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11. 发明申请

US20100256096A1 Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses 有权
标题翻译：磺酰氨基脲，羰基氨基脲，氨基脲和脲，其药物组合物，以及用于治疗出血热病毒的方法，包括与纳米病毒有关的感染
公开(公告)号：US20100256096A1
公开(公告)日：2010-10-07
申请号：US11653972
申请日：2007-01-17
申请人： Dongcheng Dai , Tove C. Bolken , Dennis E. Hruby , Thomas R. Bailey
发明人： Dongcheng Dai , Tove C. Bolken , Dennis E. Hruby , Thomas R. Bailey
IPC分类号： A61K31/675 , A61K31/18 , C07C311/15 , A61K31/536 , C07D265/36 , A61K31/5377 , C07D413/04 , A61P31/12
CPC分类号： A61K31/175 , A61K31/18 , A61K31/277 , A61K31/40 , A61K31/415 , A61K31/433 , A61K31/5377 , A61K31/538 , A61K31/675 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/42 , C07C281/06 , C07C311/49 , C07D213/70 , C07D233/84 , C07D261/10 , C07D277/36 , C07D285/06 , C07D295/20 , C07D295/22 , C07D317/66 , C07D319/18
摘要： Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pinchinde, and VSV), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
摘要翻译：公开了通过以治疗有效量施用某些新型磺酰氨基脲，羰基氨基脲，氨基脲，脲和相关化合物来治疗病毒感染的化合物，方法和药物组合物。还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。具体地，公开了治疗和预防由出血热病毒引起的病毒感染，即，包括但不限于：金杆菌科（Junin，Machupo，Guanarito，Sabia，Lassa，Tacaribe，Pinchinde和VSV），丝状病毒科埃博拉病毒和马尔堡病毒），黄病毒科（黄热病，o疮出血热和Kyasanur森林病毒病毒）和布亚病毒科（裂谷热）。

12. 发明授权

US08518951B2 Anti-arenaviral compounds 失效
标题翻译：抗-nnaviral化合物
公开(公告)号：US08518951B2
公开(公告)日：2013-08-27
申请号：US13338726
申请日：2011-12-28
申请人： Dennis E. Hruby , Tove C. Bolken , Dongcheng Dai
发明人： Dennis E. Hruby , Tove C. Bolken , Dongcheng Dai
IPC分类号： A61K31/4965
CPC分类号： A61K31/496
摘要： Described herein are 4-methyl-piperazine-1-carbothioic acid amide derivatives and analogs, as well as compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by hemorrhagic fever viruses, such as Arenaviruses.
摘要翻译：本文描述的是4-甲基 - 哌嗪-1-硫代羧酸酰胺衍生物和类似物以及含有它们的组合物，用于治疗或预防病毒感染和与之相关的疾病，特别是那些由出血热引起的病毒感染和相关疾病病毒，如沙病毒属。

13. 发明授权

US08492434B2 Antiviral drugs for treatment of arenavirus infection 失效
公开(公告)号：US08492434B2
公开(公告)日：2013-07-23
申请号：US13402167
申请日：2012-02-22
申请人： Dennis E. Hruby , Tove C. Bolken , Sean Amberg , Dongcheng Dai
发明人： Dennis E. Hruby , Tove C. Bolken , Sean Amberg , Dongcheng Dai
IPC分类号： A61K31/34 , A61K31/38 , A61K31/195 , A61K31/16
CPC分类号： C07C251/86 , A61K31/165 , A61K31/343 , C07C251/76 , C07C251/82 , C07C2601/02 , C07C2601/14 , C07C2603/20 , C07D209/40 , C07D307/68 , C07D333/22 , C07D333/38 , Y02A50/387 , Y02A50/397
摘要： Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).

14. 发明授权

US08148428B2 Antiviral drugs for treatment of arenavirus infection 有权
标题翻译：用于治疗斑马鱼病毒感染的抗病毒药物
公开(公告)号：US08148428B2
公开(公告)日：2012-04-03
申请号：US12281081
申请日：2007-03-02
申请人： Dennis E. Hruby , Tove C. Bolken , Sean Amberg , Dongcheng Dai
发明人： Dennis E. Hruby , Tove C. Bolken , Sean Amberg , Dongcheng Dai
IPC分类号： A61K31/16
CPC分类号： C07C251/86 , A61K31/165 , A61K31/343 , C07C251/76 , C07C251/82 , C07C2601/02 , C07C2601/14 , C07C2603/20 , C07D209/40 , C07D307/68 , C07D333/22 , C07D333/38 , Y02A50/387 , Y02A50/397
摘要： Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
摘要翻译：公开了通过施用治疗有效量的某些新化合物来治疗病毒感染的化合物，方法和药物组合物。还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。特别地，公开了治疗和预防由出血热病毒引起的病毒感染，即，包括但不限于：链球菌科（Junin，Machupo，Guanarito，Sabia，Lassa，Tacaribe和Pichinde），丝状病毒科（埃博拉马尔堡病毒），黄病毒科（黄热病，鄂木斯克出血热和Kyasanur森林病毒）和布尼瓦病毒（裂谷热）。

15. 发明申请

US20110027227A1 ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION 失效
标题翻译：用于治疗阿尔茨海默病感染的药物
公开(公告)号：US20110027227A1
公开(公告)日：2011-02-03
申请号：US12735392
申请日：2009-01-14
申请人： Dongcheng Dai , Dennis E. Hruby , Tove C. Bolken , Sean M. Amberg , Travis K. Warren
发明人： Dongcheng Dai , Dennis E. Hruby , Tove C. Bolken , Sean M. Amberg , Travis K. Warren
IPC分类号： A61K38/21 , A61K31/4184 , C07D403/04 , A61P31/14 , A61K39/00 , A61K31/7056 , A61K31/675 , C07D471/04 , A61K31/437
CPC分类号： C07D235/20 , A61K9/0014 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/02 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4866 , A61K31/4184 , C07D471/04
摘要： Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family is disclosed.
摘要翻译：公开了通过施用治疗有效量的某些化合物来治疗病毒感染的化合物，方法和药物组合物。还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。特别地，公开了由雷亚病毒家族引起的病毒感染的治疗和预防。

16. 发明授权

US07417069B2 Halogenated triptolide derivatives as immunomodulators and anticancer agents 失效
标题翻译：卤代雷公藤内酯衍生物作为免疫调节剂和抗癌剂
公开(公告)号：US07417069B2
公开(公告)日：2008-08-26
申请号：US11210677
申请日：2005-08-23
申请人： Dongcheng Dai , John H. Musser
发明人： Dongcheng Dai , John H. Musser
IPC分类号： A61K31/36 , C07D493/14
CPC分类号： C07D493/22
摘要： Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C═O, CHF, CF2 and C(CF3)OH; CR6 and CR13 are selected from CH, COH and CF; CR7R8, CR9R10 and CR11R12 are selected from CH2, CHOH, C═O, CHF and CF2; and CR3R4R5 is selected from CH3, CH2OH, C═O, COOH, CH2F, CHF2 and CF3; such that: at least one of R1-R13 comprises fluorine; no more than two of CR3R4R5, CR6, CR7R8, CR9R10, CR11R12, and CR13 comprises fluorine or oxygen; and, when CR1R2 is CHOH, CR3R4R5 is not CH2F.
摘要翻译：具有结构I的化合物可用于诱导细胞死亡（凋亡）和免疫抑制。在结构I中，CR 1，R 2选自CHOH，CO，CHF，CF 2和C（CF 3） OH）; CR 6和CR 13选自CH，COH和CF; R＆lt; 9＆gt; 8＆lt; 9＆gt;＆lt; 9＆lt; 10＆gt;和＆lt; 11＆gt; > 12 选自CH 2，CHOH，CO，CHF和CF 2; 和CR 3 R 4选自CH 3，CH 2，CH 2， OH，CO，COOH，CH 2，F，CHF 2和CF 3; 使得：R 1〜R 13中的至少一个包含氟; 不超过两个CR 3，R 4，R 5，CR 6，CR 7，其中，R 8，R 9，R 10，R 11，R 12，并且CR 13包括氟或氧; 当CR <1> 2 2时为CHOH时，CR 3 R 4 R 5 O >不是CH 2。

17. 发明申请

US20080004452A1 Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases 有权
标题翻译：用于治疗和预防正痘病毒感染和相关疾病的化学品，组合物和方法
公开(公告)号：US20080004452A1
公开(公告)日：2008-01-03
申请号：US11785997
申请日：2007-04-23
申请人： Robert Jordan , Thomas Bailey , Susan Rippin , Dongcheng Dai
发明人： Robert Jordan , Thomas Bailey , Susan Rippin , Dongcheng Dai
IPC分类号： C07D209/72
CPC分类号： C07D209/50 , C07D401/12 , C07D409/12 , C07D417/12
摘要： Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.
摘要翻译：使用二，三和四环酰肼衍生物及其类似物的方法，以及含有它们的药物组合物，用于治疗或预防病毒感染和与之相关的疾病，特别是由正痘病毒引起的那些病毒感染和相关疾病。

18. 发明申请

US20060128975A1 Triptolide derivatives as immunomodulators and anticancer agents 失效
公开(公告)号：US20060128975A1
公开(公告)日：2006-06-15
申请号：US11340928
申请日：2006-01-27
申请人： Dongcheng Dai , John Musser
发明人： Dongcheng Dai , John Musser
IPC分类号： A61K31/365 , C07D493/14
CPC分类号： C07D493/22
摘要： Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R1 together with R2=O (oxo); R2=OH, or, R1 and R2 together=O (oxo); CR3R5 and CR4R6 are selected from CH2, CHOH and CROH; at least one of R1, R5 and R6 is R; and at least one of CR3R5 and CR4R6 is CH2.

19. 发明授权

US07019151B2 Triptolide derivatives as immunomodulators and anticancer agents 失效
标题翻译：雷公藤内酯衍生物作为免疫调节剂和抗癌剂
公开(公告)号：US07019151B2
公开(公告)日：2006-03-28
申请号：US10738753
申请日：2003-12-16
申请人： Dongcheng Dai , John H. Musser
发明人： Dongcheng Dai , John H. Musser
IPC分类号： C07D307/93
CPC分类号： C07D493/22
摘要： Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R1 together with R2=O (oxo); R2=OH, or, R1 and R2 together=O (oxo); CR3R5 and CR4R6 are selected from CH2, CHOH and CROH; at least one of R1, R5 and R6 is R; and at least one of CR3R5 and CR4R6 is CH2.
摘要翻译：具有结构I的化合物可用于诱导细胞死亡（凋亡）和免疫抑制。在结构I中，R 1是H或R，R选自低级烷基，烯基，炔基和烯丙基，或者R 1与R 2一起 O（氧代）; R 2 = OH，或R 1和R 2一起= O（氧代）; CH 3，R 5和R 4选自CH 2，CH 2， CHOH和CROH; R 1，R 5和R 6以及R 6中的至少一个为R; 并且CR 3和R 5中的至少一个是CH 2， SUB>。

20. 发明授权

US06943259B2 Halogenated triptolide derivatives as immunomodulators and anticancer agents 失效
公开(公告)号：US06943259B2
公开(公告)日：2005-09-13
申请号：US10786663
申请日：2004-02-24
申请人： Dongcheng Dai , John H. Musser
发明人： Dongcheng Dai , John H. Musser
IPC分类号： A61K20060101 , A61K31/34 , A61K31/36 , A61K31/365 , C07D307/77 , C07D407/00 , C07D491/14 , C07D493/14 , C07D493/22
CPC分类号： C07D493/22
摘要： Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C═O, CHF, CF2 and C(CF3)OH; CR6 and CR13 are selected from CH, COH and CF; CR7R8, CR9R10 and CR11R12 are selected from CH2, CHOH, C═O, CHF and CF2; and CR3R4R5 is selected from CH3, CH2OH, C═O, COOH, CH2F, CHF2 and CF3; such that: at least one of R1-R13 comprises fluorine; no more than two of CR3R4R5, CR6, CR7R8, CR9R10, CR11R12, and CR13 comprises fluorine or oxygen; and, when CR1R2 is CHOH, CR3R4R5 is not CH2F.

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