit similar chitin-binding properties, and could be used in coupling to detection systems.
摘要翻译：称为chitovibrin的134 kDa，与钙无关的甲壳质结合凝集素由弧菌属的海洋细菌分泌。壳多糖蛋白的分泌可由几丁质或几丁质寡聚体诱导。 Chitovibrin没有显示出明显的酶活性，但对几丁质和chito-oligomers dp9及更大的亲和力。蛋白质具有3.6的等电点pH，显示耐热性，在pH 6下结合几丁质，最适pH为0-4M NaCl。 Chitovibrin可用作真菌和其他含几丁质的生物体的污渍。 Chitovibrin可用于检测几丁质的存在，特别是在诊断人类，动物和植物材料中的真菌感染时。免疫功能低下的宿主如艾滋病患者和骨髓移植患者，真菌感染是一个特别的问题，因为它们可能引起机会性感染。 chitovibrin诊断方法可以方便，广谱地诊断组织样本或体液中的真菌感染。其他较小的chitovibrin多肽片段将显示相似的几丁质结合性质，并可用于与检测系统的偶联。

14. 发明授权

US5587292A Diagnosis of fungal infections with a chitinase 失效
标题翻译：用几丁质酶诊断真菌感染
公开(公告)号：US5587292A
公开(公告)日：1996-12-24
申请号：US402772
申请日：1995-03-09
申请人： Roger A. Laine , Wai C. J. Lo
发明人： Roger A. Laine , Wai C. J. Lo
IPC分类号： C12N9/24 , G01N33/569 , G01N33/53 , G01N33/532 , G01N33/536
CPC分类号： C12Y302/01014 , C12N9/2442 , G01N33/56961 , Y10S435/96 , Y10S436/80 , Y10S436/801 , Y10S436/804 , Y10S436/805
摘要： A novel method for detecting chitin, and for diagnosing fungal infections (including yeast infections), with a chitinase or other chitin-specific binding protein. This method should allow the convenient, broad spectrum diagnosis of fungal infections in tissue samples or in body fluids. Fungal infections are a particular problem in immunocompromised hosts such as AIDS patients, where they can cause opportunistic infections. This invention overcomes difficulties experienced by prior methods of diagnosing fungal infections.
摘要翻译：一种用几丁质酶或其他几丁质特异性结合蛋白检测甲壳素和诊断真菌感染（包括酵母菌感染）的新方法。该方法应允许对组织样本或体液中真菌感染的方便，广谱的诊断。真菌感染是免疫功能低下的宿主如艾滋病患者中的特殊问题，在那里它们可引起机会性感染。本发明克服了现有诊断真菌感染方法所遇到的困难。

15. 发明授权

US5053406A Compositions and methods for preventing and treating rotaviral infections 失效
标题翻译：用于预防和治疗脊髓感染的组合物和方法
公开(公告)号：US5053406A
公开(公告)日：1991-10-01
申请号：US450198
申请日：1989-12-13
申请人： Cherly Srnka , Roger A. Laine , James Gilbert
发明人： Cherly Srnka , Roger A. Laine , James Gilbert
IPC分类号： A61K31/575
CPC分类号： A61K31/575
摘要： Compositions useful in the prevention and treatment of rotaviral infections are disclosed. The subject compositions contain cholesterol 3-sulfate or functional derivatives thereof. Cholesterol 3-sulfate avidly binds rotavirus in thin layer overlay assays and inhibits rotavirus in plaque reduction assays. These compositions can be used to prevent and ameliorate rotaviral infections.
摘要翻译：公开了用于预防和治疗轮状病毒感染的组合物。主题组合物含有胆固醇3-硫酸盐或其功能衍生物。胆固醇3-硫酸盐在薄层覆盖测定中狂热地结合轮状病毒，并在斑块减少测定中抑制轮状病毒。这些组合物可用于预防和改善轮状病毒感染。

16. 发明授权

US06890960B1 Vetiver oil extracts as termite repellent and toxicant 有权
标题翻译：香根草油提取物为白蚁驱避剂和毒物
公开(公告)号：US06890960B1
公开(公告)日：2005-05-10
申请号：US09856760
申请日：2000-10-18
申请人： Gregg Henderson , Roger A. Laine , Donald O. Heumann , Feng Chen , Betty C. R. Zhu
发明人： Gregg Henderson , Roger A. Laine , Donald O. Heumann , Feng Chen , Betty C. R. Zhu
IPC分类号： A01N31/00 , A01N31/06 , A01N35/00 , A01N35/06
CPC分类号： A01N31/06 , A01N35/06 , A01N27/00 , A01N25/08 , A01N2300/00
摘要： Extracts of vetiver oil were found to significantly repel termites. In one extract, nootkatone was isolated and found to be a significant repellent and toxicant of termites. Nootkatone significantly decreased food consumption, decreased tunneling behavior, and increased mortality in termites. Nootkatone is an effective repellent and toxicant of termites either by itself or as an addition to other materials or substrates, including mulches made from vetiver grass roots or other wood products. Nootkatone can also be used to protect construction wood from attack by Formosan subterranean termites. Nootkatone as a repellent is non-toxic to humans and other mammals and is environmentally safe. In addition, α-cedrene was found to be a weak termite repellent; and both zizanol and bicyclovetivenol were found to be repellents and toxicants of termites.
摘要翻译：发现香根草油的提取物显着排斥白蚁。在一种提取物中，分离出诺塔卡酮，发现它是一种重要的驱避剂和有毒的白蚁。 Nootkatone显着降低了食物消耗，降低了隧道行为，并增加了白蚁死亡率。 Nootkatone是一种有效的驱虫剂和有毒物质的白蚁，其本身或作为其他材料或底物的添加剂，包括由香根草草根或其他木制品制成的覆盖物。 Nootkatone也可用于保护建筑木材免受台山地下白蚁的攻击。 Nootkatone作为驱避剂对人类和其他哺乳动物无毒，对环境无害。此外，发现α-雪松是一种弱白蚁驱虫剂; 发现齐赞醇和双环己酮醇都是白蚁的驱避剂和毒物。

17. 发明授权

US06184027B2 Isolation and purification of eubacteria and fungus with catalytically inactive murein binding enzymes 失效
标题翻译：用真菌和真菌分离和纯化具有催化活性的murein结合酶
公开(公告)号：US06184027B2
公开(公告)日：2001-02-06
申请号：US09262419
申请日：1999-03-04
申请人： Roger A. Laine , Wai Chun.Jennifer Lo
发明人： Roger A. Laine , Wai Chun.Jennifer Lo
IPC分类号： C12N102
CPC分类号： C12N9/2462 , C07K14/001 , C12Q1/04 , C12Q1/18 , C12Y302/01017 , G01N33/569 , G01N33/573 , G01N2333/245 , G01N2333/40 , G01N2333/914 , G01N2333/924
摘要： Catalytically inactive murein binding enzyme diagnostic reagents and methods and kits for detecting eubacteria and fungus in biological samples.
摘要翻译：催化无活性的murein结合酶诊断试剂和用于检测生物样品中真细菌和真菌的方法和试剂盒。

18. 发明授权

US5935804A Method for detecting eubacteria in biological samples with catalytically inactive murein binding enzymes 失效
标题翻译：用催化无活性的murein结合酶检测生物样品中的真细菌的方法
公开(公告)号：US5935804A
公开(公告)日：1999-08-10
申请号：US823293
申请日：1997-03-21
申请人： Roger A. Laine , Wai C. J. Lo
发明人： Roger A. Laine , Wai C. J. Lo
IPC分类号： C07K14/00 , C12M1/00 , C12N9/24 , C12N9/36 , C12N9/96 , C12Q1/04 , C12Q1/06 , C12Q1/18 , C12Q1/26 , C12Q1/34 , C12Q1/48 , G01N33/569 , G01N33/573 , C12Q1/02
CPC分类号： C12N9/2462 , C07K14/001 , C12Q1/04 , C12Q1/18 , C12Y302/01017 , G01N33/569 , G01N33/573 , G01N2333/245 , G01N2333/40 , G01N2333/914 , G01N2333/924
摘要： A method for detecting eubacteria in biological samples with catalytically inactive murein binding enzyme is presented. The biological sample may be chemically treated with alkali to cleave peptide bonds in the sample before incubating the sample with the catalytically inactive murein binding enzyme.
摘要翻译：提出了一种利用催化无活性的murein结合酶检测生物样品中真细菌的方法。在将样品与催化无活性的murein结合酶孵育之前，生物样品可以用碱化学处理以切割样品中的肽键。

19. 发明授权

US5874097A Compositions and methods for detecting and killing termites 失效
公开(公告)号：US5874097A
公开(公告)日：1999-02-23
申请号：US988911
申请日：1997-12-11
申请人： Gregg Henderson , Jian Chen , Roger A. Laine
发明人： Gregg Henderson , Jian Chen , Roger A. Laine
IPC分类号： A01N25/00 , A01N27/00 , A01N31/14 , A01N45/00
CPC分类号： A01N45/00 , A01N25/006 , A01N27/00 , A01N31/14 , Y10S424/11
摘要： Significant concentrations of naphthalene were detected in carton nests of Formosan subterranean termites, Coptotermes formosanus Shiraki, collected from Florida, Hawaii, and Louisiana. This is the first report of naphthalene being associated with termites or any other insects. Naphthalene and other compounds associated with termite carton nests may be used to increase termite bait acceptance. New attractant molecules include 2-phenoxyethanol. New feeding stimulants include ergosterol. A list of volatile compounds associated with termite nests is presented, compounds that may be used to detect termite nests.

20. 发明授权

US5693519A Thermostable, salt tolerant, wide pH range novel chitobiase 失效
标题翻译：热稳定性，耐盐性，宽pH范围新型chitobiase
公开(公告)号：US5693519A
公开(公告)日：1997-12-02
申请号：US455837
申请日：1995-05-31
申请人： Roger A. Laine , Chin-Yih Ou
发明人： Roger A. Laine , Chin-Yih Ou
IPC分类号： C12N1/21 , C12N9/24 , C12N15/56 , C12N9/42 , C12N15/70
CPC分类号： C12Y302/01052 , C12N9/2402 , C12Y302/0102
摘要： A cloned chitobiase from a Vibrio parahemolyticus gene cloned into the plasmid pUC18 in E. coli strain DH5.alpha.. The plasmid construct, called pC120, had a 6.4 kb DNA insert. The recombinant gene expressed chitobiase activity similar to that found in native V. parahemolyticus. In addition to chitobiose, at least six additional substrates were observed to be hydrolyzed by the recombinant chitobiase, including .beta.-N-acetyl galactosamine glycosides, showing that the enzyme is an N-acetyl-hexosaminidase. The enzyme showed resistance to denaturation by 2M NaCl, was thermostable at 45.degree. C., and possessed an unusual range of activity from pH 5 to 9. The enzyme is useful in the degradation of crustacean shells. It catalyzes the production of N-acetyl-glucosamine, a compound which should be valuable as a chiral precursor or intermediate in the synthesis or manufacture of pharmaceutical compounds.
摘要翻译：克隆在大肠杆菌菌株DH5α中的质粒pUC18中的来自副溶血弧菌基因的克隆的木质素酶。称为pC120的质粒构建体具有6.4kb的DNA插入片段。重组基因表达类似于天然副溶血弧菌中发现的木质素酶活性。除了壳寡糖之外，观察到至少六个另外的底物被重组壳寡糖酶水解，包括β-N-乙酰半乳糖胺糖苷，显示该酶是N-乙酰基 - 氨基己糖苷酶。该酶显示出由2M NaCl变性的抗性，在45℃下耐热，并且具有从pH5至9的不寻常的活性范围。该酶可用于甲壳类壳的降解。它催化N-乙酰葡糖胺的生产，该化合物在药物化合物的合成或制备中应当作为手性前体或中间体有价值。

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